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Inhibition of EGFR Suppresses Ethyl Alcohol and Tobacco Cell Effects on Growth of Human Oral Keratinocytes and Human Papillomavirus 16 Entry as a Function of Furin

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Journal of Cancer Therapy 2015年第1期6卷 90-108页

作者： joel L. schwartz Alexander Munaretto Sirlata Bagchi David Crowe Gonzalo Izaguirre Department of Oral Medicine and Diagnostics University of Illinois at Chicago Chicago USA College of Dentistry University of Illinois at Chicago Chicago USA Department of Periodontics University of Illinois at Chicago Chicago USA

Background: Reported are increased risks for malignant transformation in human oral keratinocytes (HOK) from ethyl alcohol (ETOH), tobacco products or human papilloma virus oncogenic subtype 16 (HPV 16) infections. We examined various HOK cell responses to these factors to show inhibitors of epidermal growth factor receptor (EGFR) also inhibits furin;proprotein convertase (FC) and HPV 16 entry in HOK. Methods: Immortalized HOK by HPV 16 (HPV 16B) or human telomerase (hTERT);primary foreskin keratinocytes (NHFK), primary HOK, buccal keratinocytes (NHBK) and oral SCC-25 were treated with dibenz[a,l]pyrene (DBP), anthraquinone;nitrosamine (NNAL) or ethyl alcohol (ETOH) and acetaldehyde (AA). ETOH was tested for synthesis of malondialdehyde (MDA) and alcohol dehydrogenase expression (ADH). ETOH, and PAH were evaluated by Western immunoblot for oncogene changes, and phosphorylated EGFR expression. Inhibition of EGFR by WZ4002 and Erlotinib and/or carcinogens effect on HPV 16 entry were studied. A green fluorescent pseudovirus (PsV);chloromethylketone (CMK) an inhibitor of furin activity and Western immunoblot of furin cell distribution further characterized HPV 16 entry. Results: ETOH (10 μM) increased expression of phosphorylated EGFR and HPV 16 entry through furin activity, and membrane, nuclear and cytoskeletal accumulations. CMK suppressed HPV 16 entry and blockage of ADH while aldehyde dehydrogenase (ALDH) enhanced HPV 16 entry. Similarly PAH, DBP (4-8 nM), anthraquinone (98 nM) and NNAL (6.9 μM) enhanced HPV 16 entry through furin activity and membrane, nuclear and cytoskeletal accumulations. Furthermore, WZ4002 and Erlotinib suppressed expressions of phosphorylated EGFR, FC activity, and HPV 16 entry. ETOH and DBP treatments also enhanced expressions of protease activated receptor-1 (PAR-1), and p21waf1 while depressed p16 and p27KIP1 expressions in HOK/HPV 16B cells. Conclusion: EGFR inhibitors are candidates for suppression of alcohol and tobacco effects on EGFR

关键词： Ethyl Alcohol Tobacco Poly-Cyclic Aromatic Hydrocarbons Nitrosamines DNA Damage Tumor Suppressor Oncogene HPV 16 Furin Proprotein Convertase EGFR Inhibitors Phospho-L-Tyrosine Inhibitors

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Entangled photons enabled ultrafast stimulated Raman spectroscopy for molecular dynamics

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Light(Science & Applications) 2024年第8期13卷 1615-1622页

作者： Jiahao joel Fan Zhe-Yu Ou Zhedong Zhang Department of Physics City University of Hong KongKowloonHong Kong SARChina City University of Hong Kong Shenzhen Research InstituteShenzhenGuangdongChina

Quantum entanglement has emerged as a great resource for studying the interactions between molecules and *** propose a new scheme of stimulated Raman scattering with entangled photons.A quantum ultrafast Raman spectroscopy is developed for condensed-phase molecules,to monitor the exciton populations and *** results are obtained,showing an entanglement-enabled time-frequency scale not attainable by classical *** Raman signal presents an unprecedented selectivity of molecular correlation functions,as a result of the Hong-Ou-Mandel *** work suggests a new paradigm of using an unconventional interferometer as part of spectroscopy,with the potential to unveil advanced information about complex materials.

关键词： materials spectroscopy selectivity

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Gastroesophageal reflux following per-oral endoscopic myotomy:Can we improve outcomes?

