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A fuzzy cognitive map-based algorithm for predicting water consumption in Spanish healthcare centres

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Building Simulation 2023年第11期16卷 2193-2205页

作者： Gonzalo Sánchez-Barroso Jaime González-Domínguez joao Paulo Almeida-fernandes Justo García-Sanz-Calcedo Engineering Projects Area University of ExtremaduraAv.Elvas06006BadajozSpain Department of Paisagem Ambiente e OrdenamentoUniversity of EvoraR.Romão Ramalho7000-650ÉvoraPortugal

The management of water consumption in healthcare centres can have positive impacts on both the environmental performance and profitability of health *** tools assist in the decision-making process of managing the operation and maintenance of healthcare *** research aimed to integrate the empirical knowledge of experts in Healthcare Engineering and the historical data from 66 healthcare centres in a Fuzzy Cognitive *** outputs of the predictive model included water consumption,water cost,and CO_(2) emissions in healthcare facilities,along with eleven variables to discover the causes and consequences of water consumption in healthcare centres.A healthcare centre with about 12350 users,located in a city that experiences an average of 1100 heating degree days,whose facilities be moderately energy-efficient contributing over 50%with renewable energies is expected to consume 8.4 dam^(3) of water with 32.1 k€of cost,and contribute realising 30.8 ton CO_(2)eq *** use of Fuzzy Cognitive Maps for prediction can provide a high level of effectiveness in identifying the factors that contribute to water consumption and in designing key performance indicators to manage the environmental performance of healthcare *** tool is extremely effective in enhancing the performance of the management division of health systems.

关键词： water consumption Fuzzy Cognitive Maps healthcare centres Healthcare Engineering water management

Adenoid Cystic Carcinoma of the Head and Neck:Epidemiology and Predictors of Prognosis

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International Journal of Otolaryngology and Head & Neck Surgery 2013年第5期2卷 165-173页

作者： Daniel Monteiro joao Lino Teresa Bernardo joao fernandes Eurico Monteiro Department of Otorhinolaryngology and Head and Neck Surgery Saint Antonio HospitalPortoPortugal Department of Otorhinolaryngology and Head and Neck Surgery Portuguese Institute of OncologyPortoPortugal

Objectives: The biologic behavior of the adenoid cystic carcinoma (ACC) and the factors predicting outcome for these tumors are still poorly understood. Our objective is to analyze the predicting factors and the value of different treatment possibilities, since none sole treatment has been standardized. Methods: A retrospective analysis of the epidemiologic, clinical and histologic aspects of ACC, as well as treatment options and other prognostic factors of all the cases of ACC of the head and neck treated at this Institution were analyzed. From 1974 until 2011, 152 patients were diagnosed with ACC and treated at the Portuguese Institute of Oncology (Porto Centre). Main outcome measures: overall survival, local recurrence and distant metastasis were calculated by the Kaplan-Meier method. Factors predictive of outcome were identified by univariate and multivariate analysis. Results: The mean age at diagnosis was 55.8 years (range, 19-83 years). Incidence was higher in the female population, with a female to male ratio of 1.7:1 respectively. The primary tumor location was hard palate and submandibular region in 56 cases, 28 in each location (24.6%), parotid gland (17 cases, 14.9%) and oral cavity excluding palate (16 cases, 14%).Distributions according to T stage were: T1 (29.8%);T2 (30.7%);T3 (17.5%);T4 (22%). The overall 1-year, 5-year and 10-year survival for all patients were 94.6%, 60.5%, 41.6%, respectively. Conclusions: Univariate survival analysis revealed that age older than 60 years (p = 0.002), solid histologic subtype (p = 0.042), advanced clinical stage (p p = 0.036) were correlated with a poor survival. Multivariate analysis confirmed that age and advanced clinical stage were worst independent predicators of overall survival as well as perineural invasion for local recurrence and distant metastasis. In our analysis, radiotherapy did not have a relevant impact on survival, except in cases of solid histologic subtype. To analyze distant metastatic capacity

