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第九届全国免疫学学术大会

作者： Ying Zhao Jun Wang Laura Calpe-Berdiel Amanda C.Foks Bart Lammers johan kuiper Theo J.C.Van Berkel Miranda Van Eck Department of Pathology and Pathophysiology Soochow University Division of Biopharmaceutics Leiden/Amsterdam Center for Drug ResearchLeiden University Institute of Biology and Medical Sciences Soochow University

Background:LDL receptor(LDLr)and ABC-transporter A1(ABCA1)are two distinct players in cellular cholesterol *** recognizes apoprotein B100 and apoE in lipoproteins to mediate the uptake of cholesterol,while ABCA1 promotes excess cholesterol efttux to apoprotein ***:The present study aims to investigate whether LDLr deficiency influences the atheroprotective effects of leukocyte ABCA1 in *** and Results:LDLr-/-mice were transplanted with bone marrow from LDLr/ABCA1mice,LDLr/ABCA1/-mice,and their respective *** leukocyte ABCA1 deficiency reduced plasma cholesterol levels,after 8weeks of Western-type diet feeding,animals transplanted with LDLr/ABCA1and LDLr/ABCA1bone marrow developed 1.6-fold(p<0.01)and 1.4-fold(p<0.05)larger lesions,compared to their respective *** clearly indicates that the atheroprotection of leukocyte ABCA1 is not affected by ***-way ANOVA analysis also demonstrated that deletion of the leukocyte LDLr reduced lesion development(p<0.001),especially in the absence of leukocyte ***,leukocyte LDLr deficiency did not affect monocytosis,recruitment of moncocytes and macrophage foam cell ***,the deletion of leukocyte ABCA1 did reduce lymphocytosis and recruitment of T cells into the adventitia of lesions,associated with smaller lesion size in LDLr/ABCA1transplanted mice,indicating the potential contribution of lymphocytosis and recruitment ofT cells to ***:Leukocyte LDLr deficiency does not affect the atheroprotective effects of leukocyte ***,suppression of lymphocytosis and recruitment of T cells in the adventitia could contribute to the atheroprotection of Leukocyte LDLr deficiency and ABCA1.

关键词： LDL receptor ABCA1 lymphocytosis T lymphocytes atherosclerosis

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Leukocyte ABC-transporter A1 and LDL Receptor Play Independent Roles in Atherosclerosis： the Potential Contribution of T Cells

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中国动脉硬化杂志 2013年第9期21卷 I0075-I0075页

作者： Ying Zhao Jun Wang Laura Calpe-Berdiel Amanda C. Foks Bart Lammers johan kuiper Theo J.C. Van Berkel Miranda Van Eck Department of Pathology and Pathophysiology Soochow University Suzhou Jiangsu 215123 China Division of Biopharmaeeutics leiden~Amsterdam Center for Drug Research leiden University leiden 2333 CCThe Netherlands Institute of Biology and Medical Sciences Soochow University Suzhou Jiangsu 215123 China

Objective The present study aims to investigate whether LDL receptor (LDLR) deficiency influences the atheroprotective effects of leukocyte ABC-transporter A1 (ABCA1) in vivo. Methods and Results LDLR -/- mice were transplanted with bone marrow from LDLR -/-/ABCA1 -/- mice, LDLR + / +/ABCA1 -/- mice, and their respective controls. Although leukocyte ABCA1defi- ciency reduced plasma cholesterol levels, after 8 weeks of Western-type diet feeding, animals transplanted with LDLR / /ABCA1 /- and LDLR + / +/ABCA1 -/- bone marrow developed 1.6-fold ( P < 0. 01 ) and 1.4-fold ( P < 0. 05 ) larger lesions, compared to their respective controls. This clearly indicates that the atheroprotection of leukocyte ABCA1 is not affected by LDLR. Two-way ANOVA analysis also demonstrated that deletion of the leukocyte LDLR reduced lesion development ( P < 0. 001 ) , especially in the absence of leukocyte ABCA1. However, leukocyte LDLR deficiency does not affect monocytosis, recruitment of moncocytes and macrophage foam cell formation. Interestingly, the deletion of leukocyte ABCA1did reduce lymphocytosis and recruitment of T cells into the ad- ventitia of lesions. These effects are associated with smaller lesion size in LDLR -/-/ABCA1 -/- transplanted mice, indicating the potential contribution of lymphocytosis and recruitment of T cells to atherogenesis. Conclusions Leukocyte LDLR deficiency does not affect the atheroprotective effects of leukocyte ABCA1, and vice versa. Furthermore, suppression of lymphocytosis and T cell re- cruitment into the adventitia could contribute to the atheroprotection of leukocyte LDLR deficiency and ABCA1.

关键词：低密度脂蛋白受体动脉粥样硬化 ABCA1 白细胞减少 T细胞转运子单核细胞增多淋巴细胞

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Leukocyte ABCA1 is atheroprotective in absence of ApoAI

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中国病理生理杂志 2012年第11期 2009-2009页

作者： Laura CALPE-BERDIEL Josep JULVE Joan Carles ESCOL-GIL Amanda FOKS Ronald J.VAN DER SLUIS johan kuiper Francisco BLANCO-VACA Theo J.C.VAN BERKEL Jan-Albert KUIVENHOVEN Miranda VAN ECK Department of Pathophysiology School of Biology and Basic Medical SciencesSoochow UniversitySuzhou 215123China IIB Sant Pau and CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEMBarcelonaSpain 3. Division of BiopharmaceuticsLeiden/Amsterdam Center for Drug ResearchGorlaeus LaboratoriesLeiden UniversityLeidenNetherlands Departament de Bioquímicali Biologia Molecular Universitat Autònoma de BarcelonaBarcelonaSpain Department of Vascular Medicine Academic Medical CenterUniversity of AmsterdamAmsterdamNetherlands

AIM:ABC-transporter A1(ABCA1)facilitates cellular cholesterol efflux to lipid-free/poor apolipoproteins,including apolipoprotein AI(ApoAI).The aim of the present study was to investigate the importance of ApoAI for AB... 详细信息

关键词： Leukocyte ABCA1 is atheroprotective in absence of ApoAI

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