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Voxel-based meta-analysis of grey matter changes in Alzheimer’s disease

Open Journal of Applied Sciences（应用科学） 2023年第9期

作者： joaquim Bocresion

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Translational Neurodegeneration 2015年第1期4卷 39-47页

作者： Wen-Ying Wang Jin-Tai Yu Yong Liu Rui-Hua Yin Hui-Fu Wang Jun Wang Lin Tan joaquim Radua Lan Tan Department of Neurology Qingdao Municipal HospitalSchool of MedicineQingdao UniversityNo.5 Donghai Middle RoadQingdaoShandong Province 266071China College of Medicine and Pharmaceutics Ocean University of ChinaQingdao 266011China Department of Neurology Qingdao Municipal HospitalNanjing Medical UniversityNanjing 266071China Brainnetome Center Institute of AutomationChinese Academy of SciencesBeijing 100190China National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China Department of Psychosis Studies Institute of PsychiatryKing’s College LondonLondonUK Research Unit FIDMAG Germanes Hospitala’ries—CIBERSAMSant Boi de LlobregatBarcelonaSpain

Background:Voxel-based morphometry(VBM)using structural brain MRI has been widely used for the assessment of impairment in Alzheimer’s disease(AD),but previous studies in VBM studies on AD remain ***:We conducted meta-analyses to integrate the reported studies to determine the consistent grey matter alterations in AD based on VBM ***:The PubMed,ISI Web of Science,EMBASE and Medline database were searched for articles between 1995 and June *** searches were also conducted,and authors of studies were contacted for additional *** were extracted from clusters with significant grey matter difference between AD patients and healthy controls(HC).Meta-analysis was performed using a new improved voxel-based meta-analytic method,Effect Size Signed Differential Mapping(ES-SDM).Results:Thirty data-sets comprising 960 subjects with AD and 1195 HC met inclusion *** matter volume(GMV)reduction at 334 coordinates in AD and no GMV increase were found in the current *** reductions in GMV were robustly localized in the limbic regions(left parahippocampl gyrus and left posterior cingulate gyrus).In addition,there were GM decreases in right fusiform gyrus and right superior frontal *** findings remain largely unchanged in the jackknife sensitivity ***:Our meta-analysis clearly identified GMV atrophy in *** findings confirm that the most prominent and replicable structural abnormalities in AD are in the limbic regions and contributes to the understanding of pathophysiology underlying AD.

关键词： Voxel-based morphometry(VBM) Alzheimer’s disease(AD) Grey matter(GM) Meta-analysis Magnetic resonance imaging(MRI) Effect size signed differential mapping(ES-SDM)

Calculation of Percentage of Coarse Aggregate Present in Concrete Using Processing of Digital Images Obtained with a Commercial Scanner

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Journal of Chemistry and Chemical Engineering 2015年第2期9卷 136-139页

作者： Jose Renato de Castro Pessoa Joel Sanchez Dominguez Rodrigo Erthal Wilson Vanussa da Silva Charles Gil de Carvalho joaquim Teixeira de Assis Politechnical Institute of Rio de Janeiro State University Nova Friburgo 28625-570 Brazil Estacio de Sa University Nova Friburgo 28611-135 Brazil Federal Fluminense University Itaocara 28470-000 Brazil

This paper presents a method for determining the percentage of coarse aggregate in concrete specimens by image processing. The test pieces were produced with the aim of obtaining images of their cross sections through a scanner table. In order to increase the contrast between mortar and coarse aggregate the sliced surfaces were treated with the phenolphthale in solution. The images obtained in the scanner were processed in a program developed with MATLAB （matrix laboratory）. The average coarse aggregate in each section and the mean of coarse aggregate per test body were calculated. With the results, it was revealed that the method returned satisfying results when compared to the original trace of the concrete.

关键词： Concrete image processing characterization of concrete.

