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Ultrathin monolithic 3D printed optical coherence tomography endoscopy for preclinical and clinical use

Light(Science & Applications) 2020年第1期9卷 753-762页

作者： Jiawen Li Simon Thiele Bryden C.Quirk Rodney w.Kirk johan w.verjans Emma Akers Christina A.Bursill Stephen J.Nicholls Alois M.Herkommer Harald Giessen Robert A.McLaughlin Australian Research Council Centre of Excellence for Nanoscale BioPhotonics Adelaide Medical SchoolUniversity of AdelaideAdelaideSA 5005Australia Institute for Photonics and Advanced Sensing The University of AdelaideAdelaideSA 5005Australia Institute of Applied Optics(ITO)and Research Center SCoPE University of Stuttgart70569 StuttgartGermany South Australian Health and Medical Research Institute(SAHMRI) AdelaideSA 5000Australia Royal Adelaide Hospital AdelaideSA 5000Australia Monash Cardiovascular Research Centre Monash UniversityMelbourneVIC 3168Australia th Physics Institute and Research Center SCoPE University of Stuttgart70569 StuttgartGermany

Preclinical and clinical diagnostics increasingly rely on techniques to visualize internal organs at high resolution via *** endoscopic probes are necessary for imaging small luminal or delicate organs without causing trauma to ***,current fabrication methods limit the imaging performance of highly miniaturized probes,restricting their widespread *** overcome this limitation,we developed a novel ultrathin probe fabrication technique that utilizes 3D microprinting to reliably create side-facing freeform micro-optics(we built a fully functional ultrathin aberration-corrected optical coherence tomography *** is the smallest freeform 3D imaging probe yet reported,with a diameter of 0.457 mm,including the catheter *** demonstrated image quality and mechanical flexibility by imaging atherosclerotic human and mouse *** ability to provide microstructural information with the smallest optical coherence tomography catheter opens a gateway for novel minimally invasive applications in disease.

关键词： smallest utilize overcome

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Thermal Property Enhancement of a Novel Shape-Stabilized Sodium Acetate Trihydrate-Acetamide/Expanded Graphite-Based Composite Phase Change Material

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Journal of Thermal Science 2024年第4期33卷 1564-1576页

作者： AN Zhoujian HOU wenjie DU Xiaoze HUANG Zhongzheng MOMBEKI PEA Hamir johan ZHANG Dong LIU Xiaomin College of Energy and Power Engineering Lanzhou University of TechnologyLanzhou730050China Key Laboratory of Multi-supply System with Solar Energy and Biomass of Gansu Province Lanzhou730050China Gansu Natural Energy Research Institute Lanzhou730046China

Phase change materials(PCMs)are a kind of highly efficient thermal storage materials which have a bright application prospect in many fields such as energy conservation in buildings,waste heat recovery,battery thermal management and so *** inorganic hydrated salt PCMs have received increasing attention from researchers due to their advantages of being inexpensive and ***,inorganic hydrated salt PCMs are still limited by the aspects of inappropriate phase change temperature,liquid phase leakage,large supercooling and severe phase separation in the application *** this work,sodium acetate trihydrate was selected as the basic inorganic PCM,and a novel shape-stabilized composite phase change material(CPCM)with good thermal properties was prepared by adding various functional *** first,the sodium acetate trihydrate-acetamide binary mixture was prepared and the melting point was adjusted using *** the binary mixture was incorporated into expanded graphite to synthesize a novel shape-stabilized *** thermophysical properties of the resultant shape-stabilized CPCM were systematically *** microscopic morphology and chemical structure of the obtained shape-stabilized CPCM were characterized and *** experiment results pointed out that acetamide could effectively lower the melting point of sodium acetate *** obtained shape-stabilized CPCM modified with additional 18%(mass fraction)acetamide and 12%(mass fraction)expanded graphite exhibited good shape stability and thermophysical characteristics:a low supercooling degree of 1.75℃and an appropriate melting temperature of 40.77℃were obtained;the latent heat of 151.64 kJ/kg and thermal conductivity of 1.411 w/(m·K)were also ***,after 50accelerated melting-freezing cycles,the obtained shape-stabilized CPCM represented good thermal reliability.

