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Formation potential and analysis of 32 regulated and unregulated disinfection by-products: Two new simplified methods

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Journal of Environmental Sciences 2022年第7期34卷 209-221页

作者： Jillian N.Murakami Xu Zhang joanne ye Amy M.MacDonald Jorge Perez David W.Kinniburgh Susana Y.Kimura Department of Chemistry University of CalgaryCalgaryAlbertaT2N 1N4Canada Alberta Centre for Toxicology University of CalgaryCalgaryAlbertaT2N 4N1Canada

Water disinfection is an essential process that provides safe water by inactivating pathogens that cause waterborne diseases. However, disinfectants react with organic matter naturally present in water, leading to the formation of disinfection by-products(DBPs). Multi-analyte methods based on mass spectrometry(MS) are preferred to quantify multiple DBP classes at once however, most require extensive sample pre-treatment and significant resources. In this study, two analytical methods were developed for the quantification of 32 regulated and unregulated DBPs. A purge and trap(P&T) coupled with gas chromatography mass spectrometry(GC-MS) method was optimized that automated sample pre-treatment and analyzed volatile and semi-volatile compounds, including trihalomethanes(THMs), iodinated trihalomethanes(I-THMs), haloacetonitriles(HANs), haloketones(HKTs) and halonitromethanes(HNMs). LOQs were between 0.02-0.4 μg/L for most DBPs except for 8 analytes that were in the low μg/L range. A second method with liquid chromatography(LC) tandem mass spectrometry(MS/MS) was developed for the quantification of 10 haloacetic acids(HAAs) with a simple clean-up and direct injection. The LC-MS/MS direct injection method has the lowest detection limits reported(0.2-0.5 μg/L). Both methods have a simple sample pre-treatment, which make it possible for routine analysis. Hyperchlorination and uniform formation conditions(UFC) formation potential tests with chlorine were evaluated with water samples containing high and low TOC. Hyperchlorination formation potential test maximized THMs and HAAs while UFC maximized HANs. Ascorbic acid was found to be an appropriate quencher for both analytical methods. Disinfected drinking water from four water utilities in Alberta, Canada were also evaluated.

关键词： Disinfection byproducts Purge and trap LC-MS/MS Drinking water DBP formation potential HAAs HANs

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Innovations in the diagnosis and management of uveitis: promising research to address unmet patient needs

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Annals of Eye Science 2022年第1期7卷 1-7页

作者： Steven yeh ye Huang joanne Thomas Truhlsen Eye Institute University of Nebraska Medical CenterOmahaNEUSA Emory Eye Center Emory University School of MedicineAtlantaGAUSA Medical College of Georgia AugustaGAUSA.

Uveitis,or inflammation of the uveal tissues(iris,ciliary body and the choroid),and its contiguous structures,can lead to severe visual impairment and is among the leading causes of vision impairment worldwide(1).In clinical practice,specialists in uveitis and ocular immunology are called upon to manage a range of uveitis syndromes-infectious disease,noninfectious autoimmune conditions,and masquerade syndromes such as ***,ophthalmologists of all subspecialties(i.e.,medical and surgical retina,corneal surgeons,orbital/oculoplastic surgeons,and comprehensive ophthalmologists)are called upon to manage uveitis syndromes,emphasizing clear importance to understanding common uveitis syndromes,diagnostic workups,and the state-of-the-art in uveitis and ocular inflammation care.

关键词： uveitis inflammation diagnosis

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Real-world Effectiveness and Tolerability of Interferonfree Direct-acting Antiviral for 15,849 Patients with Chronic Hepatitis C:A Multinational Cohort Study

