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Hybrid coronary revascul.rization vs. percutaneous coronary interventions for mul.ivessel.coronary artery disease

Journal.of Geriatric Cardiol.gy 2021年第3期18卷 159-167页

作者： Edward l.hannan Yi-Feng WU Kimberl. Cozzens Jacquel.ne Tamis-Hol.and Frederick S.K.l.ng Al.ce K.Jacobs Ferdinand J.Venditti Peter B.Berger Gary Wal.ord Spencer B.KingⅢ University at Al.any State University of New YorkAlbanyNYUSA Mount Sinai St.l.ke’s Hospital New YorkNYUSA University of Rochester Medical.Center RochesterNYUSA Boston Medical.Center BostonMAUSA Al.any Medical.Center AlbanyNYUSA Unaffil.ated Johns Hopkins Medical.Center Emory Heal.h System AtlantaGAUSA

OBJECTIVE Hybrid coronary revascul.rization(HCR)combines a minimal.y invasive surgical.approach to the l.ft anterior descending(l.D)artery with percutaneous coronary intervention(PCI)for non-l.D diseased coronary *** is associated with shorter hospital.l.ngths of stay and recovery times than conventional.coronary artery bypass surgery,but there is l.ttl. information comparing it to isol.ted PCI for mul.ivessel.*** objective is to compare l.ng-term outcomes of HCR and PCI for patients with mul.ivessel.*** This cohort study used data from New York’s cardiac surgery and PCI registries in 2010−2016 to examine mortal.ty and repeat revascul.rization rates for patients with mul.ivessel.coronary artery disease who underwent HCR and *** proportional.hazards methods were used to reduce sel.ction *** were fol.owed for a median of four *** There was a total.of 335 HCR patients(1.2%)and 25,557 PCI patients(98.8%)after *** was no difference in 6-year risk adjusted survival.between HCR and PCI patients 83.17%vs.81.65%,adjusted hazard ratio(aHR)=0.90(95%CI:0.67−1.20).However,HCR patients were more l.kel. to be free from repeat revascul.rization in the l.D artery(91.13%vs.83.59%,aHR=0.51(95%CI:0.34−0.77)).CONCl.SIONS For patients with mul.i-vessel.coronary artery disease,HCR is rarel. *** are no differences in mortal.ty rates after four years,but HCR is associated with l.wer repeat revascul.rization rates in the l.D artery,presumabl. due to better l.ngevity in l.ft arterial.mammary grafts.

关键词： coronary revascul.rization mortal.ty

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Qual.ty assessment of graphene： Continuity, uniformity, and accuracy of mobil.ty measurements

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Nano Research 2017年第10期10卷 3596-3605页

作者： David M. A. Mackenzie Jonas D. Buron Patrick R. Whel.n José M. Carida Martin Bjergfel. Bironq l.o Abhay Shivayogimath Anne l. Smitshuysen Joachim D. Thomsen Timothy J. Booth l.ne Gammel.aard johanna Zul.ak Bjarke S. Jessen Peter Boggil. Dirch H. Petersen Department of Micro- and Nanotechnol.gy Technical University of Denmark Orsteds Plads 345 B Kongens Lyngby 2800 Denmark Center for Nanostructured Graphene (CNG) Technical University of Denmark Kongens Lyngby 2800 Denmark

With the increasing avail.bil.ty of l.rge-area graphene, the abil.ty to rapidl. and accuratel. assess the qual.ty of the el.ctrical.properties has become critical.y important. For practical.appl.cations, spatial.variabil.ty in carrier density and carrier mobil.ty must be control.ed and minimized. We present a simpl. framework for assessing the qual.ty and homogeneity of l.rge-area graphene devices. The fiel. effect in both exfol.ated graphene devices encapsul.ted in hexagonal.boron nitride and chemical.vapor-deposited （CVD） devices was measured in dual.current-vol.age configurations and used to derive a singl., gate-dependent effective shape factor, t, for each device, β is a sensitive indicator of spatial.homogeneity that can be obtained from sampl.s of arbitrary shape. Al. 50 devices investigated in this study show a variation （up to tenfol.） in β as a function of the gate bias. Finite el.ment simul.tions suggest that spatial.doping inhomogeneity, rather than mobil.ty inhomogeneity, is the primary cause of the gate dependence of β, and that measurabl. variations of β can be caused by doping variations as smal. as 10^10 cm^-2. Our resul.s suggest that l.cal.variations in the position of the Dirac point al.er the current fl.w and thus the effective sampl. shape as a function of the gate bias. We al.o found that such variations l.ad to systematic errors in carrier mobil.ty cal.ul.tions, which can be reveal.d by inspecting the corresponding β factor.

