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Movement analysis in the diagnosis and management of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 485-486页

作者： johannes Burtscher Nicolas Bourdillon Jules MJanssen Daalen Aurélien Patoz Julien FBally Martin Kopp Davide Malatesta Bastiaan RBloem Institute of Sport Sciences University of LausanneLausanneSwitzerland Radboud University Medical Center Department of NeurologyDonders Institute for BrainCognition and BehaviorCenter of Expertise for Parkinson and Movement DisordersNijmegenThe Netherlands Radboud University Medical Center Department of Medical BioSciencesNijmegenThe Netherlands Research and Development Department Volodalen Swiss Sport LabAigleSwitzerland Service of Neurology Department of Clinical NeurosciencesLausanne University Hospital(CHUV)and University of Lausanne(UNIL)LausanneSwitzerland Department of Sport Science University of InnsbruckInnsbruckAustria

Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall ***,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses *** biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024).

关键词： diagnosis Clinical eventually

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Large scale mapping of forest attributes using heterogeneous sets of airborne laser scanning and National Forest Inventory data

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Forest Ecosystems 2021年第4期8卷 872-886页

作者： Marius Hauglin johannes Rahlf johannes Schumacher Rasmus Astrup johannes Breidenbach Norwegian Institute of Bioeconomy Research AsNorway

Background:The Norwegian forest resource map(SR16)maps forest attributes by combining national forest inventory(NFI),airborne laser scanning(ALS)and other remotely sensed *** the ALS data were acquired over a time interval of 10 years using various sensors and settings,the NFI data are continuously *** of this study were to analyze the effects of stratification on models linking remotely sensed and field data,and assess the accuracy overall and at the ALS project *** and methods:The model dataset consisted of 9203 NFI field plots and data from 367 ALS projects,covering 17 Mha and 2/3 of the productive forest in ***-effects regression models were used to account for differences among ALS *** types of stratification were used to fit models:1)stratification by the three main tree species groups spruce,pine and deciduous resulted in species-specific models that can utilize a satellite-based species map for improving predictions,and 2)stratification by species and maturity class resulted in stratum-specific models that can be used in forest management inventories where each stand regularly is visually stratified *** models were compared to general models that were fit without stratifying the ***:The species-specific models had relative root-mean-squared errors(RMSEs)of 35%,34%,31%,and 12% for volume,aboveground biomass,basal area,and Lorey’s height,*** RMSEs were 2-7 percentage points(pp)smaller than those of general *** validating using predicted species,RMSEs were 0-4 *** than those of general *** stratified by main species and maturity class further improved RMSEs compared to species-specific models by up to 1.8 *** mixed-effects models over ordinary least squares models resulted in a decrease of RMSE for timber volume of 1.0-3.9 pp.,depending on the main tree *** for timber volume ranged between 19%-59% among individual ALS ***

关键词： NFI Lidar Mixed-effects models Wall-to-wall mapping

Recent status of fluidized bed technologies for producing iron input materials for steelmaking

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Particuology 2011年第1期9卷 14-23页

作者： johannes Leopold Schenk Department of Metallurgy University of Leoben Franz-Josef-Straβe 18 A-8700 Leoben Austria

Today steel is produced by two steelmaking processes, the basic oxygen furnace and the electric arc furnace, Three types of iron input materials for both processes are liquid hot metal or in solidified form as pig iron, direct reduced iron （DRI） and hot briquetted iron （HB1） as well as steel scrap. Hot metal, pig iron, DRI and HBI are virgin iron materials, which have to be produced from iron ore by the so-called ironmaking technologies. New ironmaking processes based on fluidized bed technology have been developed in the last two decades. The main advantage of these technologies is that fine ore can be directly used in the processes and prior treatment such as sintering or pelletizing can be avoided which is required for the established processes. Theoretical aspects for reduction of fine iron oxides in a fluidized bed reactor system will be explained. The fluidized bed reducing technologies utilized in the most advanced new ironmaking processes for direct use of fine ore, FINMET, Circored, FINEX~ and Hismelt will be compared.

关键词： FINEX  Circored  FINMET  HIsmelt  Fluidized bed Reactor Fine iron ore Ironmaking

Fluidization behavior and reducibility of iron ore fines during hydrogen-induced fluidized bed reduction

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Particuology 2020年第5期18卷 36-46页

作者： Daniel Spreitzer johannes Schenk Chair of Ferrous Metallurgy Montanuniversitaet LeobenFranz-Josef-Straβe 188700 LeobenAustria

A laboratory fluidized bed reactor was used to investigate the fluidization behavior and reducibility of various iron ore *** was chosen as a reducing agent across a temperature range of 873-1073 *** magnetite ore used exhibited strong sticking behavior after the initiation of metallic iron *** other tested ores fluidized sufficiently well when subjected to the same high reduction *** kinetic analysis was conducted using a previously developed model to include three rate-limiting step *** trend of apparent activation energy was correlated with the degree of ***,the influence of varying the specific gas rate was *** results show the variation in reducibility as a result of different interactions,which influence the rate-limiting mechanisms of nucleation and the undertaken chemical reactions,which vary as a function of temperature and degree of *** apparent activation energies,determined from the reduction of wtistite to metallic iron,were in the range of 15-60 kJ/mol,depending on the iron ore used and the degree of *** change in apparent activation energy deriving from the increased specific gas rate can be explained by an increasing nucleation effect,especially at lower reduction temperatures.