关键词： Adenoid Cystic Carcinoma Head and Neck Cancer Prognostic Factors

Analysing the Required Properties of Business Simulation Games to Be Used in E-Learning and Education

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Intelligent Information Management 2012年第6期4卷 348-356页

作者： Andrej Jerman Blazic Claudia Ribeiro joao fernandes joao Pereira Tanja Arh Laboratory for Open Systems and Networks Jozef Stefan InstituteLjubljanaSlovenia INESC-ID Department of Information Systems and Computer ScienceInstituto Superior TecnicoLisbonPortugal

Business simulation games are considered as effective tools for the empowerment and mediation of business content learning. They act as serious games which contribute to learning through a simulation of real-life situations and busi-ness environments. They are especially useful in the area of business management processes and business strategies. The blending of designed simulation technology and content curricula offers participants (players, students) a risk-free opportunity to test out a range of relevant strategies to drive business results. By customizing computer-based business simulations, participants can integrate key strategic and financial priorities. This paper provides a brief review of busi-ness simulations that serve learning purposes. The first part presents a short introduction and description of business games and their evaluation properties, and the second part provides a brief evaluation and analysis of selected business simulation games.

关键词： Serious Games Business Simulation Games E-Learning Problem-Based Learning Business Environment

Tracheoesophageal Voice Prosthesis Outcomes:Success or Insucess?

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International Journal of Otolaryngology and Head & Neck Surgery 2014年第1期3卷 14-22页

作者： Sara Cruz Rita Viana Joana Guimaraes joao fernandes Joaquim Castro Silva Eurico Monteiro Servico de Otorrinolaringologia Instituto Portugues de Oncologia Francisco Gentil do PortoPortoPortugal

Introduction: Total laryngectomy/pharingo-laryngectomy is a potentially aggressive surgery for advanced laryngeal/hypopharyngeal carcinomas, which results in important physical and functional changes that compromise some of the most vital functions, including speech communication. For these patients, tracheoesophageal speech is considered to be the gold standard for voice rehabilitation. Objectives: The purpose of the present study was to determinate the success rate of voice prosthesis rehabilitation, voice prosthesis lifetime and the rate of complications, and its related clinicopathologic factors. Material and Methods: Retrospective review of 92 patients who undergone tracheoesophageal puncture (TEP) performed between January 2007 and December 2012 at the Francisco Gentil Portuguese Institute of Oncology of Oporto. Age, primary disease, staging, the extent of surgical resection, radiotherapy treatment, timing of TEP, surgical and prosthesis-related complications were noted. The impact of these clinicpathological factors on functional outcome, complications of TEP and lifetime of prosthetic valves was assessed in univariate analysis. Vocal rehabilitation efficacy with voice prosthesis was assessed with the multidimensional Harrison-Robillard Shultz (HRS) Rating Scale. Lifetime of voice prosthesis and early and late complications were recorded. Results: A total of 83 patients met the study criteria, predominantly males (94%) with a mean age of 63.7 years. 77% of the patients underwent primary and 23% secondary TEP. 68.7% of patients achieved functional tracheoesophageal speech (HRS score ≥ 10), 67.2% had performed primary TEP and 73.7% had performed secondary TEP. The mean device lifetime was 9.8 months for voice prosthesis. Prosthesis-related complications occurred in 81% of the patients and the most common issues were prosthesis leakage (76%) and displacement (22%). The most common surgical-related problem was a large and deep tracheostoma. Conclusions: Our succe

关键词： Laryngeal Cancer Total Laryngectomy Tracheoesophageal Puncture Tracheoesophageal Speech Voice Prosthesis

The Evaluation of Bioremediation Potential of a Yeast Collection Isolated from Composting

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Advances in Microbiology 2014年第12期4卷 796-807页

