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MicroRNAs:Promising chemoresistance biomarkers in gastric cancer with diagnostic and therapeutic potential

World Journal of Gastroenterology 2014年第38期20卷 13658-13666页

作者： Christiane Matuszcak joerg haier Richard Hummel Kirsten Lindner Department of General and Visceral Surgery Muenster University Hospital Comprehensive Cancer Centre Muenster University Hospital

Gastric cancer(GC) is the fourth most common cancer worldwide and ranks second in global cancer mortality statistics. Perioperative chemotherapy plays an important role in the management and treatment of advanced stage disease. However,response to chemotherapy varies widely,with some patients presenting no or only minor response to treatment. Hence,chemotherapy resistance is a major clinical problem that impacts on outcome. Unfortunately,to date there are no reliable biomarkers available that predict response to chemotherapy before the start of the treatment,or that allow modification of chemotherapy resistance. MicroRNAs(miRNAs) could provide an answer to this problem. miRNAs are involved in the initiation and progression of a variety of cancer types,and there is evidence that miRNAs impact on resistance towards chemotherapeutic drugs as well. This current review aims to provide an overview about the potential clinical applicability of miRNAs as biomarkers for chemoresistance in *** authors focus in this context on the potential of miRNAs to predict sensitivity towards different chemotherapeutics,and on the potential of miRNAs to modulate sensitivity and resistance towards chemotherapy in GC.

关键词： MicroRNAs Biomarker Chemoresistance Gastric cancer Diagnostic Therapeutic

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MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines

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World Journal of Gastroenterology 2014年第40期20卷 14904-14912页

作者： Richard Hummel Corina Sie David I Watson Tingting Wang Alfiya Ansar Michael Z Michael Mark Van der Hoek joerg haier Damian J Hussey Department of Surgery Flinders University Bedford Park South Australia 5042 Australia Department of General and Visceral Surgery University of Muenster 48149 Muenster Germany Department of Gastroenterology and Hepatology Flinders University 5042 Bedford Park South Australia Australia Adelaide Microarray Centre SA Pathology 5000 Adelaide South Australia Australia Comprehensive Cancer Centre University of Muenster 48149 Muenster Germany

AIM: To investigate expression of microRNA (miRNA) and potential targets in chemotherapy resistant esophageal cancer cell lines.

关键词： Esophageal cancer MicroRNA Chemotherapy Resistance Target

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