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Development of hepatorenal syndrome in bile duct ligated rats

World Journal of Gastroenterology 2008年第28期14卷 4505-4511页

作者： Regina m Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos mauro m Teixeira Ana Cristina Sim■es e Silva Departamento de Ciências Biológicas Centro Universitário de Belo Horizonte-UNIBHAv.Mário WerneckBelo HorizonteMinas Gerais 30150-281Brazil Laboratório de Hipertenso Departamento de Fisiologia e BiofísicaInstituto de Ciências Biológicas (ICB)Universidade Federal de Minas Gerais (UFMG)Av.Antonio Carlos6627Belo HorizonteMinas Gerais 30150-281Brazil Departamento de Pediatria Faculdade de MedicinaUFMGAv.Alfredo Balena 190Belo HorizonteMinas Gerais 30150-281Brazil Departamento de Anatomia Patológica Faculdade de MedicinaUFMGAv.Alfredo Balena 190Belo HorizonteMinas Gerais 30150-281Brazil Laboratório de Imunofarmacologia Departamento de Bioquímica e ImunologiaICBUFMGAv.Antonio Carlos 6627Belo HorizonteMinas Gerais 30150-281Brazil

AIm: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. mETHODS: male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS.

关键词： Hepatorenal syndrome Bile duct ligation Renal function Renin angiotensin system

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Root Growth, Nutrition and Yield of maize with Applied Finely Limestone in Surface of Cerrado Soil

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American Journal of Plant Sciences 2014年第6期5卷 834-844页

作者： Rafael Felippe Ratke Hamilton Seron Pereira joao de Deus Gomes dos Santos Junior Joaquim JoséFrazao Juliano magalhaes Barbosa Bruno de Oliveira dias Departamento de Engenharias AgronomiaCampus Professora Cinobelina ElvasUniversidade Federal do PiauíBom JesusBrazil Instituto de Ciencias Agrárias Universidade Federal de UberlandiaUberlândiaBrazil Embrapa Centro Nacional de Pesquisa no CerradoPlanaltinaBrazil Programa de Pós-graduacao em Agronomia Universidade Federal de GoiásGoianiaBrazil

The surface applies lime to correcting soil acidity in no-tillage and promotes root development and yield of maize. However, limestone with a particle size smaller than 0.30 mm cannot promote this effect. The aim of this study was to determine the root attributes, nutrition and productivity of maize with limestone ground in no-tillage. The experimental design was randomized blocks with five treatments and four replications. The treatments consisted of different particle sizes of limestone applying superficially to the soil under NT 0) control, without lime, 1) 0.30 mm to 0.20 mm 2) 0.20 mm to 0.10 mm, 3) 0, 10 mm to 0.05 mm 4) 0.05 mm to 0.01 mm. Attributes root, leaf nutrition and grain yield of maize were evaluated in two years 2009 and 2010. The elongation of roots in a 20-40 cm depth was greater when using limestone with particle size between 0.30 mm and 0.20 mm. The root length of maize plants correlated with the levels of mn in maize leaves. The root development promoted by liming effect was not reflected in the productivity of maize.

关键词： Particle Size No-Tillage Limestone

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Tako-Tsubo Cardiomyopathy—The Role of Physical and Emotional Stressors:Two Case Report

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International Journal of Clinical medicine 2012年第2期3卷 145-150页

作者： Patrícia margarida Serra Carvalho Jandira Helena Lima joao Bernardo Cunha Patricia Gloria Dinis dias Jose Goncalo Diniz Vieira Jose manuel Nascimento Costa Internal medicine Ward Coimbra University HospitalCoimbraPortugal

Introduction: Tako-Tsubo cardiomyopathy describes a form of acute and reversible left ventricular dysfunction with a clinical presentation, ECG and cardiac biomarkers that makes it indistinguishable from acute coronary syndrome. Case Presentation: The authors present two cases of tako-tsubo cardiomyopathy in postmenopausal women, the first case following an emotional stressful event and a second case following a blood transfusion and probably associated with intravenous catecholamine perfusion. Both had unobstructed coronary arteries and regional wall-motion abnormalities typical of this syndrome. Conclusions: Tako-tsubo cardiomyopathy is a condition often misdiagnosed. A clinical presentation suggestive of acute coronary syndrome in a postmenopausal woman without history of coronary disease and in whom a precipitating stressful event can be found should lead the physician to suspect the diagnosis of tako-tsubo cardiomyopathy. This syndrome associated with blood transfusion has rarely been described.

