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Isolation, characterization and modulatory potentials of β-stigmasterol, ergosterol and xylopic acid from Anchomanes difformis on mitochondrial permeability transition pore in vitro

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Chinese Herbal Medicines 2023年第4期15卷 533-541页

作者： Kehinde Oluseun Sodeinde Akinwunmi Oluwaseun Adeoye Adedeji Adesipo Adebayo AAdeniyi john adeolu falode Tajudeen Olabisi Obafemi Samuel Olalekan Olusanya Linette Twigge Jeanet Conradie Timothy O.Mosaku Department of Chemistry Federal University Oye-EkitiEkiti State 371104Nigeria Biomembrane Toxicology and Drug Discovery UnitDepartment of BiochemistryFederal University Oye-EkitiEkiti State 371104Nigeria Department of Biochemistry Afe Babalola UniversityAdo-EkitiEkiti State 360001Nigeria Department of Chemistry University of Free StateBloemfontein 9301South Africa Department of Civil Engineering Covenant UniversityOgun State 112104Nigeria

Objective: Secondary metabolites and polyphenolic compounds from medicinal plants have been demonstrated to have multiple biological functions with promising research and development prospects. This study examined the effect of β-stigmasterol(with ergosterol) and xylopic acid isolated from Anchomanes difformis on liver mitochondrial permeability transition pore(mPTP).Methods: The compounds were isolated by vacuum liquid chromatography. Mitochondrial swelling was assessed as changes in absorbance under succinate-energized ***:1H and13C NMR spectroscopic elucidation of the isolates affirmed the presence of β-stigmasterol with ergosterol(1:0.3) and xylopic acid. The isolates reversed the increase in lipid peroxidation and inhibited the opening of mitochondrial permeability transition pores caused by calcium and *** inhibition of m PTP offers a promising therapeutic target for the treatment of mitochondrial-associated ***: Reduction in the activity of calcium ATPase and the expression of Caspase-3 and-9 were observed, suggesting that they could play a role in protecting physicochemical properties of membrane bilayers from free radical-induced severe cellular damage and be useful in the management of diseases where much apoptosis occurs.

关键词： Anchomanes difformis(Blume)Engl ergosterol mitochondrial membrane modulation β-stigmasterol transition pore xylopic acid

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