检索结果-南通市图书馆

Associations of social participation, demographic, socioeconomic and disease factors with nutritional risk in a group of older Hong Kong adults

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health 2013年第3期5卷 381-387页

作者： Louisa Ming Yan chung joanne wai yee chung Department of Health and Physical Education The Hong Kong Institute of Education Hong Kong China

Aims: To identify the impact of social participation, socio-demographic, socio-economic and disease factors on nutritional risk among older persons in Hong Kong. Background: Few published work has investigated the relative risks of social participation, demographic, socioeconomic and disease factors with malnutrition in community-living older people, this study is to investigate the associations of these risk factors on the nutritional status in better nutrition support for the old age group. Design: A crosssectional study. Methods: It was a secondary analysis of a database in a mobile community centre between January 2008 and December 2009. One thousand seven hundred and thirty one participants aged between 54 and 103 were collected. With 319 full Mini Nutritional Assessment (MNA) completed, the participants’ demographic, socio-economic data, diseases, and nutritional status were analyzed with relative risk and 95% confidence interval level to identify the factors that make them vulnerable to nutritional risk. Results: The prevalence of malnutrition in the community-dwelling old was 3.95% and 83.7% of the sample was at risk of malnutrition. Living on allowances, young old who was socially engaged and good relationship with family members were at less risk to malnutrition. Conclusions: Special attention should be taken to these groups as they are prone to develop malnutrition.

关键词： Malnutrition Social Participation Mini Nutritional Assessment Old Aged Care Malnutrition Risk Community Care

Normative reference of standing long jump indicates gender difference in lower muscular strength of pubertal growth

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health 2013年第6期5卷 6-11页

作者： Louisa Ming Yan chung Lina Pui Yu Chow joanne wai yee chung Department of Health and Physical Education The Hong Kong Institute of Education Hong Kong China Department of Health and Physical Education The Hong Kong Institute of Education Hong Kong China

Background: Although the standing long jump (SLJ) is a popular physical fitness assessment, it lacks an updated criterion-reference standard. This study generated the first normative SLJ test data for Chinese aged 8 - 18. Methods: From September 2005 to December 2011, comprehensive physical fitness assessments were conducted on 12,712 school students. The SLJ performances were significantly different between boys and girls (all age groups, p < 0.01). Results: The boys performed better than the girls in each age group. The mean difference increased as the age increased, depicting a prominent variance in muscular strength between boys and girls at age 12, and the variances became larger at age 18. Girls in the 70th percenttile performed similarly to boys performing in the 10th percentile. The onset of muscle strength for boys found in this study corresponded to the onset age of testosterone maturation of Chinese boys investigated in previous studies. Linear regression found age and BMI predicting SLJ significantly for boys and girls, explaining better SLJ results in older boy and the effect of their heavy body size. Conclusions: This study indicated a muscular strength difference between genders during growth and added supporting evidence to the hormonal influence of muscle growth during puberty.

关键词： Normative Reference Standing Long Jump Children Adolescent Lower Muscular Strength

Can a cardiorespiratory field parameter assess both cardiovascular and respiratory fitness in schoolchildren?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health 2014年第1期6卷 33-43页

作者： Louisa Ming Yan chung Lina Pui Yu Chow Eric Cheuk Kuen Tsang joanne wai yee chung Department of Health and Physical Education The Hong Kong Institute of Education Hong Kong China

Background: Cardiorespiratory fitness involves both cardiovascular and respiratory capacities. However, existing methods have been criticised for reflecting cardiovascular fitness, but not pulmonary fitness. The objective of this study was to investigate the relationship between these two testing parameters. Methods: A cross-sectional population-based physical fitness assessment was conducted in 23 schools. The body height and weight, lung capacity, and step test results of students aged 10-18 were recorded. Criterion-referenced standards from the China Sports Bureau were adopted, as they include separate measurements for cardiovascular and pulmonary fitness. Results: The Pearson coefficients of lung capacity and the step test index from 13,028 schoolchildren ranged from 0.007 to 0.086 and from 0.026 to 0.105 for boys and girls, respectively, showing that poor correlations exist between the two parameters. Cluster analysis resulted in three clusters of children with similar characteristics. A good degree of similarity was found between the two parameters in children obtaining an “excellent” grade, but only a moderate degree of similarity between the two parameters in those obtaining a “good”, “pass” or “fail” grade. Conclusion: When cardiovascular fitness and pulmonary fitness are considered separately, there is a poor correlation between them, thus indicating further studies of cardiopulmonary fitness measurements is necessary.

