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Effect of Aerobic Exercise on Protein Expression in Muscle of Obese Mexican Adolescents: A Proteomic and Bioinformatic Analysis

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Natural Science 2014年第9期6卷 641-650页

作者： Maciste H. Macías-Cervantes Juan M. Guzmán-Flores Katya Vargas-Ortiz Francisco J. Díaz-Cisneros joel ramírez-emiliano Victoriano Pérez-Vázquez Departmento de Ciencias Aplicadas al Trabajo División de Ciencias de la Salud Universidad de Guanajuato León México Departmento de Ciencias Médicas División de Ciencias de la Salud Universidad de Guanajuato León México

The beneficial effects of exercise have been recognized for many years yet the molecular mechanisms by which exercise show benefits on health are still elusive. A combination of experimental and bioinformatics approaches can be an invaluable tool to increase the cellular understanding of the molecular mechanisms that underlie the aerobic exercise in obese adolescents. Muscle skeletal proteins were separated by 2D-PAGE and changes in protein expression were revealed by ImageMaster 2D Platinum analysis software. Proteins with expression changes after aerobic exercise were identified by comparison with 2D maps from SWISS-2DPAGE and interactions of proteins were analyzed with STRING and DAVID databases. After aerobic exercise, all participants decreased glucose, insulin, total cholesterol, body mass index and waist circumference. Proteomic differential analysis revealed 10 overexpressed proteins after aerobic training, which correspond to carbonic anhydrase III, beta enolase, creatine kinase, ATP synthase beta subunit, aldolase A, glyceraldehyde-3-phosphate dehydrogenase, triosephosphate isomerase, pyruvate kinase, lactate dehydrogenase and adenylate kinase. Exercise increased glycolysis and oxidative phosphorylation pathways, which is likely to be regulated by ubiquitin c protein. In conclusion, our analysis suggested that obese adolescents show changes in their body mass index, waist circumference and serum glucose after aerobic exercise through improved protein expression patterns that aid, especially, glucose metabolism and increase the oxidative phosphorylation. The most likely explanation for the observed pattern is that ubiquitin c protein keeps the glycolytic enzymes bound within skeletal muscle, obtaining a non-degradative role in cell signaling.

关键词： Glycolysis Oxidative Phosphorylation Ubiquitin C Protein Proteomics Exercise

Brain-derived neurotrophic factor plasma levels and premature cognitive impairment/dementia in type 2 diabetes

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World Journal of Diabetes 2016年第20期7卷 615-620页

作者： Blanca Murillo Ortíz joel ramírez emiliano Edna ramos-Rodríguez Sandra Martínez-Garza Hilda Macías-Cervantes Sergio Solorio-Meza Texar Alfonso Pereyra-Nobara Unidad de Investigación en Epidemiología Clínica Unidad Médica de Alta Especialidad No. 1 BajioInstituto Mexicano del Seguro Social Departamento de Ciencias Médicas División Ciencias de la SaludUniversidad de Guanajuato

AIM To assess the relationship of brain-derived neurotrophic factor(BDNF) with cognitive impairment in patients with type 2 diabetes. METHODS The study included 40 patients with diabetes mellitus type 2(DM2), 37 patients with chronic kidney disease in hem dialysis hemodialysis therapy(HD) and 40 healthy subjects. BDNF in serum was quantified by ELISA. The Folstein Mini-Mental State Examination was used to evaluate cognitive *** The patients with DM2 and the patients in HD were categorized into two groups, with cognitive impairment and without cognitive impairment. The levels of BDNF showed significant differences between patients with DM2(43.78 ± 9.05 vs 31.55 ± 10.24, P = 0.005). There were no differences between patients in HD(11.39 ± 8.87 vs 11.11 ± 10.64 P = 0.77); interestingly, ferritin levels were higher in patients with cognitive impairment(1564 ± 1335 vs 664 ± 484 P = 0.001). The comparison of BDNF values, using a Kruskal Wallis test, between patients with DM2, in HD and healthy controls showed statistical differences(P < 0.001).CONCLUSION Low levels of BDNF are associated with cognitive impairment in patients with DM2. The decrease of BDNF occurs early and progressively in patients in HD.

关键词： Diabetes mellitus type 2 Hemodialysis Brain-derived neurotrophic factor Folstein mini-mental Premature cognitive impairment

Gastroesophageal reflux following per-oral endoscopic myotomy:Can we improve outcomes?

