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国外畜牧学（猪与禽） 2012年第1期32卷 46-47页

作者：李红 joaquim Segalés

本文主要介绍了猪圆环病毒相关病(PCVAD)的许多最新研究进展,尤其从实践的角度阐述了PCVAD的病原学、发病机理、流行病学、诊断、治疗和预防。

关键词：猪圆环病毒Ⅱ型免疫系统病原学

欧洲鼻科专家就鼻-鼻窦炎和鼻息肉问题达成一致

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欧洲鼻科专家就鼻-鼻窦炎和鼻息肉问题达成一致

基于2002-2018年MODIS数据的黄海叶绿素a时空变化研究

第三届北京国际鼻-颅底外科技术及鼻变态反应研讨会

作者： joaquim Mullol MD PhD Rhinology Unit ENT DepartmentHospital Clinic de Barcelona Clinical and Experimental Respiratory ImmunoalergyIDIBAPS 巴塞罗那加泰罗尼亚西班牙欧洲著名的鼻科学专家欧洲过敏哮喘及临床免疫学会（EAACI）美国过敏哮喘及免疫学会会员（AAAAI）

＜正＞鼻-鼻窦炎是危害健康的一类严重问题,一般人群中约10％的个体受其困扰。由之而来的是可观的直接医疗成本、一般生活质量受到严重影响、下呼吸道疾病的发病增高。近年来,鼻科学者对鼻腔和鼻窦炎症的定义和分类已付出了许多努力。...

＜正＞鼻-鼻窦炎是危害健康的一类严重问题,一般人群中约10％的个体受其困扰。由之而来的是可观的直接医疗成本、一般生活质量受到严重影响、下呼吸道疾病的发病增高。近年来,鼻科学者对鼻腔和鼻窦炎症的定义和分类已付出了许多努力。由于鼻炎和鼻窦炎在解剖关系和病理生理方

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海洋通报 2020年第1期39卷 101-110页

作者：田洪阵刘沁萍 joaquim I.Goes Helga do Rosario Gomes 杨萌萌天津工业大学经济与管理学院天津300387 哥伦比亚大学拉蒙特多尔蒂地球观测站美国纽约10964 名古屋大学环境学研究生院日本爱知4648601

浮游植物作为食物链的基础,对海洋生态系统具有重要影响。黄海作为我国重要的渔场,渔业资源面临枯竭的危险,因此对该区浮游植物进行研究具有重要意义。叶绿素a浓度是反映浮游植物生物量的重要指标。利用谷歌地球引擎平台对2002-2018年的... 详细信息

浮游植物作为食物链的基础,对海洋生态系统具有重要影响。黄海作为我国重要的渔场,渔业资源面临枯竭的危险,因此对该区浮游植物进行研究具有重要意义。叶绿素a浓度是反映浮游植物生物量的重要指标。利用谷歌地球引擎平台对2002-2018年的MODIS Aqua叶绿素a浓度数据进行处理,并研究其时空分布与变化特征,然后结合区域气候、水文与地理特征以及海洋表面温度、风速、盐度、光合有效辐射和混合层厚度数据分析了其分布与变化的原因。研究发现:受陆源营养物质输入、近岸上升流以及黄海中央冷水团影响,叶绿素a浓度分布呈现由近岸向黄海中部递减特征;在季风、气候、水文的控制下,受风速、海洋表面温度、光合有效辐射、中央冷水团的影响,叶绿素a浓度的最大值出现在4月份,而最小值出现在6、7月份;受苏北沿岸海域海水污染和水体富营养化影响,沿岸海域盐度明显增加,海州湾叶绿素a浓度增速较大;影响黄海叶绿素a浓度变化的环境因子较复杂,除了部分月份存在显著的相关影响因子外,在全年和各季中不存在主导影响因子。

关键词：叶绿素a浓度 MODIS Aqua 谷歌地球引擎黄海

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近20年渤海叶绿素a浓度时空变化

海洋学报 2019年第8期41卷 131-140页

作者：田洪阵刘沁萍 joaquim I.Goes Helga do Rosario Gomes 杨萌萌天津工业大学经济与管理学院天津300387 哥伦比亚大学拉蒙特多尔蒂地球观测站纽约州纽约10964 名古屋大学环境学研究生院爱知名古屋4648601

浮游植物作为食物链的基础,对海洋生态系统具有重要作用。渤海作为我国最大的内海和重要渔业生物的产卵场、育幼场和索饵场,该区浮游植物研究具有重要意义。叶绿素a浓度是反映浮游植物生物量的重要指标。利用Google Earth Engine平台,对... 详细信息

