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Indirect printing of hierarchical patient-specific scaffolds for meniscus tissue engineering

Bio-Design and Manufacturing 2019年第4期2卷 225-241页

作者： joao BCosta Joana Silva-Correia Sandra Pina Alain da Silva Morais Sílvia Vieira Hélder Pereira joao espregueira-mendes Rui LReis Joaquim M.Oliveira B′s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017 Barco GmrPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimaraesPortugal The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of MinhoAvepark4805-017 BarcoGuimar'sPortugal Ripoll y De Prado Sports Clinic:Murcia-Madrid FIFA Medical Centre of Excellence MurciaSpain Orthopedic Department Centro Hospitalar Póvoa de Varzim Vila do CondePortugal Clínica do Dragao Espregueira-Mendes Sports CentreFIFA Medical Centre of ExcellencePortoPortugal Dom Henrique Research Centre PortoPortugal Orthopedic Department University of MinhoBragaPortugal

The complex meniscus tissue plays a critical role in the knee. The high susceptibility to injury has led to an intense pursuit for better tissue engineering regenerative strategies, where scaffolds play a major role. In this study, indirect printed hierarchical multilayered sca ffolds composed by a silk fibroin (SF) upper layer and an 80/20 (w/w) ratio of SF/ionic-doped β-tricalcium phosphate (TCP) bottom layer were developed. Furthermore, a comparative analysis between two types of sca ffolds pro- duced using di fferent SF concentrations, i.e., 8% (w/v) (Hi8) and 16% (w/v) (Hi16) was performed. In terms of architecture and morphology, the produced sca ffolds presented homogeneous porosity in both layers and no di fferences were observed when comparing both sca ffolds. A decrease in terms of mechanical performance of the sca ffolds was observed when SF concentration decreased from 16 to 8% (w/v). Hi16 revealed a static compressive modulus of 0.66 ± 0.05 MPa and dynamical mechanical properties ranging from 2.17 ± 0.25 to 3.19 ± 0.38 MPa. By its turn, Hi8 presented a compressive modulus of 0.27 ± 0.08 MPa and dynamical mechanical properties ranging from 1.03 ± 0.08 MPa to 1.56 ± 0.13 MPa. In vitro bioactivity studies showed formation of apatite crystals onto the surface of Hi8 and Hi16 bottom layers. Human meniscus cells (hMCs) and human primary osteoblasts were cultured separately onto the top layer (SF8 and SF16) and bottom layer (SF8/TCP and SF16/TCP) of the hierarchical sca ffolds Hi8 and Hi16, respectively. Both cell types showed good adhesion and proliferation as denoted by the live/dead staining, Alamar Blue assay and DNA quanti fication analysis. Subcutaneous implantation in mice revealed weak in flammation and sca ffold’s integrity. The hierarchical indirect printed SF sca ffolds can be promising candidate for meniscus TE sca ffolding applications due their suitable mechanical properties, good biological performance and possibility of being applied in a patie

关键词： Patient-specific Indirect printing Hierarchical Silk fibroin Enzymatic-cross-linking Meniscus

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Visualizing traumatic brain injury:ocular clues for diagnosis and assessment

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Neural Regeneration Research 2025年第5期20卷 1399-1400页

作者： Morteza Abyadeh Vivek Gupta Yuyi You joao A.Paulo Mehdi Mirzaei ProGene Technologies Pty Ltd SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA

Traumatic brain injury (TBI) is defined as damage to the brain resulting from an external sudden physical force or shock to the *** is considered a silent public health epidemic causing significant death and disability *** were 64,000 TBI related deaths reported in the USA in 2020,with about US$76 billion in direct and indirect medical costs annually.