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World Journal of Gastroenterology 2024年第22期30卷 2834-2838页

作者： Inian Samarasam Raj Kumar joel Anna B Pulimood Department of Surgery Upper Gastrointestinal Surgery UnitChristian Medical College&HospitalVellore 632004TamilnaduIndia Department of Cardiothoracic Surgery Christian Medical College&HospitalVellore 632004TamilnaduIndia Department of Gastrointestinal Sciences Christian Medical College and HospitalVellore 632004Tamil NaduIndia

This editorial is an analysis the review article by Nabi et al recently published in this *** Cardia is a disease whose pathophysiology is still *** is known that there is inflammation of unknown aetiology leading to loss of ganglion cells in the muscularis *** end result is lower oesophageal sphincter spasm,loss of receptive relaxation,decreased oesophageal peristalsis,all leading on to varying degrees of *** treatment of this condition is palliative in nature,performed by myotomy of the lower oesophagus either surgically or *** reflux disease(GERD)has been associated with the myotomy performed,particularly with the Peroral Endoscopic Myotomy(POEM)*** et al have provided an excellent overview of the latest developments in predicting,preventing,evaluating,and managing GERD subsequent to *** on this theme,this review article explores the concept of using histology of the oesophageal muscle layer,to grade the disease and thereby help tailoring the length/type of myotomy performed during the POEM *** the future,will a histology based algorithm available preoperatively,help modify the POEM procedure,thereby decreasing the incidence of GERD associated with POEM?

关键词： Achalasia cardia Peroral endoscopic myotomy Laparoscopic Heller’s myotomy Histopathology Histologic grading

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Experimental and numerical investigation to elucidate the fluid flow through packed beds with structured particle packings

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Particuology 2024年第6期89卷 218-237页

作者： Shirin Patil Christian Gorges joel Lòpez Bonilla Moritz Stelter Frank Beyrau Berend van Wachem Laboratory of Technical Thermodynamics Otto-von-Guericke-Universität MagdeburgUniversitätsplatz 239106 MagdeburgGermany Chair of Mechanical Process Engineering Otto-von-Guericke-Universität MagdeburgUniversitätsplatz 239106 MagdeburgGermany

The present paper presents an experimental and numerical investigation of the dispersion of the gaseous jet flow and co-flow for the simple unit cell(SUC)and body-centred cubic(BCC)configuration of particles in packed *** experimental setup is built in such a way that suitable and simplified boundary conditions are imposed for the corresponding numerical framework,so the simulations can be done under very similar conditions as the ***,a porous plate is used for the co-flow to achieve the uniform velocity and the fully developed flow is ensured for the jet *** SUC and BCC particle beds consist of 3D-printed spheres,and the non-isotropy near the walls is mostly eliminated by placing half-spheres at the channel *** flow velocities are analysed directly at the exit of the particle bed for both beds over 36 pores for the SUC configuration and 60 pores for the BCC configuration,for particle Reynolds numbers of 200,300,and *** particle image velocimetry is experimentally arranged in such a way that the velocities over the entire region at the exit of the packed bed are obtained *** numerical method consists of a state-of-the-art immersed boundary method with adaptive mesh *** paper presents the pore jet structure and velocity field exiting from each pore for the SUC and BCC packed particle *** numerical and experimental studies show a good agreement for the SUC configuration for all flow *** the BCC configuration,some differences can be observed in the pore jet flow structure between the simulations and the experiments,but the general flow velocity distribution shows a good overall *** axial velocity is generally higher for the pores located near the centre of the packed bed than for the pores near the *** addition,the axial velocities are observed to increase near the peripheral pores of the packed *** behaviour is predominant for the BCC configuration as compared to t

关键词： Uniform particle packing Packed bed reactor Stereo particle image velocimetry Immersed boundary method

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Shifting the paradigm:A critical review of social innovation literature

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International Journal of Innovation Studies 2024年第1期8卷 45-58页

作者： Amy Phillips Rosalie Luo joel Wendland-Liu Social Innovation Program Grand Valley State UniversityGrand Rapids49504USA Ivey School of Business Western UniversityPLondonN6A 0E1Canada Social Innovation Program Grand Valley State UniversityAllendale49401USA

In this review of ten years of social innovation research(2012e2022),we define and explore three paradigms in the field:instrumentalist,strong,and *** investigate how language usage and geography play a central role in identifying which paradigms recently published scholarship falls *** we do not insist that sharp divisions exist between each paradigm,we do find that on the“instrumentalist”side,language tends to abstract or neutralize power ***,these perspectives tend to derive from Western or Eurocentric orientations or ***“strong”paradigm accepts the necessity of institutional and stakeholder engagement and seeks to engage socially excluded *** contrast,geographical diversity,attendance to historicized and systemic inequalities,and elevation of the most marginalized communities are more likely to be centered in the“democratic”*** apply this discussion to recent research in arts-related social innovation and the related field of social entrepreneurship.

关键词： Social innovation Culture Arts Social entrepreneurship Ethnocentrism

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Everything is Primitive Accumulation?

