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Journal of Energy chemistry 2024年第10期97卷 438-443,I0009页

作者： Lucas Hanssens Maarten Houlleberghs c.Vinod chandran Geert Watson Sambhu Radhakrishnan Pascal Van der Voort Joeri F.M.denayer christine E.A.Kirschhock johan A.Martens Eric Breynaert centre for Surface chemistry and catalysis-characterization and Application Team(cOK-KAT) 3001 LeuvenBelgium NMR/X-Ray Platform for convergence Research(NMRcoRe) 3001 LeuvenBelgium centre for Ordered Materials Organometallics and Catalysis(COMOC)Department of ChemistryGhent University9000 GhentBelgium department of chemical Engineering Vrije Universiteit Brussel1050 BrusselBelgium

*** circular methane energy systems In recent dec.des,methane-based energy systems have rapidly gained traction across the globe because of the increasing availability of low-cost methane production ***,fossil methane... 详细信息

关键词： Long duration energy storage Green methane carbon neutrality confined clathrate hydrates cH_(4)/cO_(2) exchange Direct gas exchange

Expression changes of mi RNA-regulated genes associated with the formation of the leafy head in cabbage

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Horticultural Plant Journal 2024年第4期10卷 1007-1019页

作者： Jorge Aleman-Baez Jose Fernando Acevedo-Zamora johan Bucher chengcheng cai Roeland E.Voorrips Guusje Bonnema Plant Breeding Wageningen University and ResearchWageningenThe Netherlands

The vegetative development of cabbage(Brassica oleracea ***)passes through seedling,rosette,folding and heading *** that form the rosette are large and mostly *** the following developmental stages,the plants produce leaves that curve inward to produce the leafy *** microRNAs and their target genes have been described participating in leaf development and leaf *** aim of this study is to investigate the role of miRNA-regulated genes in the transition from the rosette to the heading *** compared the mi RNA and gene abundances between emerging rosette and heading *** remove transcripts(miRNAs and genes)whose regulation was most likely associated with plant age rather than the change from rosette to heading stage,we utilized a non-heading collard green(*** ***)morphotype as *** resulted in 33 deMs and 1998 deGs with likely roles in the transition from rosette to heading stage in *** these 1998 deGs,we found enriched GO terms related to DNA-binding transcription factor activity,transcription regulator activity,iron ion binding,and *** predicted the target genes of these 33 deMs and focused on the subset that was differentially expressed(1998deGs)between rosette and heading stage leaves to construct mi RNA-target gene interaction *** main finding is a role for miR396b-5p targeting two Arabidopsis thaliana orthologues of GROWTH REGULATING FAcTORs 3(GRF3)and 4(GRF4)in pointed cabbage head formation.

关键词： Brassica oleracea var.capitata RNA sequencing miRNA-target gene network leafy head formation

Medicinal chemistry strategies towards the development of non-covalent SARS-coV-2 Mpro inhibitors

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Acta Pharmaceutica Sinica B 2024年第1期14卷 87-109页

作者： Letian Song Shenghua Gao Bing Ye Mianling Yang Yusen cheng Dongwei Kang Fan Yi Jin-Peng Sun Luis Menéndez-Arias johan Neyts Xinyong Liu Peng Zhan department of Medicinal chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Shenzhen Research Institute of Shandong University Shenzhen 518057China The Key Laboratory of Infection and Immunity of Shandong Province Department of PharmacologySchool of Basic Medical SciencesShandong UniversityJinan 250012China Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China centro de Biologı´a Molecular“Severo Ochoa”(consejo Superior de Investigaciones cientı´ficas&Autonomous University of Madrid) Madrid 28049Spain KU Leuven Department of Microbiology and ImmunologyRega Institute for Medical ResearchLaboratory of Virology and ChemotherapyLeuven 3000Belgium