关键词： Cardiovascular Fitness Pulmonary Fitness Cardiorespiratory Fitness Field Assessment Schoolchildren

Testicular sperm extraction and intracytoplasmic sperm injection in non obstructive azoospermia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2000年第3期 54-58页

作者： Ng Hung Yu Ernest, Lau yee Lan, Yeung Shu Biu, So wai Ki, Tam Po Chor and Ho Pak chung

Objective To report the experience in sperm extraction from testicular biopsies (TESE) performed from March 1996 to July 1998 in men with non obstructive azoospermia (NOA) Methods Comparisons of age, volume of both testes, serum FSH and testosterone in men, and histology of testicular samples in the first cycles between cycles with spermatozoa found and those without spermatozoa found were performed Comparisons of fertilization, cleavage and pregnancy rates between cycles with spermatozoa injected and those with spermatids injected were performed Results Spermatozoa were found in only 12 out of 26 first TESE cycles (46 2%) and other cycles had spermatids (round cells) only Age of men, history of mumps orchitis/oligozoospermia, volume of both testes and serum FSH/testosterone levels in men were not significantly different between cycles with and without spermatozoa The fertilization rate was significantly higher in cycles with spermatozoa injected than those with round cell injections (63 3% vs 23 2%, P <0 0001, Chi squared test) The pregnancy rate was 14 3% per cycle when spermatozoa were injected Conclusions TESE followed by Intracytoplasmic sperm injection (ICSI) is an effective treatment in patients with NOA Less than half of the patients undergoing TESE had spermatozoa recovered Age of men, volume of both testes and serum FSH/ testosterone levels in men were not useful in predicting successful recovery Compared to using ejaculated and epididymal spermatozoa, fertilization and pregnancy rates were achieved when testicular spermatozoa were used for ICSI

关键词： Intracytoplasmic sperm injection · non obstructive azoospermia · testicular sperm extraction

在线全文

学校读者我要写书评

暂无评论

从工业革命(工业1.0)到外科4.0

中华消化外科杂志 2020年第9期19卷 919-924页

作者：刘允怡林伟棋杨重光中华人民共和国香港特别行政区新界沙田香港中文大学医学院

外科1.0到外科4.0这一类名词均源自“工业4.0”。2011年德国汉诺威工业博览会提出工业4.0。18世纪工业革命起源于英国,其工业发展有4个重要阶段,分别被称为工业1.0、工业2.0、工业3.0和工业4.0,每个发展阶段均有重要科学发明和应用推广... 详细信息

外科1.0到外科4.0这一类名词均源自“工业4.0”。2011年德国汉诺威工业博览会提出工业4.0。18世纪工业革命起源于英国,其工业发展有4个重要阶段,分别被称为工业1.0、工业2.0、工业3.0和工业4.0,每个发展阶段均有重要科学发明和应用推广。基于工业发展的4个阶段,2018年Hooshair A首先提出外科发展从外科1.0到外科4.0的概念,与工业发展一致。虽然两者发展时间不同,但均以重大科学发现为基础。21世纪初标志着进入外科4.0,5个重要的科学成果包括大数据、人工智能、自动化、现代机器人、5G通讯,推动外科4.0的发展。20年间各环节发展均十分迅速,每个环节的发展均带动另一环节的需求,环环相扣,呈现一个急速向上发展的良性循环。笔者预测:外科4.0仍会迅速再发展,从环环相扣式发展变为不同环节融合发展和整体科技融合发展,进而到达外科5.0。在外科4.0起步时期预测外科5.0将会来临貌似具有野心,但笔者肯定这是科学发展的必然趋势,外科5.0不但会到临,还会在不远的将来到临。

关键词：工业革命工业4.0 外科4.0 外科5.0 科学发展

在线全文

学校读者我要写书评

暂无评论

护理本科生创新与创意思维课程的建设与发展

中华护理教育 2022年第6期19卷 508-513页

作者：杨芷钟慧仪周英杨韵华汪国成香港都会大学护理及健康学院中国香港特别行政区999077 广州医科大学护理学院广州中医药大学护理学院

创新能力培养是一个系统复杂的发展过程。创新与创意思维课程以提升护理学专业学生创新能力为核心目标,课程设计结合全新的以挑战为本的学习方法,鼓励学生以团队形式独立自主探索问题,将学习活动从课堂扩展到当地社区,学会创造性地解决... 详细信息

创新能力培养是一个系统复杂的发展过程。创新与创意思维课程以提升护理学专业学生创新能力为核心目标,课程设计结合全新的以挑战为本的学习方法,鼓励学生以团队形式独立自主探索问题,将学习活动从课堂扩展到当地社区,学会创造性地解决现实问题。粤港合作教学团队在2015年首次将以挑战为本的学习方法应用于内地护理学专业学生创新能力的培养,并在实践过程中依托多层次的课程评价进行持续质量改进。该文总结了创新与创意思维课程的建设发展过程,同时基于学生的学习机会和体验以及思维、态度和情感的变化,探索学生创新能力的发展过程,为课程改革和学生创新能力发展提供参考。