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Fudan Journal of the Humanities and Social Sciences 2024年第2期17卷 337-360页

作者： David S.Pena joel Wendland-Liu Palm Beach State College Palm Beach GardensFLUSA Grand Valley State University AllendaleMIUSA

This paper explores the Marxist concept of primitive accumulation and its relationship to capitalist development. Primitive accumulation occurs as a historical process before the complete emergence of capitalism as the dominant mode of production. Primitive accumulation is distinguished from other forms of exploitation employed by capitalist societies to spread capitalism into non-capitalist regions. An exploration of different interpretations of primitive accumulation within Marxist theory highlights the transition from primary accumulation to capitalist accumulation in specific contexts. This paper provides a comprehensive overview of the multifaceted nature of primitive accumulation and its significance in the development of capitalism. It argues that many uses of primitive accumulation in the present context are erroneous.

关键词： Marxism Primitive accumulation Origins of capitalism Political economy

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Urban Air Pollution May Enhance COVID-19 Case-Fatality and Mortality Rates in the United States

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The Innovation 2020年第3期1卷 114-122页

作者： Donghai Liang Liuhua Shi Jingxuan Zhao Pengfei Liu Jeremy A.Sarnat Song Gao joel schwartz Yang Liu Stefanie T.Ebelt Noah Scovronick Howard H.Chang Gangarosa Department of Environmental Health Rollins School of Public HealthEmory University1518 Clifton Road NEAtlantaGA 30322USA Surveillance and Health Services Research Program American Cancer SocietyAtlantaGAUSA School of Earth and Atmospheric Sciences Georgia Institute of TechnologyAtlantaGAUSA GeoDS Lab Department of GeographyUniversity of Wisconsin-MadisonMadisonWIUSA Department of Environmental Health Harvard T.H.Chan School of Public HealthBostonMAUSA Department of Biostatistics and Bioinformatics Rollins School of Public HealthEmory UniversityAtlantaGAUSA

BACKGROUND The novel human coronavirus disease 2019(COVID-19)pandemic has claimed more than 600,000 lives worldwide,causing tremendous public health,social,and economic *** the risk factors of COVID-19 are still under investigation,environmental factors,such as urban air pollution,may play an important role in increasing population susceptibility to COVID-19 *** We conducted a cross-sectional nationwide study using zero-inflated negative binomial models to estimate the association between longterm(2010–2016)county-level exposures to NO2,PM2.5,and O3 and county-level COVID-19 case-fatality and mortality rates in the United *** used both single-and multi-pollutant models and controlled for spatial trends and a comprehensive set of potential confounders,including state-level test positive rate,county-level health care capacity,phase of epidemic,population mobility,population density,sociodemographics,socioeconomic status,race and ethnicity,behavioral risk factors,and *** From January 22,2020,to July 17,2020,3,659,828 COVID-19 cases and 138,552 deaths were reported in 3,076 US counties,with an overall observed case-fatality rate of 3.8%.County-level average NO2 concentrations were positively associated with both COVID-19 case-fatality rate and mortality rate in single-,bi-,and tri-pollutant *** adjusted for co-pollutants,per interquartile-range(IQR)increase in NO2(4.6 ppb),COVID-19 case-fatality rate and mortality rate were associated with an increase of 11.3%(95%CI 4.9%–18.2%)and 16.2%(95%CI 8.7%–24.0%),*** did not observe significant associations between COVID-19 case-fatality rate and long-term exposure to PM2.5 or O3,although per IQR increase in PM2.5(2.6 mg/m3)was marginally associated,with a 14.9%(95%CI 0.0%–31.9%)increase in COVID-19 mortality rate when adjusted for *** Long-term exposure to NO2,which largely arises from urban combustion sources such as traffic,may enhanc

关键词： AIR POLLUTION NITROGEN DIOXIDE COVID-19 CASEFATALITY RATE MORTALITY

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Long-term effects of PM_(2.5) components on incident dementia in the northeastern United States

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The Innovation 2022年第2期3卷 95-102页

作者： Jing Li Yifan Wang Kyle Steenland Pengfei Liu Aaron van Donkelaar Randall V.Martin Howard H.Chang W.Michael Caudle joel schwartz Petros Koutrakis Liuhua Shi Department of Environmental Health Harvard T.H.Chan School of Public HealthBostonMA 02115USA Gangarosa Department of Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30322USA School of Earth and Atmospheric Sciences Georgia Institute of TechnologyAtlantaGA 30332USA Department of Energy Environmental&Chemical EngineeringWashington University at St.LouisMO 63130USA Department of Biostatistics and Bioinformatics Rollins School of Public HealthEmory UniversityAtlantaGA 30322USA

Growing evidence has linked long-term fine particulate matter(PM_(2.5))exposure to neurological *** is known about the individual effects of PM_(2.5) components.A population-based cohort study investigated the association between long-term(1-year average)exposure to PM_(2.5) components and dementia incidence among the elderly population(age,R65 years)in the United States.

