检索结果-南通市图书馆

The Threshold Percolation Volume Fraction of Vitreous Silica on the Thermal Expansion Behavior of Quartz

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science and Chemical Engineering 2019年第6期7卷 1-6页

作者： José Antonio Alves Júnior joao baptista baldo The Federal University of Sao Carlos(UFSCar) Materials Engineering Department(DEMa)Sao CarlosSPBrazil

In this work, it is shown how the additions of vitreous silica of particle size ?C.

关键词： Quartz Vitreous Silica Thermal Expansion Behavior Percolation Threshold

The Effect of Nano-Alumina Particles Generated in Situ in the Matrix of Ultralow and No Cement 85 wt%Al_(2)O_(3) Refractory Castables

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science and Chemical Engineering 2019年第6期7卷 7-22页

作者： José Antonio Alves Júnior joao baptista baldo Department of Materials Engineering Federal University of Sao Carlos via Washington LuisSao CarlosSPBrazil

Advanced high alumina refractory castables of ultra-low and to cement types, are well-known because of their ability on developing similar and/or superior thermal and mechanical properties. Following the recent trend of including nanoparticles in refractory castables, in this work, it is presented a novel way to obtain the benefit effects on the thermal and mechanical properties, promoted by the development in situ, of alumina’s nanoparticles in the matrix of castable (85 wt% Al2O3). The alumina nanoparticles were originated in situ after firing, due to the pyrolysis and oxidation of an aqueous resin, produced by the Pechini process. The resin played a double role, one as mixing liquid vehicle and the other as the aluminum oxide nanoparticles precursor. The results indicate a strong increase in flexural strength and elastic modulus as well as leading to a higher residual strength after thermal shock.

关键词： Low Cement Refractory Castable Alumina Nanoparticles Elastic Modulus Impulse Excitation Technique

Visualizing traumatic brain injury:ocular clues for diagnosis and assessment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1399-1400页

作者： Morteza Abyadeh Vivek Gupta Yuyi You joao A.Paulo Mehdi Mirzaei ProGene Technologies Pty Ltd SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA

Traumatic brain injury (TBI) is defined as damage to the brain resulting from an external sudden physical force or shock to the *** is considered a silent public health epidemic causing significant death and disability *** were 64,000 TBI related deaths reported in the USA in 2020,with about US$76 billion in direct and indirect medical costs annually.

关键词： diagnosis ocular injury

Significance of the balance between intracellular glutathione and polyethylene glycol for successful release of small interfering RNA from gold nanoparticles

在线全文

学校读者我要写书评

暂无评论

Nano Research 2015年第10期8卷 3281-3292页

作者： Mark McCully Yulan Hernandez joao Conde Pedro V. baptista Jesus M. de la Fuente Andrew Hursthouse David Stirling Catherine C. Berry CentreforCellEngineering UniversityofGlasgowGlasgowG128QQScotlandUK InstituteofNanoscienceofAragon UniversityofZaragozaZaragoza50018Spain MassachusettsInstituteofTechnology InstituteforMedicalEngineeringandScienceHarvard-MITDivisionforHealthSciencesandTechnologyCambridgeMassachusetts02139USA UCIBIO DepartamentodeCienciasdaVidaFaculdadedeCienciaseTecnologiaUniversidadeNovadeLisboaCampusdeCaparicaCaparica2829-516Portugal InstitutodeCienciadeMaterialesdeAragon(ICMA) CSIC-UniversidaddeZaragozac/PedroCerbuna12Zaragoza50009Spain InstituteofNanoBiomedicineandEngineering KeyLaboratoryforThinFilmandMicrofabricationTechnologyoftheMinistryofEducationResearchInstituteofTranslationMedicineShanghaiJiaoTongUniversityDongchuanRoad800Shanghai200240China SchoolofScience UniversityoftheWestofScotlandPaisleyPA12BEScotlandUK