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World Journal of Gastroenterology 2024年第22期30卷 2834-2838页

作者： Inian Samarasam Raj Kumar joel Anna B Pulimood Department of Surgery Upper Gastrointestinal Surgery UnitChristian Medical College&HospitalVellore 632004TamilnaduIndia Department of Cardiothoracic Surgery Christian Medical College&HospitalVellore 632004TamilnaduIndia Department of Gastrointestinal Sciences Christian Medical College and HospitalVellore 632004Tamil NaduIndia

This editorial is an analysis the review article by Nabi et al recently published in this *** Cardia is a disease whose pathophysiology is still *** is known that there is inflammation of unknown aetiology leading to loss of ganglion cells in the muscularis *** end result is lower oesophageal sphincter spasm,loss of receptive relaxation,decreased oesophageal peristalsis,all leading on to varying degrees of *** treatment of this condition is palliative in nature,performed by myotomy of the lower oesophagus either surgically or *** reflux disease(GERD)has been associated with the myotomy performed,particularly with the Peroral Endoscopic Myotomy(POEM)*** et al have provided an excellent overview of the latest developments in predicting,preventing,evaluating,and managing GERD subsequent to *** on this theme,this review article explores the concept of using histology of the oesophageal muscle layer,to grade the disease and thereby help tailoring the length/type of myotomy performed during the POEM *** the future,will a histology based algorithm available preoperatively,help modify the POEM procedure,thereby decreasing the incidence of GERD associated with POEM?

关键词： Achalasia cardia Peroral endoscopic myotomy Laparoscopic Heller’s myotomy Histopathology Histologic grading

Experimental and numerical investigation to elucidate the fluid flow through packed beds with structured particle packings

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Particuology 2024年第6期89卷 218-237页

作者： Shirin Patil Christian Gorges joel Lòpez Bonilla Moritz Stelter Frank Beyrau Berend van Wachem Laboratory of Technical Thermodynamics Otto-von-Guericke-Universität MagdeburgUniversitätsplatz 239106 MagdeburgGermany Chair of Mechanical Process Engineering Otto-von-Guericke-Universität MagdeburgUniversitätsplatz 239106 MagdeburgGermany

The present paper presents an experimental and numerical investigation of the dispersion of the gaseous jet flow and co-flow for the simple unit cell(SUC)and body-centred cubic(BCC)configuration of particles in packed *** experimental setup is built in such a way that suitable and simplified boundary conditions are imposed for the corresponding numerical framework,so the simulations can be done under very similar conditions as the ***,a porous plate is used for the co-flow to achieve the uniform velocity and the fully developed flow is ensured for the jet *** SUC and BCC particle beds consist of 3D-printed spheres,and the non-isotropy near the walls is mostly eliminated by placing half-spheres at the channel *** flow velocities are analysed directly at the exit of the particle bed for both beds over 36 pores for the SUC configuration and 60 pores for the BCC configuration,for particle Reynolds numbers of 200,300,and *** particle image velocimetry is experimentally arranged in such a way that the velocities over the entire region at the exit of the packed bed are obtained *** numerical method consists of a state-of-the-art immersed boundary method with adaptive mesh *** paper presents the pore jet structure and velocity field exiting from each pore for the SUC and BCC packed particle *** numerical and experimental studies show a good agreement for the SUC configuration for all flow *** the BCC configuration,some differences can be observed in the pore jet flow structure between the simulations and the experiments,but the general flow velocity distribution shows a good overall *** axial velocity is generally higher for the pores located near the centre of the packed bed than for the pores near the *** addition,the axial velocities are observed to increase near the peripheral pores of the packed *** behaviour is predominant for the BCC configuration as compared to t

关键词： Uniform particle packing Packed bed reactor Stereo particle image velocimetry Immersed boundary method

Shifting the paradigm:A critical review of social innovation literature

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International Journal of Innovation Studies 2024年第1期8卷 45-58页

作者： Amy Phillips Rosalie Luo joel Wendland-Liu Social Innovation Program Grand Valley State UniversityGrand Rapids49504USA Ivey School of Business Western UniversityPLondonN6A 0E1Canada Social Innovation Program Grand Valley State UniversityAllendale49401USA

In this review of ten years of social innovation research(2012e2022),we define and explore three paradigms in the field:instrumentalist,strong,and *** investigate how language usage and geography play a central role in identifying which paradigms recently published scholarship falls *** we do not insist that sharp divisions exist between each paradigm,we do find that on the“instrumentalist”side,language tends to abstract or neutralize power ***,these perspectives tend to derive from Western or Eurocentric orientations or ***“strong”paradigm accepts the necessity of institutional and stakeholder engagement and seeks to engage socially excluded *** contrast,geographical diversity,attendance to historicized and systemic inequalities,and elevation of the most marginalized communities are more likely to be centered in the“democratic”*** apply this discussion to recent research in arts-related social innovation and the related field of social entrepreneurship.

关键词： Social innovation Culture Arts Social entrepreneurship Ethnocentrism

Everything is Primitive Accumulation?

