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communications in Theoretical Physics 2021年第12期73卷 78-85页

作者： Yu-Han Ma c P Sun Hui Dong Graduate School of china Academy of Engineering Physics Beijing 100193China Beijing computational Science Research center Beijing 100193China

The efficiency at the maximum power(EMP)for finite-time carnot engines established with the low-dissipation model,relies significantly on the assumption of the inverse proportion scaling of the irreversible entropy generationΔS^(ir)on the operation timeτ,i.e.ΔS^(ir)∝1/τ.The optimal operation time of the finite-time isothermal process for EMP has to be within the valid regime of the inverse proportion ***,such consistency was not tested due to the unknown coefficient of the 1/τ-*** this paper,we reveal that the optimization of the finite-time two-level atomic carnot engines with the low-dissipation model is consistent only in the regime ofη_(c)c)is the carnot efficiency,andδis the compression ratio in energy level difference of the heat engine *** the large-η_(c)regime,the operation time for EMP obtained with the low-dissipation model is not within the valid regime of the 1/τ-scaling,and the exact EMP of the engine is found to surpass the well-known boundη_(c)=η_(c)/(2-η_(c)).

关键词： finite-time thermodynamics low-dissipation model quantum heat engine efficiency at maximum power irreversible entropy generation

Nanotechnology for colorectal cancer detection and treatment

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World Journal of Gastroenterology 2022年第46期28卷 6497-6511页

作者： Purnima Gogoi Geetika kaur Nikhlesh k Singh Integrative Biosciences center OVASWayne State University School of MedicineDetroitMI 48202United States

colorectal cancer(cRc)is the third most diagnosed cancer and the second leading cause of cancer-related mortality in the United *** the globe,people in the age group older than 50 are at a higher risk of *** and environmental risk factors play a significant role in the development of *** detected early,cRc is preventable and ***,available screening methods and therapies for cRc treatment reduce the incidence rate among the population,but the micrometastasis of cancer may lead to ***,the challenge is to develop an alternative therapy to overcome this *** plays a vital role in cancer treatment and offers targeted chemotherapies directly and selectively to cancer cells,with enhanced therapeutic ***,nanotechnology elevates the chances of patient survival in comparison to traditional *** potential of nanoparticles includes that they may be used simultaneously for diagnosis and *** exciting properties of nanoparticles have enticed researchers worldwide to unveil their use in early cRc detection and as effective *** review discusses contemporary methods of cRc screening and therapies for cRc treatment,while the primary focus is on the theranostic approach of nanotechnology in cRc treatment and its *** addition,this review aims to provide knowledge on the advancement of nanotechnology in cRc and as a starting point for researchers to think about new therapeutic approaches using nanotechnology.

关键词： Nanoparticles colorectal cancer carbon nanotubes Dendrimers Quantum dots

Mantle avalanches in a Venus-like stagnant lid planet

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Earth and Planetary Physics 2024年第5期8卷 686-702页

作者： Madeleine c.kerr Dave R.Stegman Institute of Geophysics and Planetary Physics Scripps Institution of OceanographyUniversity of CaliforniaSan DiegoLa JollaCAUSA

Stagnant lid planets are characterized by a globe-encircling,conducting lid that is thick and strong,which leads to reduced global surface heat ***,the mantles of such planets can have warmer interiors than Earth,and interestingly,a pyrolitic mantle composition under warmer conditions is predicted to have a distinctly different mantle transition zone compared to the present-day Earth(Hirose,2002;Stixrude and Lithgow-Bertelloni,2011;Ichikawa et al.,2014;Dannberg et al,2022).Instead of olivine primarily transforming into its higher-pressure polymorphs such as wadsleyite and then ringwoodite,at pressures corresponding to 410 km and 520 km depth in Earth,respectively,it instead transforms into a mineral assemblage of wadsleyite,majorite,and ferropericlase(WMF),and then to majorite+ferropericlase(MF),before finally transforming into bridgmanite at pressures corresponding to 660 km depth in Earth(Stixrude and Lithgow-Bertelloni,2011;Ichikawa et al.,2014).convective motions in stagnant lid planets are dominated by small-scale instabilities(cold drips)forming within the mobile rheological sublayer under the rigid *** ASPEcT and a thermodynamic model of a pyrolitic mantle composition generated by HeFESTo,we show that under certain conditions,the small drips can pond atop the WMF-MF mineral phase *** barrier to convective flow arises from the WMF mineral phase assemblage having an effective negative thermal expansivity(Stixrude and Lithgow-Bertelloni,2022).Although large-scale downwellings that typically occur within mobile lid planets are able to pass through the WMF zone without difficulty(Dannberg et al.,2022;Li RP et al.,2024),the smaller and less negatively buoyant nature of downwelling drips in stagnant lid planets are more susceptible to these effects,which leads to an ephemeral layering of the *** numerical models show that in stagnant lid planets with mantle potential temperatures that exceed 1900 k,the smaller,cold drips from t