The therapeutic promise of small interfering RNAs （siRNAs） for specific gene silencing is dependent on the successful delivery of functional siRNAs to the cytoplasm. Their conjugation to an established delivery platform, such as gold nanoparticles, offers tremendous potential for treating diseases and advancing our understanding of cellular processes. Their success or failure is dependent on both the uptake of the nanoparticles into the cells and subsequent intracellular release of the functional siRNA. In this study, utilizing gold nanoparticle siRNA-mediated delivery against C-MYC, we aimed to determine if we could achieve knockdown in a cancer cell line with low levels of intracellular glutathione, and determine the influence, if any, of polyethylene glycol （PEG） ligand density on knockdown, with a view to determining the optimal nanoparticle design to achieve C-MYC knockdown. We demonstrate that, regardless of the PEG density, knockdown in cells with relatively low glutathione levels can be achieved, as well as the possible effect of steric hindrance of PEG on the availability of the siRNA for cleavage in the intracellular environment. Gold nanoparticle uptake was demonstrated via transmission electron microscopy and mass spectroscopy, while knockdown was determined at the protein and physiological levels （cells in S-phase） by in-cell westerns and BrdU incorporation, respectively.

关键词： gold nanoparticles PEG glutathione siRNA drug delivery

Peripheral nerve regeneration with conduits:use of vein tubes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第4期10卷 529-533页

作者： Rodrigo Guerra Sabongi Marcela Fernandes joao baptista Gomes dos Santos Department of Orthopedics and Traumatology Escola Paulista de MedicinaFederal University of Sao Paulo Division of Hand Surgery Department of Orthopedics and TraumatologyEscola Paulista de MedicinaFederal University of Sao Paulo

Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the com-plexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made to develop an alternative to the au-tologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous experimental and clinical trials. The use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit.

关键词： peripheral nerve injury nerve graft nerve conduit Wallerian degeneration neurotrophic factors veins autografts nerve regeneration

Bone marrow-derived mesenchymal stem cells versus adipose-derived mesenchymal stem cells for peripheral nerve regeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第1期13卷 100-104页

作者： Marcela Fernandes Sandra Gomes Valente Rodrigo Guerra Sabongi joao baptista Gomes dos Santos Vilnei Mattioli Leite Henning Ulrich Arthur Andrade Nery Maria José da Silva Fernandes Division of Hand and Upper Limb Surgery Department of Orthopedics and Traumatology Universidade Federal de Sao Paulo Sao Paulo Brazil Department of Biochemistry Institute of Chemistry Universidade de Sao Paulo Sao Paulo Brazil Division of Neurosciences Department of Neurology and Neurosurgery Universidade Federal de Sao Paulo Sao Paulo Brazil

Studies have confirmed that bone marrow-derived mesenchymal stem cells （MSCs） can be used for treatment of several nervous system diseases. However, isolation of bone marrow-derived MSCs （BMSCs） is an invasive and painful process and the yield is very low. Therefore, there is a need to search for other alterative stem cell sources. Adipose-derived MSCs （ADSCs） have phenotypic and gene expression profiles similar to those of BMSCs. The production of ADSCs is greater than that of BMSCs, and ADSCs proliferate faster than BMSCs. To compare the effects of venous grafts containing BMSCs or ADSCs on sciatic nerve injury, in this study, rats were randomly divided into four groups： sham （only sciatic nerve exposed）, Matrigel （MG; sciatic nerve injury ＋ intravenous transplantation of MG vehicle）, ADSCs （sciatic nerve injury ＋ intravenous MG containing ADSCs）, and BMSCs （sciatic nerve injury ＋ intravenous MG containing BMSCs） groups. Sciatic functional index was calculated to evaluate the function of injured sciatic nerve. Morphologic characteristics of nerves distal to the lesion were observed by toluidine blue staining. Spinal motor neurons labeled with Fluoro-Gold were quantitatively assessed. Compared with sham-operated rats, sciatic functional index was lower, the density of small-diameter fibers was significantly increased, and the number of motor neurons significantly decreased in rats with sciatic nerve injury. Neither ADSCs nor BMSCs significantly improved the sciatic nerve function of rats with sciatic nerve injury,increased fiber density, fiber diameters, axonal diameters, myelin sheath thickness, and G ratios （axonal diameter/fiber diameter ratios） in the sciatic nerve distal to the lesion site. There was no significant difference in the number of spinal motor neurons among ADSCs, BMSCs and MG groups. These results suggest that neither BMSCs nor ADSCs provide satisfactory results for peripheral nerve repair when using MG as the conductor for engraftment.

