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Mozambique’s response to cyclone Idai:how collaboration and surveillance with water,sanitation and hygiene (WASH) interventions were used to control a cholera epidemic

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Infectious Diseases of Poverty 2020年第3期9卷 121-124页

作者： joaquim Domingos Lequechane Arlete Mahumane Falume Chale Crescêncio Nhabomba Cristolde Salomão Clemente Lameira Sérgio Chicumbe Cynthia SemáBaltazar Beira Operational Research Center National Institute of Health from MozambiqueBeiraSofalaMozambique National Institute of Health MaputoMozambique Planning and Statistics Department Sofala Provincial Health DirectorateBeiraMozambique

Cyclone Idai,which hit Mozambique in March 2019,was one of the worst climate-related natural disasters on record in the Southern Hemisphere causing massive destruction of housing and disruption to vital infrastructure including the electrical grid,communications and water *** two million people were affected with over 600 deaths,hundreds of thousands of people displaced accompanied by rapid spread of *** describe emergency measures taken by the Government of Mozambique,in collaboration with multilateral partners,to establish a real-time disease surveillance system,implement interventions recommended by a Water,Sanitation and Hygiene(WASH)taskforce and rapidly scale up a massive community vaccination program to control a cholera epidemic.

关键词： Cyclone Idai Mozambique Cholera Sanitation Disaster Disease outbreak Water supply

Transient and DNA-free in vivo CRISPR/Cas9 genome editing for flexible modeling of endometrial carcinogenesis

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Cancer Communications 2023年第5期43卷 620-624页

作者： Raúl Navaridas Maria Vidal-Sabanés Anna Ruiz-Mitjana Aida Perramon-Güell Cristina Megino-Luque David Llobet-Navas Xavier Matias-Guiu joaquim Egea Mario Encinas Lídia Bardia Julien Colombelli Xavier Dolcet Oncological Pathology Group Department of Basic Medical SciencesUniversity of LleidaBiomedical Research Institute of LleidaLleidaSpain Molecular Mechanisms and Experimental Therapy in Oncology-Oncobell Program Bellvitge Biomedical Research Institute’L’Hospitalet de LlobregatBarcelonaSpain Department of Pathology Bellvitge HospitalUniversity of BarcelonaBellvitge Biomedical Research InstituteL’Hospitalet de LlobregatBarcelonaSpain Department of Pathology Arnau de Vilanova HospitalUniversity of LleidaBiomedical Research Institute of LleidaLleidaSpain Cancer Networking Biomedical Research Center Institute of Health Carlos IIIMadridSpain Molecular Developmental Neurobiology Group Department of Basic Medical SciencesUniversity of LleidaBiomedical Research Institute of LleidaLleidaSpain Developmental and Oncogenic Signalling Group Department of ExperimentalMedicineUniversity of LleidaBiomedical Research Institute of LleidaLleidaSpain Advanced Digital Microscopy Core Facility Institute for Research in BiomedicineBarcelona Institute of Science and TechnologyBarcelonaSpain

Dear Editor,The Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)and CRISPR-associated protein 9(Cas9)(CRISPR/Cas9)-mediated generation of somatically genetically engineered mouse models have emerged as a new approach for in vivo modeling of cancer[1].Here,we describe a novel DNA-free,easy,rapid,flexible,multiplexable,and robust method to model endometrial neoplasia by CRISPR/Cas9 ribonucleoprotein(RNP)electroporation into the uterus of mice.