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 646-658页

作者： Fanpu Ji Sally Tran Eiichi Ogawa Chung-Feng Huang Takanori Suzuki Yu Jun Wong Hidenori Toyoda Dae Won Jun Liu Li Haruki Uojima Akito Nozaki Makoto Chuma Cheng-Hao Tseng Yao-Chun Hsu Masatoshi Ishigami Takashi Honda Masanori Atsukawa Hiroaki Haga Masaru Enomoto Huy Trinh Carmen Monica Preda Phillip Vutien Charles Landis Dong Hyun Lee Tsunamasa Watanabe Hirokazu Takahashi Hiroshi Abe Akira Asai Yuichiro Eguchi Jie Li Xiaozhong Wang Jia Li Junping Liu Jing Liang Carla Pui-Mei Lam Rui Huang Qing ye Hongying Pan Jiajie Zhang Dachuan Cai Qi Wang Daniel Q.Huang Grace Wong Vincent Wai-Sun Wong Junyi Li Son Do Norihiro Furusyo Makoto Nakamuta Hideyuki Nomura Eiji Kajiwara Eileen L.Yoon Sang Bong Ahn Koichi Azuma Kazufumi Dohmen Jihyun An Do Seon Song Hyun Chin Cho Akira Kawano Toshimasa Koyanagi Aritsune Ooho Takeaki Satoh Kazuhiro Takahashi Ming-Lun yeh Pei-Chien Tsai Satoshi Yasuda Yunyu Zhao Yishan Liu Tomomi Okubo Norio Itokawa Mi Jung Jun Toru Ishikawa Koichi Takaguchi Tomonori Senoh Mingyuan Zhang Changqing Zhao Raluca Ioana Alecu Wei Xuan Tay Pooja Devan joanne Kimiko Liu Ritsuzo Kozuka Elena Vargas-Accarino Ai-Thien Do Mayumi Maeda Wan-Long Chuang Jee-Fu Huang Chia-yen Dai Ramsey Cheung Maria Buti Junqi Niu Wen Xie Hong Ren Seng Gee Lim Chao Wu Man-Fung Yuen Jia Shang Qiang Zhu Yoshiyuki Ueno Yasuhito Tanaka Jun Hayashi Ming-Lung Yu Mindie H.Nguyen Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxiChina Division of Gastroenterology and Hepatology Department of MedicineStanford University Medical CenterPalo AltoCAUSA Department of General Internal Medicine Kyushu University HospitalFukuokaJapan Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Hepatitis Research Center College of Medicine and Center for Liquid Biopsy and Cohort ResearchKaohsiung Medical UniversityKaohsiung Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical SciencesNagoyaJapan Gastroenterology&Hepatology Changi General HospitalSinghealthSingapore Singhealth Duke-NUS Medicine Academic Clinical Program Singapore Department of Gastroenterology Ogaki Municipal HospitalOgakiJapan Department of Internal Medicine Hanyang UniversityCollege of MedicineSeoulKorea Hanyang Institute of Bioscience and Biotechnology Hanyang UniversitySeoulKorea Department of Hepatology The Third People's Hospital of Kunming CityKunmingYunnanChina Department of Gastroenterology Internal MedicineKitasato University School of MedicineSagamiharaJapan Gastroenterological Center Yokohama City University Medical CenterYokohamaJapan Division of Gastroenterology and Hepatology Department of Internal MedicineE-Da Cancer HospitalKaohsiung Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoyaJapan Division of Gastroenterology and Hepatology Nippon Medical SchoolTokyoJapan Department of Gastroenterology Yamagata University Faculty of MedicineYamagataJapan Department of Transfusion Medicine and Department of Hepatology Osaka Metropolitan University Graduate School of MedicineOsakaJapan San Jose Gastroenterology San JoseCAUSA Gastroenterology&Hepatology Department Clinic Fundeni InstituteBucharestRomania Division of Gastroenterology and Hepatology University of WashingtonSeattleWAUSA Department of

Background and Aims:As practice patterns and hepatitis C virus(HCV)genotypes(GT)vary geographically,a global real-world study from both East and West covering all GTs can help inform practice policy toward the 2030 HCV elimination *** study aimed to assess the effectiveness and tolerability of DAA treatment in routine clinical practice in a multinational cohort for patients infected with all HCV GTs,focusing on GT3 and ***:We analyzed the sustained virological response(SVR12)of 15,849 chronic hepatitis C patients from 39 Real-World Evidence from the Asia Liver Consortium for HCV clinical sites in Asia Pacific,North America,and Europe between 07/01/2014–07/01/***:The mean age was 62±13 years,with 49.6%*** demographic breakdown was 91.1%Asian(52.9%Japanese,25.7%Chinese/Taiwan residents,5.4%Korean,3.3%Malaysian,and 2.9%Vietnamese),6.4%White,1.3%Hispanic/Latino,and 1%Black/***,34.8%had cirrhosis,8.6%had hepatocellular carcinoma(HCC),and 24.9%were treatment-experienced(20.7%with interferon,4.3%with direct-acting antivirals).The largest group was GT1(10,246[64.6%]),followed by GT2(3,686[23.2%]),GT3(1,151[7.2%]),GT6(457[2.8%]),GT4(47[0.3%]),GT5(1[0.006%]),and untyped GTs(261[1.6%]).The overall SVR12 was 96.9%,with rates over 95%for GT1/2/3/6 but 91.5%for ***12 for GT3 was 95.1%overall,98.2%for GT3a,and 94.0%for ***12 was 98.3%overall for GT6,lower for patients with cirrhosis and treatment-experienced(TE)(93.8%)but≥97.5%for tretment-naive patients regardless of cirrhosis *** multivariable analysis,advanced age,prior treatment failure,cirrhosis,active HCC,and GT3/4 were independent predictors of lower SVR12,while being Asian was a significant predictor of achieving ***:In this diverse multinational realworld cohort of patients with various GTs,the overall cure rate was 96.9%,despite large numbers of patients with cirrhosis,HCC,TE,and GT3/***12 for GT3/6 with cirrhosis and TE was lower but st

