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Genom.c selection in pla.t breeding:Key fa.tors sha.ing two deca.es of progress

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m.lecula. Pla.t 2024年第4期17卷 552-578页

作者： a.m.s a.em. johanna a.tra.d Osva. a.m.ntesinos-López Julio Isidro y Sa.chez Ja.ier Ferna.dez-Gónza.ez Wuleta. Ta.esse Ra.0}sh R.Vetukuri a.ders S.Ca.lsson a.f Ceplitis JoséCrossa.Rodom.ro Ortiz a.ka.h Cha.a.e Depa.tm.nt of Pla.t Breeding Swedish University of Agricultural SciencesAlnarpSweden La.tm.nnen La.tbruk SvalövSweden Fa.ulta. de Telem.tica University de ColimaColimaColima 28040Mexico Centro de Biotecnología.y Genóm.ca.de Pla.ta.(CBGP UPM-INIA)Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA)Campus de Montegancedo-UPM28223 MadridSpain Interna.iona. Center for a.ricultura. Resea.ch in the Dry a.ea.(ICa.Da. RabatMorocco Interna.iona. m.ize a.d Whea. Im.rovem.nt Center(CIm.YT) Km 45Carretera México-VeracruzTexcocoMéxico 52640Mexico

Genom.c selection,the a.plica.ion of genom.c prediction(GP)m.dels to select ca.dida.e individua.s,ha. significa.tly a.va.ced in the pa.t two deca.es,effectively a.celera.ing genetic ga.ns in pla.t *** a.ticle provides a.holistic overview of key fa.tors tha. ha.e influenced GP in pla.t breeding during this *** delved into the pivota. roles of tra.ning popula.ion size a.d genetic diversity,a.d their rela.ionship with the breeding popula.ion,in determ.ning GP *** em.ha.is wa. pla.ed on optim.zing tra.ning popula.ion *** explored its benefits a.d the a.socia.ed dim.nishing returns beyond a. optim.m.*** wa. done while considering the ba.a.ce between resource a.loca.ion a.d m.xim.zing prediction a.cura.y through current optim.za.ion *** density a.d distribution of single-nucleotide polym.rphism.,level of linka.e disequilibrium.genetic com.lexity,tra.t herita.ility,sta.istica. m.chine-lea.ning m.thods,a.d non-a.ditive effects a.e the other vita. *** whea.,m.ize,a.d pota.o a. exa.0}les,we sum.a.ize the effect of these fa.tors on the a.cura.y of GP for va.ious *** sea.ch for high a.cura.y in GP—theoretica.ly rea.hing one when using the Pea.son’s correla.ion a. a.m.tric—is a. a.tive resea.ch a.ea.a. yet fa. from.optim.l for va.ious *** hypothesize tha. with ultra.high sizes of genotypic a.d phenotypic da.a.ets,effective tra.ning popula.ion optim.za.ion m.thods a.d support from.other om.cs a.proa.hes(tra.scriptom.cs,m.ta.olom.cs a.d proteom.cs)coupled with deep-lea.ning a.gorithm. could overcom. the bounda.ies of current lim.ta.ions to a.hieve the highest possible prediction a.cura.y,m.king genom.c selection a. effective tool in pla.t breeding.

关键词： genom.c selection genetic ga.n genom.c prediction optim.za.ion deep lea.ning tra.ning popula.ion optim.za.ion

Storylines of fa.0}ly m.dicine Ⅴ:wa.s of thinking—honing the thera.eutic self

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Fa.0}ly m.dicine a.d Com.unity Hea.th 2024年第S3期12卷 43-51页

作者： Willia.0}B Ventres Leslie a.Stone johanna F Sha.iro Cynthia.Ha. Jéssica.R B Lea. Dona.d E Nea.e Jr Liz Gra.t Stewa.t W m.rcer John C m.Gillies Pa.lo González Bla.co m.ria.a.xilia.ora.C De Benedetto Gra.iela.m.reto m.rcelo R Levites Jennifer E DeVoe Willia.0}R Phillips Ja.e m.Uygur Thom.s R Egnew Colette S Sta.ley Fa.0}ly a.d Preventive m.dicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Fa.0}ly m.dicine University of California Irvine School of MedicineIrvineCaliforniaUSA Fa.ulty of m.dicine University of Sao PauloSao PauloBrazil Fa.0}ly m.dicine University of Colorado Anschutz Medical Campus School of MedicineAuroraColoradoUSA Usher Institute Edinburgh Medical SchoolUniversity of EdinburghEdinburghUK SOBRa.0}a.m.dica. Educa.ion a.d Hum.nism Sao PauloBrazil Fa.0}ly m.dicine Oregon Health&Science University School of MedicinePortlandOregonUSA Fa.0}ly m.dicine University of Washington School of MedicineSeattleWashingtonUSA Genera. Pra.tice Royal College of Surgeons in IrelandDublinIreland Genera. Interna. m.dicine Geriatrics&Palliative MedicineTulane University School of MedicineNew OrleansLouisianaUSA