关键词： CRISPR/Cas9 DNA CRISPR

副猪嗜血杆菌感染诊断方法和最新基因分型方法的研究进展

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国外畜牧学（猪与禽） 2008年第5期28卷 52-57页

作者：李艳刘静 Alex Olvera joaquim Segales

副猪嗜血杆菌可引起猪格拉塞病和其它许多疾病,对与该菌有关的疾病进行诊断通常依赖于临床症状、病理变化和细菌分离,但由于有无毒菌株(nonvirulentstrain)的存在及其在健康仔猪上呼吸道上的早期定殖,使得对该菌的诊断变得较为复杂。而... 详细信息

副猪嗜血杆菌可引起猪格拉塞病和其它许多疾病,对与该菌有关的疾病进行诊断通常依赖于临床症状、病理变化和细菌分离,但由于有无毒菌株(nonvirulentstrain)的存在及其在健康仔猪上呼吸道上的早期定殖,使得对该菌的诊断变得较为复杂。而且,在同一猪场甚至是同一只猪体内可能存在多种不同的菌株,因此确定可导致临床发病的特定菌株显得尤为重要。最近,科研人员开发了一些针对副猪嗜血杆菌的基因分型方法,目的是确定该菌的基因型与其毒力强度之间的关系。由于缺乏副猪嗜血杆菌完整基因组序列及其致病因子(viru-lencefactor)的知识,因此将副猪嗜血杆菌的基因型与其毒力联系起来极富挑战性。

关键词：副猪嗜血杆菌格拉塞病猪基因分型诊断

Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction

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Asian Journal of Andrology 2007年第2期9卷 241-244页

作者： Enrico de Andrade Alexandre A. de Mesquita joaquim de Almeida Claro Priscila M. de Andrade Valdemar Ortiz Mário Paranhos Miguel Srougi Sector of Sexual Medicine Division of Urological Clinic of Sāo Paulo University Sāo Paulo Brazil Discipline of Urology Sāo Paulo Federal University Sāo Paulo Brazil

Aim： To examine the treatment efficacy of Korean Red Ginseng （KRG） in impotent men with erectile dysfunction （ED）. Methods： A total of 60 patients presenting mild or mild to moderate ED were enrolled in a double-blind, placebo-controlled study in which the efficacies of KRG and a placebo were compared. The patients received either 1 000 mg （3 times daily） of KRG or a placebo. Results： The five-item version of the International Index of Erectile Function （IIEF-5） score after the treatment was significantly higher in the KRG group compared with that before the treatment （from 16.4±2.9 to 21.0±6.3, P 〈 0.0001）. In contrast, there was no difference before and after the treatment in the placebo group （from 17.0±3.1 to 17.7±5.6, P 〉 0.05）. In the KRG group, 20 patients （66.6%）, reported improved erection, significant in the global efficacy question （P 〈 0.01）; in the placebo group there was no significance. Scores on questions 2 （rigidity）, 3 （penetration）, 4 and 5 （maintenance）, were significantly higher for KRG than those for the placebo when those questions were answered after 12 weeks of each treatment （P 〈 0.01）. When the score in the KRG group was compared to the placebo group after the treatment, there was a significant improvement in total score （IIEF-5 score） in questions 3 and 5 for the KRG-treated group （P 〈 0.001 and P 〈 0.0001, respectively）. The levels of serum testosterone, prolactine and cholesterol after the treatment were not statistically significant different between the KRG and the placebo group （P 〉 0.05）. Conclusion： Our data show that KRG can be an effective alternative to the invasive approaches for treating male ED.

关键词： penis impotence ginseng penile erection

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副猪嗜血杆菌感染研究的新进展

国外畜牧学（猪与禽） 2000年第6期20卷 50-52页

作者：袁森泉林颖 joaquim Segales 西班牙巴塞罗那自治大学解剖病理教研室

Antithrombotic treatment in chronic heart failure and sinus rhythm: Systematic review

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World Journal of Meta-Analysis 2015年第1期3卷 36-42页

作者： Daniel Caldeira Inês Cruz Rita Calé Cristina Martins Helder Pereira joaquim J Ferreira Fausto J Pinto Joo Costa Cardiology Department Hospital Garcia de Orta Clinical Pharmacology Unit Instituto de Medicina Molecular Laboratory of Clinical Pharmacology Faculty of MedicineUniversity of Lisbon Cardiology Department CCUL CAML Faculty of Medicine Evidence Based Medicine Centre Faculty of Medicine University of Lisbon Portuguese Collaborating Centre of the Cochrane Iberoamerican Network Faculty of Medicine University of Lisbon

