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The Third International Conference on Solid State and Integrated Circuit Technology

作者： john E.J.Schmitz john adachi Process Development Engineering Thin Films Division Genus Inc. 515 Ellis Street Mountain View CA 94043 USA Process Development Engineering Thin Films Division Genus Inc. 515 Ellis Street Mountain View CA 94043 USA

＜正＞ Several issues which exist in poly-cide gate electrode applications will be reviewed in this presentation. Among those are film adhesion, step coverage, and gate oxide thickness control. It will be pointed out that WSix based on SiH6/WF6 chemistry exhibits certain shortcomings such as limited step coverage when applied in circuits with design rules smaller than 0.5um,such as 16MbDRAM and beyond. Fortunately, WSix based on SiH2Cl2/WF6 chemistry appears very promising for application in gate electrodes in ULSI devices.

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New simulation model for bone formation markers in osteoporosis patients treated with once-weekly teriparatide

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Bone Research 2014年第4期2卷 252-258页

作者： Sakae Tanaka Taiji adachi Tatsuhiko Kuroda Toshitaka Nakamura Masataka Shiraki Toshitsugu Sugimoto Yasuhiro Takeuchi Mitsuru Saito john P Bilezikian Department of Orthopaedic Surgery Faculty of MedicineUniversity of TokyoTokyoJapan Department of Biomechanics Institute for Frontier Medical SciencesKyoto UniversityKyotoJapan Medical Affairs Department Asahi Kasei Pharma CorporationTokyoJapan National Center for Global Health and Medicine TokyoJapan Research Institute and Practice for Involutional Diseases NaganoJapan Internal Medicine 1 Shimane University Faculty of MedicineIzumoJapan Toranomon Hospital Endocrine Center TokyoJapan Department of Orthopaedic Surgery Jikei University School of MedicineTokyoJapan Metabolic Bone Diseases Program Division of EndocrinologyDepartment of MedicineCollege of Physicians and SurgeonsColumbia UniversityNew YorkUSA

Daily 20-mg and once-weekly 56.5-mg teriparatide（parathyroid hormone 1–34） treatment regimens increase bone mineral density（BMD） and prevent fractures, but changes in bone turnover markers differ between the two regimens. The aim of the present study was to explain changes in bone turnover markers using once-weekly teriparatide with a simulation model. Temporary increases in bone formation markers and subsequent decreases were observed during once-weekly teriparatide treatment for 72 weeks. These observations support the hypothesis that repeated weekly teriparatide administration stimulates bone remodeling, replacing old bone with new bone and leading to a reduction in the active remodeling surface. A simulation model was developed based on the iterative remodeling cycle that occurs on residual old bone. An increase in bone formation and a subsequent decrease were observed in the preliminary simulation. For each fitted time point, the predicted value was compared to the absolute values of the bone formation and resorption markers and lumbar BMD. The simulation model strongly matched actual changes in bone turnover markers and BMD. This simulation model indicates increased bone formation marker levels in the early stage and a subsequent decrease. It is therefore concluded that remodeling-based bone formation persisted during the entire treatment period with once-weekly teriparatide.

关键词： bone New simulation model for bone formation markers in osteoporosis patients treated with once-weekly teriparatide BMD

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VAPOR-LIQUID EQUILIBRIUM IN THE SYSTEM CARBON DIOXIDE/ISO-PENTANE FROM 253 TO 443 K AT PRESSURES UP TO 10 MPa

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Chinese Journal of Chemical Engineering 1992年第2期 157-163页

作者：程华哲 john A. Zollweg William B. Streett Beijing Research Institute of Chemical Industry School of Chemical Engineering Cornell University Ithaca NY14853 U.S.A.

Equilibrium pressures and compositions for the binary mixture carbon dioxide-iso-pentane were measured on nine isotherms from 253K to the iso-pentane critical temperature. On each isotherm, the entire pressure range of phase coexistence was covered. The mixture critical line has been located and is shown to be contiuous in Pressure-Temperature-Composition (P-T-X) space between the critical points of the pure components. Comparisons are made between the experimental results obtained by Besserer-Robinson and this work with predictions of the Soave-Redlich Kwong, Peng-Robinson, Kubic-Martin, and adachi-Lu-Sugle cubic equations of state. None was able to correlate the data within our estimated experimental error.

关键词： iso-pentane carbon dioxide phase equilibrium

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