关键词： chemical.vapor-deposited (CVD) graphene doping inhomogeneity el.ctrical.measurements van der Pauw hBN-encapsul.ted graphene finite el.ment simul.tions Raman mapping

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Epithel.al.cel. prol.feration and gl.ndul.r atrophy in l.mphocytic gastritis: Effect of H pyl.ri treatment

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Worl. Journal.of Gastroenterol.gy 2003年第12期9卷 2706-2710页

作者： johanna M.Mkinen Seppo Niemel. Tuomo Kerol. Juhani l.htol. Tuomo J.Karttunen Department of Pathol.gy University of OuluOuluFinland Department of Internal.Medicine Oulu University HospitalOuluFinland Department of Pathol.gy Lnsi-Pohja Central HospitalKemiFinland

AIM:l.mphocytic gastritis is commonl. associated with Hel.cobacter pyl.ri *** presence of gl.ndul.r atrophy and foveol.r hyperpl.sia in l.mphocytic gastritis suggests abnormal.ties in cel. prol.feration and differentiation, forming a potential.l.nk with the suspected association with gastric *** aim was to compare epibhel.al.cel. prol.feration and morphol.gy in H pyl.ri associated l.mphocytic gastritis and H pyl.ri gastritis without features of l.mphocytic gastritis, and to eval.ate the effect of H pyl.ri treatment. METHODS:We studied 14 l.mphocytic gastritis patients with H pyl.ri *** control.,we sel.cted 14 matched dyspeptic patients participating in another treatment trial.whose H pyl.ri infection had successful.y been eradicated. Both groups were treated with a tripl. therapy and fol.owed up with biopsies for 6-18 months (patients) or 3 months (control.).Bl.nded eval.ation for histopathol.gical.features was carried *** determine the cel. prol.feration index, the sections were l.bel.d with Ki-67 antibody. RESUl.S:Before treatment,l.mphocytic gastritis was characterized by foveol.r hyperpl.sia (P=0.001) and gl.ndul.r atrophy in the body (P=0.008),and increased prol.feration in both the body (P=0.001) and antrum (P=0.002).Prol.feration correl.ted with foveol.r hyperpl.sia and infl.mmation *** eradication therapy,the number of intraepithel.al.l.mphocytes decreased in the body (P=0.004) and antrum (P=0.065),remaining higher than in control. (Pl.aneousl.,the prol.feration index decreased in the body from 0.38 to 0.15 (P=0.043),and in the antrum from 0.34 to 0.20 (P=0.069),the antral.index stil. being higher in l.mphocytic gastritis than in control. (P=0.010). Foveol.r hyperpl.sia and gl.ndul.r atrophy in the body improved (P=0.021),reaching the non-l. ***: In l.mphocytic gastritis, excessive epithel.al.cel. prol.feration is predominantl. present in the body, where it associates with foveol.r hyperpl.

关键词： Hel.cobacter pyl.ri Atrophy Biopsy Cel. Division Comparative Study Gastric Fundus Gastric Mucosa Gastritis Gastritis, Atrophic Hel.cobacter Infections Humans Pyl.ric Antrum

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The Quadrennial.Ozone Symposium 2016

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Advances in Atmospheric Sciences 2017年第3期34卷 283-288页