关键词： sodium acetate trihydrate melting point modification agent expanded graphite shape stability thermal conductivity enhancement

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Juvenile polyposis syndrome

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world Journal of Gastroenterology 2011年第44期17卷 4839-4844页

作者： Lodewijk AA Brosens Danielle Langeveld w Arnout van Hattem Francis M Giardiello G johan A Offerhaus Department of Pathology University Medical Centre Utrecht Department of Pathology Academic Medical Centre Division of Gastroenterology Department of Medicine The Johns Hopkins University School of Medicine

Juvenile polyposis syndrome is a rare autosomal dominant syndrome characterized by multiple distinct juvenile polyps in the gastrointestinal tract and an increased risk of colorectal *** cumulative life-time risk of colorectal cancer is 39% and the relative risk is *** polyps have a distinctive histology characterized by an abundance of edematous lamina propria with inflammatory cells and cystically dilated glands lined by cuboidal to columnar epithelium with reactive ***,juvenile polyposis syndrome is defined by the presence of 5 or more juvenile polyps in the colorectum,juvenile polyps throughout the gastrointestinal tract or any number of juvenile polyps and a positive family history of juvenile *** about 50%-60% of patients diagnosed with juvenile polyposis syndrome a germline mutation in the SMAD4 or BMPR1A gene is *** genes play a role in the BMP/TGF-beta signalling *** has been suggested that cancer in juvenile polyposis may develop through the socalled "landscaper mechanism" where an abnormal stromal environment leads to neoplastic transformation of the adjacent epithelium and in the end invasive *** of this rare disorder is important for patients and their families with regard to treatment,follow-up and screening of at risk *** clinician confronted with the diagnosis of a juvenile polyp should therefore consider the possibility of juvenile polyposis *** addition,juvenile polyposis syndrome provides a unique model to study colorectal cancer pathogenesis in general and gives insight in the molecular genetic basis of *** review discusses clinical manifestations,genetics,pathogenesis and management of juvenile polyposis syndrome.

关键词： Juvenile polyposis syndrome Hamartoma Colorectal cancer SMAD4 BMPR1A

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Structure,Characterization and Thermal Properties of the Form-Stable Paraffin/High-Density Polyethylene/Expanded Graphite/Epoxy Resin Composite PCMs for Thermal Energy Storage

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Journal of Thermal Science 2023年第6期32卷 2104-2114页

作者： MOMBEKI PEA Hamir johan AN Zhoujian DU Xiaoze SHI Tianlu ZHANG Dong School of Energy and Power Engineering Lanzhou University of TechnologyLanzhou730050China Key Laboratory of Complementary Energy System of Biomass and Solar Energy Gansu ProvinceLanzhou730050China

The form-stable paraffin/high-density polyethylene/expanded graphite/epoxy resin composite phase change materials(CPCMs),exhibiting suitable thermal properties,including low melting temperature,high conductivity and high phase change enthalpy,was developed in this ***,paraffin(PA)was utilized as a core ***-density polyethylene(HDPE)was utilized for the shape stabilization and preventing the PCMs *** graphite(EG)was used to increase its thermal conductivity and act also in the porous supporting *** resin(ER)was used to provide flexible encapsulated scaffold morphology and keep a highly tight network structure of the ***,the physical architecture,the chemical architecture and thermal behavior properties of specimens were investigated by using the spectroscopy and calorimetry *** scanning electron microscope(SEM),X-ray diffraction(XRD)and fourier transform infrared spectrometer FTIR tests have shown good uniformity structure and good compatibility of *** addition,the thermal conductivity tests revealed that the thermal conductivity of PA,initially 0.31 w/(m·K)improved up to 1.9 times by adding the 6 wt%mass fraction of EG in composite ***,the differential scanning calorimeter(DSC)measurements indicated that PA melting enthalpy,initially 231 J/g decreased up to 125 J/g with the increase of the amount of HDPE which was due to the limitation caused by the atomic network constructed by the base *** thermogravimetric analyzer(TGA)and leakage-proof revealed the enhancement of the degradation of PA with the raise of amount of the HDPE into the ***,the proposed form-stable CPCMs are a great candidate for the thermal regulation and thermal energy storage employment.