浮游植物作为食物链的基础,对海洋生态系统具有重要作用。渤海作为我国最大的内海和重要渔业生物的产卵场、育幼场和索饵场,该区浮游植物研究具有重要意义。叶绿素a浓度是反映浮游植物生物量的重要指标。利用Google Earth Engine平台,对1997–2010年的宽视场海洋观测传感器(SeaWiFS)叶绿素a浓度数据和2002–2018年的水色卫星中分辨率成像光谱仪传感器(MODISAqua)叶绿素a浓度数据进行合并,并研究其时空变化特征。研究表明,近20年来,渤海全年叶绿素a浓度增加了14.1%,且增加显著。叶绿素a浓度在所有季节都呈现增加趋势;除11月外,其他各月都呈现稳定或增加趋势。从滦河入河口沿岸至渤海海峡的渤海中部,叶绿素a浓度增加较明显。同时也分析了海洋表面温度、风速和降水量数据。夏季渤海周边区域降水量和风速增加以及秋季海表温度的降低都有助于同季叶绿素a浓度的升高。渤海浮游植物可能受陆源营养物质输入影响较大。

关键词：叶绿素a浓度降水海洋表面温度风速 SeaWiFS MODIS Aqua Google Earth Engine 渤海

Adjuvant Therapy on Cancer of the Lower Rectum. Evaluation of the Effects of Preoperative Radiotherapy on the Prognosis of Patients with Cancer of the Lower Rectum

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Journal of Cancer Therapy 2012年第6期3卷 912-919页

作者： Jose Alfredo Reis Neto Jose Alfredo Reis Junior Odorino Kagohara joaquim Simoes Neto Sergio OBanci Luciane HOliveira Surgery Catholic University of CampinasCampinasBrazil Surgery Clinica Reis NetoCatholic University CampinasCampinasBrazil Coloproctology Clinica Reis NetoCatholic University CampinasCampinasBrazil.

Aims: The prognosis on treatment of the cancer of the rectum has not changed in the last fifty years. Survival rates of 50 to 55% seems immutable in several published series. The main cause for those results is the high incidence of recurrence, either local or widespread. Local recurrence is directly related to the number of undifferentiated cells and to the grade of wall invasion. Widespread recurrence depends specifically on the lymphatic and vascular spreading. So any kind of treatment that would diminish the number of undifferentiated cells and the size or the tumor wall penetration would certainly decrease the local recurrence rate, lengthening the interval free from cancer and, perhaps, modifying the long term survival rate. Between 1978 and 2009, a total of 538 patients with adenocarcinoma of the lower rectum (from the pectinate line to 10 cm above) were treated by preoperative radiotherapy. Methodology: The same protocol was used in all the patients – 400 cGy, 200 cGy/day, during 4 consecutive weeks (anterior and posterior pelvic fields) by means of a Linear Megavoltage Accelerator (25 MeV). Surgery was performed 2 months after completion of the radiotherapy. Results: Statistical analysis of the whole group showed that preoperative radiotherapy does decrease frequency of undifferentiated cells. Moreover, the incidence of local recurrence diminished after irradiation by 3.4%. Preoperative radiotherapy reduces tumor volume (ERUS) and wall invasion, as well as the mortality rate due to local recurrence (2.4%) and alters long-term survival rate (80.1%). Conclusion: Preoperative radiotherapy is really effective in reducing the number of undifferentiated cells and in diminishing the tumor volume and the carcinomatous infiltration of the rectal wall.

关键词： Rectal Cancer Cancer of the Lower Rectum Irradiation Preoperative Radiotherapy Local Recurrence Mortality Survival

On the Thermodynamical Black Hole Stability in the Space-Time of a Global Monopole in f(R)-Gravity

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Journal of High Energy Physics, Gravitation and Cosmology 2019年第3期5卷 587-611页

作者： Francisco Bento Lustosa Maria Emilia Xavier Guimaraes Cristine Nunes Ferreira joaquim Lopes Neto Jose Abdalla Helayel-Neto Departamento de Fsica Teorica Instituto de FsicaUniversidade do Estado do Rio de JaneiroRio de JaneiroBrazil Instituto de Fsica Universidade Federal FluminenseCampus da Praia VermelhaNiteroiBrazil Nucleo de Estudos em Fsica Instituto Federal de Educacao Ciencia e Tecnologia FluminenseRio de JaneiroBrazil Instituto de Fsica Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Centro Brasileiro de Pesquisas Fsicas Rio de JaneiroBrazil

In this work, we re-assess a class of black hole solutions in a global monopole spacetime in the framework of an f(R)-gravity model. Our main line of investigation consists in considering a region close enough to the black hole, but such that the weak field approximation is still valid. The stability of the black hole is studied in terms of its thermodynamical properties, with the radial coordinate written as a power-law function with the status of the main factor underneath the stability of the model. We obtain the explicit expressions for the thermodynamical quantities of the black hole as functions of the event horizon, by considering both the Hawking and the local temperatures. The phase transitions that may occur in this system, including the Hawking-Page phase transition, are inspected with particular attention. We work out and contemplate a solution of special interest in which one of the parameters is related to the cosmological constant. Our main result sets out to establish a comparison between both the Hawking and the local formalisms for the black hole in the framework of the f(R)-gravity in the particular space-time adopted here.