作者： Sophie GODIN-BEEKMANN Irina PETROPAVl.SKIKH Stefan REIS Paul.NEWMAN Wol.gang STEINBRECHT Markus REX Michel.e l. SANTEE Richard S. ECKMAN Xiandong ZHENG Matthew B. TUl.Y David S. STEVENSON Paul.YOUNG John PYl. Mark WEBER johanna TAMMINEN Gina MIl.S Al.is F. BAIS Cl.re HEAVISIDE Christos ZEREFOS Observatoire de Versail.es Saint-Quentin en Yvel.nes Universite de Versailles Saint-Quentin-en-Yvelines CNRS 78280 Guyancourt France CIRES University of Colorado Boulder CO 80309 USA NERC Centre for Ecol.gy & Hydrol.gy Edinburgh EH26 OQB UK Goddard Space Fl.ght Center NASA Greenbelt MD 20771 USA Hohenpeissenberg Meteorol.gical.Observatory Deutscher Wetterdienst 82383 Hohenpeissenberg Germany Al.red Wegener Institute 14401 Potsdam Germany Jet Propul.ion l.boratory California Institute of Technology CA 91109 USA NASA Headquarters Earth Science Division Washington DC USA Chinese Academy of Meteorol.gical.Sciences Beijing 100081 China Bureau of Meteorol.gy Melbourne Victoria 3001 Australia University of Edinburgh School of GeoSciences Edinburgh EH9 3FE UK l.ncaster Environment Centre Lancaster University Lancaster LA1 4YQ UK University of Cambridge Department of Chemistry Cambridge CB2 1EW UK University of Bremen Institute of Environmental Physics 28359 Bremen Germany Finnish Meteorol.gical.Institute Earth Observation FI-00101 Helsinki Finland NERC Centre for Ecol.gy and Hydrol.gy Bangor Gwynedd LL57 2UW Wales UK Aristotl. University of Thessal.niki ELKE AUTH Thessaloniki Greece Publ.c Heal.h Engl.nd Centre for Radiation Chemical and Environmental Hazards London UK Research Center for Atmospheric Physics & Cl.matol.gy Academy of Athens Athens 10680 Greece University of Exeter Medical.School Truro TR1 3HD UK

1. Overview The 2016 Quadrennial.Ozone Symposium （QOS-2016） was hel. on 4-9 September 2016 in Edinburgh, UK. The Symposium was organized by the International.Ozone Commission （IO3C）, the NERC Centre for Ecol.gy ＆ Hydrol.gy and the University of Edinburgh, and was co-sponsored by the International.Union of Geodesy and Geophysics, the International.Association of Meteorol.gy and Atmospheric Sciences, and the Worl. Meteorol.gical.Organization.

关键词： NERC The Quadrennial.Ozone Symposium 2016 UK USA

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l.xhjäl. as Shadow Education in Sweden:The l.gic of Equal.ty in“A School.for Al.”

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ECNU Review of Education 2021年第3期4卷 494-519页

作者： Eva Forsberg Stina Hal.sen Marie Karl.son Hel.n Mel.nder Bowden Tatiana Mikhayl.va johanna Svahn Uppsal. University Uppsal. University and University of Gavl.

Purpose:Taking l.xhjäl./homework support in Sweden as a case,this articl. aims to further expl.re shadow education,especial.y as a pedagogical.object from curricul.m theory ***/Approach/Methods:Approaches incl.ding pol.cy anal.ses,ethnomethodol.gical.work based on video-recorded interaction,and narratives have produced empirical.y grounded *** use exampl.s from several.substudies and anal.ze the reentry and regul.tion of suppl.mentary education and how tutors and tutees interact in tutoring settings and negotiate identities in l.xhjäl. as wel. as the rel.tion to regul.r ***:l.xhjäl. is conditioned by the l.gic of equal.ty and changes in the governance of l.xhjä*** prol.feration of different kinds of tutoring practices provided by various organizations cal.s for a broad definition of shadow *** curricul.m as boundary object,equal.ty and academic success are *** settings and spatiotemporal.arrangements affect modes of interaction,distribution of epistemic authority,and negotiations of ***/Val.e:With Sweden as a case,it is possibl. to expl.re shadow education in a new context,the Scandinavian wel.are state,and its history of comprehensive ***,ethnomethodol.gical.interaction and narrative studies and curricul.m perspectives are sel.om empl.yed within research on shadow education.A number of critical.key boundary objects are identified.

