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The contribution of resources and capabilities to the competitiveness： The case of Port of Sines

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Chinese Business Review 2009年第3期8卷 14-26页

作者： Susana Garrido Azevedo joao ferreira Department of Management and Economics University of Beira Interior Covilha 6200-209 Portugal

The main objective of this paper is to analyse the competitiveness of the main maritime Port sited in Portugal - Port of Sines. This paper is developed under the resource-based view approach. A literature review about the resource-based view is presented with a special highlight on the contribution of organisation owns＇ resources to the competitiveness. With this study we intend to emphasize the applicability of a management theory to a different type of organisation which only recently starts to be preoccupied with its competitiveness. A case study methodology is used in order to collect all information needed about its main resources and capabilities of Port and also its competitiveness. The resources analysed in this paper are： The infrastructures, the accessibilities, the Port operations and also the information systems used on it. Also, a set of performance data is analysed as the main indicators of competitiveness. After that, a conceptual model is presented in order to systematise the main resources and capabilities under which the competitiveness of the Port of Sines is built on.

关键词： competitiveness sea Port resource-based view case study

Concepts perception of strategy and strategic management： University case study

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Chinese Business Review 2009年第7期8卷 48-64页

作者： Mainardes Emerson ferreira joao Andrade Silveli Department of Management and Economics University of Beira Interior Covilha 6200-209 Portugal

Aiming to reveal the university students＇ understanding in management as for the strategy and strategic management phenomena, this study accomplishes a phenomenographic research to assess the future managers＇ market perception. It was chosen university students in Management of a Portuguese University. We conclude that the strategy definitions obtained are an assembly of the diverse existing concepts. Concerning to strategic management it was perceived an approach with one of the main existing concepts. The findings raise interesting issues with respect to the difficulties felt by new managers in translating their theoretical definitions in real examples in the organizations.

关键词： strategy strategic management phenomenographic concepts perception

Stem cell homing, tracking and therapeutic efficiency evaluation for stroke treatment using nanoparticles: A systematic review

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World Journal of Stem Cells 2020年第5期12卷 381-405页

作者： Mariana Penteado Nucci Igor Salerno Filgueiras joao Matias ferreira Fernando Anselmo de Oliveira Leopoldo Penteado Nucci Javier Bustamante Mamani Gabriel Nery Albuquerque Rego Lionel Fernel Gamarra LIM44 Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 05529-060Brazil Hospital Israelita Albert Einstein Sao Paulo 05529-060Brazil Centro Universitário do Planalto Central BrasíliaDFBrazil

BACKGROUND Stroke is the second leading cause of death *** is a real need to develop treatment strategies for reducing neurological deficits in stroke survivors,and stem cell(SC)therapeutics appear to be a promising alternative for stroke therapy that can be used in combination with approved thrombolytic or thrombectomy ***,the efficacy of SC therapy depends on the SC homing ability and engraftment into the injury site over a long period of ***,tracking SCs from their niche to the target tissues is a complex *** To evaluate SC migration homing,tracking and therapeutic efficacy in the treatment of stroke using nanoparticles METHODS A systematic literature search was performed to identify articles published prior to November 2019 that were indexed in PubMed and *** following inclusion criteria were used:(1)Studies that used in vivo models of stroke or ischemic brain lesions;(2)Studies of SCs labeled with some type of contrast agent for cell migration detection;and(3)Studies that involved in vivo cellular homing and tracking *** A total of 82 articles were identified by indexing in Scopus and Pub *** inclusion criteria were applied,35 studies were selected,and the articles were assessed for eligibility;ultimately,only 25 studies were *** of the selected studies used SCs from human and mouse bone marrow labeled with magnetic nanoparticles alone or combined with fluorophore *** cells were administered in the stroke model(to treat middle cerebral artery occlusion in 74%of studies and for photothrombotic induction in 26%of studies).Fiftythree percent of studies used xenogeneic grafts for cell therapy,and the migration homing and tracking evaluation was performed by magnetic resonance imaging as well as other techniques,such as near-infrared fluorescence imaging(12%)or bioluminescence assays(12%).CONCLUSION Our systematic review provided an up-to-date evaluation of SC migration hom

