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Alpha2-adrenergic receptor activation reinstates motor deficits in rats recovering from cortical injury

Neural Regeneration Research 2023年第4期18卷 875-880页

作者： Gabriela García-Díaz Laura ERamos-Languren Carmen Parra-Cid joel lomelí Sergio Montes Camilo Ríos Antonio Bueno-Nava Ignacio Valencia-Hernández Rigoberto González-Piña Department of Pharmacology Section of Postgraduate Studies and ResearchHigh Medical SchoolInstituto Politécnico NacionalSalvador Díaz MirónAlcaldía Miguel HidalgoMexico CityMexico Department of Neurobiology of Aging and Brain Damage Coordination of Psychobiology and NeurosciencesFaculty of PsychologyNational Autonomous University of MexicoAv.Universidad 3040Col.Copilco UniversidadAlcaldía CoyoacánMexico CityMexico Direction of Research National Institute of Rehabilitation LGIICalz.Mexico-Xochimilco 289Col.Arenal de GuadalupeAlcaldía TlalpanMexico CityMexico Department of Pharmacology Multidisciplinary Academic Unit Reynosa-Aztlan ReynosaAutonomous University of Tamaulipascalle 16 y lago de ChapalaCol.AztlánTamaulipasMexico Department of Neurochemistry National Institute of Neurology and Neurosurgery MVSAv.Insurgentes Sur 3877Col.La FamaAlcaldia TlalpanMexico CityMexico Department of Special Education University of the AmericasPuebla 223Col.RomaAlcaldía CuauhtémocMexico CityMexico

Norepinephrine plays an important role in motor functional recovery after a brain injury caused by ferrous *** of norepinephrine release by clonidine is correlated with motor deficits after motor cortex *** aim of this study was to analyze the role ofα-adrenergic receptors in the restoration of motor deficits in recovering rats after brain *** rats were randomly assigned to the sham and injury groups and then treated with the following pharmacological agents at 3 hours before and 8 hours,3 days,and 20 days after ferrous chloride-induced cortical injury:saline,clonidine,efaroxan(a selective antagonist ofα-adrenergic receptors)and clonidine+*** sensorimotor score,the immunohistochemical staining forα-adrenergic receptors,and norepinephrine levels were *** hours post-injury,the sensorimotor score and norepinephrine levels in the locus coeruleus of the injured rats decreased,and these effects were maintained 3 days ***,20 days later,clonidine administration diminished norepinephrine levels in the pons compared with the sham *** effect was accompanied by sensorimotor *** effects were blocked by *** conclusion,an increase inα-adrenergic receptor levels was observed after *** restores motor deficits in rats recovering from cortical injury,an effect that was prevented by *** underlying mechanisms involve the stimulation of hypersensitiveα-adrenergic receptors and inhibition of norepinephrine activity in the locus *** results of this study suggest thatαreceptor agonists might restore deficits or impede rehabilitation in patients with brain injury,and therefore pharmacological therapies need to be prescribed cautiously to these patients.

关键词： alpha2-adrenoceptors ambulatory behavior clonidine cortical injury efaroxan functional recovery immunohistochemistry motor deficit norepinephrine sensorimotor score

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Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

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Optical properties of Weyl semimetals

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National Science Review 2019年第2期6卷 206-208页

作者： joel E.Moore Department of Physics University of California Materials Science Division Lawrence Berkeley National Laboratory

The behavior of electrons in ordinary metals is dominated by physics near the Fermi surface. Indeed, many of the first successes of the quantum theory of solids, such as understanding the large specific heat of metals, followed from applications of the Fermi surface concept. Great effort has been devoted in recent years to semimetals in which the Fermi surface shrinks to a set of Dirac or Weyl points, where four

关键词： As Ta Optical properties of Weyl semimetals

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Effect of Cambering on the Aerodynamic Performance of Heaving Airfoils

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Journal of Bionic Engineering 2009年第4期6卷 398-404,406-407页

作者： joel E.Guerrero Postdoctoral Research Fellow Department of CivilEnvironmental and Architectural EngineeringUniversity of GenoaVia Montallegro 1Genoa16145Italy

In the present work,a parametric numerical study is conducted in order to assess the effect of airfoil cambering on the aerodynamic performance of rigid heaving *** incompressible Navier-Stokes equations are solved in their velocity-pressure formulation using a second-order accurate in space and time finite-difference *** tackle the problem of moving boundaries,the governing equations are solved on overlapping structured *** numerical simulations are performed at a Reynolds number of Re=1100 and at different values of Strouhal number and reduced *** results obtained show that the airfoil cambering geometric parameter has a strong influence on the average lift coefficient,while it has a smaller impact on the average thrust coefficient and propulsive efficiency of heaving airfoils.