关键词：创新能力以挑战为本的学习本科课程改革

Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study

在线全文

学校读者我要写书评

暂无评论

National Science Review 2022年第3期9卷 96-109页

作者： Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui chung chung Yip Chan Peng chung Cheow Ser yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow Genome Institute of Singapore Agency for Science Technology and Research Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences School of Biological Sciences Nanyang Technological University Division of Biosciences Faculty of Life Sciences Division of Surgery and Surgical Oncology National Cancer Centre Department of Hepato-Pancreato-Biliary and Transplant Surgery Singapore General Hospital Division of Hepatobiliary and Pancreatic Surgery Department of Surgery University Surgical Cluster National University Health System Hepato-Pancreato-Biliary Surgery Unit Department of Surgery National Cancer Institute Division of Pathology National Cancer Institute Department of Surgery Faculty of Medicine University of Malaya Department of Surgery and Center for Liver Disease Management and Transplantation The Medical City 13. Department of Laboratories The Medical City Department of Pathology Singapore General Hospital Institute for Infocomm Research ASTAR Department of Pathology National University Health System Translational Immunology Institute (TII) Sing Health Duke-NUS Academic Medical Centre Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Cancer Science Institute of Singapore National University of Singapore Division of Medical Oncology National Cancer Center Singapore Cardiovascular Research Institute National University of Singapore National University Healthcare System Singhealth-Duke-NUS Academic Surgery Program Duke-NUS Graduate Medical School Institute of Molecular and Cell Biology Agency for Science Technology and Research

Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types.

关键词： hepatocellular carcinoma intra-tumor heterogeneity phenotypic evolution tumor evolution

Molecular basis of von Hippel-Lindau syndrome in Chinese patients

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2011年第2期124卷 237-241页

作者： SIU wai-kwan MA Ronald Ching-wan LAM Ching-wan MAK Chloe Miu YUEN Yuet-ping LO Fai-man Ivan CHAN Kin-wan LAM Siu-fung LING Siu-cheung TONG Sui-fan SO Wing-yee CHOW Chun-chung TANG Mary Hoi-yin TAM wing-hung CHAN Albert Yan-wo Department of Pathology Princess Margaret Hospital Hong Kong China Department of Medicine & Therapeutics The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong China Department of Pathology Li Ka Shing Faculty of Medicine The University of Hong Kong Queen Mary Hospital Hong Kong China Clinical Genetic Service Department of Health Hong Kong China Department of Medicine and Geriatrics Princess Margaret Hospital Hong Kong China Department of Paediatrics and Adolescent Medicine Princess Margaret Hospital Hong Kong China Department of Obstetrics & Gynaecology Tsan Yuk Hospital Hong Kong China Department of Obstetrics & Gynaecology The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong China

Background Von Hippel-Lindau （VHL） syndrome is an autosomal dominant familial cancer syndrome predisposing the affected individuals to multiple tumours in various *** genetic basis of VHL in Southern Chinese is largely *** this study,we characterized the mutation spectrum of VHL in nine unrelated Southern Chinese *** Nine probands with clinical features of VHL,two symptomatic and eight asymptomatic family members were included in this *** diagnosis was performed twice for one *** probands had only isolated bilateral *** VHL gene was screened for mutations by polymerase chain reaction,direct sequencing and multiplex ligation-dependent probe amplification （MLPA）.Results The nine probands and the two symptomatic family members carried heterozygous germline *** different VHL mutations were identified in the nine *** splicing mutation,NM_000551.2：c.463＋1G〉T,was *** other seven VHL mutations,c.233A〉G [***78Ser],c.239G〉T [***80lle],c.319C〉G [***107Gly],c.481C〉T [***161X],c.482G〉A [***161GIn],c.499C〉T [***167Trp] and an exon 2 deletion,had been previously *** asymptomatic family members were positive for the mutation and the other five tested *** prenatal diagnosis,the fetuses were positive for the *** Genetic analysis could accurately confirm VHL syndrome in patients with isolated tumours such as sporadic phaeochromocytoma or epididymal papillary *** detection in asymptomatic family members allows regular tumour surveillance and early intervention to improve their ***-based diagnosis can have an important impact on clinical management for VHL families.

关键词： von Hippel-Lindau syndrome VHL gene Chinese VHL mutations

ISIS:A Trilingual Conversational System with Learning Capabilities and Combined Interaction and Delegation Dialogs

在线全文

学校读者我要写书评

暂无评论

ISIS:A Trilingual Conversational System with Learning Capabi...