关键词： form-stable CPCMs paraffin expanded graphite high density polyethylene epoxy resin thermal energy storage

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Fitness and health benefits of team handball training for young untrained women--A cross-disciplinary RCT on physiological adaptations and motivational aspects

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Journal of Sport and Health Science 2018年第2期7卷 139-148页

作者： Therese Hornstrup johan M.wikman Bjorn Fristrup Susana Povoas Eva w.Helge Signe H.Nielsen Jorn w.Helge Jesper L.Andersen Lars Nybo Peter Krustrup Department of Nutrition Exercise and Sports University of Copenhagen Copenhagen N 2200 Denmark Research Center in Sports Sciences Health Sciences and Human Development CIDESD University Institute of Maia ISMAI Maia 4475-690 Portugal Center of Healthy Aging Department of Biomedical Sciences University of Copenhagen Copenhagen N 2200 Denmark Institute of Sports Medicine Copenhagen Bispebjerg Hospital Copenhagen NV 2400 Denmark Department of Sports Science and Clinical Biomechanics SDU Sport and Health Sciences Cluster (SHSC) University of Southern Denmark Odense 3450 Denmark Sport and Health Sciences University of Exeter Exeter EX1 2LU UK

Purpose: The present study evaluated the effects of regular participation in small-sided team handball training on body composition, osteogenic response, physical performance, and cardiovascular risk factors, as well as well-being and motivation, in young untrained ***: Twenty-eight untrained 20- to 30-year-old women were randomized to a handball training group(HG; n = 14, height 170 ± 5 cm, weight 73 ± 11 kg, VO_(2peak) 37.7 ± 4.1 mL/min/kg) that trained 1.7 ± 0.3 times per week over 12 weeks(70 min 4 v 4 handball sessions) or an inactive control group(CG; n = 14, 169 ± 5 cm, 71 ± 12 kg, 38.1 ± 3.7 mL/min/kg). Physiological and psychological and motivational training adaptations were assessed pre-and post-intervention by dual-energy X-ray Absorptiometry(DXA) scans, blood sampling, physical tests, and ***: The average heart rate(HR) over all training sessions was equal to 85% ± 6% HR_(max). Between-group intervention effects were observed in favor of HG for muscle mass(2.1%, p = 0.024), proximal femur bone mineral density(0.8%, p = 0.041), Yo-Yo IE1 intermittent endurance test level 1(IE1) performance(35%, p were observed in any of the measured physiological variables after the training period. Compared to CG, HG had an increase in intrinsic motivation(p well-being subscale "energy"(p = 0.010).Conclusion: Participation in regular recreational team handball training organized as small-sided games has marked beneficial effects on physical performance, musculoskeletal fitness, well-being, and motivation in untrained young women.

关键词： Bone mineral density (BMD) Intensity Intermittent Motivation Muscle mass Physical performance Recreational handball well-being

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The effect of particle size and amount of inoculum on fungal treatment of wheat straw and wood chips

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Journal of Animal Science and Biotechnology 2017年第1期8卷 217-225页

作者： Sandra J. A. van Kuijk Anton S. M. Sonnenberg johan J. P. Baars wouter H. Hendriks John w. Cone Animal Nutrition Group Wageningen University De Elst 1 6708WD Wageningen The Netherlands Plant Breeding Wageningen University Droevendaalsesteeg 1 6708PB Wageningen The Netherlands