AIM: To assess the efficacy and safety of antithrombotic drugs(antiplatelet or anticoagulant drugs) compared to no antithrombotic treatment or placebo in patients with heart failure(HF) and sinus rhythm. METHODS: We searched Medline and Cochrane Library for randomized controlled trials evaluating antithrombotic treatment and no antithrombotic treatment in patients with HF and sinus rhythm. Risk ratio(RR) and 95%CIs were estimated performing meta-analysis with random effects method. RESULTS: Two studies met the inclusion criteria: Heart failure Long-term Antithrombotic Study and Warfarin/Aspirin Study in Heart failure, with 336 patients and mean follow-up 1.8-2.25 years. Stroke risk was not reduced by acetylsalicylic acid(RR = 1.18, 95%CI: 0.17-8.15), oral anticoagulation(RR = 0.30, 95%CI: 0.03-2.65) or overall antithrombotic drugs(RR = 0.52, 95%CI: 0.10-2.74). Acetylsalicylic acid showed a significant increased risk of worsening HF(RR = 1.78, 95%CI: 1.08-2.92), while oral anticoagulation had no impact in this outcome(RR = 1.03, 95%CI: 0.61-1.75). Overall antithrombotic drugs showed a significant risk increase of major bleeding(RR = 6.99, 95%CI: 0.89-54.64). CONCLUSION: Best available evidence does not support the routine use of antithrombotic drugs in patients with HF and sinus rhythm. These drugs, particularly oral anti-coagulation has the hazard of increase significantly major bleeding risk.

关键词： Heart failure Sinus rhythm Platelet aggregation inhibitors Anticoagulants

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针灸配合中成药治疗登革热临床分析

实用中医药杂志 2008年第9期24卷 553-554页

作者：李杜非 Filomeno joaquim da Saldanha 成都市温江区中医医院四川成都611130 东帝汶GUIDO VALADARES国家医院

目的:观察针灸配合中成药治疗登革热的临床疗效。方法:将126例分为两组,观察组64例用针灸、拔罐配合板蓝根冲剂、Vc银翘片和云南白药治疗;西药组62例高热时采用物理降温,必要时使用退热药,如高热不退可短期应用肾上腺皮质激素,有出血倾... 详细信息

目的:观察针灸配合中成药治疗登革热的临床疗效。方法:将126例分为两组,观察组64例用针灸、拔罐配合板蓝根冲剂、Vc银翘片和云南白药治疗;西药组62例高热时采用物理降温,必要时使用退热药,如高热不退可短期应用肾上腺皮质激素,有出血倾向者加止血药。治疗2周后进行疗效观察。结果:白细胞、血小板恢复正常时间治疗组为(6.5±0.77)天、对照组为(7.48±0.89)天。治疗组、对照组三期持续时间分别为(2.12±1.17)天、(2.13±1.11)天、(4.12±1.18)天和(3.11±1.16)天、(3.16±1.18)天、(5.19±2.14)天。两组比较差异有非常显著性意义(P<0.01)。结论:针灸配合中成药治疗登革热能促进白细胞、血小板的更快恢复正常,缩短发热期、出疹期、恢复期各期持续时间,其疗效明显优于西药对症支持治疗。

关键词：登革热针灸疗法中成药对照治疗

Influence of a nucleotide oligomerization domain 1 (NOD1) polymorphism and NOD2 mutant alleles on Crohn's disease phenotype

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World Journal of Gastroenterology 2007年第41期13卷 5446-5453页

作者： Elisabet Cantó Elena Ricart David Busquets David Monfort Esther García-Planella Dolors González joaquim Balanzó José L Rodríguez-Sánchez Sílvia Vidal Department of Immunology Sant Pau Hospital & Research Inst.Sant Pau HospitalBarcelona 08025Spain Department of Gastroenterology CIBER-EHD.Clinic HospitalBarcelona-08025Spain Department of Digestive Pathology Sant Pau HospitalBarcelona 08025Spain