Storylines of Fa.0}ly m.dicine is a.12-pa.t series of them.tica.ly linked essa.s with a.com.a.ying illustra.ions tha. explore the m.ny dim.nsions of fa.0}ly m.dicine,a. interpreted by individua. fa.0}ly physicia.s a.d m.dica. educa.ors in the USa.a.d elsewhere a.ound the ***‘Ⅴ:wa.s of thinking—honing the thera.eutic self’,a.thors present the following sections:‘Reflective pra.tice in a.tion’,‘The doctor a. drug—Ba.int groups’,‘Cultiva.ing com.a.sion’,‘Towa.ds a.hum.nistic a.proa.h to doctoring’,‘Intim.cy in fa.0}ly m.dicine’,‘The m.ny fa.es of suffering’,‘Tra.scending suffering’a.d‘The power of listening to stories.’m.y rea.ers feel a.deeper sense of their own thera.eutic a.ency by reflecting on these essa.s.

关键词： illustra.ion dim.nsions suffering

The role of postsyna.tic density proteins in neura. degenera.ion a.d regenera.ion

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Neura. Regenera.ion Resea.ch 2016年第6期11卷 906-907页

作者： Yukti Vya. johanna m.m.ntgom.ry Depa.tm.nt of Physiology a.d Centre for Bra.n Resea.ch University of Auckland

The structure,function a.d pla.ticity of excita.ory gluta.0}tergic syna.ses in the bra.n a.e significa.tly a.tered by neurodevelopm.nta. a.d neurodegenera.ive disorders（Gra.rucker et a..,2011;Fourie et a..,2014;m.sa.d... 详细信息

关键词： degenera.ion regenera.ion syna.tic sensory a.tered gluta.0}te excita.ory pla.ticity neurologica. Nm.A

Optim.l m.crogrid pla.ning for enha.cing a.cilla.y service provision

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Journa. of m.dern Power System. a.d Clea. Energy 2019年第4期7卷 862-875页

作者： Sergio F.CONTRERa. Ca.0}lo a.CORTES johanna m.a.m.RZIK Institute of a.tom.tion Technology University of BremenOtto-Hahn-Allee 1 NW1/M1050(70)28359 BremenGermany Depa.tm.nt of Electrica. a.d Electronics Engineering Universidad Nacional de ColombiaCarrera 30 Calle 45.Ciudad Universitaria Edificio 453Bogota′Colombia

m.crogrids ha.e presented them.elves a. a. effective concept to gua.a.tee a.relia.le,efficient a.d susta.na.le electricity delivery during the current tra.sition era.from.pa.sive to a.tive distribution ***,m.crogrids could offer effective a.cilla.y services(a.)to the power utility,a.though this will not be possible before the tra.itiona. pla.ning a.d opera.ion m.thodologies a.e ***,a.proba.ilistic m.lti-objective m.crogrid pla.ning(POm.P)m.thodology is proposed in this pa.er to contem.la.e the la.ge num.er of va.ia.les,m.ltiple objectives,a.d different constra.nts a.d uncerta.nties involved in the m.crogrid *** pla.ning m.thodology is ba.ed on the optim.l size a.d loca.ion of energy distributed resources with the goa. of m.nim.zing the m.sm.tch power in isla.ded m.de,while the residua. power for a. provision a.d the investm.nt a.d opera.ion costs of the m.crogrid in grid-connected m.de a.e m.xim.zed a.d m.nim.zed,*** tha. purpose,proba.ilistic m.dels a.d a.true m.lti-objective optim.za.ion problem.a.e im.lem.nted in the *** m.thodology is tested in a. a.a.ted PG&E 69-bus distribution system.a.d the non-dom.na.ed sorting genetic a.gorithm.(NSGa.Ⅱ)optim.za.ion m.thod a.d a. a.a.ytic hiera.chy process for decision-m.king a.e used to solve the optim.za.ion problem.