关键词： Tako-Tsubo Left Ventricle Postmenopausal Stress

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Root Growth, Nutrition and Yield of maize with Applied Different Limestone Particle Size in the Cerrado Soil

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American Journal of Plant Sciences 2014年第4期5卷 463-472页

作者： Rafael Felippe Ratke Hamilton Seron Pereira joao de Deus Gomes dos Santos Junior Joaquim JoséFrazao Juliano magalhaes Barbosa Bruno de Oliveira dias Departamento de Engenharias AgronomiaCampus Professora Cinobelina ElvasUniversidade Federal do PiauíBom JesusBrazil Instituto de Ciencias Agrárias Universidade Federal de UberlandiaUberlandiaBrazil Embrapa Centro Nacional de Pesquisa no CerradoPlanaltinaBrazil Programa de Pós-Graduacao em Agronomia Universidade Federal de GoiásGoianiaBrazil

The limestone with smaller particle size provides rapid correction of soil acidity. However, the limestone with large particles can promote bigger root growth, and may still have a residual effect on the soil. The aim of this study was to evaluate the residual effect of the application and incorporation of different limestone with a particle size bigger than 0.30 mm in root growth, nutrition and yield of maize in Cerrado soil. A randomized completed block utilized in this experiment, with five treatments and four replications. The grain sizes of dolomitic limestone incorporated into the Oxisol were: 0 (control, no-lime), 2.00-0.82 mm, 0.82-0.56 mm, 0.56-0.30 mm, 0.30-0.20 mm, in doses of 6.5 t·ha-1, 3.9 t·ha-1, 2.6 t·ha-1 and 1.3 t·ha-1 respectively. The limestone applied in introduction no-tillage. The maize were evaluated of root attributes, nutrition and grain yield in two years 2009 and 2010. The use of limestone particle size of 2.00-0.82 mm, and the quantity of 6.5 t·ha-1 applied to the soil and incorporated showed elongation and root growth of maize thin depth of 20-40 cm in the soil. In that, same proposed management of the limestone was the highest maize grain yield in the first year. The rooting characteristics evaluated correlated with leaf Ca and Cu and maizegrain yield.

关键词： Limestone No-Tillage Zea mays

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Continuous positive airway pressure acutely increases exercise duration in children with severe therapy-resistant asthma:a randomized crossover trial

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World Journal of Pediatrics 2021年第2期17卷 189-196页

作者： Claudia Silva Schindel Daniele Schiwe joao Paulo Heinzmann-Filho Natalia Evangelista Campos Paulo marcio Pitrez marcio Vinicius Fagundes Donadio Laboratory of Pediatric Physical Activity Centro Infant.Pontiffcia Universidade Catolica do Rio Grande do Sul(PUCRS)Av.Ipiranga6690.2°andarPorto AlegreRS CEP 90610-000.Brazil Hospital moinhos de Vento Porto AlegreBrazil and Centro InfantPontiffcia Universidade Catolica do Rio Grande do Sul(PUCRS)Porto Alegre.Brazil