Sensitivity Analysis and Calibration of Hydrological Modeling of the Watershed Northeast Brazil

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Journal of Environmental Protection 2015年第8期6卷 837-850页

作者： Marinoé Gonzaga da Silva Antenor de Oliveira de Aguiar Netto Ramiro joaquim de Jesus Neves Anderson Nascimento do Vasco Carina Almeida Gregório Guirado Faccioli Campus Sã o Cristóvã o Federal Institute of Sergipe S&#227 o Cristóvã o Brazil

Mathematical models of the quantity and quality of water in hydrographic basins enable simulation of a wide variety of processes, including the production of water and sediments, and the dynamics of point and nonpoint sources of pollution. These models have become increasingly complex, requiring large amounts of input data, which can increase the uncertainty of the results of simulations. For this reason, it is essential to perform calibration and validation procedures. The objective of this work was to conduct sensitivity analysis and calibration of a distributed hydrological model (SWAT) applied to the flows of water in the watershed of the Poxim River. Satisfactory performance of the model was indicated by the values obtained for the Nash-Sutcliffe efficiency coefficient (0.77), the percent bias (5.05), the root mean square error (0.48), and the ratio of the RMSE to the standard deviation of the observations (RSR) (0.49). The set of parameters identified here could be used for the simulation and evaluation of other scenarios.

关键词： Sensitivity Analysis Calibration Hydrological Model Watershed

Aggressive Dorsal Vertebral Hemangioma Causing Compressive Mielopathy

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Open Journal of Medical Imaging 2021年第3期11卷 85-91页

作者： Ana Carla Farias Pimentel Mariana Santos Leite Pessoa Francisca Estefânia Mesquita Maciel de Lima Manuel joaquim Diógenes Teixeira Cláudio Régis Sampaio Silveira Ana Carla Farias Pimentel MD Radiologist Hospital Geral de Fortaleza (HGF) Fortaleza-CE Brazil Mariana Santos Leite Pessoa MD Radiology Resident Hospital Geral de Fortaleza (HGF) Fortaleza-CE Brazil Francisca Estefania Mesquita Maciel de Lima MD Pathologist Laboratório Mikros Fortaleza-CE Brazil Manuel joaquim Diógenes Teixeira MD Orthopedist Hospital Geral de Fortaleza (HGF) Fortaleza-CE Brazil Cláudio Régis Sampaio Silveira MD Radiologist Hospital Geral de Fortaleza (HGF) Fortaleza-CE Brazil Hospital S?o Carlos Fortaleza-CE Brazil

Vertebral hemangiomas are common benign lesions of the spine, characterized by abnormal vascular proliferation, being commonly asymptomatic incidental findings, presenting symptoms in only a small portion of affected individuals. In a smaller number of cases, however, hemangiomas can present an expansive effect and extra-osseous extension, determining a mass effect and neurological symptoms, being therefore called aggressive hemangiomas. On MRI, aggressive hemangiomas are characterized by having a larger vascular component and a smaller fat component, thus producing a low signal on T1-weighted images. We illustrate the case of a young male patient who presented with pain in the upper thoracic spine, who developed paraparesis and ascending sensory deficit and progressive lower limbs, progressing to paraplegia and loss of sphincter control.

关键词： Aggressive Vertebral Hemangioma Compressive Myelopathy Magnetic Resonance Imaging

Tricuspid Valve Endocarditis in a Patient with Congenital Heart Disease

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Journal of Pharmacy and Pharmacology 2018年第5期6卷 502-508页

作者： Barbara Liss de Sousa Freire Suyane Gomes Leite Jose Antonio de Lima Neto Eduardo Ferreira Almeida joaquim David Carneiro Neto Bruna Theresa de Sousa Freire Hospital do Coracao de Sobral Sobral 62042240 Brazil

The present study reports a case of a young patient who presented for 3 months dyspnea, edema of lower limbs, fever and important weight loss. She evolved with acute fever, hematemesis and focal seizures. An echocardiogram was performed demonstrating file presence of interventricular, interatrial, and extensive echogenic imaging and of poorly defined borders throughout the septal cusp of the tricuspid valve, suggestive of vegetation, chest tomography that observed several foci of pulmonary abscess and blood culture evidencing the presence of Staphylococcus aureus. She was treated with Vancomycin, Meropenem and Amphotericin, along with clinical support. She underwent surgery to exchange the tricuspid valve for a biological prosthesis, evolving with clinical improvement and receiving discharge from hospital.

关键词： Congenital heart disease infective endocarditis interventricular communication echocardiography.

