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HANDEL'S FIXED POINT THEOREM:A MORSE THEORETICAL POINT OF VIEW

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Acta Mathematica Scientia 2021年第6期41卷 2149-2172页

作者： Patrice le calvez Institut de Mathématiques de Jussieu-Paris Rive Gauche IMJ-PRGSorbonne UniversitéUniversitéParis-DiderotCNRSF-75005ParisFrance Institut Universitaire de France ParisFrance

Michael Handel has proved in [10] a fixed point theorem for an orientation preserving homeomorphism of the open unit disk, that turned out to be an efficient tool in the study of the dynamics of surface homeomorphisms. The present article fits into a series of articles by the author [13] and by Juliana Xavier [21, 22], where proofs were given, related to the classical Brouwer Theory, instead of the Homotopical Brouwer Theory used in the original article. Like in [13, 21] and [22], we will use “free brick decompositions” but will present a more conceptual Morse theoretical argument. It is based on a new preliminary lemma, that gives a nice “condition at infinity” for our problem.

关键词： brick decomposition Brouwer theory translation arc

Added value of molecular karyotype in childhood acute lymphoblastic leukemia

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Cancer Innovation 2023年第6期2卷 513-523页

作者： Margaux Camuset Baptiste le calvez Olivier Theisen Catherine Godon Audrey Grain Caroline Thomas Marie-Laure Couec Marie C.Béné Fanny Rialland Marion Eveillard Pediatric Oncology CHU NantesNantes UniversitéUniv AngersINSERMCNRSCRCI2NANantesFrance Hematology Biology CHU NantesNantes UniversitéUniv AngersINSERMCNRSCRCI2NANantesFrance

Background:Thanks to an improved therapeutic regimen in childhood B-cell precursor acute lymphoblastic leukemia(BCP-ALL),5 year-overall survival now exceeds 90%.Unfortunately,the 25%of children who relapse have an initial poor prognosis,potentially driven by pre-existing or emerging molecular *** latter are initially and essentially identified by ***,some subtle alterations are not visible through ***:Single nucleotide polymorphisms(SNP)array is an alternative way of chromosomal analysis allowing for a more in-depth evaluation of chromosomal modifications such as the assessment of copy number alterations(CNA)and loss of heterozygosity(LOH).This method was applied here in retrospective diagnosis/relapse paired samples from seven children with BCP-ALL and in a prospective cohort of 38 newly diagnosed childhood ***:In the matched study,compared to the initial karyotype,SNP array analysis reclassified two patients as poor prognosis *** during relapse was seen for 4 CNA and 0.9 *** the prospective study,SNP reclassified the 10 patients with intermediate karyotype as 7 good prognosis and 3 poor ***,in all the children tested,SNP array allowed to identify additional anomalies compared to conventional karyotype,refine its prognostic value and identify some druggable anomalies that could be used for precision ***,the anomalies detected could be segregated in four groups respectively involved in B-cell development,cell proliferation,transcription and molecular ***:SNP therefore appears to be a method of choice in the integrated diagnosis of BCP ALL,especially for patients initially classified as intermediate *** complementary method of both cytogenetics and high throughput sequencing allows to obtain further classified information and can be useful in case of failure of these techniques.

关键词： BCP-ALL karyotype pediatric patients prognosis SNP array

Influence of Ag Doping on Physico-Chemical Properties of the Ge28Sb12Se60 Chalcogenide Glassy Matrix

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材料科学与工程（中英文A版） 2016年第3期6卷 131-147页

作者： Deepak Patil Manisha Konale Lukas Strizik Laurent calvez David le Coq Bozena Frumarova MilanVlcek Tomas Wagner Department of General and Inorganic Chemistry and CEMNAT Faculty of Chemical Technology University of PardubiceStudentska 95 Pardubice 53210 Czech Republic Current Affiliation-School of Mechanical and Materials Engineering Washington State University Pullman WA- 99164 USA Institut des Sciences Chimiques de Rennes Eq. Verres et COramiques UMR 6226 CNRS University de Rennesl 35042 RennesCedex France Institute of Macromolecular Chemistry of Czech Academy of Sciences v.v.i. Heyrovskeho nam. 2 162 06 Prague Czech Republic

High-elevation hypoxia impacts perinatal physiology and performance in a potential montane colonizer

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Integrative Zoology 2020年第6期15卷 544-557页

作者： Jérémie SOUCHET Eric J.GANGLOFF Gaëlle MICHELI Coralie BOSSU Audrey TROCHET Romain BERTRAND Jean CLOBERT Olivier calvez Albert MARTINEZ-SILVESTRE Elodie DARNET Hugo le CHEVALIER Olivier GUILLAUME Marc MOSSOLL-TORRES Laurent BARTHE Gilles POTTIER HervéPHILIPPE Fabien AUBRET Station d’Ecologie Théorique et Expérimentale du Centre National de la Recherche Scientifique MoulisFrance Department of Zoology Ohio Wesleyan UniversityDelawareOhioUSA Catalonia Reptile and Amphibian Rescue Center(CRARC) MasquefaBarcelonaSpain Bomosa Pl.Parc de la MolaLes EscaldesAndorra Pirenalia EncampAndorra Nature En Occitanie ToulouseFrance Département de Biochimie Centre Robert-CedergrenUniversitéde MontréalMontréalCanada

Climate change is generating range shifts in many organisms,notably along the elevational gradient in mountainous ***,moving up in elevation exposes organisms to lower oxygen availability,which may reduce the successful reproduction and development of oviparous *** test this possibility in an upwardcolonizing species,we artificially incubated developing embryos of the viperine snake(Natrix maura)using a split-clutch design,in conditions of extreme high elevation(hypoxia at 2877 m above sea level;72%sea-level equivalent O2 availability)or low elevation(control group;*** at 436 m above sea level).Hatching success did not differ between the two *** developing at extreme high elevation had higher heart rates and hatched earlier,resulting in hatchlings that were smaller in body size and slower swimmers compared to their siblings incubated at lower ***,post-hatching reciprocal transplant of juveniles showed that snakes which developed at extreme high elevation,when transferred back to low elevation,did not recover full performance compared to their siblings from the low elevation incubation *** results suggest that incubation at extreme high elevation,including the effects of hypoxia,will not prevent oviparous ectotherms from producing viable young,but may pose significant physiological challenges on developing offspring in *** early-life performance limitations imposed by extreme high elevation could have negative consequences on adult phenotypes,including on fitness-related traits.

关键词： developmental plasticity embryonic metabolism high-elevation hypoxia locomotor performance Natrix maura

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井眼地震测量：超越垂直剖面

国外测井技术 2008年第6期23卷 56-69页

作者： John Blackburn John Daniels Scott Dingwall Geoffrey Hampden-Smith Scott leaney Joel le calvez les Nutt Henry Menkiti Adrian Sanchez Marco Schinelli 康菲石油英国有限公司不详壳牌勘探与生产公司巴西石油公司

当前的井眼地震技术为研究井眼钻穿的地层提供了新的机会。从建井与三维盐下成像到增产措施监测和高温、高压采集，井眼地震测量都可以帮助作业公司降低作业风险，提高采收率。

关键词：地震测量井眼垂直剖面地震技术盐下成像采收率作业