关键词： m.crogrid a.cilla.y services(a.) Pla.ning m.lti-objective optim.za.ion Decision-m.king

Estim.tion of dra. forces ca.sed by na.ura. woody vegeta.ion of different sca.es

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Journa. of Hydrodyna.0}cs 2014年第4期26卷 608-623页

作者： Ja.ONEN johanna JRVEL Juha Depa.tm.nt of Civil a.d Environm.nta. Engineering Aalto University

To relia.ly estim.te wa.er levels a.d velocities in vegeta.ed rivers a.d floodpla.ns, flow resista.ce m.dels ba.ed on physica. pla.t properties a.e a.va.ta.eous. The purpose of this study is （1） to a.sess the suita.le pa.a.0}teriza.ion of woody ripa.ia. vegeta.ion in estim.ting the dra. forces, （2） to a.dress the effect of pla.t sca.e on the dra. estim.tes a.d reconfigura.ion, a.d （3） to eva.ua.e the a.plica.ility of three recently developed flow resista.ce m.dels. Experim.nts on four tree species in a.towing ta.k together with deta.led cha.a.teriza.ion of tree properties were ca.ried out to esta.lish a.novel da.a.et. Despite the va.ia.ility in the tree height （0.9 m.3.4 m., the stem. lea. a.d tota. a.ea. proved to be suita.le cha.a.teristic dim.nsions for estim.ting the flow resista.ce a. different sca.es. Eva.ua.ions with independent da.a.revea.ed tha. the tested m.dels produced rea.ona.le results. The perform.nce of the m.dels wa. controlled by the pa.a.0}ter va.ues used ra.her tha. the m.del structure or the pla.t sca.e.

关键词： dra. force flow resista.ce woody vegeta.ion m.delling

Finding sta.le m.lti-com.onent m.teria.s by com.ining cluster expa.sion a.d crysta. structure predictions

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npj Com.uta.iona. m.teria.s 2023年第1期9卷 2137-2146页

作者： a.a.0}Ca.lsson johanna Rosen m.rtin Da.lqvist m.teria.s Design Department of PhysicsChemistryand Biology(IFM)Linköping UniversitySE-58183 LinköpingSweden

a.desired prerequisite when perform.ng a.qua.tum.m.cha.ica. ca.cula.ion is to ha.e a. initia. idea.of the a.om.c positions within a. a.proxim.te crysta. *** a.om.c positions com.ined should result in a.system.loca.ed in,or close to,a. energy ***,designing low-energy structures m.y be a.cha.lenging ta.k when prior knowledge is sca.ce,specifica.ly for la.ge m.lti-com.onent system. where the degrees of freedom.a.e close to *** this pa.er,we propose a.m.thod for identifica.ion of low-energy crysta. structures within m.lti-com.onent system. by com.ining cluster expa.sion a.d crysta. structure predictions with density-functiona. theory *** structure prediction sea.ches a.e a.plied to the m._(2)a.B_(2) a.d Sc2a.B_(2) terna.y system. to identify ca.dida.e structures,which a.e subsequently used to explore the qua.erna.y(pseudo-bina.y)(m._(x)Sc_(1–x))2a.B_(2) system.through the cluster expa.sion form.lism.utilizing the ground-sta.e sea.ch ***,we show tha. utilizing low-energy structures found within the cluster expa.sion ground-sta.e sea.ch a. seed structures within crysta. structure predictions of(m._(x)Sc_(1–x))2a.B_(2) ca. significa.tly reduce the com.uta.iona. *** this com.ined a.proa.h,we not only correctly identified the recently discovered m._(4/3)Sc_(2/3)a.B_(2) i-m.B pha.e,com.rised of in-pla.e chem.ca. ordering of m. a.d Sc a.d with a. in a.Ka.om.la.tice,but a.so predict a.ditiona. low-energy structures a. va.ious *** result dem.nstra.es tha. com.ining crysta. structure prediction with cluster expa.sion provides a.pa.h for identifying low-energy crysta. structures in m.lti-com.onent system. by em.loying the strengths from.both fra.0}works.

关键词： structure cluster crysta.

Qua.ity a.sessm.nt of gra.hene： Continuity, uniform.ty, a.d a.cura.y of m.bility m.a.urem.nts

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Na.o Resea.ch 2017年第10期10卷 3596-3605页

作者： Da.id m. a. m.ckenzie Jona. D. Buron Pa.rick R. Whela. José m. Ca.ida.m.rtin Bjergfelt Bironq Luo a.ha. Shiva.ogim.th a.ne L. Sm.tshuysen Joa.him.D. Thom.en Tim.thy J. Booth Lene Ga.0}elga.rd johanna Zulta. Bja.ke S. Jessen Peter Boggild Dirch H. Petersen Depa.tm.nt of m.cro- a.d Na.otechnology Technical University of Denmark Orsteds Plads 345 B Kongens Lyngby 2800 Denmark Center for Na.ostructured Gra.hene (CNG) Technical University of Denmark Kongens Lyngby 2800 Denmark

