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How does zebrafish support new strategies for neuroprotection and neuroregeneration in hypoxia-related diseases?

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Neural Regeneration Research 2016年第7期11卷 1069-1070页

作者： Emerson S.Silva joao Batista T.Rocha Diogo O.Souza Marcos M.braga Programa de Pos-Graduacao em Bioquimica Departamento de Bioquimica Instituto de ciencias basicas da saude Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil Programa de Pos-Graduacao em Bioquimica Toxicologica Departamento de Bioquimica e Biologia Molecular Centro de ciencias Naturais e Exatas Universidade Federal de Santa Maria Santa MariaRS Brazil Instituto Nacional de Ciencia e Tecnologia em Excitotoxicidade e Neuroprotecao Universidade Federal do Rio Grande do Sul PortoAlegre RS Brazil

Hypoxia is a condition found commonly in several disorders,such as ischemia,asthma,anemia and neonatal *** subjected suddenly to high altitude or extreme exercise are also challenged to low oxygen（O2）*** the brain p... 详细信息

关键词： How does zebrafish support new strategies for neuroprotection and neuroregeneration in hypoxia-related diseases

Current role and future perspectives of cardiac rehabilitation in coronary heart disease

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World Journal of Cardiology 2021年第12期13卷 695-709页

作者： Eduardo M Vilela Ricardo Ladeiras-Lopes Ana joao Joana braga Susana Torres Sofia Viamonte José Ribeiro Madalena Teixeira José P Nunes Ricardo Fontes-Carvalho Department of Cardiology Centro Hospitalar de Vila Nova de Gaia/EspinhoVila Nova de Gaia 4434-502Portugal Department of Surgery and Physiology Cardiovascular Research Unit(UnIC)Faculty of MedicineUniversity of PortoPorto 4200-319Portugal Centro de Reabilitação do Norte Centro Hospitalar de Vila Nova de Gaia/EspinhoVila Nova de Gaia 4405-565Portugal Faculty of Medicine University of PortoPorto 4200-319Portugal

Ischaemic heart disease(IHD)is a major cause of morbidity and mortality *** there have been major advances in this field,these patients are still a higher risk *** such,strategies to mitigate risk and tailor secondary prevention measures are of the utmost *** rehabilitation(CR),encompassing several domains including exercise training,cardiovascular risk factor optimization,nutritional and psychological assessments,as well as other ancillary interventions has shown to be one of the pillars in the contemporary management of patients with ***,CR is associated with several benefits in this population,ranging from functional capacity to improvements in *** this,there are still several issues concerning the optimal application of CR which are still not fully ascertained,such as lack of referral and completion,as well as questions related to programme design(particularly among patients with multiple comorbidities).In this review,we aim at presenting a pragmatic overview on the current role of CR in the management of individuals with IHD,while also discussing some of the caveats in the current data,as well as future concepts which could help improve the uptake and personalization of this pivotal time-tested intervention.

关键词： Cardiac rehabilitation Secondary prevention Myocardial infarction Ischaemic heart disease Cardiovascular diseases

Indirect printing of hierarchical patient-specific scaffolds for meniscus tissue engineering

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Bio-Design and Manufacturing 2019年第4期2卷 225-241页

作者： joao BCosta Joana Silva-Correia Sandra Pina Alain da Silva Morais Sílvia Vieira Hélder Pereira joao Espregueira-Mendes Rui LReis Joaquim M.Oliveira B′s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017 Barco GmrPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimaraesPortugal The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of MinhoAvepark4805-017 BarcoGuimar'sPortugal Ripoll y De Prado Sports Clinic:Murcia-Madrid FIFA Medical Centre of Excellence MurciaSpain Orthopedic Department Centro Hospitalar Póvoa de Varzim Vila do CondePortugal Clínica do Dragao Espregueira-Mendes Sports CentreFIFA Medical Centre of ExcellencePortoPortugal Dom Henrique Research Centre PortoPortugal Orthopedic Department University of MinhoBragaPortugal