关键词： Hepatitis C virus Liver cirrhosis Hepatocellular carcinoma Genotype DAA REAL-C

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钙钛矿中晶体缺陷的表征及其对电池性能的影响

钙钛矿中晶体缺陷的表征及其对电池性能的影响

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第五届新型太阳能电池学术研讨会

作者： Wei Li Mathias Uller Rothmann ye Zhu joanne Etheridge Yi-Bing Cheng ARC Centre of Excellence in Exciton Science Monash University 硅酸盐建筑材料国家重点实验室武汉理工大学

有机-无机杂化钙钛矿太阳能电池是一种新型薄膜光伏技术,其最高光电转化效率已达22.7%。进一步提升该体系电池的光电转化效率有赖于对材料的晶体结构、晶型转化和晶体缺陷,界面等微观结构进行深入的研究。然而有机-无机杂化钙钛矿中的... 详细信息

有机-无机杂化钙钛矿太阳能电池是一种新型薄膜光伏技术,其最高光电转化效率已达22.7%。进一步提升该体系电池的光电转化效率有赖于对材料的晶体结构、晶型转化和晶体缺陷,界面等微观结构进行深入的研究。然而有机-无机杂化钙钛矿中的有机基团在电子束或离子束的照射下产生永久的破坏。这使得通过透射电子显微镜和聚焦离子束来研究该类材料的微观结构带来极大的挑战。在这个报告中,我们首先通过细致的分析在透射电子显微镜中CHNHPbI钙钛矿在不同电子束的束流之下,其结构和化学成分的持续变化。我们发现在极低的束流之下,CHNHPbId的已经遭受到根本破坏,束流越大破坏的程度越快。即使将CHNHPbI冷却到液氮的温度,破坏一样无法缓解和避免。钙钛矿的晶体结构在离子束下也会被破坏,因此目前通过聚焦离子束来制备有机-无机杂化钙钛矿透射电子显微镜的样品是无法有效分析该体系材料的原始微观结构。在此基础上,我们在国际上首次发现并证明了CHNHPbI杂化钙钛矿和传统无机氧化物钙钛矿一样,广泛存在大量的孪晶,并且直接观测出,这种孪晶的产生是为了释放CHNHPbI从高温的立方相向常温的四方相转变而积累的应力。这项结果的重要性在于,揭示了在杂化钙钛矿晶体的内部有孪晶界这种特殊的界面,它可以很大程度影响由光激发的电子和空穴分离、复合和传输,从而有助于解释CHNHPbI电流-电压特性中的迟滞特性,以及其优异的光电转化效率。将有机基团替代为无机离子所得到的CsPbIBr无机钙钛矿在电子束下稳定性可以得到大幅度的提高。因此可以使用先进电子显微镜技术对其微观结构进行更加深入的研究。我们通过阴极发光以及透射电子显微镜对于CsPbIBr的微观结构以及发光特性从纳米尺度进行了研究。该研究突破了传统光致发光无法达到的微观尺度,揭示了原先均匀分布的I和Br离子在光照或者电子束下产生团聚的原因,并直接观察到I离子在CsPbIBr晶体内部产生聚集。这也是国际上首次在如此高分辨精度下,揭示了混合阴离子在钙钛矿晶粒内是如何发生聚集。这个过程促进了CsPbIBr电池中离子迁移,从而导致了较大的电流-电压迟滞。因此通过研究无机CsPbIBr钙钛矿晶粒中阴离子的移动,揭示出组分分离对于电池性能的巨大影响,为杂化钙钛矿电池的研究提供了很好的借鉴。

关键词：钙钛矿太阳能电池晶体缺陷透射电子显微镜聚焦离子束阴极发光

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MA1-xFAxPbI3体系中晶体内部面缺陷对太阳能电池性能的作用机理研究

MA1-xFAxPbI3体系中晶体内部面缺陷对太阳能电池性能的作用机理研...