Background Lower exercise tolerance is an important component of asthma and the possible effects of non-invasive ven-tilation on exercise capacity in individuals with severe therapy-resistant asthma(STRA)are *** study aimed to evaluate the immediate effect of continuous positive airway pressure(CPAP)on exercise tolerance in children with *** We performed a controlled,randomized,crossover clinical trial including subjects aged 6 to 18 years old diagnosed with ***,anthropometric and lung function data were *** participants in the intervention group(IG)used CPAP(PEEP 10cmH2O and FiO20.21)for a period of 40 *** in the control group(CG)used CPAP with mini-mum PEEP at 1 cmH20 also for 40 ***,subjects from both groups underwent cardiopulmonary exercise testing(CPET).After a 15-day washout period,on a subsequent visit,subjects participated in the opposite group to the initial *** Thirteen subjects with a mean age of 12.30±1.7 years were *** variables of peak expiratory flow(PEF)and forced expiratory volume in the first second(FEV1)before using CPAP and after performing CPET did not show sig-nificant *** CPET results,there was no significant difference(P=0.59)between groups at peak exercise for oxygen consumption—VO2(CG:33.4±6.3 and IG:34.5±5.9,mL kg^(-1)min^(-1)).However,the IG(12.4±2.1)presented a total test time(min)significantly(P=0.01)longer than the CG(11.5±1.3).Conclusion The results suggest that the use of CPAP before physical exercise increases exercise duration in children and adolescents with STRA.

关键词： Asthma Non-invasive ventilation Oxygen consumption Exercise test Exercise tolerance Exercise-induced bronchospasm

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Effects of Barium Stress in Brassica juncea and Cakile maritima:The Indicator Role of Some Antioxidant Enzymes and Secondary metabolites

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Phyton-International Journal of Experimental Botany 2021年第1期90卷 145-158页

作者： Houda Bouslimi Renata Ferreira Nesrine Dridi Pedro Brito Susete martins-dias Isabel Caçador Noomene Sleimi Laboratory of Resources Materials and EcosystemsFaculty of Sciences of BizerteUniversity of CarthageJarzounaBizerte7021Tunisia Centro de Recursos Naturais e Ambiente Instituto Superior TécnicoUniversidade de LisboaLisbon1049-001Portugal Instituto Português do mare da Atmosfera Rua Dr.Alfredo Magalhães RamalhoLisbon1495-006Portugal Centro de Recursos Naturais e Ambiente DBEInstituto Superior TécnicoUniversidade de LisboaLisbon1049-001Portugal marine and Environmental Sciences Centre Faculdade de CiênciasUniversidade de LisboaCampo GrandeLisbon1749-016Portugal

Soil contamination by toxic trace metal elements,like barium(Ba),may stimulate various undesirable changes in the metabolic activity of *** plant responses are fast and with,direct or indirect,generation of reactive oxygen species(ROS).To cope with the stress imposed by the ROS production,plants developed a dual cellular system composed of enzymatic and non-enzymatic players that convert ROS,and their by-products,into stable nontoxic *** assess the Ba stress response of two Brassicaceae species(Brassica juncea,a glycophyte,and Cakile maritime,a halophyte),plants were exposure to different Ba concentrations(0,100,200,300 and 500µm).The plants response was evaluated through their morphology and development,the determination of plant leaves antioxidant enzymatic activities and by the production of plants secondary *** indicated that the two Brassicaceae species have the ability to survive in an environment containing Ba(even at 500µm).The biomass production of *** was slightly affected whereas an increase in biomass *** was *** stress imposed by Ba activated the antioxidant defense system in the two species,noticed by the changes in the leaves activity of catalase(CAT),ascorbate peroxidase(APX)and guaicol peroxidase(GPX),and of the secondary metabolites,through the production of total phenols and *** enzymatic response was not similar within the two plant species:CAT and APX seem to have a more important role against the oxidative stress in *** while in *** is ***,total phenols and flavonoids production was more significant in the plants aerial part than in the roots,of the both *** the two Brassicaceae species response was different,in both plants catalytic and non-catalytic transformation of ROS occurs,and both were able to overcome the Ba toxicity and prevent the cell damage.