关键词： Stem cell Nanoparticles Homing Tracking Near-infrared fluorescence image Cellular therapy Magnetic resonance image Bioluminescence Stroke

Magnetic bioassembly platforms towards the generation of extracellular vesicles from human salivary gland functional organoids for epithelial repair

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Bioactive Materials 2022年第12期7卷 151-163页

作者： Ajjima Chansaenroj Christabella Adine Sawanya Charoenlappanit Sittiruk Roytrakul Ladawan Sariya Thanaphum Osathanon Sasitorn Rungarunlert Ganokon Urkasemsin Risa Chaisuparat Supansa Yodmuang Glauco R.Souza joao N.ferreira Avatar Biotechnologies for Oral Health and Healthy Longevity Research Unit Faculty of DentistryChulalongkorn UniversityBangkok10330Thailand Faculty of Dentistry National University of Singapore119077SingaporeSingapore Department of Biomedical Engineering Faculty of EngineeringNational University of Singapore119077SingaporeSingapore Functional Ingredients and Food Innovation Research Group National Center for Genetic Engineering and BiotechnologyNational Science and Technology Development AgencyPathum Thani12120Thailand The Monitoring and Surveillance Center for Zoonotic Diseases in Wildlife and Exotic Animals Faculty of Veterinary ScienceMahidol UniversityNakhon Pathom73170Thailand Department of Anatomy Faculty of DentistryChulalongkorn UniversityBangkok10330Thailand Department of Preclinical and Applied Animal Science Faculty of Veterinary ScienceMahidol UniversityNakhon Pathom73170Thailand Research Affairs Faculty of MedicineChulalongkorn UniversityBangkok10330Thailand University of Texas Health Sciences Center at Houston HoustonTX77030USA Nano3D Biosciences Inc. HoustonTX77030USA Greiner Bio-One North America Inc MonroeNC28110USA

Salivary glands(SG)are exocrine organs with secretory units commonly injured by ***-engineered organoids and extracellular vesicles(EV)are currently under investigation as potential strategies for SG ***,three-dimensional(3D)cultures of SG functional organoids(SGo)and human dental pulp stem cells(hDPSC)were generated by magnetic 3D bioassembly(M3DB)*** growth factor 10(FGF10)was used to enrich the SGo in secretory epithelial *** 11 culture days via M3DB,SGo displayed SG-specific acinar epithelial units with functional properties upon *** consistently develop 3D hDPSC in vitro,3 culture days were sufficient to maintain hDPSC undifferentiated genotype and phenotype for EV *** isolation was performed via sequential centrifugation of the conditioned media of hDPSC and SGo *** were characterized by nanoparticle tracking analysis,electron microscopy and *** were in the exosome range for hDPSC(diameter:88.03±15.60 nm)and for SGo(123.15±63.06 nm).Upon ex vivo administration,exosomes derived from SGo significantly stimulated epithelial growth(up to 60%),mitosis,epithelial progenitors and neuronal growth in injured SG;however,such biological effects were less distinctive with the ones derived from ***,these exosome biological effects were investigated by proteomic *** spectrometry profiling of SGo exosomes predicted that cellular growth,development and signaling was due to known and undocumented molecular targets downstream of *** were identified as one of the novel targets requiring further ***,M3DB platforms can generate exosomes with potential to ameliorate SG epithelial damage.