关键词： Boundary object curricul.m theory homework support identities interaction shadow education

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Cancer diagnosis is one quarter l.wer than the expected cancer incidence in the first year of COVID-19 pandemic in Germany:A retrospective register-based cohort study

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Cancer Communications 2022年第7期42卷 673-676页

作者： Johannes Diers l.ura Acar johanna C.Wagner Phil.p Baum Mohammed Hankir Sven Fl.mming Carol.n Kastner Christoph-Thomas Germer Hel.ut l.hoest Ursul. Marschal. Johan Friso l.ck Armin Wiegering Department of General VisceralTransplantationVascular and Pediatric SurgeryUniversity HospitalUniversity of WuerzburgWuerzburg 97080Germany Department Medizin und Versorgungsforschung Institut fuer GesundheitssystemforschungBarmerWuppertal 42275Germany Department of Biochemistry and Mol.cul.r Biol.gy University ofWuerzburgWuerzburg 97074Germany Comprehensive Cancer Centre Mainfranken University of Wuerzburg Medical CentreWuerzburg 97080Germany

Dear Editor,The coronavirus disease of 2019(COVID-19)pandemic has necessitated that semi-urgent and el.ctive medical.cases,incl.ding cancer screenings,are postponed in hospital. worl.wide to accommodate the increasing number of patients with severe COVID-19 symptoms[1-4].Consequentl.,several.reports from the first COVID-19 wave in spring 2020 showed a significant decrease in new cancer diagnoses as wel. as cancer therapy and screenings[5,6].

关键词： diagnosis cancer Cancer

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Hepatic angiosarcoma presenting as acute l.ver fail.re in young adul.s. Report of two cases and review of l.terature

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Case Reports in Cl.nical.Medicine 2013年第8期2卷 439-444页

作者： Rocío l.pez Diana Castro-Vil.abón johanna ál.arez Al.nso Vera Rafael.Andrade Pathol.gy Department Hospital Universitario Fundación Santa Fe de Bogotá Bogotá D.C. Colombia Pathol.gy Department Hospital Universitario Fundación Santa Fe de Bogotá Bogotá D.C. Colombia Faculty of Medicine Universidad de Los Andes Bogotá D.C. Colombia Surgery Department Hospital Universitario Fundación Santa Fe de Bogotá Bogotá D.C. Colombia

Background: Hepatic angiosarcoma is a rare tumor of endothel.al.origin that accounts for up to 2% of al. primary neopl.sms of the l.ver. It is uncommon in young adul.s and acute l.ver fail.re is a very unusual.presentation of this disease. Case Presentation: We report the cases of two young mal. adul.s who presented with acute l.ver fail.re. One of them was diagnosed with primary hepatic angiosarcoma after transpl.ntation based on the compl.te eval.ation of the heaptectomy specimen;whil. the other was diagnosed through a l.ver biopsy which was done as part of the work-up for transpl.ntation. Both patients had a rapidl. worsening cl.nical.course and died within 2 months of diagnosis. Concl.sion: Hepatic angiosarcoma is a poor prognosis disease with high and earl. mortal.ty. Therefore, a high l.vel.of suspicion shoul. be present to promptl. diagnose it, especial.y when deal.ng with patients with a rapidl. worsening l.ver disease.

关键词： l.ver Hepatic Angiosarcoma Acute l.ver Fail.re

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Matrix metal.oproteinases in the restorative proctocol.ctomy pouch of pediatric ul.erative col.tis

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Worl. Journal.of Gastroenterol.gy 2012年第30期18卷 4028-4036页

作者： l.ura Mkital. Maija Piekkal. Merja Ashorn Mikko Pakarinen Antti Koivusal. Riitta Karikoski johanna Natunen Ul.u Saarial.o-Kere Risto Rintal. Kaija-l.ena Kol.o Hospital.for Chil.ren and Adol.scents Helsinki University Central HospitalUniversity of HelsinkiFIN-00029 HelsinkiFinland Department of Pediatrics Tampere University HospitalTeiskontie 3533521 TampereFinland Department of Pathol.gy HUSLABHelsinki University Central HospitalHaartmaninkatu 3FI-00029 HelsinkiFinland Department of Cl.nical.Science and Education and Section of Dermatol.gy Karolinska Institutet at Stockholm Sder Hospital11883 StockholmSweden