作者： Bianca Trama joao Daniel Santos fernandes Geórgia Labuto Júlio Cézar Franco de Oliveira Cristina Viana-Niero Renata C. Pascon Marcelo A. Vallim Departamento de Ciencias Biologicas—Universidade Federal de Sao Paulo Diadema Sao Paulo Brasil

The influence of xenobiotic compounds on environment and on living organisms has been reported as an imminent public health problem. Among them we can list the contamination by Alkanes present in petroleum, hydrocarbons and organic contaminant substances from industrial effluents. Also, heavy metals are of particular interest because of their persistence in the environment contaminating the food webs. Among the innovative solutions for treatment of contaminated water and soil is the use of biological materials like living or dead microorganisms. Yeasts exhibit the ability to adapt to extreme condition such as temperature, pH and levels of organic and inorganic contaminants that make them a potential material to be used to remediate contaminated environment application. The goal of this work was to search for yeast isolates capable to use n-hexadecane (alkane hydrocarbon) as a primary carbon source and for those able to tolerate high concentration of lead (Pb) within a collection of 90 isolates obtained from the Sao Paulo Zoo composting system. The isolated yeast strains were identified by mass spectrometry (MALDI-TOF-MS) and by sequencing of the ribosomal DNA (18S and D1/D2) conserved regions. We found that the collection bares 23 isolates capable of utilizing n-hexadecane and one which is able to tolerate high concentration of lead (Pb) with a high biosorption index compared to the reference yeast strains (BY4742, PE-2, CAT-1 and BG-1). These results confirm the initial hypothesis that the Sao Paulo Zoo composting is the source for diverse yeasts species with biotechnological application potential.

关键词： Biosorption Lead Yeast Trichosporon montevideense Saccharomyces cerevisiae

Water catchment with native species in the Brazilian Semiarid

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Agricultural Sciences 2014年第2期5卷 152-156页

作者： joao Vianey fernandes Pimentel Hugo Orlando Carvallo Guerra Francisco Jardel Rodrigues da Paixao Luciano F.Marques Leandro do Vale Francisca N.Brito Agroecology and Environment of Federal Institute of Education Science and Technology of Rio Grande do Norte(UFRN) QuixeramobimBrazil Agricultural Engineering Department of Graduate Agricultural EngineeringFederal University of Campina Grande(DEAG/UFCG)Campina GrandeBrazil Technological Axis Natural Resources Centec Institute/Fatec Sertao Central QuixeramobimBrazil State University of Maranhao(UEMA) BalsasBrazil Agribusiness Centec Institute/FATEC Sertao Central Undergraduate Scholarship Foundation Protection Research of CearáFUNCAPQuixeramobimBrazil

Xerophyticplants are well adapted to the semiarid conditions because they have a high potential for the use of rainwater. They can store it in their roots (xylopodiums). The Amburanacearensis, commonly called Cumaru, native of the Brazilian semiarid, is very important because of its multiple-use: good quality wood, active food ingredient, perfume and medicine production. However, its management is practically unknown. Aiming to know more about this culture, an experiment was conducted to quantify the Cumaruwater needs, evaluate its water-use efficiency and the capacity of roots to store water. Five levels of water (0%, 25%, 50%, 75% and 100% of evapotranspiration) and five-plant spacing (0.20 × 0.20 m, 0.20 × 0.10 m, 0.20 × 0.05 m, 0.10 × 0.10 m and 0.05 × 0.05 m) were tested, and the results obtained analyzed statistically throughout F test. No influence of soil water level and plant spacing in the moisture content of the whole plant, in the aerial part or in the xylopodiums was observed. However, there was an effect of the treatments on the water stored in the whole plant in the aerial part or in the roots, per unit area. More than 80% of the water was stored in the roots. The crop growing with the smaller spacing without irrigation was shown to be quite efficient in using the rainwater, compared with traditional cultures irrigated.