关键词： northeastern incident exposure

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Size and crystallinity effect on the ultrafast optical response of chemically synthesized silver nanoparticles

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Journal of Materiomics 2024年第3期10卷 594-600页

作者： Nadzeya Khinevich Domantas Peckus Asta Tamuleviciene Gerda Klimaite joel Henzie Tomas Tamulevicius Sigitas Tamulevicius Institute of Materials Science of Kaunas University of Technology K.Barsausko St.59LT-51423KaunasLithuania Department of Physics Kaunas University of TechnologyStudentu˛St.50LT-51368KaunasLithuania International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)Tsukuba305-0044Japan

The excited localized surface plasmon(LSP)in metallic nanoparticles is known to relax through several processes such as electron-electron scattering,electron-phonon coupling,and phonon-phonon *** the current research,the ultrafast electron-phonon(e-ph)coupling relaxation processes for different average sizes and crystallinity of chemically synthesized silver nanoparticles were evaluated utilizing transient absorption *** nanoparticle size and crystallinity of similar linear dimension polycrystalline spherical and monocrystalline cubic nanoparticles ranging from ca.30-60 nm was related to their electron relaxation time constants and revealed very different *** the monocrystalline nanocubes,the electron-phonon coupling was not dependent on the cube edge length,while for the polycrystalline nanospheres,it was linearly decreasing with *** demonstrate that the e-ph coupling time constant could be used to evaluate crystallinity and crystallite size in plasmonic metal nanoparticles when the size(surface area)of the nanoparticle is known.

关键词： Silver nanospheres Silver nanocubes Electron-phonon coupling Transient absorption spectroscopy Crystallite size Polycrystalline structure

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长期炭黑暴露与颈动脉内中膜厚度：标准化衰老研究

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环境与职业医学 2014年第5期31卷 414-418页

作者： Elissa H.Wilker Murray A.Mittleman Brent A.Coull Alexandros Gryparis Michiel L.Bots joel schwartz David Sparrow 王晓宇汪源 Cardiovascular Epidemiology Research Unit Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Environmental Health Harvard School of Public HealthBostonMassachusettsUSA Department of Epidemiology Harvard School of Public HealthBostonMassachusettsUSA Department of Biostatistics Harvard School of Public HealthBostonMassachusettsUSA Julius Center for Health Sciences and Primary Care Utrechtthe Netherlands Normative Aging Study Veterans Affairs Boston Healthcare SystemBostonMassachusettsUSA Department of Medicine Boston University School of MedicineBostonMassachusettsUSA

[背景]有证据表明,空气污染与动脉粥样硬化相关,且交通源颗粒物是此相关性极其重要的归因。[目的]研究居住在马塞诸塞州大波士顿地区的老年男性长期炭黑暴露与颈总动脉内中膜厚度(CIMT)之间的相关性。[方法]在标准化衰老研究参与者进行... 详细信息

[背景]有证据表明,空气污染与动脉粥样硬化相关,且交通源颗粒物是此相关性极其重要的归因。[目的]研究居住在马塞诸塞州大波士顿地区的老年男性长期炭黑暴露与颈总动脉内中膜厚度(CIMT)之间的相关性。[方法]在标准化衰老研究参与者进行首次CIMT测量之前,评估他们住址处的一年平均炭黑暴露水平。使用混合效应模型评估炭黑水平估值与CIMT之间的相关性,计算重复的结果测定指标。在二次分析中,研究居住在主干道附近或住宅100 m内的日均交通流量是否与CIMT相关。[结果]2004—2008年间,共有380名参与者(97%自述为白种人)接受了首次访问。每隔1.5年,分别有340名(89%)参与者接受了二次访问,260名(68%)参与者接受了三次访问。第一次检查时,参与者的年龄(均数±标准差)为(76±6.4)岁,CIMT(均数±标准差)为(0.99±0.18)mm。根据完全校正的模型,一年平均炭黑暴露每增加1个四分位数间距范围(0.26μg/m3),CIMT增加1.1%(95%CI:0.1%～1.7%)。[结论]在老年男性中,根据空间分辨暴露估值得出的年平均炭黑浓度与CIMT相关。本文的结果表明,长期空气污染暴露与动脉粥样硬化之间存在相关性。

关键词： CIMT 衰老研究空气污染年平均内中膜厚度波士顿地区交通源颈总动脉协变量基线值

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