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Open Journal of Pathology 2016年第1期6卷 8-13页

作者： Michael Losos basil M. Kahwash Miriam Conces joel Thompson Riten Kumar Samir b. Kahwash Department of Pathology The Ohio State University Wexner Medical Center Columbus OH USA Indiana University Indianapolis IN USA Department of Pathology and Laboratory Medicine Nationwide Children’s Hospital Columbus OH USA Department of Pediatrics The Ohio State University Division of Hematology/Oncology/BMT Nationwide Children’s Hospital Columbus OH USA

Jacobsen syndrome (JS) is a rare, inherited disorder, characterized by facial and skull dysmorphism, mental retardation, and platelet abnormalities. Paris-Trousseau syndrome (PTS) is a platelet function disorder that may be encountered in patients affected by JS. PTS is manifested by a mild lifelong bleeding tendency. Morphologically, the presence of large fused platelet alpha granules is characteristic. We present a case of Jacobsen syndrome in a child and highlight the typical morphologic and ultrastructure findings of platelets.

关键词： Jacobsen Syndrome Paris-Trousseau Syndrome Platelet Microscopic Findings Electron Microscopy

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先天性内斜视

国际眼科纵览 1988年第2期 77-83页

作者： Leonard b nelson 袁乃芬

一、临床表现 (一)视力人们已知先天性内斜视和弱视的关系,但很难确定其准确的发病率。Costenbader报告500例先天性内斜视,其中弱视205例,许多婴儿“交叉注视”。一些进行婴幼儿视力试验研究的作者指出,选择性注视开始后几个月即可

关键词：先天性内斜视过矫内直肌下斜肌截除术眼球后退综合征隐性眼球震颤潜伏性眼球震颤斜视角角膜缘切口手术矫正欠矫结膜切口遮盖试验斜视遮盖检查法

Experimental salt cavern in offshore ultra-deep water and well designevaluation for CO_(2) abatement

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International Journal of Mining Science and Technology 2019年第5期29卷 641-656页

作者： Alvaro Maia da Costa Pedro V.M.Costa Antonio C.O.Miranda Mariana b.R.Goulart Okhiria D.Udebhulu nelson F.F.Ebecken Ricardo C.Azevedo Sérgio M.de Eston Giorgio de Tomi Andre b.Mendes Julio R.Meneghini Kazuo Nishimoto Claudio Mueller Sampaio Camila brandao Alexandre breda University of Sao Paulo(USP) Sao Paulo 01000-000Brazil Modecom-Technology in Geomechanics and Computing Modeling Rio de Janeiro 27570-000Brazil Department of Civil and Environment Engineering University of Brasília(UnB)Brasília 70000-000Brazil COPPE Federal University of Rio de JaneiroRio de Janeiro 27570-000Brazil Technology Division of Shell Shell BrazilRio de Janeiro 27570-000Brazil

This paper presents a proposal for an experimental salt cavern in offshore ultra-deep water for CO2 abatement,including the instrumentation plan and well conceptual design evaluated for carbon capture and storage(CCS)*** studies are based on applied computational mechanics associated with field experimentation that has contributed to the technical feasibility of the underground potash mine at the State of Sergipe in *** knowhow allowed the stability analysis of several salt caverns for brine production at the State of Alagoas in brazil and to the drilling through stratified thick layers of salt of the pre-salt reservoirs in Santos ***,this knowledge has been applied in the design of onshore and offshore salt caverns opened by dissolution for storage of natural gas and *** geomechanical study,through the application of computational mechanics,of offshore giant salt caverns of 450 m high by 150 m in diameter,shows that one cavern can store about 4 billion Sm3 or 7.2 million tons of *** the construction of the giant cavern,which will be the first gas storage offshore in the world,it has been decided to develop an experimental one,with smaller size,to obtained field *** experimental cavern will allow the calibration of parameters to be used in the structural integrity analysis of the cavern and well for storage of natural gas which is rich in CO2 under high pressure.

关键词： Salt cavern Pre-salt reservoir Geomechanical study Carbon capture and storage

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先天性无虹膜

国际眼科纵览 1985年第2期 75-80页

作者： Leonard b nelson 葛琪

先天性无虹膜(aniridia,以下简称无虹膜),是一种双侧性的、少见的全眼球疾病。除虹膜外,还累及角膜、前房角、晶体、视网膜和视神经。虹膜发育不良虽是本病最明显的临床症状,但并非影响视功能的决定因素。视力减退与黄斑中心凹未发育、... 详细信息