关键词： Salivary gland Hyposalivation Human dental pulp stem cells Magnetic bioassembly Organoids Exosome

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阿尔托德·圣卡塔琳娜城市复兴

景观设计 2016年第6期 104-109页

作者： joao ferreira Nunes

该项目的设计符合人们对冥想空间的理解和期望，在城市空间中打造一处迷人而独特的区域，同时满足了里斯本市民的特殊需求。偶然经过这里的游客和里斯本的市民都会来到这个“冥想空间”，他们帮助设计师重新发现项目的场地特点。

关键词：城市复兴阿尔托城市空间里斯本设计师塔市民

Ammonia Sensing System Based on Wavelength Modulation Spectroscopy

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Photonic Sensors 2015年第2期5卷 109-115页

作者： Duarte VIVEIROS joao ferreira Susana O. SILVA Joana RIBEIRO Deolinda FLORES Jose L. SANTOS Orlando FRAZAO Jose M. BAPTISTA INESC Porto Rua do Campo Alegre 687 4169-007 Porto Portugal Geology Center of the University of Porto and Department of Geosciences Environment and Spatial Plannings Facultyof Science at University of Porto Rua do Campo Alegre 687 4169-007 Porto Portugal Department of Physics and Astronomy Faculty of Science at University of Porto Rua do Campo Alegre 687 4169-007 Porto Portugal Competence Center of Exact Sciences and Engineering University of Madeira Campus da Penteada 9000-390 Funchal Portugal

A sensing system in the near infrared region has been developed for ammonia sensing based on the wavelength modulation spectroscopy （WMS） principle. The WMS is a rather sensitive technique for detecting atomic/molecular species, presenting the advantage that it can be used in the near-infrared region by using the optical telecommunications technology. In this technique, the laser wavelength and intensity were modulated by applying a sine wave signal through the injection current, which allowed the shift of the detection bandwidth to higher frequencies where laser intensity noise was typically lower. Two multi-pass cells based on free space light propagation with 160 cm and 16 cm of optical path length were used, allowing the redundancy operation and technology validation. This system used a diode laser with an emission wavelength at 1512.21nm, where NH3 has a strong absorption line. The control of the NH3 gas sensing system, as well as acquisition, processing and data presentation was performed.

关键词： Ammonia sensing fiber optic system near infrared region wavelength modulation spectroscopy,environment

The use of Artificial Neural Networks to estimate seismic damage and derive vulnerability functions for traditional masonry

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Frontiers of Structural and Civil Engineering 2020年第3期14卷 609-622页

作者： Tiago Miguel ferreira joao ESTEVAO Rui MAIO Romeu VICENTE ISISE Institute of Science and Innovation for Bio-Sustainability(IB-S)Department of Civil EngineeringUniversity of MinhoGuimaraes 4800-058Portugal Department of Civil Engineering University of AlgarveFaro 8005-139Portugal RISCO Department of Civil EngineeringUniversity of AveiroAveiro 3810-193Portugal

ABSTRACT This paper discusses the adoption of Artificial Intelligence-based techniques to estimate seismic damage,not with the goal of replacing existing approaches,but as a mean to improve the precision of empirical *** such,damage data collected in the aftermath of the 1998 Azores earthquake(Portugal)is used to develop a comparative analysis between damage grades obtained resorting to a classic damage formulation and an innovative approach based on Artificial Neural Networks(ANNs).The analysis is carried out on the basis of a vulnerability index computed with a hybrid seismic vulnerability asssment methodology,which is subsequently used as input to both *** results obtained are then compared with real post-earthquake damage observation and critically discussed taking into account the level of adjustment achieved by each ***,a computer routine that uses the ANN as an approximation function is developed and applied to derive a new vulnerability curve *** general terms,the ANN developed in this study allowed to obtain much better approximations than those achieved with the original vulnerability approach,which has revealed to be quite ***,the proposed vulnerability curve expression was found to provide a more accurate damage prediction than the traditional analytical expressions.