The complex meniscus tissue plays a critical role in the knee. The high susceptibility to injury has led to an intense pursuit for better tissue engineering regenerative strategies, where scaffolds play a major role. In this study, indirect printed hierarchical multilayered sca ffolds composed by a silk fibroin (SF) upper layer and an 80/20 (w/w) ratio of SF/ionic-doped β-tricalcium phosphate (TCP) bottom layer were developed. Furthermore, a comparative analysis between two types of sca ffolds pro- duced using di fferent SF concentrations, i.e., 8% (w/v) (Hi8) and 16% (w/v) (Hi16) was performed. In terms of architecture and morphology, the produced sca ffolds presented homogeneous porosity in both layers and no di fferences were observed when comparing both sca ffolds. A decrease in terms of mechanical performance of the sca ffolds was observed when SF concentration decreased from 16 to 8% (w/v). Hi16 revealed a static compressive modulus of 0.66 ± 0.05 MPa and dynamical mechanical properties ranging from 2.17 ± 0.25 to 3.19 ± 0.38 MPa. By its turn, Hi8 presented a compressive modulus of 0.27 ± 0.08 MPa and dynamical mechanical properties ranging from 1.03 ± 0.08 MPa to 1.56 ± 0.13 MPa. In vitro bioactivity studies showed formation of apatite crystals onto the surface of Hi8 and Hi16 bottom layers. Human meniscus cells (hMCs) and human primary osteoblasts were cultured separately onto the top layer (SF8 and SF16) and bottom layer (SF8/TCP and SF16/TCP) of the hierarchical sca ffolds Hi8 and Hi16, respectively. Both cell types showed good adhesion and proliferation as denoted by the live/dead staining, Alamar Blue assay and DNA quanti fication analysis. Subcutaneous implantation in mice revealed weak in flammation and sca ffold’s integrity. The hierarchical indirect printed SF sca ffolds can be promising candidate for meniscus TE sca ffolding applications due their suitable mechanical properties, good biological performance and possibility of being applied in a patie

关键词： Patient-specific Indirect printing Hierarchical Silk fibroin Enzymatic-cross-linking Meniscus

Current advances in solid free-form techniques for osteochondral tissue engineering

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Bio-Design and Manufacturing 2018年第3期1卷 171-181页

作者： joao Bebiano Costa Joana Silva-Correia Rui Luis Reis Joaquim Miguel Oliveira B's Research Group I3Bs - Research Institute onBiomaterials Biodegradables and Biomimetics University ofMinho Headquarters of the European Institute of Excellenceon Tissue Engineering and Regenerative Medicine AveParkParque de Ciencia e Tecnologia Zona Industrial da Gandra4805-017 Barco Guimaraes Portugal ICVS/3B's-PT Government Associate Laboratory Braga Guimarfies Portugal The Discoveries Centre for Regenerative and PrecisionMedicine Headquarters at University of MinhoAvepark 4805-017 Barco Guimaraes Portugal

Osteochondral （OC） lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments have increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds＇ processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form （SFF） techniques. These techniques allow tuning different properties at the micro-macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.

关键词： Solid free-form Osteochondral Tissue engineering Scaffolds

Flexible neural probes:a review of the current advantages,drawbacks,and future demands

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 153-167页

作者： Sara PIMENTA joao R.FREITAS JoséH.CORREIA CMEMS-UMinho University of MinhoGuimarães4800-058Portugal LABBELS-Associate Laboratory Braga/GuimarãesPortugal

Brain diseases affect millions of people and have a huge social and economic *** use of neural probes for studies in animals has been the main approach to increasing knowledge about neural network ***,neuroscientists are trying to develop new and more effective therapeutic approaches to treating neurological *** implementation of neural probes with multifunctionalities(electrical,optical,and fluidic interactions)has been increasing in the last few years,leading to the creation of devices with high temporal and spatial *** the applicability of,and elements integrated into,neural probes has also led to the necessity to create flexible interfaces,reducing neural tissue damage during probe implantation and increasing the quality of neural acquisition *** this paper,we review the fabrication,characterization,and validation of several types of flexible neural probes,exploring the main advantages and drawbacks of these ***,future developments and applications are ***,this review aims to present the currently available flexible devices and future appropriate avenues for development as possible guidance for future engineered devices.