The main protease(M^(pro))of SARS-coV-2 is an attractive target in anti-cOVID-19 therapy for its high conservation and major role in the virus life *** covalent M^(pro)inhibitor nirmatrelvir(in combination with ritonavir,a pharmacokinetic enhancer)and the non-covalent inhibitor ensitrelvir have shown efficacy in clinical trials and have been approved for therapeutic *** antiviral drugs are needed to fight the pandemic,while non-covalent M^(pro)inhibitors could be promising alternatives due to their high selectivity and favorable *** non-covalent M^(pro)inhibitors with desirable properties have been developed based on available crystal structures of M^(pro).In this article,we describe medicinal chemistry strategies applied for the discovery and optimization of non-covalent M^(pro)inhibitors,followed by a general overview and critical analysis of the available *** viewpoints and insights into current strategies for the development of non-covalent M^(pro)inhibitors are also discussed.

关键词： cOVID-19 SARS-coV-2 Main protease Non-covalent inhibitors Medicinal chemistry strategies

儿童早期空气污染与呼吸道感染:EScAPE项目中10个欧洲出生队列的分析

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环境与职业医学 2014年第3期31卷 202-202页

作者： Elaina A.MacIntyre Ulrike Gehring Anna Molter Elaine Fuertes claudia Klümper Ursula Kramer Ulrich Quass Barbara Hoffmann Mireia Gascon Bert Brunekreef Gerard H.Koppelman Rob Beelen Gerard Hoek Matthias Birk johan c.de jongste H.A.Smit Josef cyrys Olena Gruzieva Michal Korek Anna Bergstrom Raymond M.Agius Frank de Vocht Angela Simpson Daniela Porta Francesco Forastiere chiara Badaloni Giulia cesaroni Ana Esplugues Ana Fernández-Somoano Aitana Lerxundi Jordi Sunyer Marta cirach Mark J.Nieuwenhuijsen Goran Pershagen Joachim Heinrich

[背景]将交通源空气污染作为幼儿期呼吸道感染的危险因素的研究很少。[目的]在10个欧洲出生队列——BAMSE（瑞典）、GASPⅡ（意大利）、GINIplus和LISAplus（德国）、MAAS（英国）、PIAMA（荷兰）和4个INMA队列（西班牙）——中研究空... 详细信息

[背景]将交通源空气污染作为幼儿期呼吸道感染的危险因素的研究很少。[目的]在10个欧洲出生队列——BAMSE（瑞典）、GASPⅡ（意大利）、GINIplus和LISAplus（德国）、MAAS（英国）、PIAMA（荷兰）和4个INMA队列（西班牙）——中研究空气污染与肺炎、哮喘及中耳炎之间的相关性，并使用meta分析得出综合效应估值。[方法]评价家长报告的医师诊断的儿童早期肺炎、中耳炎以及哮喘与全年平均污染物水平[二氧化氮（NO2）、氮氧化物（NOx）、≤2．5gm的颗粒物（PM2.5）、PM2.5吸光度、PM10、PM2.5-10（粗PM）]间的关联，污染物浓度的估计采用土地利用回归模型并根据孩子的出生住址分配。作为EScAPE项目的一部分，每个研究区域都采用相同的方案建立回归模型。用logistic回归来计算每个研究校正后的效应估值，用随机效应meta分析来计算合并的估计值。[结果]除了PM2.5外的所有污染物，肺炎的合并校正优势比（OR）均升高（例如，N02每增加10μg／m3，OR=1．30，95％cI：1．02～1．65；PM10每增加10μg／m3的OR=1．76，95％cI：1．00—3．09）。对于中耳炎和哮喘，除了NO2与中耳炎问的关联（每10μg／m3对应的OR=1．09，95％cI：1．02～1．16），所有分析的结果均无显著性。[结论]对EScAPE项目中10个欧洲出生队列进行的meta分析为空气污染和儿童早期肺炎之间的相关性找到一致性的证据，也为与中耳炎间的相关性找到了一些证据。

关键词：早期肺炎呼吸道感染出生队列空气污染欧洲儿童 meta分析 logistic

Preclinical and clinical evidence of the association of colibactinproducing Escherichia coli with anxiety and depression in colon cancer

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World Journal of Gastroenterology 2024年第21期30卷 2817-2826页