关键词： diagnosis ocular injury

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Induced pluripotent stem cells, a giant leap for mankind therapeutic applications

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World Journal of Stem Cells 2019年第7期11卷 421-430页

作者： JoséBraganca joao AndréLopes Leonardo mendes-Silva joao Miguel Almeida Santos Department of Biomedical Sciences and Medicine University of AlgarveFaro 8005-139Portugal Centre for Biomedical Research(CBMR) University of AlgarveFaro 8005-139Portugal

Induced pluripotent stem cells(iPSC)technology has propelled the field of stem cells biology,providing new cells to explore the molecular mechanisms of pluripotency,cancer biology and aging.A major advantage of human iPSC,compared to the pluripotent embryonic stem cells,is that they can be generated from virtually any embryonic or adult somatic cell type without destruction of human *** addition,iPSC can be generated from somatic cells harvested from normal individuals or patients,and used as a cellular tool to unravel mechanisms of human development and to model diseases in a manner not possible *** these fundamental aspects of human biology and physiology that are revealed using iPSC or iPSC-derived cells,these cells hold an immense potential for cell-based therapies,and for the discovery of new or personalized pharmacological treatments for many ***,we review some of the current challenges and concerns about iPSC *** introduce the potential held by iPSC for research and development of novel health-related *** briefly present the efforts made by the scientific and clinical communities to create the necessary guidelines and regulations to achieve the highest quality standards in the procedures for iPSC generation,characterization and long-term ***,we present some of the audacious and pioneer clinical trials in progress with iPSC-derived cells.

关键词： Induced pluripotent stem cells Reprogramming Cell-based therapy Stem cell banking Disease modelling

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Development of metal organic fromwork-199 immobilized zeolite foam for adsorption of common indoor VOCs

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Journal of Environmental Sciences 2017年第5期29卷 321-330页

作者： Vipin K.Saini joao Pires School of Environment and Natural Resources Doon UniversityDehradun 248001India Department of Chemistry and Biochemistry Faculty of SciencesUniversity of LisbonLisbon 1749-016Portugal

Reticulated foam shaped adsorbents are more efficient for the removal of volatile organic compounds（VOCs）,particularly from low VOC-concentration indoor air streams. In this study composite structure of zeolite and metal organic frameworks（MOFs）,referred as ZMF,has been fabricated by immobilization of fine MOF-199 powder on foam shaped Zeolite Socony Mobil-5（ZSM-5）Zeolitic structure,referred as ZF. The ZMF possess a uniform and well-dispersed coating of MOF-199 on the porous framework of ZF. It shows higher surface area,pore volume,and VOCs adsorption capacity,as compared to ***-fabrication changes in selective adsorption properties of ZMF were studied with three common indoor VOCs（benzene,n-hexane,and cyclohexane）,using gravimetric adsorption technique. The adsorption capacity of ZMF with different VOCs follow the order of benzene 〉 n-hexane 〉 cyclohexane. In comparison with MOF-199 and ZF,the composite structure ZMF shows improvement in selectivity for benzene from other two VOCs. Further,improvement in efficiency and stability of prepared ZMF was found to be associated with its high MOF loading capacity and unique morphological and structural properties. The developed composite structure with improved VOCs removal and recyclability could be a promising material for small to limited scale air pollution treatment units.

关键词： VOCs Adsorption Composite materials Selectivity Zeolite foam MOFs HKUST-1

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PHASE-FIELD MODELING OF ELASTIC EFFECTS IN EUTECTIC GROWTH WITH MISFIT STRESSES

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第1期4卷 34-50页

作者： ZOHREH EBRAHIMI joao REZENDEH AICES Graduate School RWTH Aachen University D-52056 AachenGermany Institute of Minerals Engineering(GHI)RWTH Aachen University D-52056 AachenGermany

Elastic interactions,arising from a difference of lattice spacing between two coherent phases in eutectic alloys with misfit stresses,can have an influence on microstructural pattern formation of eutectic colonies during solidification *** a thermodynamic point of view the elastic energy contributes to the free energy of the phases and modifies their mutual ***,the elastic stresses will have an effect on stability of lamellae,lamellae spacing and growth *** this paper,a phase-field model is employed to investigate the influence of elastic misfits in eutectic *** model reduces to the traditional sharp-interface model in a thin-interface limit,where the microscopic interface width is small but *** elastic model is designed,based on linear microelasticity theory,to incorporate the elastic energy in the phase-field *** and numerical approaches,required to model elastic effects,are formulated and the stress distributions in eutectic solidification structures are *** twodimensional simulations are performed for directed eutectic growth and the simulation results for different values of the misfit stresses are illustrated.