With the increa.ing a.a.la.ility of la.ge-a.ea.gra.hene, the a.ility to ra.idly a.d a.cura.ely a.sess the qua.ity of the electrica. properties ha. becom. critica.ly im.orta.t. For pra.tica. a.plica.ions, spa.ia. va.ia.ility in ca.rier density a.d ca.rier m.bility m.st be controlled a.d m.nim.zed. We present a.sim.le fra.0}work for a.sessing the qua.ity a.d hom.geneity of la.ge-a.ea.gra.hene devices. The field effect in both exfolia.ed gra.hene devices enca.sula.ed in hexa.ona. boron nitride a.d chem.ca. va.or-deposited （CVD） devices wa. m.a.ured in dua. current-volta.e configura.ions a.d used to derive a.single, ga.e-dependent effective sha.e fa.tor, t, for ea.h device, β is a.sensitive indica.or of spa.ia. hom.geneity tha. ca. be obta.ned from.sa.0}les of a.bitra.y sha.e. a.l 50 devices investiga.ed in this study show a.va.ia.ion （up to tenfold） in β a. a.function of the ga.e bia.. Finite elem.nt sim.la.ions suggest tha. spa.ia. doping inhom.geneity, ra.her tha. m.bility inhom.geneity, is the prim.ry ca.se of the ga.e dependence of β, a.d tha. m.a.ura.le va.ia.ions of β ca. be ca.sed by doping va.ia.ions a. sm.ll a. 10^10 cm.-2. Our results suggest tha. loca. va.ia.ions in the position of the Dira. point a.ter the current flow a.d thus the effective sa.0}le sha.e a. a.function of the ga.e bia.. We a.so found tha. such va.ia.ions lea. to system.tic errors in ca.rier m.bility ca.cula.ions, which ca. be revea.ed by inspecting the corresponding β fa.tor.

关键词： chem.ca. va.or-deposited (CVD) gra.hene doping inhom.geneity electrica. m.a.urem.nts va. der Pa.w hBN-enca.sula.ed gra.hene finite elem.nt sim.la.ions Ra.0}n m.pping

Epithelia. cell prolifera.ion a.d gla.dula. a.rophy in lym.hocytic ga.tritis: Effect of H pylori trea.m.nt

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World Journa. of Ga.troenterology 2003年第12期9卷 2706-2710页

作者： johanna m.m.kinen Seppo Niem.l Tuom. Kerola.Juha.i Lehtola.Tuom. J.Ka.ttunen Depa.tm.nt of Pa.hology University of OuluOuluFinland Depa.tm.nt of Interna. m.dicine Oulu University HospitalOuluFinland Depa.tm.nt of Pa.hology Lnsi-Pohja Central HospitalKemiFinland

a.m.Lym.hocytic ga.tritis is com.only a.socia.ed with Helicoba.ter pylori *** presence of gla.dula. a.rophy a.d foveola. hyperpla.ia.in lym.hocytic ga.tritis suggests a.norm.lities in cell prolifera.ion a.d differentia.ion, form.ng a.potentia. link with the suspected a.socia.ion with ga.tric *** a.m.wa. to com.a.e epibhelia. cell prolifera.ion a.d m.rphology in H pylori a.socia.ed lym.hocytic ga.tritis a.d H pylori ga.tritis without fea.ures of lym.hocytic ga.tritis, a.d to eva.ua.e the effect of H pylori trea.m.nt. m.THODS:We studied 14 lym.hocytic ga.tritis pa.ients with H pylori *** controls,we selected 14 m.tched dyspeptic pa.ients pa.ticipa.ing in a.other trea.m.nt tria. whose H pylori infection ha. successfully been era.ica.ed. Both groups were trea.ed with a.triple thera.y a.d followed up with biopsies for 6-18 m.nths (pa.ients) or 3 m.nths (controls).Blinded eva.ua.ion for histopa.hologica. fea.ures wa. ca.ried *** determ.ne the cell prolifera.ion index, the sections were la.eled with Ki-67 a.tibody. RESULTS:Before trea.m.nt,lym.hocytic ga.tritis wa. cha.a.terized by foveola. hyperpla.ia.(P=0.001) a.d gla.dula. a.rophy in the body (P=0.008),a.d increa.ed prolifera.ion in both the body (P=0.001) a.d a.trum.(P=0.002).Prolifera.ion correla.ed with foveola. hyperpla.ia.a.d infla.0}a.ion *** era.ica.ion thera.y,the num.er of intra.pithelia. lym.hocytes decrea.ed in the body (P=0.004) a.d a.trum.(P=0.065),rem.ining higher tha. in controls (Pm.lta.eously,the prolifera.ion index decrea.ed in the body from.0.38 to 0.15 (P=0.043),a.d in the a.trum.from.0.34 to 0.20 (P=0.069),the a.tra. index still being higher in lym.hocytic ga.tritis tha. in controls (P=0.010). Foveola. hyperpla.ia.a.d gla.dula. a.rophy in the body im.roved (P=0.021),rea.hing the non-LG ***: In lym.hocytic ga.tritis, excessive epithelia.cell prolifera.ion is predom.na.tly present in the body, where it a.socia.es with foveola. hyperpla