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Fudan Journal of the Humanities and Social Sciences 2024年第2期17卷 337-360页

作者： David S.Pena joel Wendland-Liu Palm Beach State College Palm Beach GardensFLUSA Grand Valley State University AllendaleMIUSA

This paper explores the Marxist concept of primitive accumulation and its relationship to capitalist development. Primitive accumulation occurs as a historical process before the complete emergence of capitalism as the dominant mode of production. Primitive accumulation is distinguished from other forms of exploitation employed by capitalist societies to spread capitalism into non-capitalist regions. An exploration of different interpretations of primitive accumulation within Marxist theory highlights the transition from primary accumulation to capitalist accumulation in specific contexts. This paper provides a comprehensive overview of the multifaceted nature of primitive accumulation and its significance in the development of capitalism. It argues that many uses of primitive accumulation in the present context are erroneous.

关键词： Marxism Primitive accumulation Origins of capitalism Political economy

The “Dead Universe” Theory: Natural Separation of Galaxies Driven by the Remnants of a Supermassive Dead Universe

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Natural Science 2024年第6期16卷 65-101页

作者： joel Almeida Department of Theology and Metaphysics UniFil University Curitiba Brazil

This article explores the dead universe theory as a novel interpretation for the origin and evolution of the universe, suggesting that our cosmos may have originated from the remnants of a preceding universe. This perspective challenges the conventional Big Bang theory, particularly concerning dark matter, the expansion of the universe, and the interpretation of phenomena such as gravitational waves.

关键词： Dead Universe Theory Heat Death of the Universe Big Bang Theory Universe’s Ultimate Fate Universe Expansion Big Freeze Universe Cosmological Models End of Universe Theories Natural Galaxy Drift Future of the Universe Universe Cooling Down Cosmology and Entropy

Characterizations That Help Explain Particle and Cosmic Data

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第3期10卷 1304-1357页

作者： Thomas joel Buckholtz Ronin Institute for Independent Scholarship Montclair USA

This paper suggests explanations for otherwise seemingly unexplained data about elementary particles and cosmology. The explanations have bases in coordinate-based modeling and in integer-based characterizations for some catalogs. One catalog features properties—including charge, mass, and angular momentum—of objects. Another catalog features all known and some possible elementary particles. Assumptions include that multipole-expansion mathematics has uses regarding long-range interactions, such as gravity, and that nature includes six isomers of all elementary particles other than long-range-interaction bosons. One isomer associates with ordinary matter. Five isomers are associated with dark matter. Multipole notions help explain large-scale aspects such as the rate of expansion of the universe.

关键词： Elementary Particles Dark Matter Rate of Expansion of the Universe Galaxy Formation Neutrino Masses Vacuum Energy Dark Energy Quantum Gravity

Audit of Neonatal Jaundice as Experienced at a Mission Hospital in Western Nigeria

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Open Journal of Pediatrics 2024年第1期14卷 50-62页

作者： joel-Medewase Victor Idowu Department of Paediatrics and Child Health Ladoke Akintola University of Technology Ogbomoso Nigeria

Introduction: Neonatal jaundice (NNJ) is a common disorder in neonates that can impact negatively on the brain and cause death. The peculiarities in aetiology and solutions for different settings are a knowledge gap. This informed the desire to determine local aetiology and solutions for neonatal jaundice in a missionary hospital in Abeokuta, Southwestern Nigeria. Methods: Consecutive consenting babies diagnosed with significant neonatal jaundice were studied between July 2016 and June 2019. Institutional ethical consent was obtained. A proforma was used to obtain socio-demographic data and other relevant information such as age, sex, birthweight, gestational age and history regarding the jaundice. All the information obtained was inputted into a computer and analysed with SPSS version 16. Results: A total of 179 babies with neonatal jaundice comprising of 120 (67.0%) boys and 59 (33.0%) girls with ages ranging between 1 and 12 days (mean 2.7 ± 2.9) were studied. Prematurity, ABO incompatibility, neonatal sepsis and glucose-6-phosphate enzyme deficiency accounted for over 80% of the causes of significant NNJ. Sixty (33.5%) of the 179 babies studied developed acute bilirubin encephalopathy and 11 (6.1%) mortalities were recorded. Higher proportions of babies that were out-born with spontaneous vaginal delivery modes had acute bilirubin encephalopathy (p < 0.05). Mothers with formal education had better outcome compared to mothers without, in terms of mortalities (p < 0.05). Conclusion: Neonatal jaundice is still a significant cause of morbidity and mortality in the neonatal age group. Maternal education is key to good outcome in neonatal jaundice.

关键词： Jaundice Neonates Bilirubinaemia Encephalopathy and Outcomes