关键词： Brassica juncea Cakile maritima antioxidant enzymes barium stress oxidative stress secondary metabolites

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Boosting energy-storage capability in carbon-based supercapacitors using low-temperature water-in-salt electrolytes

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Journal of Energy Chemistry 2022年第7期31卷 521-530,I0013页

作者： joao Pedro A.Santos manuel J.Pinzón érick A.Santos Rafael Vicentini Cesar J.B.Pagan Leonardo m.Da Silva Hudson Zanin Brazilian Renewable Energies Center for Innovation on New EnergiesSchool of Electrical and Computer EngineeringUniversity of CampinasSao Paulo 13083-852Brazil Department of Semiconductors Instruments and PhotonicsSchool of Electrical and Computer EngineeringUniversity of CampinasSao Paulo 13083-852Brazil Laboratory of Fundamental and Applied Electrochemistry Department of ChemistryFederal University of Jequitinhonha e Mucuri’s ValleyMinas Gerais 39100-000Brazil

Supercapacitors(SCs) are high-power energy storage devices with ultra-fast charge/discharge *** using concentrated aqueous-based electrolytes can work at low temperatures due to their intrinsic properties, such as higher freezing point depression(FPD) and robustness. Besides the traditional organic-and aqueous-based(salt-in-water) electrolytes used in SCs, water-in-salt(WISE) sodium perchlorate electrolytes offer high FPD, non-flammability, and low-toxicity conditions, allowing the fabrication of safer, environmentally friendly, and more robust devices. For the first time, this work reports a comprehensive study regarding WISE system’s charge-storage capabilities and physicochemical properties under low-temperature conditions(T mesoporous carbon-based electrodes. The effect of temperature reduction on the electrolyte viscosity and electrical properties was investigated using different techniques and the in-situ(or operando) Raman spectroscopy under dynamic polarization *** cell voltage, equivalent series resistance, and specific capacitance were investigated as a function of the temperature. The cell voltage(U) increased ~ 50%, while the specific capacitance decreased ~20%when the temperature was reduced from 25 ℃ to -10 ℃. As a result, the maximum specific energy(E = CU^(2)/2) increased ~ 100%. Therefore, low-temperature WISEs are promising candidates to improve the energy-storage characteristics in SCs.

关键词： Carbon supercapacitors Water-in-salt electrolytes Low-temperature charge-storage Specific energy improvement at low temperatures

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Cytocompatible cellulose nanofibers from invasive plant species Agave americana *** Ricinus communis L.:a renewable green source of highly crystalline nanocellulose

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第6期22卷 450-461页

作者： Olga L.EVDOKImOVA Carla S.ALVES Radenka m.KRSmANOVIC WHIFFEN Zaida O.RTEGA Helena TOmáS joao R.ODRIGUES CQm-Centro de Quimica da madeira MMRGUniversidade da MadeiraCampus Universitario da Penteada9020-105 FunchalPortugal Faculty of Polytechnics University of Donja GoricaOktoih 18 WOO PodgoricaMontenegro Departamento de Ingenieria de Procesos Universidad de Las Palmas de Gran Canaria35017 Las Palmas de Gran CanariaLas PalmasSpain School of materials Science and Engineering/Center for Nano Energy materials Northwestern Polytechnical UniversityXi'an 710072China

In this study,the fibers of invasive species Agave americana *** Ricinus communis *** successfully used for the first time as new sources to produce cytocompatible and highly crystalline cellulose *** nanofibers were obtained by two methods,based on either alkaline or acid *** morphology,chemical composition,and crystallinity of the obtained materials were characterized by scanning electron microscopy(SEm)together with energy-dispersive X-ray spectroscopy(EDX),dynamic light scattering(DLS),X-ray diffraction(XRD),and Fourier transform infrared(FTIR)*** crystallinity indexes(CIs)of the cellulose nanofibers extracted from *** and *** were very high(94.1%and 92.7%,respectively).Biological studies evaluating the cytotoxic effects of the prepared cellulose nanofibers on human embryonic kidney 293 T(HEK293 T)cells were also *** nanofibers obtained using the two different extraction methods were all shown to be cytocompatible in the concentration range assayed(i.e.,0-500μg/mL).Our results showed that the nanocellulose extracted from *** and *** fibers has high potential as a new renewable green source of highly crystalline cellulose-based cytocompatible nanomaterials for biomedical applications.