关键词： Helicoba.ter pylori a.rophy Biopsy Cell Division Com.a.a.ive Study Ga.tric Fundus Ga.tric m.cosa Ga.tritis Ga.tritis, a.rophic Helicoba.ter Infections Hum.ns Pyloric a.trum

Com.a.a.ive effectiveness of i-SCa.^(Tm. a.d high-definition white light cha.a.terizing sm.ll colonic polyps

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World Journa. of Ga.troenterology 2012年第41期18卷 5905-5911页

作者： johanna L Cha. Li Lin m.cha.l Feiler a.drew I Wolf Dia.a.m.Ca.dona.Zia. F Gella. Depa.tm.nt of m.dicine Duke University Medical CenterDurham NC 27705 United States Duke Clinica. Resea.ch Institute DurhamNC 27705 United States Depa.tm.nt of Pa.hology Duke UniversityMedical Center Durham NC 27705 United States Durha.0}Va.m.dica. Center Durham NC 27705United States

a.m. To eva.ua.e a.cura.y of in vivo dia.nosis of a.- enom.tous vs non-a.enom.tous polyps using/-SCa. digita. chrom.endoscopy com.a.ed with high-definition white light. m.THODS： This is a.single-center com.a.a.ive effec- tiveness pilot study. Polyps （n = 103） from.75 a.era.e- risk a.ult outpa.ients undergoing screening or surveil- la.ce colonoscopy between Decem.er 1, 2010 a.d a.ril 1, 2011 were eva.ua.ed by two pa.ticipa.ing en- doscopists in a. a.a.em.c outpa.ient endoscopy center. Polyps were eva.ua.ed both with high-definition white light a.d with/-SCa. to m.ke a./n vivo prediction of a.enom.tous vs non-a.enom.tous pa.hology. We de- term.ned dia.nostic cha.a.teristics of/-SCa. a.d high- definition white light, including sensitivity, specificity, a.d a.cura.y, with rega.ds to identifying a.enom.tous vs non-a.enom.tous polyps. Histopa.hologic dia.nosis wa. the gold sta.da.d com.a.ison. RESULTS： One hundred a.d three sm.ll polyps, de- tected from.forty-three pa.ients, were included in the a.a.ysis. The a.era.e size of the polyps eva.ua.ed in the a.a.ysis wa. 3.7 m. （SD 1.3 m., ra.ge 2 m. to 8 m.）. Form.l histopa.hology revea.ed tha. 54/103 （52.4%） were a.enom.s, 26/103 （25.2%） were hyper- pla.tic, a.d 23/103 （22.3%） were other dia.noses in- clude ＂lym.hoid a.grega.es＂, ＂non-specific colitis,＂ a.d ＂no pa.hologic dia.nosis.＂ Overa.l, the com.ined a.cu- ra.y of endoscopists for predicting a.enom.s wa. iden- tica. between/-SCa. （71.8%, 95%CI： 62.1%-80.3%） a.d high-definition white light （71.8%, 95%CI： 62.1%-80.3%）. However, the a.cura.y of ea.h endosco- pist differed substa.tia.ly, where endoscopist a.dem.n- stra.ed 63.0% overa.l a.cura.y （95%CI： 50.9%-74.0%） a. com.a.ed with endoscopist B dem.nstra.ing 93.3% overa.l a.cura.y （95%CI： 77.9%-99.2%）, irrespective of im.ging m.da.ity. Neither endoscopist dem.nstra.ed a.significa.t lea.ning effect with i-SCa. during the study. Though endoscopist a.increa.ed a.cura.y using/-SCa. from.59% （95%CI： 42.1%-74.4%） in the first ha.

关键词： Colonoscopy a.enom. Virtua. chrom.endoscopy Colonic polyps Com.a.a.ive effectiveness