Background： The aim of this study was to optimize the fungal treatment of lignocellulosic biomass by stimulating the colonization. wheat straw and wood chips were treated with Ceriporiopsis subvermispora and Lentinula edodes with various amounts of colonized millet grains（0.5, 1.5 or 3.0 % per g of wet weight of substrate） added to the substrates. Also, wheat straw and wood chips were chopped to either 0.5 or 2 *** of the fungal treatment after 0, 2, 4, 6, or 8 wk of incubation was determined by changes in chemical composition, in vitro gas production（IVGP） as a measure for rumen degradability, and ergosterol content as a measure of fungal ***： Incomplete colonization was observed for C. subvermispora treated wheat straw and L. edodes treated wood chips. The different particle sizes and amounts of inoculum tested, had no significant effects on the chemical composition and the IVGP of C. subvermispora treated wood chips. Particle size did influence *** treatment of wheat straw. The L. edodes treatment of 2 cm wheat straw resulted in a more selective delignification and a higher IVGP than the smaller particles. Addition of 1.5 % or 3 % L. edodes inoculum to wheat straw resulted in more selective delignification and a higher IVGP than addition of 0.5 % ***： Particle size and amount of inoculum did not have an effect on C. subvermispora treatment of wood chips. At least 1.5 % L. edodes colonized millet grains should be added to 2 cm wheat straw to result in an increased IVGP and acid detergent lignin（ADL） degradation.

关键词： Amount of inoculum Fungal treatment In vitro rumen degradability Lignin degradation Lignocellulosic biomass Particle size

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Cenozoic low temperature cooling history of the eastern Lhasa terrane:Implications for high-relief topography of external drainage area in the southern Tibetan Plateau

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Geoscience Frontiers 2023年第5期14卷 126-140页

作者： wenbo Su Zhiyuan He Linglin Zhong Stijn Glorie Kanghui Zhong johan De Grave Laboratory for Mineralogy and Petrology Department of GeologyGhent UniversityKrijgslaan 281 S89000 GhentBelgium College of Earth Sciences Chengdu University of TechnologyChengdu 610059China Department of Earth Sciences School of Physical SciencesThe University of AdelaideSA-5005Australia

The Tibetan Plateau geographically contains internal and external drainage areas based on the distributions of river flows and *** internal and external drainage areas display similar highelevations,while their topographic reliefs are not comparable;the former shows a large low-relief surface,whereas the latter is characterized by relatively high *** eastern Lhasa terrane is a key tectonic component of the Tibetan *** is characterized by high topography and relief,but the thermal history of its basement remains relatively poorly *** this study we report new apatite fission track data from the eastern part of the central Lhasa terrane to constrain the thermo-tectonic evolution of the external drainage area in the southern Tibetan ***-one new AFT ages and associated thermal history models reveal that the basement underlying the external drainage area in southern Tibet experienced three main phases of rapid cooling in the *** Paleocene-early Eocene(-60–48 Ma)cooling was likely induced by crustal shortening and associated rock exhumation,due to accelerated northward subduction of the NeoTethys oceanic lithosphere.A subsequent cooling pulse lasted from the late Eocene to early Oligocene(-40–28 Ma),possibly due to the thickening and consequential erosion of the Lhasa lithosphere resulted from the continuous northward indentation of the India plate into *** most recent rapid cooling event occurred in the middle Miocene-early Pliocene(-16–4 Ma),likely induced by accelerated incision of the Lhasa River and local thrust *** AFT ages and published low-temperature thermochronological data reveal that the external drainage area experienced younger cooling events compared with the internal drainage area,and that the associated differentiated topographic evolution initiated at ca.30 *** contributing factors for the formation of the high-relief topography mainly contain active surface uplift,fault activity,

关键词： Cenozoic Apatite fission track thermochronology Exhumation Lhasa terrane External drainage area Tibetan Plateau

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Soil Metagenome of Tropical white Sand Heath Forests in Borneo:what Functional Traits Are Associated with an Extreme Environment within the Tropical Rainforest?

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Pedosphere 2019年第1期29卷 12-23页