先天性无虹膜(aniridia,以下简称无虹膜),是一种双侧性的、少见的全眼球疾病。除虹膜外,还累及角膜、前房角、晶体、视网膜和视神经。虹膜发育不良虽是本病最明显的临床症状,但并非影响视功能的决定因素。视力减退与黄斑中心凹未发育、视神经发育不良以及并发性白内障、青光眼和角膜混浊均有密切关系。无虹膜还可为全身性缺陷的一部分,包括智力发育迟缓,生殖器的先天异常和Wilms瘤。

关键词：先天性无虹膜发育不良视盘角膜混浊视神经先天异常视力减退中心凹角膜疾病脑神经视力障碍房角青光眼

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德国 “杯酒人生”之路任重道远

中国葡萄酒 2013年第2期 120-125页

作者： joel. b. Payne

如今，德国红葡萄酒呈异军突起之势，如德国黑比诺正在逐渐受到重视。这是自然演化，还是全球变暖，抑或两者兼有宁无论如何。新时代的德国红酒不仅极大地改变了德国本土的风景，还慢慢地延伸至国外市场。

关键词：红葡萄酒德国人生自然演化全球变暖国外市场黑比诺

Grosses Gewāchs：德国的“列级庄”：

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中国葡萄酒 2013年第1期 124-125页

作者： joel. b, Payne

休·约翰逊（Hugh Johnson）曾有意撰文写道，自己很纳闷剑桥大学为何不开设一个教大家读德国酒标的讲座呢。对于这种暗讽，每一个曾站在德国酒货架前，被德国酒标上生涩难懂又饶舌的词汇而搞糊涂的顾客，他们只能摇头苦笑。今天让我们... 详细信息

休·约翰逊（Hugh Johnson）曾有意撰文写道，自己很纳闷剑桥大学为何不开设一个教大家读德国酒标的讲座呢。对于这种暗讽，每一个曾站在德国酒货架前，被德国酒标上生涩难懂又饶舌的词汇而搞糊涂的顾客，他们只能摇头苦笑。今天让我们读懂德国酒标依然是件难事，诸多繁文缛节的标准令人云里雾里，但德国优质酒分级却让人心神驰往。

关键词：德国 chs 剑桥大学约翰逊酒标优质酒国酒

Fluidized-bed bioreactor Applications for biological Wastewater Treatment： A Review of Research and Developments

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Engineering 2017年第3期3卷 330-342页

作者： Michael J. nelson George Nakhla Jesse Zhu Particle Technology Research Center The University of Western Ontario London ON N6A 5B9 Canada

Wastewater treatment is a process that is vital to protecting both the environment and human health. At present, the most cost-effective way of treating wastewater is with biological treatment processes such as the activated sludge process, despite their long operating times. However, population increases have created a demand for more efficient means of wastewater treatment, Fluidization has been demonstrated to in- crease the efficiency of many processes in chemical and biochemical engineering, but it has not been widely used in large-scale wastewater treatment. At the University of Western Ontario, the circulating fluidized-bed bioreactor （CFbbR） was developed for treating wastewater. In this process, carrier particles develop a biofilm composed of bacteria and other microbes. The excellent mixing and mass transfer characteristics inherent to fluidization make this process very effective at treating both municipal and industrial wastewater. Studies of lab- and pilot-scale systems showed that the CFbbR can remove over 90% of the influent organic matter and 80% of the nitrogen, and produces less than one-third as much biological sludge as the activated sludge process. Due to its high efficiency, the CFbbR can also be used to treat wastewaters with high organic solid concentrations, which are more difficult to treat with conventional methods because they require longer residence times; the CFbbR can also be used to reduce the system size and footprint. In addition, it is much better at handling and recovering from dynamic loadings （i.e., varying influent volume and concentrations） than current systems. Overall, the CFbbR has been shown to be a very effective means of treating wastewa- ter, and to be capable of treating larger volumes of wastewater using a smaller reactor volume and a shorter residence time. In addition, its compact design holds potential for more geographically localized and isolat- ed wastewater treatment systems.

关键词： Wastewater biological wastewater treatment Fluidized-bed technology Fluidized-bed reactor biological nutrient removal bio-particles High-efficiency process

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bacterial Contamination of blood and blood Products at Mbarara Regional blood bank in Rural South Western Uganda

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Advances in Infectious Diseases 2013年第3期3卷 205-209页