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第八届新型太阳能材料科学与技术学术研讨会

作者：李蔚 Mathias Uller Rothmann ye Zhu 程一兵 Udo Bach joanne Etheridge 武汉理工大学 Monash University

有机-无机杂化钙钛矿太阳能电池具有优异的光电转换效率、较长的载流子扩散长度和较低的复合速率。这也导致了人们长期以来认为有机-无机杂化钙钛矿中的晶体缺陷,在电学上不会对光生载流子的收集和复合产生不利的影响,从而对太阳能电池... 详细信息

有机-无机杂化钙钛矿太阳能电池具有优异的光电转换效率、较长的载流子扩散长度和较低的复合速率。这也导致了人们长期以来认为有机-无机杂化钙钛矿中的晶体缺陷,在电学上不会对光生载流子的收集和复合产生不利的影响,从而对太阳能电池的光电转化性能影响较小。我们通过超低剂量透射电子显微镜,在国际上首次揭示了钙钛矿中的面缺陷(层错、孪晶等)会对有机-无机杂化钙钛矿太阳能电池的性能重要的影响。通过改变MA

关键词：钙钛矿太阳能电池孪晶层错迟滞非辐射复合

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沙利度胺衍生物的设计合成及其抗肿瘤活性研究

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中国药物化学杂志 2008年第1期18卷 16-22页

作者：赵荔华刘超美吴秋业张鲁榕 KIM joanne 第二军医大学药学院有机化学教研室上海200433 University of Rochester Department of Radiation Oneology Rochester NY 14642

目的设计合成1,3-二氢-1,3-二氧代-2H-异吲哚-N-取代沙利度胺衍生物,并对其进行体外抗肿瘤活性测试。方法以2-氨基-β-D-吡喃葡萄糖盐酸盐为原料,经过6步反应得到化合物N-(3′,4′,6′-三乙酰-1′-溴代吡喃葡萄糖)-1,3-二氢-1,3-二氧代-... 详细信息

目的设计合成1,3-二氢-1,3-二氧代-2H-异吲哚-N-取代沙利度胺衍生物,并对其进行体外抗肿瘤活性测试。方法以2-氨基-β-D-吡喃葡萄糖盐酸盐为原料,经过6步反应得到化合物N-(3′,4′,6′-三乙酰-1′-溴代吡喃葡萄糖)-1,3-二氢-1,3-二氧代-2H-异吲哚,该化合物经过溴代、取代反应得到目标化合物。通过对4T1细胞存活率的测试测定20个目标化合物体外抗肿瘤活性。结果设计合成的20个目标化合物均未见文献报道,所有化合物均经过1H-NMR谱确证,部分化合物经IR、MS谱确证。结论所有目标化合物对4T1细胞均具有一定的抑制生长作用,表明所合成的沙利度胺衍生物均有一定的抗肿瘤活性。

关键词：沙利度胺衍生物抗肿瘤活性 4T1细胞存活率 SRB法

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Families of Dothideomycetes

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Fungal Diversity 2013年第6期63卷 1-313页