关键词： Nanofiber Nanocellulose Agave americana L. Ricinus communis L. Crystallinity Invasive species Biomedical application

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Protection status as determinant of carbon stock drivers in Cerrado sensu stricto

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Journal of Plant Ecology 2020年第3期13卷 361-368页

作者： Kelly marianne Guimarães Pereira Natielle Gomes Cordeiro marcela de Castro Nunes Santos Terra marcela Venelli Pyles Christian dias Cabacinha Josémárcio de mello Eduardo van den Berg Department of Biology Federal University of LavrasCampus UniversitárioCEP 37200-000LavrasMinas Gerais stateBrazil Department of Forest Sciences Federal University of LavrasCampus UniversitárioCEP 37200-000LavrasMinas Gerais stateBrazil Department of Forest Sciences Institute of Agrarian SciencesFederal University of Minas GeraisCampus Regional de Montes ClarosCEP 39.404-547Montes ClarosMinas Gerais stateBrazil

Aims Natural vegetation plays an important role in global carbon cycling and ***,the Cerrado(Brazilian savannah)is considered a carbon sink because of its intrinsic *** aim was to evaluate how the aboveground biomass and biodiversity relationship change between three Cerrado remnants with different protection status:a‘control area’(Legal Reserve area),a protected area(PA)and a non-protected area(Non-PA).methods All three studied fragments are situated in northern minas Gerais state,*** estimated the aboveground carbon stocks based on the forest *** also measured three dimensions of biodiversity metrics for each plot:functional trait dominance,taxonomic diversity and functional *** following functional traits were evaluated for the species:wood density,maximum diameter and seed *** carried out generalized linear models seeking to evaluate how carbon stocks,community-weighted mean(CWm)trait values,species richness and diversity,and functional diversity indices differ among the *** Findings The Cerrado areas without protection status had lower carbon stocks,species richness,species diversity,functional richness and functional dispersion,whereas both PA and Non-PA had lower CWm maximum diameter and seed size compared with the Legal Reserve control *** linear models showed that carbon stocks,species and functional richness metrics were correlated within and across sites,and thus,species richness could serve as a good proxy for functional richness and carbon *** carbon stocks were positively driven by species richness and CWm maximum diameter,while they were negatively driven by functional *** richness,species diversity and CWm seed size appeared in the set of best models,but with no significant direct effect on carbon ***,we concluded that absence of protection in the Cerrado areas decreases both species richness and carbon stocks.

关键词： functional traits biodiversity biomass storage Brazilian Savanna human impacts

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3D printed millireactors for process intensification

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Chinese Journal of Chemical Engineering 2020年第1期28卷 180-190页

作者： Harrson S.Santana Alan C.Rodrigues mariana G.m.Lopes Felipe N.Russo joao L.Silva Jr Osvaldir P.Taranto School of Chemical Engineering University of CampinasBrazil Federal Institute of Education Science and Technology of South of Minas GeraisBrazil

The scope of the present research aims at demonstrating the 3D printing use in the manufacturing of microchannels for chemical process applications. A comparison among digital model processing applications for 3D print(slicers) and a print layer thickness analysis were performed. The 3D print fidelity was verified in several devices, including the microchannels’ printing with and without micromixer zones. In order to highlight the 3D print potential in Chemical Engineering, the biodiesel synthesis was also carried out in a millireactor manufactured by 3D printing. The millireactor operated under laminar flow regime with a total flow rate of 75.25 ml·min^-1(increment of about 130 times over traditional microdevices used for biodiesel production).The printed millireactor provided a maximum yield of Ethyl Esters of 73.51% at 40 ℃, ethanol:oil molar ratio of7 and catalyst concentration of 1.25 wt% and residence time about 10 s. As a result of flow rate increment attained in the millireactor, the number of required units for scaling-up the chemical processes is reduced. Using the approach described in the present research, anyone could produce their own millireactor for chemical process in a simple way with the aid of a 3D printer.

关键词： Process intensification 3D printer millireactors micromixers microdevices Biodiesel

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