作者： G. b. Matte Aloysius bazira joel Richard Apecu boum Yap II Frederick byarugaba Department of Microbiology Faculty of Medicine Mbarara University of Science and Technology (MUST) Mbarara Uganda

background: Screening blood donors has practically eliminated viral and bacterial pathogens in blood used for transfusion. However, transfusion-associated bacterial sepsis remains an important health-care concern and the commonest cause of transfusion-related fatality in resource limited settings. Data on bacterial contamination of blood are scarce while the demand of blood transfusion is continuously growing. Therefore we conducted a study to determine the prevalence and type of bacterial contamination in donor blood and blood products, at the Mbarara Regional blood bank. Methodology: A total of 510 units of screened blood and blood products consisting of refrigerated whole blood and packed cells were randomly sampled following aseptic procedures from Mbarara Regional blood bank. Two samples from each unit were collected in universal containers containing brain Heart Infusion broth and incubated at 37℃ for up to 7 days. Subcultures were carried out on blood agar, Chocolate agar and MacConkey agar. Isolates were identified by standard microbiologic techniques and drug susceptibility testing was performed by Kirby bauer disc diffusion method. Results: Of the 510 samples collected between June and October 2012, 18 (3.5%) samples showed growth. The contaminants were Staphylococcus aureus 17/18 (94.4%) and Streptococcus viridans 1/18 (5.6%). Isolates were sensitive to erythomycin, ampicillin, chloramphenicol and ciprofloxacin and resistant to penicillin and cloxacillin. Conclusion: blood and blood products from Mbarara Regional blood have unacceptable levels of bacterial contamination that can affect patient safety especially in an area with high malaria endemicity. Therefore it is critical to improve hygiene precautions in order to minimize bacterial contamination and ensure patient safety.

关键词： bacterial Contamination blood/blood Products Staphylococci

A new heparin fragment decreases liver ischemia-reperfusion injury

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 190-192页

作者： Enio R Vasques Estela RR Figueira joel A Rocha-Filho Cinthia Lanchotte Jorge LS Ximenes Helena b Nader Ivarne LS Tersariol Marcelo A Lima Tiago Rodrigues JoséEM Cunha Eleazar Chaib Luiz AC D’Albuquerque Flávio HF Galvão Laboratorio de Investigaçao Medica 37 Departamento de GastroenterologiaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246-903Brazil Departamento de Gastroenterologia Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão PauloBrazil Disciplina de Anestesiologia Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão PauloBrazil Departamento de bioquimica Universidade Federal de São PauloSão PauloBrazil Universidade Federal do AbC Santo AndreSão PauloBrazil Serviço de Transplante de Figado e Orgaos do Aparelho Digestivo Departamento de GastroenterologiaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão PauloBrazil

To the Editor:Ischemia-reperfusion injury following surgery and transplantation can lead to irreversible multiorgan *** calcium overload is associated to cellular death during ischemiareperfusion.A recently discovered heparin fragment (HF),trisulfated disaccharide (TD),that acts on sodium-calcium exchanger(NCX) decreasing intracellular Ca^(2+),showed effectiveness on protecting hepatocytes from ischemia-reperfusion injury [1].

关键词： irreversible heparin injury

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C-reactive protein in gallbladder diseases:diagnostic and therapeutic insights

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biophysics Reports 2020年第Z1期6卷 49-67页

作者： Ibraheem M.Rajab Daniel Majerczyk Margaret E.Olson Jenna M.b.Addams Mihee L.Choe Matthew S.nelson Lawrence A.Potempa College of Pharmacy Roosevelt University

The gallbladder is an important component of the hepatobiliary system whose primary function is to aid in digestion of foodstuffs, excretion of drugs and facilitate removal of waste products from the *** gall bladder is principally a storage organ for bile, chemically modified salts and acids of cholesterol which are synthesized in the liver and which function as surfactants to solubilize fatty substances of limited aqueous solubility. Any disruption in the amount or activity of bile surfactant can lead to an accumulation of insoluble molecular clumps(e.g., gallstones) that deposit in and obstruct fluid movement within the gallbladder, and which can lead to pathological congestion and tissue *** natural host defense response to any event that causes tissue damage is to stimulate inflammation,which non-specifically but aggressively reacts to the stimuli so to remove the cause and repair damaged tissues. The C-reactive protein(CRP) is a primarily hepatically produced serum protein whose blood levels increase within 6–10 h of any tissue-damaging event. The extent with which it increases correlates with the level of tissue damage and associated inflammation. CRP levels are reported to be of value in diagnosing acute cholecystitis severity, in predicting the outcome and prognosis of cancerassociated gallbladder resection, and in helping identify cystic structures during emergency laparoscopic cholecystectomies. As an understanding of distinctive CRP structural isoforms is evolving, its role not only as a biomarker but as regulator of both physiologic and pathophysiologic processes of inflammation may be relevant in the understanding of and treatment approaches for gallbladderassociated disease.

关键词： C-reactive protein Monomeric C-reactive Inflammation Gallbladder Gallstone Cholecystitis Cholesterol