关键词： Venus mantle avalanches numerical modelling phase transitions

The Man Behind the Monk Happy Monk's Founder Jeremy Sargent Shares His Vision

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城市漫步（GBA版） 2016年第10期 73-73页

作者： jocelyn RIcHARDS 不详

A resident of Guangzhou for almost 20 years,Jeremy Sargent is very much your modern-day Renaissance *** between managing all three Happy Monk locations,he is also a full-time legal consultant in china,chairman of the British chamber,advisor to New Zealand Trade and Enterprise and Honorary Legal Advisor of the British consulate-General *** 2012,he was awarded an QBE in the Queen's New Year's Honour list in recognition of his legal work and services to British businesses in *** month,we chatted with Sargent about his vision for the Monk and advice for aspiring restaurateurs in Guangzhou.

关键词： legal Renaissance Happy

Microstructures of co-axially folded vein segments and crenulation cleavage： Evidence for dissolution phenomena in the chamba Thrust Sheet, western Himalayas

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Episodes 2004年第2期27卷 119-124页

作者： B.k.Sharma A.M.Bhola DepartmentofGeology UniversityofDelhiDelhi-110007India.

The metasediments in the chamba region experienced three phases of deformation: DF1, DF2 and *** quartz veins are co-folded with the F2 crenulation folds. Their geometric and tectonic significance is studied by microstructures and shortening adjacent to the discrete crenulation cleavage, S2. Microstructures of folded vein segments, their geometric changes and truncation to cleavage (S2) are mainly due to pressure-solution phenomena and the estimated volume loss from reconstructed vein segments range from 16 to 25.5%,which is closely related to volume decrease (26%) calculated from the polydeformed slates of North Wales areas.

关键词：显微结构变质沉积物地质学石英纹理

Simplified hydrodynamic models for the analysis of marine propellers in a wake-field

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Journal of Hydrodynamics 2013年第6期25卷 954-965页

作者： DURANTE D. DUBBIOSO G. TESTA c. cNR-INSEAN The Italian Ship Model Basin

This paper presents a comparison among different hydrodynamic models for the analysis of the unsteady loads delivered by a marine propeller working in an axial, non-uniform inflow. Specifically, for a propeller subjected to a wake-field dominated by local high-frequency changes in space, the unsteady hydroloads predicted by the Nakatake formulation are compared with those given by the Theodorsen and Sears theories, respectively. Drawbacks and potentialities of these approaches are highlighted to assess a computationally efficient hydrodynamic solver for the analysis of operating conditions where propeller blades are significantly perturbed by a multi-harmonic onset-flow. Guidelines coming from this investigation may drive the choice of a fast and reliable unsteady propeller modeling that represents a good trade-off between accuracy of simulation and cost of computation within implementation in computational Fluid Dynamics （cFD） solvers. The hydrodynamic formulations herein proposed are validated through numerical comparisons with the （accurate but computationally expensive） propeller loads predicted by a fully 3-D panel-method Boundary Element Method （BEM） solver, suited for the analysis of propellers operating in a complex hydrodynamic environment.