AIM： To examine genetic variation of nucleotide oligomerization domain 1 （NOD/） and NOD2, their respective influences on Crohn＇s disease phenotype and gene-gene interactions. METHODS：（ND1＋32656＊1） NOD1 polymorphism and SNPS, SNP12 and SNP13 of NOD2 were analyzed in 97 patients and 50 controls. NOD2 variants were determined by reaction restriction fragment length polymorphism analysis. NOD1 genotyping and NOD2 variant confirmation were performed by specific amplification and sequencing. RESULTS： The distribution of NOD1 polymorphism in patients was different from controls （P = 0.045） and not altered by existence of NOD2 mutations. In this cohort, 30.92% patients and 6% controls carried at least one NOD2 variant （P 〈 0.001） with R702W being the most frequent variant. Presence of at least one NOD2 mutation was inversely associated with colon involvement （9.09% with colon vs 36.4% with ileal or ileocolonic involvement, P = 0.04） and indicative of risk of penetrating disease （52.63% with penetrating vs 25.64% with non-penetrating or stricturing behavior, P = 0.02）. L1007finsC and double NOD2 mutation conferred the highest risk for severity of disease （26.3% with penetrating disease vs 3.8% with non-penetrating or stricturing behavior presented L1007finsC, P = 0.01 and 21.0% with penetrating disease vs 2.5% with non-penentrating or stricturing behavior carried double NOD2 mutation, P = 0.007）. Exclusion of patients with NOD2 mutations from phenotype/NODl-genotype analysis revealed higher prevalence of ＊1＊1 genotype in groups of younger age at onset and colonic location.CONCLUSION： This study suggests population differences in the inheritance of risk NOD1 polymorphism and NOD2 mutations. Although no interaction between NOD1-NOD2 was noticed, a relationship between disease location and Nod-like receptor molecules was established.

关键词： Crohn's disease Nucleotide oligomerization domain 1 Nucleotide oligomerization domain 2

Effect of Freshwater Influx on Phytoplankton in the Mandovi Estuary (Goa, India) during Monsoon Season: Chemotaxonomy

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Journal of Water Resource and Protection 2013年第3期5卷 349-361页

作者： Sushma G. Parab S. G. Prabhu Matondkar Helga do R. Gomes joaquim I. Goes Lamont Doherty Earth Observatory at Columbia University New York USA National Institute of Oceanography Dona Paula Goa India

The Mandovi estuary is a prominent water body that runs along the west coast ofIndia. It forms an estuarine network with the adjacent Zuari estuary, connected via the Cumbharjua canal. The physico-chemical conditions seen in the Mandovi estuary are influenced by two factors: the fresh water runoff during the monsoon season (June-September) and the tidal influx of coastal seawater during the summer (October to May) season. However, the effects of monsoon related changes on the phytoplankton of the Mandovi estuary are not yet fully understood. An attempt to understand the same has been made here by applying the process of daily sampling at a fixed station throughout the monsoon season. It was noticed that the onset of the monsoon is responsible for an increase in nitrate levels upto 26 μM from a (chl a) as high as 14 μg·L-1 during the same period. The phytoplankton population was observed through both chemotaxonomy and microscopy and was found to be composed mainly of diatoms. CHEMTAX analysis further uncovers the presence of several other groups of phytoplankton, the presence of which is yet to be reported in many other tropical estuaries. It includes chrysophytes, cyanobacteria, prasinophytes, prymnesiophytes and chlorophytes. The appearance of phytoplankton groups at various stages of the monsoon was recorded, and this data is discussed in relation to environmental changes in the Mandovi estuary during the monsoon season.

关键词： Phytoplankton Pigment Analysis Monsoon Freshwater Runoff CHEMTAX