Oral Cancer:Health Promotion and Visual Screening—A Study Report

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Journal of Cancer Therapy 2013年第8期4卷 1313-1320页

作者： Augusta P.Silveira Augusta Marques Miguel Pavao Eurico Monteiro Gabriela Pereira joaquim Goncalves Luís Castro Maria Ines Guimaraes Bernardete Carvalho Claudia Ribeiro Teresa Sequeira Faculty of Heath Sciences Fernando Pessoa UniversityPortoPortugal Centre of Health Studies and Research Coimbra UniversityCoimbraPortugal Non-Governmental Organization(NGO):Mundo A Sorrir PortoPortugal Portuguese Institute for Oncology PortoPortugal Instituto Politecnico do Cavado e do Ave BarcelosPortugal Porto Portugal Well Medical Spa PortoPortugal Health Sciences Department Portuguese Catholic UniversityViseuPortugal

Background: Oral cancer presents a heterogeneous geographic incidence. Annually, more than 275,000 new cases are diagnosed worldwide. In spite of the easy accessibility of oral cavity during physical examination, most malignancies are not diagnosed until late stages of disease. Methods: Oral health promotion was our main objective, risk factors were identified and oral cavity self-examination was promoted. The population considered (n = 1117) was divided in two main age groups—a youngest (individuals under 25 years old) mostly targeted for oral cancer awareness and oral cavity self examination promotion, and an older group having accumulated potential risk exposure. Results: The results obtained revealed smoking habits and fruits-vegetables consumption deficit as the highest risks factors found. Considering a Risk Factor Exposure Index analysis, individuals with secondary level of instruction and living in sub-urban areas assumed the highest risk exposure. Alcohol consumption had also contributed as a significant risk exposure. Conclusions: Some of these risk factors work as biological reward of quality of life deficit. A wide comprehension of the problem requires a multidisciplinary approach necessarily involving Health and Social Sciences in order to target the core of oral cancer health promotion. An effective epidemiological strategy must thus support three major aspects: population knowledge, sensitization and visual screening.

关键词： Oral Cancer Visual Screening Oral Health Promotion Epidemiological Strategies

Sevoflurane Preconditioning and Total Knee Arthroplasty Bleeding: Randomized Controlled Trial

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Journal of Biosciences and Medicines 2023年第2期11卷 254-264页

作者： Ricardo S. A. Laurino Raphael C. Gregnanini Alberto Kanasiro Renata V. S. Laurino Márcia U. de Rezende joaquim E. Vieira ostgraduate Program of Anesthesiology Surgical Sciences and Perioperative Medicine Faculdade de Medicina da Universidade de S&atildeo Paulo S&atildeo Paulo Brazil Private Practice S&atildeo Paulo Brazil Faculdade de Medicina da Universidade de Sã o Paulo S&atildeo Paulo Brazil Hospital Universitário da Universidade de Sã o Paulo S&atildeo Paulo Brazil Instituto de Ortopedia e Traumatologia Faculdade de Medicina da Universidade de S&atildeo Paulo S&atildeo Paulo Brazil Department of Surgery Faculdade de Medicina da Universidade de S&atildeo Paulo S&atildeo Paulo Brazil

Background: Total knee arthroplasty (TKA) is a highly complex and effective surgery even though its perioperative bleeding may increase the need for blood transfusion and its associated infection risk, cardiovascular overload, increased costs, and mortality. As the tourniquet reduces intraoperative bleeding, it may be associated with postoperative bleeding, venous thrombosis, and distal ischemia. The reperfusion may trigger a local and systemic inflammatory response. Anesthetic preconditioning (APC) with sevoflurane minimizes ischemia-reperfusion syndrome (IRS). This study evaluated the effects of APC with sevoflurane on perioperative bleeding in TKA. Methods: We allocated 30 patients into two groups: a sevo group (sevoflurane 2% for 15 minutes before the tourniquet) and a control group (propofol infusion). Laboratory tests were collected right before the tourniquet (LAB PRE, in the operating room) and after its release at four moments: LAB POST (immediately after), LAB 2 (two hours after), LAB 12 (12 hours after), and LAB 24 (24 hours after). The volume of the suction drain was measured at one, two, 12, and 24 hours after the end of the surgery. Antifibrinolytics were not administered. Results: There was no statistically significant difference in bleeding-related variables, such as drained volume and hemoglobin and hematocrit measurements. Drainage volume was higher in the first two hours after the procedure, while hematocrit decreased pre- to postoperatively and between two and 12 hours post-procedure. Conclusion: Sevoflurane as an anesthetic preconditioning did not reduce postoperative bleeding in TKA surgery.