作者： Fabien Rondepierre Maëva Meynier johan Gagniere Vincent deneuvy Anissa deneuvy Gwenaelle Roche Elodie Baudu Bruno Pereira Richard Bonnet Nicolas Barnich Frédéric Antonio carvalho denis Pezet Mathilde Bonnet Isabelle Jalenques Service de Psychiatrie de l’Adulte A et Psychologie Médicale CHU Clermont-FerrandClermont-Ferrand 63000France M2iSH UMR 1071INSERMUniversity of Clermont AuvergneINRAE USC 1382Clermont-Ferrand 63001France NeuroDol UMR 1107INSERMUniversity of Clermont AuvergneClermont-Ferrand 63001France department of Digestive Surgery CHU de Clermont-FerrandClermont-Ferrand 63001France Biostatistics Unit Department of Clinical Research and InnovationCHU Clermont-FerrandClermont-Ferrand 63000France department of Bacteriology CHU de Clermont-FerrandClermont-Ferrand 63001France Universitéclermont Auvergne INPCNRSClermont Auvergne Institut PascalClermont-Ferrand 63000France

BAcKGROUND The association between the intestinal microbiota and psychiatric disorders is becoming increasingly *** gut microbiota contributes to colorectal carcinogenesis(cRc),as demonstrated with colibactin-producing Escherichia coli(coPEc).AIM To evaluate the association between coPEc prevalence and anxiety-and depressive-like behaviors with both preclinical and clinical *** Patients followed after a cRc surgery and for whom the prevalence of coPEc has been investigated underwent a psychiatric *** were compared according to the coPEc *** parallel c57BL6/J wild type mice and mice with a cRc susceptibility were chronically infected with a coPEc *** behavior was assessed using the Elevated Plus Maze test,the Forced Swimming Test and the Behavior recognition system PhenoTyper®.RESULTS In a limited cohort,all patients with coPEc colonization presented with psychiatric disorders several years before cancer diagnosis,whereas only one patient(17%)without coPEc *** result was confirmed in c57BL6/J wildtype mice and in a cRc susceptibility mouse model(adenomatous polyposis colimultiple intestinal neoplasia/+).Mice exhibited a significant increase in anxiety-and depressive-like behaviors after chronic infection with a coPEc *** This finding provides the first evidence that coPEc infection can induce microbiota-gut-brain axis disturbances in addition to its procarcinogenic properties.

关键词： colorectal cancer colibactin Escherichia coli colibactin-producing Escherichia coli Inflammation Anxiety depression Behavior

Exhuming the Meso-cenozoic Kyrgyz Tianshan and Siberian Altai-Sayan:A review based on low-temperature thermochronology

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Geoscience Frontiers 2016年第2期7卷 155-170页

作者： Stijn Glorie johan de Grave centre for Tectonics Resources and Exploration(TRaX)Department of Earth SciencesSchool of Physical SciencesThe University of Adelaide dept.Geology & Soil Science MINPET GroupGhent University

Thermochronological datasets for the Kyrgyz Tianshan and Siberian Altai-Sayan within central Asia reveal a punctuated exhumation history during the Meso-cenozoic. In this paper, the datasets for both regions are collectively reviewed in order to speculate on the links between the Meso-cenozoic exhumation of the continental Eurasian interior and the prevailing tectonic processes at the plate margins. Whereas most of the thermochronological data across both regions document late Jurassic -cretaceous regional basement cooling, older landscape relics and dissecting fault zones throughout both regions preserve Triassic and cenozoic events of rapid cooling, respectively. Triassic cooling is thought to reflect the Qiangtang-Eurasia collision and/or rifting/subsidence in the West Siberian basin. Alternatively, this cooling signal could be related with the terminal terrane-amalgamation of the central Asian Orogenic Belt. For the Kygyz Tianshan, late Jurassic-cretaceous regional exhumation and cenozoic fault reactivations can be linked with specific tectonic events during the closure of the Palaeo-Tethys and Neo-Tethys Oceans, respectively. The effect of the progressive consumption of these oceans and the associated collisions of cimmeria and India with Eurasia probably only had a minor effect on the exhumation of the Siberian Altai-Sayan. More likely, tectonic forces from the east （present-day co- ordinates） as a result of the building and collapse of the Mongol-Okhotsk orogen and rifting in the Baikal region shaped the current Siberian Altai-Sayan topography. Although many of these hypothesised links need to be tested further, they allow a first-order insight into the dynamic response and the stress propagation pathways from the Eurasian margin into the continental interior.