关键词： actuator disk airfoil theories Boundary Element Method (BEM) hydrodynamics

Oncogenes, Oncogenesis, and Oxygen Radicals

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Biomedical and Environmental Sciences 1990年第2期3卷 183-201页

作者： SAURA c.SAHU Molecular Toxicology Laboratory Division of Toxicological Studies Food and Drug Administration Washington D.C. 20204

The role that free radicals in general and oxygen radicals in particular play in carcinogenesis has attracted considerable attention in recent years. The oxygen radicals are undesirable but inevitable products of aerobic metabolism in the normal living cell. The cellular antioxidant defense system maintains an appropriate balance between necessary oxidative events and those that are excessive. When this critical balance cannot be maintained because of the overloading of the cellularredox system, oxygen radicals can induce cell damage. They can influence carcinogenesis by inducing DN A damage from direct oxidation or indirectly from DNA-binding products of lipid peroxidation. Oxygen radicals can induce conformational changes in the plasma membrane by lipid peroxidation and protein degradation, thus influencing membrane-associated cellular activities. They are capable of affecting membrane-bound protein kinases, growth factors and their receptors, and, therefore, signal transduction and oncogene activation. Thus, the oxygen radicals can have a major influence on oncogenes and oncogenesis. (c)1990 Academic ***.

关键词： gene and Oxygen Radicals Oncogenes Oncogenesis

THE BREW Drink coronas, Win Big

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城市漫步（GBA版） 2016年第7期 62-62页

作者： jocelyn RIcHARDS 不详

Going to The Brew just got infinitely more exciting-and that’s on top of a delicious revamped menu by Executive chef kevin Mckellar and stellar new brunch *** could be better than eggs Blackstone with crispy American bacon,roasted tomatoes and house hollandaise sauce on a homemade cheddar biscuit(RMB58),you say?How about a corona special that gives you the chance to win a trip to Thailand,all expenses paid?

关键词： Win offering BREW

Novel method for ranking batsmen in Indian Premier League

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Data Science and Management 2023年第3期6卷 158-173页

作者： M.k.Manju Abin Oommen Philip Department of computer Science&Engineering Toch Institute of Science&TechnologyErnakulamKerala682313India Department of cSE-cyber Security Indian Institute of Information TechnologyKottayam686635India

Sports analytics have benefited immensely from the growth and popularity of artificial intelligence and machine *** techniques enable sports analysts to evaluate player performance more effectively.A literature review of player performance evaluation methods shows the need to develop a new performance evaluation index for Twenty20(T20)cricket.A novel framework was proposed to evaluate batsman strength based on individual performance,role in the team,and team ***,proposed ranking systems are derived from static networks,that is,the aggregation of game results over ***,the scores of the players(or teams)fluctuate over ***,defeating a renowned player during peak performance is more rewarding than defeating the same player during other *** account for this,we propose a new method and apply it to the T20 format Indian Premier *** method serves three main purposes:First,it creates a new performance index for players to rank them more accurately and ***,the players are clustered based on their *** the third phase,a social network analysis approach is applied to visualize and analyze crickets as a network to gain better insights into players’team *** novel approach is a helpful index for sports coaches,analysts,cricket fans,and managers to evaluate player performance and rank for future aspects.

关键词： Indian Premier League Social network analysis Artificial intelligence Machine learning

How single-cell immunology is benefiting from microfluidic technologies

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Microsystems & Nanoengineering 2020年第1期6卷 728-741页

作者： Fabien c.Jammes Sebastian J.Maerkl Institute of Bioengineering School of EngineeringEcole Polytechnique Federale de LausanneLausanneSwitzerland

The immune system is a complex network of specialized cells that work in concert to protect against invading pathogens and tissue *** in this network often result in excessive or absent immune responses leading to allergies,autoimmune diseases,and *** of the mechanisms and their regulation remain poorly *** cells are highly diverse,and an immune response is the result of a large number of molecular and cellular interactions both in time and *** bulk methods are often prone to miss important details by returning population-averaged *** is a need in immunology to measure single cells and to study the dynamic interplay of immune cells with their *** in the fields of microsystems and microengineering gave rise to the field of microfluidics and its application to *** systems enable the precise control of small volumes in the femto-to nanoliter *** controlling device geometries,surface chemistry,and flow behavior,microfluidics can create a precisely defined microenvironment for single-cell studies with spatio-temporal *** features are highly desirable for single-cell analysis and have made microfluidic devices useful tools for studying complex immune *** addition,microfluidic devices can achieve high-throughput measurements,enabling in-depth studies of complex *** has been used in a large panel of biological applications,ranging from single-cell genomics,cell signaling and dynamics to cell–cell interaction and cell migration *** this review,we give an overview of state-of-the-art microfluidic techniques,their application to single-cell immunology,their advantages and drawbacks,and provide an outlook for the future of single-cell technologies in research and medicine.

关键词： fluid network details