关键词： nerve regeneration mesenchymal stem cells adipose-derived mesenchmal stem cells sciatic nerve Matrigel sciatic functional index neural regeneration

The Contribution of Accounting for the Definition of Performance Indicators： The Case of Higher Education Institutions

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Accounting and Auditing 2012年第4期8卷 537-548页

作者： Carmem Pereira Leal joao baptista Carvalho Carlos Machado-Santos UTAD University Vila Real Portugal University of Minho Braga Portugal

The influence of the New Public Management （NPM） principles in Portuguese Public Administration, particularly in higher education, has led these institutions on a path of adaptation of structures and systems in order to improve their decision-making processes. Public organizations must, at the present, to consider the strategic issues that are of vitally importance to their survival. In this context, the Balanced Scorecard （BSC）, due to its intrinsic characteristics, is presented as value added in attempts to link the set of objectives with the corporate strategy; determining, a priori, a course of action that must be constantly monitored. Our research analyzes the issues underlining the development of a model of performance management based on the BSC and formatted to a higher education institution （HEI）. The analysis of the results confirms the viability of applying an evaluation model constructed within a specific framework. In addition, the analysis attests the importance of performance indicators in this model of evaluation, specifically those of accounting, and consequently, the added contribution they can make in the process of decision-making within HEI, particularly, in current times when the priority is to achieve more with fewer resources.

关键词： higher education performance indicators accgunting balanced scorecard (BSC)

Development of metal organic fromwork-199 immobilized zeolite foam for adsorption of common indoor VOCs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2017年第5期29卷 321-330页

作者： Vipin K.Saini joao Pires School of Environment and Natural Resources Doon UniversityDehradun 248001India Department of Chemistry and Biochemistry Faculty of SciencesUniversity of LisbonLisbon 1749-016Portugal

Reticulated foam shaped adsorbents are more efficient for the removal of volatile organic compounds（VOCs）,particularly from low VOC-concentration indoor air streams. In this study composite structure of zeolite and metal organic frameworks（MOFs）,referred as ZMF,has been fabricated by immobilization of fine MOF-199 powder on foam shaped Zeolite Socony Mobil-5（ZSM-5）Zeolitic structure,referred as ZF. The ZMF possess a uniform and well-dispersed coating of MOF-199 on the porous framework of ZF. It shows higher surface area,pore volume,and VOCs adsorption capacity,as compared to ***-fabrication changes in selective adsorption properties of ZMF were studied with three common indoor VOCs（benzene,n-hexane,and cyclohexane）,using gravimetric adsorption technique. The adsorption capacity of ZMF with different VOCs follow the order of benzene 〉 n-hexane 〉 cyclohexane. In comparison with MOF-199 and ZF,the composite structure ZMF shows improvement in selectivity for benzene from other two VOCs. Further,improvement in efficiency and stability of prepared ZMF was found to be associated with its high MOF loading capacity and unique morphological and structural properties. The developed composite structure with improved VOCs removal and recyclability could be a promising material for small to limited scale air pollution treatment units.

关键词： VOCs Adsorption Composite materials Selectivity Zeolite foam MOFs HKUST-1

PHASE-FIELD MODELING OF ELASTIC EFFECTS IN EUTECTIC GROWTH WITH MISFIT STRESSES

在线全文

学校读者我要写书评

暂无评论

International Journal of Modeling, Simulation, and Scientific Computing 2013年第1期4卷 34-50页

作者： ZOHREH EBRAHIMI joao REZENDEH AICES Graduate School RWTH Aachen University D-52056 AachenGermany Institute of Minerals Engineering(GHI)RWTH Aachen University D-52056 AachenGermany

Elastic interactions,arising from a difference of lattice spacing between two coherent phases in eutectic alloys with misfit stresses,can have an influence on microstructural pattern formation of eutectic colonies during solidification *** a thermodynamic point of view the elastic energy contributes to the free energy of the phases and modifies their mutual ***,the elastic stresses will have an effect on stability of lamellae,lamellae spacing and growth *** this paper,a phase-field model is employed to investigate the influence of elastic misfits in eutectic *** model reduces to the traditional sharp-interface model in a thin-interface limit,where the microscopic interface width is small but *** elastic model is designed,based on linear microelasticity theory,to incorporate the elastic energy in the phase-field *** and numerical approaches,required to model elastic effects,are formulated and the stress distributions in eutectic solidification structures are *** twodimensional simulations are performed for directed eutectic growth and the simulation results for different values of the misfit stresses are illustrated.

关键词： Elastic energy misfit stress eutectic growth.