关键词： central Asia Tianshan Altai Sayan Thermochronology Exhumation Fault reactivation

Exhuming Asia-A thermochronological perspective： Preface

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Geoscience Frontiers 2016年第2期7卷 153-154页

作者： Stijn Glorie johan de Grave centre for Tectonics Resources and Exploration(TRaX)Department of Earth SciencesSchool of Physical SciencesThe University of AdelaideAdelaideSA 5005Australia department of Geology &Soil Science MINPET GroupGhent University281-S8 KrijgslaanGhent 9000Belgium

Asia is the largest continent on Earth and records a prolonged history of continental growth and tectonic reactivation during the Phanerozoic. Several tectonic forces at the continental palaeomargins induced mountain building, both at the margins themselves （e.g. the Himalayas） and into the continental interior （e.g. the Tianshan）.

关键词： Asia Exhuming Asia-A thermochronological perspective

May Traditional chinese Medicine Reduce the Risk of developing Rheumatoid Arthritis?An One-armed Prospective Study

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clinical complementary Medicine and Pharmacology 2024年第1期4卷 10-18页

作者： Kaixin Gao Qi Liang Dongyun Li chuanning Li Maojie Wang Xiumin chen Qingchun Huang Zehuai Wen Per-johan Jakobsson Runyue Huang The Second Affiliated Hospital of Guangzhou University of chinese Medicine(Guangdong Provincial Hospital of chinese Medicine) Guangzhou 510006GuangdongChina The Second clinical Medical college Guangzhou University of Chinese MedicineGuangzhou 510006GuangdongChina State Key Laboratory of Dampness Syndrome of chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120GuangdongChina Guangdong Provincial Key Laboratory of chinese Medicine for Prevention and Treatment of Refractory chronic Diseases Guangzhou 510403GuangdongChina Guangdong-Hong Kong-Macao Joint Lab on chinese Medicine and Immune Disease Research Guangzhou 510000GuangdongChina The key unit of methodology of clinical research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000GuangdongChina Rheumatology Unit Department of Medicine SolnaKarolinska InstituteKarolinska University HospitalStockholm 17177Sweden department of Doctor-Patient Relationship The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630GuangdongChina

Background:Rheumatoid arthritis(RA)is a worldwide public health *** and prevention before the onset of rheumatic diseases is a new direction in current ***:The aim of this study was to evaluate the potential and feasibility of traditional chinese medicine(TcM)in the prevention of ***:This was a single-armed prospective clinical *** participants were recruited from a single center in Guangdong,*** who were tested positive for anti-cyclic citrullinated peptide antibody(anti-ccP)and/or rheumatoid factor(RF),had no synovitis and never been treated with disease-modifying anti-rheumatic drugs(DMARDs),were enrolled to take the Huayu-Qiangshen-Tongbi(HQT)decoction orally twice daily,200 mL each time for 24 *** outcome was the proportion of patients who met 2010 AcR(American college of Rheumatology)/EULAR(European League Against Rheumatism)classification criteria of RA during *** outcomes included levels of anti-ccP,RF,erythrocyte sedimentation rate(ESR),c-reactive protein(cRP),assessment of signs and symptoms,and radiographic progression by magnetic resonance imaging(MRI).Results:19 individuals were enrolled in the study,4 of which withdrew because of the epidemic of *** the observation period,3 individuals(20%)developed RA and they had longer morning stiffness(P=0.009)and more obvious synovial enhancement in MRI(P=0.041)at baseline when compared with those who did not develop *** 24 weeks of intervention,there were improvements in 28-swollen joint count(SJc28)(P=0.046),Visual Analog Scale(VAS)(P=0.019),Patient’s Global Assessment(PtGA)(P=0.019)and Physician’s Global Assessment(PGA)(P=0.031),but no statistical significance was observed in the levels of anti-ccP,RF,ESR,cRP,morning stiffness,28-tender joint count(TJc28),Health Assessment Questionnaire(HAQ)and magnetic resonance imaging(MRI)analysis(P>0.05).conclusion:The HQT formula is safe and could improve joint symptoms and s