作者： Kevin D.Hyde E.B.Gareth Jones Jian-Kui Liu Hiran Ariyawansa Eric Boehm Saranyaphat Boonmee Uwe Braun Putarak Chomnunti Pedro W.Crous Dong-Qin Dai Paul Diederich Asha Dissanayake Mingkhuan Doilom Francesco Doveri Singang Hongsanan Ruvishika Jayawardena James D.Lawrey Yan-Mei Li Yong-Xiang Liu Robert Lücking Jutamart Monkai Lucia Muggia Matthew P.Nelsen Ka-Lai Pang Rungtiwa Phookamsak Indunil C.Senanayake Carol A.Shearer Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Nalin N.Wijayawardene Saowanee Wikee Hai-Xia Wu Ying Zhang Begoña Aguirre-Hudson S.Aisyah Alias AndréAptroot Ali H.Bahkali Jose L.Bezerra D.Jayarama Bhat Erio Camporesi Ekachai Chukeatirote Cécile Gueidan David L.Hawksworth Kazuyuki Hirayama Sybren De Hoog Ji-Chuan Kang Kerry Knudsen Wen-Jing Li Xing-Hong Li Zou-Yi Liu Ausana Mapook Eric H.C.McKenzie Andrew N.Miller Peter E.Mortimer Alan J.L.Phillips Huzefa A.Raja Christian Scheuer Felix Schumm joanne E.Taylor Qing Tian Saowaluck Tibpromma Dhanushka N.Wanasinghe Yong Wang Jian-Chu Xu Supalak Yacharoen Ji-ye Yan Min Zhang Key Laboratory for Plant Biodiversity and Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201Yunnan China World Agroforestry Centre East Asia NodeHeilongtanKunming 650201China Institute of Excellence in Fungal Research Chiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Institute Ocean Earth Sciences Kuala Lumpur 50603SelangorMalaysia Department of Botany and Microbiology King Saudi UniversityRiyadhSaudi Arabia 42 Longacre Drive LivingstonNJ 07039USA Institut für Biologie Bereich Geobotanik und Botanischer GartenHerbariumMartin-Luther-UniversitätNeuwerk 2106099 Halle(Saale)Germany CBS-KNAW Fungal Biodiversity Centre Uppsalalaan 83584CT UtrechtThe Netherlands Musée National d’histoire Naturelle 25 rue Munster2160 LuxembourgLuxembourg Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Via dei Funaioli 22 57126 LivornoItaly Department of Environmental Science and Policy George Mason University4400 University DriveFairfaxVA 22030-4444USA International Fungal Research and Development Centre Key Laboratory of Resource Insect Cultivation&Utilization State Forestry AdministrationKunming 650224People’s Republic of China The Research Institute of Resource Insects Chinese Academy of ForestryKunming 650224People’s Republic of China Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyangGuizhou 550006People’s Republic of China Science and Education Integrative Research(Botany)The Field Museum1400 South Lake Shore DriveChicagoIL 60605-2496USA Institute of Plant Sciences University of GrazHolteigasse 68010 GrazAustria Department of Life Science University of TriesteVia L.Giorgieri 10TriesteItaly Committee on Evolutionary Biology University of Chicago1025 E.57th StreetChicagoIL 60637USA Institute ofMarine Biology and Center of Excellence for the Oceans Taiwan

Dothideomycetes comprise a highly diverse range of fungi characterized mainly by asci with two wall layers(bitunicate asci)and often with fissitunicate *** species are saprobes,with many asexual states comprising important plant *** are also endophytes,epiphytes,fungicolous,lichenized,or lichenicolous *** occur in terrestrial,freshwater and marine habitats in almost every part of the *** accept 105 families in Dothideomycetes with the new families Anteagloniaceae,Bambusicolaceae,Biatriosporaceae,Lichenoconiaceae,Muyocopronaceae,Paranectriellaceae,Roussoellaceae,Salsugineaceae,Seynesiopeltidaceae and Thyridariaceae introduced in this *** family is provided with a description and notes,including asexual and asexual states,and if more than one genus is included,the type genus is also *** family is provided with at least one figure-plate,usually illustrating the type genus,a list of accepted genera,including asexual genera,and a key to these genera.A phylogenetic tree based on four gene combined analysis add support for 64 of the families and 22 orders,including the novel orders,Dyfrolomycetales,Lichenoconiales,Lichenotheliales,Monoblastiales,Natipusillales,Phaeotrichales and *** paper is expected to provide a working document on Dothideomycetes which can be modified as new data comes to *** is hoped that by illustrating types we provide stimulation and interest so that more work is carried out in this remarkable group of fungi.

关键词： Acrospermales Asterinales Botryosphaeriales Capnodiales Dothideales Dyfrolomycetales Hysteriales Jahnulales Lichenoconiales Lichenotheliales Microthyriales Monoblastiales Myriangiales Mytilinidiales Natipusillales Patellariales Phaeotrichales Phylogeny Pleosporales Strigulales Taxonomy Trypetheliales Tubeufiales Type species Venturiales

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