关键词： Arthroplasty Replacement Knee Anesthesia General Anesthesia Spinal Sevoflurane Postoperative Hemorrhage

全日制放牧BMY牛的活体采卵-体外胚胎生产-胚胎移植研究

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畜牧兽医学报 2013年第1期44卷 38-48页

作者：和占星王喆张继才王安奎金显栋袁希平 joaquim M.Garcia Marina R.de Lima 何永珍黄必志云南省草地动物科学研究院昆明650212 Department of Preventive Veterinary Medicine and Animal Reporduction Faculty of Agricultural and Veterinary SciencesSao Paulo State University

为建立BMY牛的活体采卵(OPU)-体外胚胎生产(IVP)-胚胎移植(ET)快速扩繁技术体系,从人工草地全放牧牛群中选择健康的经产空怀BMY牛作为供体(n=14)集中OPU一次;卵母细胞经TCM-199体外成熟培养(IVM)、Fert-TALP液体外受精(IVF),受精卵用合... 详细信息

为建立BMY牛的活体采卵(OPU)-体外胚胎生产(IVP)-胚胎移植(ET)快速扩繁技术体系,从人工草地全放牧牛群中选择健康的经产空怀BMY牛作为供体(n=14)集中OPU一次;卵母细胞经TCM-199体外成熟培养(IVM)、Fert-TALP液体外受精(IVF),受精卵用合成输卵管液(SOF)体外培养(IVC)生产胚胎;BMY牛受体(n=81)用CUE-MATETM孕酮阴道栓+EB+FSH+PG方法同期发情处理,对黄体合格的移植OPU-IVP来源鲜胚。研究结果表明:①OPU头均获卵母细胞23.50枚,获10枚以上卵母细胞的供体占85.7%;IVP的平均囊胚数和可用胚数分别为5.21和4.00枚;OPU前8～9d卵巢上有黄体(CL)的供体,头均获卵母细胞数及IVP的囊胚数、可移植胚数、囊胚率和可移植胚率分别比对照组高7.28枚(P0.05)。结果显示,BMY母牛具有良好的OPU潜力,但个体间差异较大;可通过严格供体选择及改善IVP技术等措施,实现OPU-IVP效率最大化。CUE-MATETM+EB+FSH+PG同期发情处理方法适于在牛规模化胚胎移植(ET)和人工授精(AI)中应用。综合应用OPU、IVP、同期发情和ET技术是加快优良BMY牛扩繁的重要途径之一。

关键词： BMY牛全日制放牧超声波引导采卵体外胚胎生产胚胎移植

Use of antiepileptic drugs in children with brain tumors: A review for acute management

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Journal of Acute Disease 2018年第5期7卷 181-185页

作者： Jennifer Herrera-Bejarano Amit Agrawal Claudia Marcela Navas Valbuena Guru Dutta Satyarthee Chandramouli Balasubramanian Andrei F.joaquim George Chater Cure Luis Rafael Moscote-Salazar Physician Universidad del RosarioBogotaColombia Professor of Neurosurgery MM Institute of Medical Sciences&ResearchMaharishi Markandesh(w)ar UniversityMullana-Ambala133-207.HaryanaIndia Physician Universidad Industrial de SantanderUISBucaramangaColombia Assistant Professor of Neurosurgery All India Institute of Medical SciencesNew DelhiIndia Department of Neurosurgery Birmingham Children's HospitalBirminghamUK Department of Neurology Neurosurgery DivisionUniversity of Campinas(UNICAMP)Campinas-SPBrazil Neurosurgeon Clinica General del NorteBarranquillaColombia Neurosurgeon-Critical Care University of CartagenaCartagena de IndiasColombia

Patients with primary or secondary tumors in the central nervous system may have seizures resulting from direct tissue damage,metabolic abnormalities,infection,or toxic side effects of *** pediatric patients,it is more frequent to use drugs to control secondary *** this article,we discuss the main nuances of antiepileptic drugs for the proper management of children with central nervous system tumors.

关键词： Antiepileptic drugs Brain tumors Neuro oncology Seizures