关键词： Black Hole f(R)-Gravity Hawking Temperature Global Monopole Cosmological Constant

Mozambique’s response to cyclone Idai:how collaboration and surveillance with water,sanitation and hygiene (WASH) interventions were used to control a cholera epidemic

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Infectious Diseases of Poverty 2020年第3期9卷 121-124页

作者： joaquim Domingos Lequechane Arlete Mahumane Falume Chale Crescêncio Nhabomba Cristolde Salomão Clemente Lameira Sérgio Chicumbe Cynthia SemáBaltazar Beira Operational Research Center National Institute of Health from MozambiqueBeiraSofalaMozambique National Institute of Health MaputoMozambique Planning and Statistics Department Sofala Provincial Health DirectorateBeiraMozambique

Cyclone Idai,which hit Mozambique in March 2019,was one of the worst climate-related natural disasters on record in the Southern Hemisphere causing massive destruction of housing and disruption to vital infrastructure including the electrical grid,communications and water *** two million people were affected with over 600 deaths,hundreds of thousands of people displaced accompanied by rapid spread of *** describe emergency measures taken by the Government of Mozambique,in collaboration with multilateral partners,to establish a real-time disease surveillance system,implement interventions recommended by a Water,Sanitation and Hygiene(WASH)taskforce and rapidly scale up a massive community vaccination program to control a cholera epidemic.

关键词： Cyclone Idai Mozambique Cholera Sanitation Disaster Disease outbreak Water supply

Transient and DNA-free in vivo CRISPR/Cas9 genome editing for flexible modeling of endometrial carcinogenesis

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Cancer Communications 2023年第5期43卷 620-624页

作者： Raúl Navaridas Maria Vidal-Sabanés Anna Ruiz-Mitjana Aida Perramon-Güell Cristina Megino-Luque David Llobet-Navas Xavier Matias-Guiu joaquim Egea Mario Encinas Lídia Bardia Julien Colombelli Xavier Dolcet Oncological Pathology Group Department of Basic Medical SciencesUniversity of LleidaBiomedical Research Institute of LleidaLleidaSpain Molecular Mechanisms and Experimental Therapy in Oncology-Oncobell Program Bellvitge Biomedical Research Institute’L’Hospitalet de LlobregatBarcelonaSpain Department of Pathology Bellvitge HospitalUniversity of BarcelonaBellvitge Biomedical Research InstituteL’Hospitalet de LlobregatBarcelonaSpain Department of Pathology Arnau de Vilanova HospitalUniversity of LleidaBiomedical Research Institute of LleidaLleidaSpain Cancer Networking Biomedical Research Center Institute of Health Carlos IIIMadridSpain Molecular Developmental Neurobiology Group Department of Basic Medical SciencesUniversity of LleidaBiomedical Research Institute of LleidaLleidaSpain Developmental and Oncogenic Signalling Group Department of ExperimentalMedicineUniversity of LleidaBiomedical Research Institute of LleidaLleidaSpain Advanced Digital Microscopy Core Facility Institute for Research in BiomedicineBarcelona Institute of Science and TechnologyBarcelonaSpain

Dear Editor,The Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)and CRISPR-associated protein 9(Cas9)(CRISPR/Cas9)-mediated generation of somatically genetically engineered mouse models have emerged as a new approach for in vivo modeling of cancer[1].Here,we describe a novel DNA-free,easy,rapid,flexible,multiplexable,and robust method to model endometrial neoplasia by CRISPR/Cas9 ribonucleoprotein(RNP)electroporation into the uterus of mice.

关键词： CRISPR/Cas9 DNA CRISPR

副猪嗜血杆菌感染诊断方法和最新基因分型方法的研究进展

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国外畜牧学（猪与禽） 2008年第5期28卷 52-57页

作者：李艳刘静 Alex Olvera joaquim Segales

副猪嗜血杆菌可引起猪格拉塞病和其它许多疾病,对与该菌有关的疾病进行诊断通常依赖于临床症状、病理变化和细菌分离,但由于有无毒菌株(nonvirulentstrain)的存在及其在健康仔猪上呼吸道上的早期定殖,使得对该菌的诊断变得较为复杂。而... 详细信息

副猪嗜血杆菌可引起猪格拉塞病和其它许多疾病,对与该菌有关的疾病进行诊断通常依赖于临床症状、病理变化和细菌分离,但由于有无毒菌株(nonvirulentstrain)的存在及其在健康仔猪上呼吸道上的早期定殖,使得对该菌的诊断变得较为复杂。而且,在同一猪场甚至是同一只猪体内可能存在多种不同的菌株,因此确定可导致临床发病的特定菌株显得尤为重要。最近,科研人员开发了一些针对副猪嗜血杆菌的基因分型方法,目的是确定该菌的基因型与其毒力强度之间的关系。由于缺乏副猪嗜血杆菌完整基因组序列及其致病因子(viru-lencefactor)的知识,因此将副猪嗜血杆菌的基因型与其毒力联系起来极富挑战性。

关键词：副猪嗜血杆菌格拉塞病猪基因分型诊断