关键词： Fluidized bed Iron ore reduction Hydrogen Fluidization behavior Kinetic analysis

Sucrose transporters and plasmodesmal regulation in passive phloem loading

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Journal of Integrative Plant Biology 2017年第5期59卷 311-321页

作者： johannes Liesche College of Life Science Northwest A&F University No 3 Taicheng Road Yangling 712100 China Biomass Energy Center for Arid and Semi-arid lands Northwest A&F University Yangling 712100 China

An essential step for the distribution of carbon throughout the whole plant is the loading of sugars into the phloem in source organs. In many plants, accumulation of sugars in the sieve element-companion cell （SE-CC） complex is mediated and regulated by active processes. However, for poplar and many other tree species, a passive symplasmic mechanism of phloem loading has been proposed, characterized by symplasmic continuity along the pre-phloem pathway and the absence of active sugar accumulation in the SE-CC complex. A high overall leaf sugar concentration is thought to enable diffusion of sucrose into the phloem. In this review, we critically evaluate current evidence regarding the mechanism of passive syrnplasmic phloem loading, with a focus on the potential influence of active sugar transport and plasmo- desmal regulation. The limited experimental data, com- bined with theoretical considerations, suggest that a concomitant operation of passive symplasmic and active phloem loading in the same minor vein is unlikely. However, active sugar transport could well play an important role in how passively loading plants might modulate the rate of sugar export from leaves. Insights into the operation of this mechanism has direct implications for our understanding of how these plants utilize assimilated carbon.

关键词： William J. Lucas University of California Davis USA

Mapping forest age using National Forest Inventory,airborne laser scanning,and Sentinel-2 data

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Forest Ecosystems 2020年第4期7卷 793-806页

作者： johannes Schumacher Marius Hauglin Rasmus Astrup johannes Breidenbach National Forest Inventory Norwegian Institute of Bioeconomy ResearchÅsNorway

Background:The age of forest stands is critical information for forest management and conservation,for example for growth modelling,timing of management activities and harvesting,or decisions about protection ***,area-wide information about forest stand age often does not *** this study,we developed regression models for large-scale area-wide prediction of age in Norwegian *** model development we used more than 4800 plots of the Norwegian National Forest Inventory(NFI)distributed over Norway between latitudes 58°and 65°N in an 18.2 Mha study *** variables were based on airborne laser scanning(ALS),Sentinel-2,and existing public map *** performed model validation on an independent data set consisting of 63 spruce stands with known ***:The best modelling strategy was to fit independent linear regression models to each observed site index(SI)level and using a SI prediction map in the application of the *** most important predictor variable was an upper percentile of the ALS heights,and root mean squared errors(RMSEs)ranged between 3 and 31 years(6%to 26%)for SI-specific models,and 21 years(25%)on *** deviance(MD)ranged between^(−1) and 3 *** models improved with increasing SI and the RMSEs were largest for low SI stands older than 100 *** a mapped SI,which is required for practical applications,RMSE and MD on plot level ranged from 19 to 56 years(29%to 53%),and 5 to 37 years(5%to 31%),*** the validation stands,the RMSE and MD were 12(22%)and 2 years(3%),***:Tree height estimated from airborne laser scanning and predicted site index were the most important variables in the models describing ***,we obtained good results,especially for stands with high *** models could be considered for practical applications,although we see considerable potential for improvements if better SI maps were available.

关键词： Forest age Lidar Optical satellite images Remote sensing Forest inventory

Application of dynamic image analysis to the optical characterisation of fibrous bulk material

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Particuology 2024年第7期90卷 51-60页

作者： johannes Lunewski Eberhard Schmidt Institute of Particle Technology University of WuppertalGermany

Dynamic image analysis provides an automated evaluation method to determine the size and shape of multiple particles. This method represents a common application for ordinary bulk material. The latest draft of ISO 13322–2:2021 describes the state of the art, but lacks instructions for handling fibrous bulk material. Interlocking fibres complicate the measurement conditions and require a disentanglement of fibrous samples during a pre-dispersion step. A further error source includes the fibre orientation inside the measurement zone of the device. If the thresholding algorithm fails to differentiate between the fibre projection area and the background, a subsequent image optimisation solves the problem. This article addresses the mentioned problems by analysing cotton cellulose and polyacrylonitrile fibres. Besides the execution of a pre-dispersion step, the experiments compare the discrepancies between dry and wet dispersion. Here, the software packages PAQXOS and ImageJ perform the image evaluation. In this case, the wet dispersion setup with a subsequent image evaluation by ImageJ provides comprehensible results.

关键词： Bootstrap method Dynamic image analysis Fibre diameter Fibre length distribution Natural fibres Synthetic fibres

Encapsulation of Ru(II) Polypyridine Complexes for Tumor-Targeted Anticancer Therapy

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Biomedical Engineering Frontiers 2023年第1期4卷 52-65页

作者： johannes Karges Faculty of Chemistry and Biochemistry Ruhr-University BochumUniversitasstrasse 15044780 BochumGermany.

Ru(II)polypyridine complexes have attracted much attention as anticancer agents because of their unique photophysical,photochemical,and biological *** their promising therapeutic profile,the vast majority of compounds are associated with poor water solubility and poor cancer *** the different strategies employed to overcome these pharmacological limitations,many research efforts have been devoted to the physical or covalent encapsulation of the Ru(II)polypyridine complexes into *** article highlights recent developments in the design,preparation,and physicochemical properties of Ru(II)polypyridine complex-loaded nanoparticles for their potential application in anticancer therapy.

关键词： properties. pyridine complexes