关键词： Elastic energy misfit stress eutectic growth.

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Imbalance in T-cell differentiation as a biomarker of chronic diabetic foot ulceration

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Cellular & Molecular Immunology 2019年第10期16卷 833-834页

作者： joao Moura joao Rodrigues Marta Gonçalves Claudia Amaral Margarida Lima Eugenia Carvalho Center for Neuroscience and Cell Biology(CNC) University of CoimbraCoimbraPortugal INEB-Instituto Nacional de Engenharia Biomedica University of PortoPortoPortugal I3S-Instituto de Investigaçao e Inovaçao em Saude University of PortoPortoPortugal Department of Hematology Hospital de Santo Antonio(HSA)Centro Hospitalar Universitario do Porto(CHUP)PortoPortugal Unidade Multidisciplinar de Investigaçao Biomedica(UMIB/ICBAS/UP) PortoPortugal Department of Endocrinology Hospital de Santo Antonio(HSA)Centro Hospitalar Universitário do Porto(CHUP)PortoPortugal Department of Geriatrics University of Arkansas for Medical Sciences(UAMS)and Arkansas Children’s Hospital Research Institute(ACHRI)Little RockArkansas 72202USA

Diabetes is a growing epidemic due to the systematic increase in overweight and obesity,and chronic diabetic foot ulcers(DFUs)are the most debilitating and costly complication of *** is still essential for DFU care,but early detection is limited because we do not have a good DFU ***,we report the preliminary results of a large longitudinal study to test the effectiveness of the use of T-cell phenotype and TCR repertoire diversity as DFU *** results show that the ratio of effector/naïve T-cells and the number of TCR expansions are valuable biomarkers of DFU prognosis.

关键词： diabetic chronic obesity

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Intelligent negotiation model for ubiquitous group decision scenarios

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Frontiers of Information Technology & Electronic Engineering 2016年第4期17卷 296-308页

作者： joao CARNEIRO Diogo MARTINHO Goreti MARREIROS Paulo NOVAIS GECAD-Knowledge Engineering and Decision Support Group Institute of EngineeringPolytechnic of PortoPorto 4200-072Portugal ALGORITMI Centre University of MinhoGuimaraes 4800-058Portugal

Supporting group decision-making in ubiquitous contexts is a complex task that must deal with a large amount of factors to succeed. Here we propose an approach for an intelligent negotiation model to support the group decision-making process specifically designed for ubiquitous contexts. Our approach can be used by researchers that intend to include arguments, complex algorithms, and agents' modeling in a negotiation model. It uses a social networking logic due to the type of communication employed by the agents and it intends to support the ubiquitous group decision-making process in a similar way to the real process, which simultaneously preserves the amount and quality of intelligence generated in face-to-face meetings. We propose a new look into this problem by considering and defining strategies to deal with important points such as the type of attributes in the multicriterion problems, agents' reasoning, and intelligent dialogues.

关键词： Group decision support systems Ubiquitous computing Automatic negotiation Social networks Multi-agent systems

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Influence of climate fluctuations on Pinus palustris growth and drought resilience

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Forest Ecosystems 2023年第6期10卷 681-689页

作者： joao Campoa Joshua Puhlick CENSE–Center for Environmental and Sustainability Research CHANGE-Global Change and Sustainability InstituteDepartment of Environmental Sciences and EngineeringNOVA School of Science and TechnologyNOVA University LisbonCampus de Caparica2829-516 CaparicaPortugal The Jones Center at Ichauway 3988 Jones Center Drive39870NewtonGAUSA