关键词： heaving airfoils structured overlapping grids incompressible Navier-Stokes equations airfoil cambering

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Science： a world without borders

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Protein & Cell 2015年第8期6卷 551-552页

作者： joel Haywood CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China

In 2010 the effects of the global financial crisis were still being felt in the UK. Stock market confidence levels were low, unemployment levels were high and job opportunities were few and far between especially for new graduates with little work experience. Unfortunately for my partner, her recent graduation and search for job opportunities within the finance and law sector could not have come at a more unsuitable time. China however had better weathered the storm of the financial crisis and presented itself as a more familiar and fruitful climate for my partner to further develop her career. Furthermore.

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The evolution and refinements of varicocele surgery

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Asian Journal of Andrology 2016年第2期18卷 171-178,J0002页

作者： joel L Marmar Director of Men's Health Services Planned Parenthood of Southern New Jersey 317 S. Broadway Camden NJ 08103 USA.

Varicoceles had been recognized in clinical practice for over a century. Originally, these procedures were utilized for the management of pain but, since 1952, the repairs had been mostly for the treatment of male infertility. However, the diagnosis and treatment of varicoceles were controversial, because the pathophysiology was not clear, the entry criteria of the studies varied among centers, and there were few randomized clinical trials. Nevertheless, clinicians continued developing techniques for the correction of varicoceles, basic scientists continued investigations on the pathophysiology of varicoceles, and new outcome data from prospective randomized trials have appeared in the world＇s literature. Therefore, this special edition of the Asian Journal of Andrology was proposed to report much of the new information related to varicoceles and, as a specific part of this project, the present article was developed as a comprehensive review of the evolution and refinements of the corrective procedures.

关键词： antegrade sclerosis laparoscopic varicocelectomy microsurgical varicocelectomy percutaneous embolization varicocelectorny

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ON THE ALGORITHMIC COMPLEXITY OF STATIC STRUCTURES

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Journal of Systems Science & Complexity 2010年第6期23卷 1037-1053页

作者： joel RATSABY J. CHASKALOVIC joel RATSABY Dept. of Electrical and Electronics Engineering Ariel University Center of Samaria Ariel Israel Department of Mathematics Ariel University Center of Samaria Ariel Israel and IJLRDA University Pierre and Marie Curie-Paris VI France.

This paper provides a first indication that this is true for a system comprised of a static structure described by hyperbolic partial differential equations and is subjected to an external random input force. The system deforms the randomness of an input force sequence in proportion to its algorithmic complexity. The authors demonstrate this by numerical analysis of a one-dimensional vibrating elastic solid （the system） on which we apply a maximally-random force sequence （input）. The level of complexity of the system is controlled via external parameters. The output response is the field of displacements observed at several positions on the body. The algorithmic complexity and stochasticity of the resulting output displacement sequence is measured and compared against the complexity of the system. The results show that the higher the system complexity, the more random-deficient the output sequence.

关键词： Data compression descriptional complexity randomness static structure.

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Multi-frequency dielectrophoretic characterization of single cells

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Microsystems & Nanoengineering 2018年第1期4卷 156-164页

作者： Alex Jaffe joel Voldman Department of Electrical Engineering and Computer Science Massachusetts Institute of TechnologyCambridgeMAUSA

We explore the use of dielectrophoresis to discern the electrical properties of single cells by observing them at multiple *** first simulate experimental conditions to show that as we increase the number of measured frequencies,we are able to better discriminate among different ***,we use the simulation to find the optimal number and value of frequencies to use to best discriminate among different cells in *** then fabricate a microfluidic device,calibrate it with polystyrene beads,and characterize it with BA/F3 *** this device,we test three different activation levels of HL60 cells treated with cytochalasin D using the optimal frequency sequence obtained in simulation to determine the differences in discrimination abilities depending on the number of frequencies *** quantify the discrimination abilities of the optimal one,two,and three frequencies by minimizing 0-1 loss.

关键词： optimal beads characterization

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Stochastic-periodic Homogenization of Maxwell＇s Equations with Linear and Periodic Conductivity

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Acta Mathematica Sinica,English Series 2017年第1期33卷 117-152页

作者： joel FOTSO TACHAGO Hubert NNANG Faculty of Science Department of Mathematics and Computer Science University of Bamenda P. O. Box 39 Bambili Cameroon Higher Teachers Training College University of Yaounde I P. O. Box 47 Yaounde Cameroon

Stochastic-periodic homogenization is studied for the Maxwell equations with the linear ＂and periodic electric conductivity. It is shown by the stochastic-two-scale convergence method that the sequence of solutions t... 详细信息

关键词： Maxwell's equations dynamical system stochastic two-scale convergence

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Perspectives on the clinical management ocalized prostate cancer

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Asian Journal of Andrology 2014年第4期16卷 511-514页

作者： joel B Nelson Department of Urology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA.

Defined broadly, prostate cancer has two states： An indolent histologicalmanifestation of a locally proliferative and invasive process or a clinically relevant, potentially lethal disease. Likewise, the management of clinically localized prostate cancer must address two questions： what sort of disease is this and what needs to be done.

关键词： @@

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