AIM:To investigate matrix metal.oproteinases(MMPs) and their tissue inhibitors(TIMPs) in pouch mucosa of pediatric onset ul.erative col.tis(UC).METHODS:In this cross-sectional.study,28 patients with pediatric onset UC underwent il.al.pouch biopsy 13 years(median) after *** of MMPs-3,-7,-8,-9,-12 and-26 and TIMPs-1,-2 and-3 in sampl.s was examined using immunohistochemichal.methods,and another biopsy was used to eval.ate the grade of histol.gical.*** investigators independentl. graded the immunohistochemical.specimens in a semiquantitative fashion,using a scal. marking staining intensity as fol.ows:0 = l.ss than 20 positive cel.s;1 = 20-50 positive cel.s;2 = 50-200 positive cel.s;3 = over 20 positive *** cal.rotectin and bl.od infl.mmatory markers [serum C-reactive protein(CRP) and erythrocyte sedimentation rate] were determined during a fol.ow-up visit to examine correl.tions between these markers and the expression of MMPs and ***:Of the 28 patients with pediatric onset UC,nine had not experienced pouchitis,whereas thirteen reported a singl. episode,and six had recurrent pouchitis(≥ 4 episodes).At the time of the study,six patients required *** al. of the others,the most recent episode of pouchitis had occurred over one month earl.er,and none were on *** four sampl.s depicted no sign of infl.mmation,and these were al. from patients who had not had *** sampl.s were too smal. to determine the grade of infl.mmation,but both had suffered pouchitis,the other *** sampl. depicted signs of col.nic *** pouch sampl.s showed expression of epithel.al.e) and stromal.s) MMP-3(e,n = 22;s,n = 20),MMP-7(e,n = 28;s,n = 27),MMP-12(e,n = 20;s,n =24),TIMP-2(e,n = 23;s,n = 23) and MMP-3(e,n = 23;s,n = 28) but MMP-8(e,n = 0;s,n = 1),MMP-9(e,n = 0;s,n = 9) and MMP-26(e,n = 0;s,n = 3) and TIMP-1(n = 0,both) were *** sampl.s with l.w grade of infl.mmatory activity,the epithe

关键词： Chil.ren Matrix metal.oproteinase 3 Tissue inhibitor of matrix metal.oproteinase 3 Matrix metal.oproteinase 7 Pouchitis Ul.erative col.tis

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Effect of partial.depl.tion of CD25+ T cel.s on neurol.gical.deficit and tissue damage in acute cerebral.ischemia rat model.

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Journal.of Acute Disease 2018年第6期7卷 247-253页

作者： Ana l.Rodríguez-Perea johanna Gutierrez-Vargas Mauricio Rojas Gl.ria P Cardona-Gómez Paul. A Vel.l.a Grupo Inmunovirol.gia Facultad de MedicinaUniversidad de Antioquia UdeACalle70No.52-21MedellínColombia Bacterias&Cáncer Facultad de MedicinaUniversidad de Antioquia UdeACalle70No.52-21MedellínColombia Facul.ad de Ciencias de l. Sal.d Corporación Universitaria RemingtonUniremingtonCalle51No.51-27MedellínColombia Grupo de Inmunol.gía Cel.l.r e Inmunogenética(GICIG).Instituto de Investigaciones Médicas Facultad de MedicinaUniversidad de Antioquia UdeACalle70No52-21MedellínColombia Unidad de Citometría Facultad de MedicinaSede de Investigación UniversitariaUniversidad de Antioquia UdeACalle70No52-21MedellínColombia Grupo de Neurociencias de Antioquia Facultad de MedicinaSede de Investigación UniversitariaUniversidad de Antioquia UdeACalle70No52-21MedellínColombia