关键词： Artificial Neural Networks seismic vulnerability masonry buildings damage estimation,vulnerability curves

Tunable Super-Structured Fiber Bragg Gratings with Perfect Sequences Based on m-Sequence

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Journal of Electronic Science and Technology 2017年第4期15卷 358-363页

作者： joao S.Pereira Marco P.M.ferreira Marko Gasparovic Instituto de Telecomunicacoes Lisboa 1049-001 Portugal Institute Polytechnic of Leiria Leiria 2411-901 Portugal Centro de Investigaao em Informaica e Comunicacoes Institute Polytechnic of Leiria Leiria 2411-901Portugal

Recently, a tunable fiber Bragg grating(FBG) was developed by using stress-responsive colloidal crystals. In this paper, we have simulated the application of these nanoparticles into the super-structured fiber Bragg grating(SSFBG) written with perfect sequences derived from a short maximal-length sequence. A tunable SSFBG will be available to overcome the prohibitive temperature variation of the optical codecs. Nevertheless,we presented a method to implement coherent time spreading optical code-division multiple-access(OCDMA) where a unique code(or perfect sequence) can be reused and mixed with different wavelengths to obtain a tunable wavelength-division multiplexing(WDM)system. In order to maximize the binary throughput, we have selected a unique short maximal-length sequence composed of 7 chips that can be tuned with 7 different optical wavelengths. We found thousands of different tunable combinations that presented power contrast ratios(P/C) higher than 12 dB. When a WDM-OCDMA system used 2 different combinations simultaneously, the perfect binary detection with error correction codes was achieved successfully. The tunable SSFBG with colloidal crystals will be a simple and good alternative choice for fiber-to-the-home(FTTH) communications.

关键词： Optical code-division multiple-access(OCDMA) super-structured fiber Bragg grating(SSFBG) wavelength-division multiplexing OCDMA(WDM-OCDMA)

New-onset diabetes after kidney transplantation:Incidence and associated factors

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World Journal of Diabetes 2018年第7期9卷 132-137页

作者： Vania Gomes Florbela ferreira JoséGuerra Maria joao Bugalho Endocrinology Diabetes and Metabolism DepartmentSanta Maria HospitalLisbon 1649-035Portugal Nephrology and Kidney Transplantation Department Santa Maria HospitalLisbon 1649-035Portugal

AIM To determine the incidence and associated factors of new-onset diabetes after transplantation(NODAT) in a Portuguese central hospital. METHODS This single-center retrospective study involved consecutive adult nondiabetic transplant recipients, who had undergone kidney transplantation between January 2012 and March 2016. NODAT was diagnosed according to the criteria of the American Diabetes Association. Data were collected from an institutional database of the Nephrology and Kidney Transplantation Department(Santa Maria Hospital, Lisbon, Portugal) and augmented with data of laboratorial parameters collected from the corresponding patient electronic medical records. Exclusion criteria were preexisting diabetes mellitus, missing information and follow-up period of less than 12 mo. Data on demographic and clinical characteristics as well as anthropometric and laboratorial parameters were also collected. Patients were divided into two groups: With and without NODAT-for statistical *** A total of 156 patients received kidney transplantduring the study period, 125 of who were included in our analysis. NODAT was identified in 27.2% of the patients(n = 34; 53% female; mean age: 49.5 ± 10.8 years; median follow-up: 36.4 ± 2.5 mo). The incidence in the first year was 24.8%. The median time to diagnosis was 3.68 ± 5.7 mo after transplantation, and 76.5% of the patients developed NODAT in the first 3 mo. In the group that did not develop NODAT(n = 91), 47% were female, with mean age of 46.4 ± 13.5 years and median follow-up of 35.5 ± 1.6 mo. In the NODAT group, the pretransplant fasting plasma glucose(FPG) levels were significantly higher [101(96.1-105.7) mg/d L vs 92(91.4-95.8) mg/d L, P = 0.007] and pretransplant impaired fasting glucose(IFG) was significantly more frequent(51.5% vs 27.7%, P = 0.01). Higher pretransplant FPG levels and pretransplant IFG were found to be predictive risk factors for NODAT development [odds ratio(OR): 1.059, P = 0.003; OR: 2.77

关键词： New-onset diabetes after transplant Incidence Kidney transplantation Impaired fasting glucose Immunosuppression