关键词： Brain knowledge Flexible interface Multifunctional probe

Conformal and continuous deposition of bifunctional cobalt phosphide layers on p-silicon nanowire arrays for improved solar hydrogen evolution

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Nano Research 2018年第9期11卷 4823-4835页

作者： Sitaramanjaneva Mouli Thalluri Jerome Borme Kang Yu Junyuan Xu Isilda Amorim joao Gaspar Liang Qiao Paulo Ferreira Pedro Alpuim Lifeng Liu International Iberian Nanotechnology Laboratory (INL) Av. Mestre. Jose Veiga Braga 4715-330 Portugal Materials Science and Engineering Program University of Texas at Austin Austin TX78712 USA Deportment of Chemistry State Key Laboratory of Molecular Engineering of Polymers and Institute of Biomedical Sciences Fudon University Shanghai 200433 China Mechanical Engineering Department and IDMEC Instituto Superior Tdcnico University of Lisbon Av. Rovisco Pais Lisboa 1049-007 Portugal Center of Physics University of Minho Braga 4710-057 Portugal

Vertically aligned p-silicon nanowire （SiNW） arrays have been extensively investigated in recent years as promising photocathodes for solar-driven hydrogen evolution. However, the fabrication of SiNW photocathodes with both high photoelectrocatalytic activity and long-term operational stability using a simple and affordable approach is a challenging task. Herein, we report conformal and continuous deposition of a di-cobalt phosphide （C02P） layer on lithography- patterned highly ordered SiNW arrays via a cost-effective drop-casting method followed by a low-temperature phosphorization treatment. The as-deposited C02P layer consists of crystalline nanoparticles and has an intimate contact with SiNWs, forming a well-defined SiNW@Co2P core/shell nanostructure. The conformal and continuous Co2P layer functions as a highly efficient catalyst capable of substantially improving the photoelectrocatalytic activity for the hydrogen evolution reaction （HER） and effectively passivates the SiNWs to protect them from photo-oxidation, thus prolonging the lifetime of the electrode. As a consequence, the SiNW@Co2P photocathode with an optimized C02P layer thickness exhibits a high photocurrent density of -21.9 mA·cm^-2 at 0 V versus reversible hydrogen electrode and excellent operational stability up to 20 h for solar-driven hydrogen evolution, outperforming many nanostructured silicon photocathodes reported in the literature. The combination of passivation and catalytic functions in a single continuous layer represents a promising strategy for designing high-performance semiconductor photoelectrodes for use in solar-driven water splitting, which may simplify fabrication procedures and potentially reduce production costs.

关键词： solar-driven hydrogenevolution silicon nanowire cobalt phosphide photoelectrochemical water splitting drop-casting

葡萄牙现代生态夯土住宅设计——葡萄牙一层民居

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设计家 2016年第1期 108-113页

作者： Ana Morgado Lara Pinho Mariada Paz braga Mariado Carmo Caldeira joao Morgado Blaanc

项目位于一个大的葡萄园中间,葡萄园地势平坦,周边是一片软木橡树林.建筑仅一层,却与周边环境和谐共处,在设计过程中,项目最少程度地影响整个周边环境,给人以安静和谐的感觉.三个大小相似的长方体构成了建筑的不同功能区,每一个长方体... 详细信息

项目位于一个大的葡萄园中间,葡萄园地势平坦,周边是一片软木橡树林.建筑仅一层,却与周边环境和谐共处,在设计过程中,项目最少程度地影响整个周边环境,给人以安静和谐的感觉.三个大小相似的长方体构成了建筑的不同功能区,每一个长方体都有一个平面屋顶,为了充分结合葡萄园的景色与房屋不同功能分布,建筑被设计成“直角”状.