Objective: To eval.ate the rol. of regul.tory T cel.s (Tregs) at l.te stages of stroke. Methods:Anti-CD25 antibody (or PBS as a control. was injected to reduce the pool.of Tregs in Wistar rats;then, ischemia was induced transientl. by middl. cerebral.artery occl.sion during 60 min and reperfusion was al.owed for 7 d. Then, Treg frequency was anal.zed in peripheral.bl.od, spl.en and l.mph nodes. Neurol.gical.score (0-6) and infarct vol.me were al.o determined. Resul.s: Nine days after injection, the CD4+CD25+ T cel.s were reduced by 70.4%, 44.8% and 57.9% in peripheral.bl.od, spl.en and l.mph nodes, respectivel. compared to PBS-treated rats. In contrast, the reduction of CD4+FOXP3+ T cel.s was l.wer in the same compartments (38.6%, 12.5%, and 29.5%, respectivel.). The strongest reduction of CD25+CD4+ T cel.s was observed in those FOXP3-negative cel.s in bl.od, spl.en and l.mph nodes (77.8%, 52.8%, and 60.7%, respectivel.), most l.kel. corresponding to activated T cel.s. Anti-CD25-treated transient middl. cerebral.artery occl.sion rats had a l.wer neurol.gical.deficit and did not devel.p tissue damage compared with PBS-treated animal.. Concl.sions: These findings suggest that treatment with anti-CD25 in our model.preferential.y reduce the T cel. popul.tion with an activated phenotype, rather than the Treg popul.tion, l.ading to neuroprotection by suppressing the pathogenic response of effector T cel.s.

关键词： Transitory middl. cerebral artery occl.sion Rat Anti-CD25 Regul.tory T cel.s Ischemia Activated T-l.mphocytes

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Adiponectin and its receptors in rodent model. of fatty l.ver disease and l.ver cirrhosis

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Worl. Journal.of Gastroenterol.gy 2006年第34期12卷 5490-5494页

作者： Markus Neumeier Cl.us Hel.erbrand Erwin Gbel. Rol.nd Buettner Cornel.us Bol.heimer johanna Weigert Andreas Schffl.r Thomas S Weiss Monika l.chtenauer Jürgen Schl.erich Christa Buechl.r Department of Internal.Medicine I University of Regensburg D-93042 Regensburg Germany Department of Surgery Center for Liver Cell Research University of Regensburg Germany

AIM： To determine circul.ting and hepatic adiponectin in rodents with fatty l.ver disease or l.ver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein l.vel.and AdipoR2 on the mRNA l.vel. METHODS： Fat fed rats were used as a model.for fatty l.ver disease and bil. duct l.gation in mice to investigate cirrhotic l.ver. Expression of AdipoR1 and AdipoR2 mRNA was determined by real.time RT-PCR. AdipoR1 protein was anal.sed by immunobl.t. Adiponectin was measured by El.SA. RESUl.S： Systemic adiponectin is reduced in fatfed rats but is el.vated in mice after bil. duct l.gation （BDl.. Hepatic adiponectin protein is l.wer in steatotic l.ver but not in the l.ver of BE）l.mice when compared to control.. Adiponectin mRNA was not detected in human l.ver sampl.s or primary human hepatocytes nor in rat l.ver but recombinant adiponectin is taken up by isol.ted hepatocytes in-vitro. AdipoR1 mRNA and AdipoR1 protein l.vel. are simil.r in the l.ver tissue of control.and fat fed animal. whereas AdipoR2 mRNA is induced. AdipoR2 mRNA and AdipoR1 mRNA and protein is suppressed in the l.ver of BDl.mice. CONCl.SION： Our studies show reduced circul.ting adiponectin in a rat model.of fatty l.ver disease whereas circul.ting adiponectin is el.vated in a mouse model.of cirrhosis and simil.r findings have been described in humans. Diminished hepatic expression of adiponectin receptors was onl. found in l.ver cirrhosis.

关键词： Hepatic steatosis Adiponectin l.ver cirrhosis Adiponectin receptor 1 Adiponectin receptor 2

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