关键词： Rheumatoid arthritis(RA) Prevention Traditional chinese medicine(TcM) Huayu-Qiangshen-Tongbi decoction(HQT) clinical trial

combined hepatocellular and cholangiocellular carcinoma presenting with radiological characteristics of focal nodular hyperplasia

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World Journal of Gastroenterology 2009年第31期15卷 3940-3943页

作者： Inneke Willekens Anne Hoorens caroline Geers Bart Op de Beeck Frederik Vandenbroucke johan de Mey department of Radiology and Pathology

combined hepatocellular and cholangiocellular carcinoma (cHcc-cc) is a rare tumor type containing unequivocal elements of both hepatocellular carcinoma and cholangiocarcinoma that are intimately mixed. Although these tumors are usually considered to be more related to hepatocellular carcinoma than to cholangiocarcinoma, they sometimes, in contrast to hepatocellular carcinoma, contain a significant amount of fibrous stroma. This might in some cases explain atypical radiological features. We report a case of a cHcc-cc in a 47-year-old female that resembled focal nodular hyperplasia on Magnetic Resonance Imaging. correlation of imaging and serum levels of α-fetoprotein and cA19.9 can help to make the correct diagnosis preoperatively.

关键词： combined hepatocellular cholangiocellular carcinoma Magnetic resonance imaging

cenozoic low temperature cooling history of the eastern Lhasa terrane:Implications for high-relief topography of external drainage area in the southern Tibetan Plateau

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Geoscience Frontiers 2023年第5期14卷 126-140页

作者： Wenbo Su Zhiyuan He Linglin Zhong Stijn Glorie Kanghui Zhong johan de Grave Laboratory for Mineralogy and Petrology Department of GeologyGhent UniversityKrijgslaan 281 S89000 GhentBelgium college of Earth Sciences Chengdu University of TechnologyChengdu 610059China department of Earth Sciences School of Physical SciencesThe University of AdelaideSA-5005Australia

The Tibetan Plateau geographically contains internal and external drainage areas based on the distributions of river flows and *** internal and external drainage areas display similar highelevations,while their topographic reliefs are not comparable;the former shows a large low-relief surface,whereas the latter is characterized by relatively high *** eastern Lhasa terrane is a key tectonic component of the Tibetan *** is characterized by high topography and relief,but the thermal history of its basement remains relatively poorly *** this study we report new apatite fission track data from the eastern part of the central Lhasa terrane to constrain the thermo-tectonic evolution of the external drainage area in the southern Tibetan ***-one new AFT ages and associated thermal history models reveal that the basement underlying the external drainage area in southern Tibet experienced three main phases of rapid cooling in the *** Paleocene-early Eocene(-60–48 Ma)cooling was likely induced by crustal shortening and associated rock exhumation,due to accelerated northward subduction of the NeoTethys oceanic lithosphere.A subsequent cooling pulse lasted from the late Eocene to early Oligocene(-40–28 Ma),possibly due to the thickening and consequential erosion of the Lhasa lithosphere resulted from the continuous northward indentation of the India plate into *** most recent rapid cooling event occurred in the middle Miocene-early Pliocene(-16–4 Ma),likely induced by accelerated incision of the Lhasa River and local thrust *** AFT ages and published low-temperature thermochronological data reveal that the external drainage area experienced younger cooling events compared with the internal drainage area,and that the associated differentiated topographic evolution initiated at ca.30 *** contributing factors for the formation of the high-relief topography mainly contain active surface uplift,fault activity,

关键词： cenozoic Apatite fission track thermochronology Exhumation Lhasa terrane External drainage area Tibetan Plateau