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CXCL9 and CXCL10 display an agedependent profile in Chagas patients:a cohort study of aging in Bambui,Brazil

Infectious Diseases of Poverty 2020年第3期9卷 132-132页

作者： Fernanda Fortes de Araújo Karen Cecília Lima Torres Sérgio Viana Peixoto Antonio Luiz Pinho Ribeiro Juliana Vaz Melo Mambrini Vitor Bortolo Rezende Maria Luiza Lima Silva Antônio Ignácio Loyola Filho Andréa teixeira-Carvalho Maria Fernanda Lima-Costa Olindo Assis Martins-Filho Integrated Research Group in Biomarkers Rene Rachou InstituteOswaldo Cruz FoundationAvenida Augusto de Lima1715–Barro Preto–Belo HorizonteMinas Gerais 30190-002Brazil 不详

Background:Chagas disease is endemic in Latin America and still represents an important public health problem in the *** cardiomyopathy is the most significant chronic form due to its association with morbidity and *** last decade has seen increasing evidence that inflammatory cytokines and chemokines are responsible for the generation of inflammatory infiltrate and tissue damage,with chronic chagasic cardiomyopathy patients presenting a pro-inflammatory immune *** studies have evaluated the role of chemokines in experimental *** infection,few have addressed their systemic profile,especially for human infection and in aging *** present work aimed to use the data from a large population based study of older adults,conducted in an endemic area for Chagas disease,to examine the association between serum levels of cytokines and chemokines,*** infection and electrocardiogram(ECG)***:The present work evaluated serum levels of CCL2,CXCL9,CXCL10,CCL5,CXCL8,IL-1β,IL-6,TNF,IL-12 and IL-10 by Flow Cytometric Bead Array assay(CBA)and the results expressed in pg/*** baseline survey started in January 1st 1997,with 1284 participants of an aged population-based *** signed an informed consent at baseline and at each subsequent visit and authorized death certificate and medical records ***:Our results demonstrated that Chagas disease patients had higher serum levels of CXCL9,CXCL10 and IL-1βand lower serum levels of CCL5 than non-infected ***,our data demonstrated that CXCL9 and CXCL10 increased in an age-dependent profile in Chagas disease ***:Together,this study provided evidences that serum biomarkers increase along the age continuum and may have potential implications for establishing clinical management protocols and therapeutic intervention in Chagas disease patients.

关键词： Chagas disease Immune biomarkers Chemokines Cytokines Cohort

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Relationship between Mollicutes and spontaneous abortion:An epidemiological analysis

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World Journal of Obstetrics and Gynecology 2021年第1期10卷 1-15页

作者： Maria Tânia Silva Oliveira Caline Novais teixeira Oliveira Lucas Santana Coelho da Silva Hellen Braga Martins Oliveira Raquel Sousa Freire Lucas Miranda Marques Maria Luísa Cordeiro Santos Fabrício Freirede Melo Cláudio Lima Souza Márcio Vasconcelos Oliveira Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil Universidade Estadual Santa cruz Universidade Estadual Santa CruzIlhéus 45662900BahiaBrazil

BACKGROUND Abortion is of great importance in public health,as it is among the main causes of maternal morbidity and *** addition to sociodemographic-and lifestylerelated factors,studies have associated infections of the genital tract with higher rates of ***,the exacerbated presence and rise of Mollicutes in the genitourinary tract may be related to higher rates of *** To perform an epidemiological analysis of women who had spontaneous abortions and placental colonization by Mollicutes in a maternity *** This cross-sectional study involved the collection of data and biological material from women hospitalized due to spontaneous abortion or term *** sample consisted of 89 women who miscarried and 20 women who had full term *** collection was carried out in three stages:(1)Conducting research on the information and clinical data in medical records of patients hospitalized due to abortion;(2)Application of a semi-structured questionnaire to identify the patient's epidemiological profile and(3)Collection of placental *** samples were collected after the curettage procedure(abortion)and after placental expulsion(delivery),both performed by an *** identification in the fragments was performed by real-time polymerase chain *** this study,the following explanatory variables were considered:(1)Sociodemographic variables;(2)Variables related to access to health services;(3)Variables related to lifestyle;and(4)Variables related to sexual and reproductive health,all of which were used to perform descriptive,univariate and multivariate *** In the final model,placental colonization by Mollicutes was independently associated with the variables age[odds ratio(OR)=7.55;CI:2.37-24.03]and menarche(OR=3.43;CI:1.03-11.44).In this investigation,the prevalence of Mollicutes colonization by at least one of the following three species:Mycoplasma hominis,Ureaplasma urealyti

关键词： Miscarriage Epidemiology Mollicutes Primary prevention

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