关键词： Xerophytic Xylopodium Semiarid Water Use Efficient

Ulcerated Lesion in Buccal Mucosa in a Patient with Paracoccidioidomycosis——Case Report

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Journal of Biosciences and Medicines 2017年第10期5卷 44-50页

作者： Giovanna Lima Vaz Livia Cristina de Melo Pino Aline Gabriela Santos Costa Ibrahim Yahia El Somailli joao Roberto Resende fernandes Elayne Christina Meireles Martins Daniel Cohen Goldemberg Aline Hellen da Silva Camacho Rhanna Neves Cirqueira Daniel Almeida da Costa College of Medicine of Valenca—FAA/Cesva ValencaBrazil National Cancer Institute—INCA Rio de JaneiroBrazil Centro Universitario de Belo Horizonte-UNIBH Belo HorizonteBrazil

Paracoccidioidomycosis is the most prevalent systemic mycosis in Latin America. It is a fungal infection caused by the dimorphic fungus Paracoccidioides brasiliensis. This microorganism can penetrate the human body through direct contact and can cause intense lymphadenopathy, ulcerated lesions in the oral cavity and in the skin among other alterations. In this study, we report a case of paracoccidioidomycosis with unusual clinical presentation, as it manifested in the female sex and although it did not present any relevant complaints of respiratory focus, it presented a single ulcerated lesion in the buccal mucosa. A biopsy of the lesion and a mycological examination revealed Paracoccidioidesbrasiliensis infection.

关键词： Paracoccidioidomycosis Paracoccidioides brasiliensis Endemic Mycosis

Quantification of theophylline or paracetamol in milk matrices by high-performance liquid chromatography

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Journal of Pharmaceutical Analysis 2017年第6期7卷 401-405页

作者： Tania A.P.fernandes joao P.Aguiara Ana I.fernandes joao F.Pinto CiiEM-Centro de Investigacao Interdisciplinar Egas Moniz Instituto Superior de Cinncias da Saude Egas MonizCampus Universitario-Quinta da GranjaMonte de Caparica2829-511 CaparicaPortugal iMed.UL-Dep.Tecnologia Farmaceutica Faeuldade de FarmdciaUniversidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal

A simple, accurate and sensitive high-performance liquid chromatography （HPLC） method was developed, validated and applied to the determination of either theophylline or paracetamol in milk-based samples. The method allowed drug quantification in fresh and powdered milk with a relatively short run time of analysis and it was also successfully applied to the quantification of the drugs in solid dosage forms intended for pediatric use. Moreover, the main significant advantages over other published works are the simplicity of the sample preparation, reduced assay time and sample loss. The method meets the International Conference on Harmonization guideline for analytical methods validation regarding specificity, linearity, accuracy, precision, specificity and robustness as required by health authorities and applied by industry while designing and marketing new drug products. The technique encompasses the separation of the analytes with a reverse phase C18 column under isocrafic conditions and UV detection at 272 nm and 243 nm, respectively, for theophylline and paraeetamol. The lower limit of quantification for both drugs was determined as 0.2 μg/mL and the between-batch accuracy was 99.7%. This HPLC method allows quantification of theophylline and paracetamol in milk matrices and it can be applied in the design, development and production of milk-based pediatric dosage forms.

关键词： Liquid chromatography Fresh milk Powdered milk Paracetamol Theophylline

Peripheral nerve regeneration with conduits:use of vein tubes

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Neural Regeneration Research 2015年第4期10卷 529-533页

作者： Rodrigo Guerra Sabongi Marcela fernandes joao Baptista Gomes dos Santos Department of Orthopedics and Traumatology Escola Paulista de MedicinaFederal University of Sao Paulo Division of Hand Surgery Department of Orthopedics and TraumatologyEscola Paulista de MedicinaFederal University of Sao Paulo

Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the com-plexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made to develop an alternative to the au-tologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous experimental and clinical trials. The use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit.

关键词： peripheral nerve injury nerve graft nerve conduit Wallerian degeneration neurotrophic factors veins autografts nerve regeneration