作者： Dorsaf KERFAHI Binu M.TRIPATHI johan w.Ferry SLIK Rahayu S.SUKRI Salwana JAAFAR Ke DONG Matthew Chidozie OGwU Hyo-Ki KIM Jonathan M.ADAMS Department of Biological Sciences Seoul National University Korea Polar Research Institute Faculty of Science Universiti Brunei Darussalam College of Natural Sciences Kyonggi University Celemics Inc.612 Avison Biomedical Research Center Yonsei Medical Center Division of Agrifood and Environment School of Water Energy and Environment Building 52a Cranfield University

white sand heath forests(wS) or kerangas, an unusual variant of tropical forests in Borneo, characterized by open scrubby vegetation, low productivity, and distinctive plant species composition and soil microbial community, are regarded as a stressful lowpH and/or nutrient environment. we investigated whether the functional soil metagenome also shows a predicted set of indicators of stressful conditions in wS. Based on stress-tolerant strategies exhibited by larger organisms, we hypothesized that genes for stress tolerance, dormancy, sporulation, and nutrient processing are more abundant in the soil microbiota of wS. we also hypothesized that there is less evidence of biotic interaction in white sand soils, with lower connectivity and fewer genes related to organismic interactions. In Brunei, we sampled soils from a wS and a normal primary dipterocarp forest, together with an inland heath, an intermediate forest type. Soil DNA was extracted, and shotgun sequencing was performed using Illumina HiSeq platform, with classification by the Metagenomics Rapid Annotation using Subsystem Technology(MG-RAST). The results, on one hand, supported our hypothesis(on greater abundance of dormancy, virulence, and sporulation-related genes). However, some aspects of our results showed no significant difference(specifically in stress tolerance, antibiotic resistance, viruses, and clustered regularly interspaced short palindrome repeats(CRISPRs)). It appears that in certain respects, the extreme white sand environment produces the predicted strategy of less biotic interaction, but exhibits high soil microbiota connectivity and functional diversity.

关键词： antibiotic resistance biotic interaction kerangas microbial community microbiota shotgun metagenomics stress tolerance tropical forest

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Creating the semantic web with RDF : professional developer's guide

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2001年

作者： Hjelm johan.

来源：畅想之星图书光盘版（南... 评论

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Mucosal-associated invariant T cells and oral microbiome in persistent apical periodontitis

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International Journal of Oral Science 2019年第2期11卷 131-142页

作者： Haleh Davanian Rogier Aaron Gaiser Mikael Silfverberg Luisa w. Hugerth Michal J. Sobkowiak Liyan Lu Katie Healy johan K. Sandberg Peggy Nasman Jorgen Karlsson Leif Jansson Lars Engstrand Margaret Sallberg Chen Department of Dental Medicine Karolinska InstitutetHuddingeSweden Department of Microbiology Tumor and Cell Biology and Science for Life LaboratoryKarolinska InstitutetStockholmSweden Clinical Genomics Facility Science for Life LaboratorySolnaSweden Department of Medicine Karolinska InstitutetHuddingeSweden Clinic of Endodontics and Periodontology Eastman Institute StockholmStockholmSweden

Opportunistic bacteria in apical periodontitis (AP) may pose a risk for systemic ***-associated invariant T (MAIT) cells are innate-like T cells with a broad and potent antimicrobial activity important for gut mucosal *** was recently shown that MAIT cells are present in the oral mucosal tissue,but the involvement of MAIT cells in AP is ***,comparison of surgically resected AP and gingival tissues demonstrated that AP tissues express significantly higher levels of Vα7.2-Jα33,Vα7.2- Jα20,Vα7.2-Jα12,Cα and tumour necrosis factor (TNF),interferon (IFN)-γ and interleukin (IL)-17A transcripts,resembling a MAIT cell ***,in AP tissues the MR1-restricted MAIT cells positive for MR1–5-OP-RU tetramer staining appeared to be of similar levels as in peripheral blood but consisted mainly of CD4^+ *** gingival tissues,the AP microbiome was quantitatively impacted by factors like fistula and high patient age and had a prominent riboflavin-expressing bacterial *** merged in an integrated view,the examined immune and microbiome data in the sparse partial least squares discriminant analysis could identify bacterial relative abundances that negatively correlated with Vα7.2-Jα33,Cα,and IL-17A transcript expressions in AP,implying that MAIT cells could play a role in the local defence at the oral tissue *** conclusion,we describe the presence of MAIT cells at the oral site where translocation of oral microbiota could take *** findings have implications for understanding the immune sensing of polymicrobial-related oral diseases.

关键词： apical periodontitis(AP) Mucosal-associated invariant T(MAIT) AP

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