关键词：住宅设计葡萄牙民居生态环境和谐葡萄园设计过程周边环境

PillCam~ SB3 capsule: Does the increased frame rate eliminate the risk of missing lesions?

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World Journal of Gastroenterology 2016年第10期22卷 3066-3068页

作者： Sara Monteiro Francisca Dias de Castro Pedro Boal Carvalho Maria joao Moreira Bruno Rosa José Cotter Department of Gastroenterology Hospital Senhora da Oliveira Rua dos Cutileiros Creixomil 4835-044 Guimaraes Portugal Life and Health Sciences Research Institute (ICVS) School of Health Sciences University of Minho 4710-057 Braga Portugal ICVS/3B's PT Government Associate Laboratory 4710-057 Braga/Guimaraes Portugal

Since its emergence in 2000, small bowel capsule endoscopy(SBCE) has assumed a pivotal role as an investigation method for small bowel diseases. The PillCam SB2-ex offers 12 h of battery time, 4 more than the previous version(SB2). Rahman et al recently found that the PillCam SB2-ex has a significantly increased completion rate, although without higher diagnostic yield, compared with the SB2. We would like to discuss these somewhat surprising results and the new potentialities of the PillCam SB3 regarding the diagnostic yield of small bowel studies. PillCam SB3 offers improved image resolution and faster adaptable frame rate over previous versions of SBCE. We recently compared the major duodenal papilla detection rate obtained with PillCam SB3 and SB2 as a surrogate indicator of diagnostic yield in the proximal small bowel. The PillCam SB3 had a significantly higher major duodenal papilla detection rate than the PillCam SB2(42.7% vs 24%, P = 0.015). Thus, the most recent version of the PillCam capsule, SB3, may increase diagnostic yield, particularly in the proximal segments of the small bowel.

关键词： PillCam~ SB2 PillCam~ SB3 Capsule endoscopy Diagnostic yield Lesions Frames

Antimicrobial Action and Scaring of 10%Green Banana Shell in Chronic Wounds

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Open Journal of Medical Microbiology 2018年第3期8卷 47-55页

作者： Ana Beatriz Alkimim Teixeira Loyola Rafael Vieira Fernandes joao Victor braga Mendes Nadir Alves de Oliveira Neta Luiz Francisley de Paiva Adriana Rodrigues dos Anjos Mendonca Dênia Amélia Novato Castelli Von Atzingen Department of Applied Health Sciences Faculty of Health SciencesThe Universidade do Vale do SapucaíPouso AlegreBrazil Faculty of Medicine Sapucai Valley University(UNIVáS)Pouso AlegreBrazil Laboratory of Microbiological Research Sapucai Valley University(UNIVáS)Pouso AlegreBrazil Department of Applied Health Sciences Sapucai Valley University(UNIVAS)Pouso AlegreBrazil Department of Bioethics Faculty of Health SciencesSapucai Valley University(UNIVáS)Pouso AlegreBrazil

The percentage of diabetic patients with contaminated lesions increases from 3% to 10%. Treatment with herbal products shows benefits in their use, as well as antioxidant and antifungal activities. Objective: to evaluate the antimicrobial action of 10% banana peel gel and the contraction of diabetic and venous wounds. Methods: individual, analytical, interventional, longitudinal, prospective, randomized study from February to December 2015. Five patients were included in the study;3 with venous ulcer and 2 with diabetic wound. Application of 10% green banana peel gel and weekly samples were performed. After six days, the second collection was performed. The samples were seeded in the Mannitol salt agar culture medium, MacConkey agar and Saboraund agar with chloramphenicol for isolation of cocci and Gram-positive and Gram-negative bacilli;and fungi. The total counts of bacteria were determined by PCA (Plate Count Agar) and measurement of the lesion margin. There was a reduction of microorganisms with the use of the gel in 53.57% of the patients, and reduction of wound areas in 48.1%.

关键词： Musa sapientum Phytotherapy Products with Antimicrobial Action Healing Wounds and Injuries