The longleaf pine(Pinus palustris Mill.)ecosystem is an endangered ecosystem in the southeastern USA,and efforts to restore the species are ***,in recent decades,the region has experienced drastic fluctuations between wet and dry growing season conditions from year to year,and it is not fully understood how these fluctuations have influenced the growth of *** address this topic,we cored *** trees in woodlands of southwest Georgia and used dendrochronology techniques to determine how climate fluctuations have influenced the growth and drought resilience of *** also cored slash pine(Pinus elliottii Engelm.)trees in the same woodlands to compare growth between *** *** growth was less impacted by adverse climate conditions compared to ***,the strength of correlations between *** growth and temperature,precipitation,and Palmer Drought Severity Index(PDSI)changed over *** recent decades,climate conditions during the growing season became more influential on *** growth than the previous year's *** is concerning given that drought severity during the growing season has been *** results also indicate that *** was less resilient to droughts during the 2000s and 2010s than to those of the *** this new climate paradigm,our results suggest that *** might be more susceptible to growth reductions and less resistant to droughts than once *** work highlights the importance of understanding the impact of novel climate conditions on *** and has implications for restoration efforts,such as using silvicultural treatments that reduce tree vulnerability to drought(e.g.,thinning)and promote other climate-adapted species in mixture with ***.

关键词： Longleaf pine Slash pine Pinus elliottii Climate change Dendrochronology Dendroclimatology Forest disturbances

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TLBO with variable weights applied to shop scheduling problems

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CAAI Transactions on Intelligence Technology 2019年第3期4卷 148-158页

作者： Leonardo Ramos Rodrigues joao Paulo Pordeus Gomes Electronics Division Institute of Aeronautics and SpacePraca Marechal Eduardo Gomes50Sao Josedos Campos 12228-904Brazil Computer Science Department Federal University of CearaRua Campus do PiciSnFortaleza 60440-554Brazil

The teaching–learning-based optimisation (TLBO) algorithm is a population-based metaheuristic inspired on the teaching–learning process observed in a classroom. It has been successfully used in a wide range of applications. In this study, the authors present a variant version of TLBO. In the proposed version, different weights are assigned to students during the student phase, with higher weights being assigned to students with better solutions. Three different approaches to assign weights are investigated. Numerical experiments with benchmark instances of the flow-shop and the job-shop scheduling problems are carried out to investigate the performance of the proposed approaches. They compare the proposed approaches with the original TLBO algorithm and with two variants of TLBOs proposed in the literature in terms of solution quality, convergence speed and simulation time. The results obtained by the application of a Friedman statistical test showed that the proposed approaches outperformed the original version of TLBO in terms of convergence, with no significant losses in the average makespan. The additional simulation time required by the proposed approaches is small. The best performance was achieved with the approach of assigning a fixed weight to half the students with the best solutions and assigning zero to other students.

关键词： TLBO variable weights shop scheduling problems

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3D Progressive Damage Based Macro-Mechanical FE Simulation of Machining Unidirectional FRP Composite

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Chinese Journal of Mechanical Engineering 2018年第3期31卷 128-143页

作者： Yan-Li He joao-Paulo Davim Hong-Qian Xue Key Laboratory of Contemporary Design and Integrated Manufacturing Technology of Ministry of Education School of Mechanical EngineeringNorthwestern Polytechnical University Department of Mechanical Engineering University of AveiroCampus Santiago

Finite element(FE) simulation is a powerful tool for investigating the mechanism of machining fiber?reinforced polymer composite(FRP). However in existing FE machining simulation works,the two?dimensional(2 D) progressive damage models only describe material behavior in plane stress,while the three?dimensional(3 D) damage models always assume an instantaneous sti ness reduction pattern. So the chip formation mechanism of FRP under machin?ing is not fully analyzed in general stress state. A 3 D macro?mechanical based FE simulation model was developed for the machining of unidirectional glass fiber reinforced plastic. An energy based 3 D progressive damage model was proposed for damage evolution and continuous sti ness degradation. The damage model was implemented for the Hashin?type criterion and Maximum stress criterion. The influences of the failure criterion and fracture energy dissipa?tion on the simulation results were studied. The simulated chip shapes,cutting forces and sub?surface damages were verified by those obtained in the reference experiment. The simulation results also show consistency with previous 2 D FE models in the reference. The proposed research provides a model for simulating FRP material behavior and the machining process in 3 D stress state.

关键词： FRP Macro mechanical Machining Finite element Progressive damage

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