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Composition of inflammatory infiltrate and its correlation with HBV/HCV antigen expression

World Journal of Gastroenterology 2008年第25期14卷 4040-4046页

作者： Bozena Walewska-Zielecka Kazimierz Madalinski joanna Jablonska Paulina Godzik joanna Cielecka-Kuszyk Bogumila Litwinska Department of Virology National Institute of Public Health National Institute of Hygiene Department of Hepatology and AIDS Warsaw Medical University

AIM： To study the composition of liver inflammatory infiltrate in biopsy material from patients chronically infected with hepatotropic viruses and to evaluate the correlation of inflammatory infiltrate with hepatitis B virus （HBV） and hepatitis C virus （HCV） viral antigen expression in chronic B and C hepatitis. METHODS： The phenotype of inflammatory cells was evaluated by the EnVision system, using a panel of monoclonal antibodies. HBV and HCV antigens were detected with the use of monoclonal anti-HBs, polyclonal anti-HBc and anti-HCV antibodies, respectively. RESULTS： The cellular composition of liver inflammatory infiltrate was similar in the patients with B and C hepatitis：～50%-60% of cells were T helper lymphocytes. Approximately 25% were T cytotoxic lymphocytes; B lymphocytes comprised 15% of inflammatory infiltrate; other cells, including NK, totalled 10%. Expression of HLA antigens paralleled inflammatory activity. Portal lymphadenoplasia was found more often in hepatitis C （54.5%） than in hepatitis B （30.6%）. Expression of HB-cAg was found more often in chronic B hepatitis of moderate or severe activity. Overall inflammatory activity in HBV-infected cases did not correlate with the intensity of HBsAg expression in hepatocytes. Inflammatory infiltrates accompanied the focal expression of HCV antigens. A direct correlation between antigen expression and inflammatory reaction in situ was noted more often in hepatitis C than B. CONCLUSION： Irrespective of the etiology and activity of hepatitis, components of the inflammatory infiltrate in liver were similar. Overall inflammatory activity did not correlate with the expression of HBsAg and HCVAg; HBcAg expression, however, accompanied chronic hepatitis 8 of moderate and severe activity.

关键词： Chronic B and C hepatitis Inflammatoryinfiltrate Lymphoid follicle Lymphadenoplasia

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K^(+)/Cl^(−) co-transporter-2 upmodulation: a multi-modal therapy to treat spinal cord injury

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Neural Regeneration Research 2022年第9期17卷 1984-1986页

作者： Shane V.Hegarty joanna Stanicka AXONIS Therapeutics Inc.LabCentralCambridgeMAUSA

Herein,the rationale and supporting evidence for the promise of developing K+/Cl−co-transporter-2(KCC2)neuromodulatory therapies for spinal cord injury(SCI)is *** is commonly a life-changing,unforeseen neuro t rauma that has devastating consequences for the injured person,their families and society as a *** less than 1%of patients have a complete recovery,the vast majority of people after SCI have significant disabilities and can be entirely dependent upon others for assistance in their activities of daily *** socioeconomic costs are a significant global burden,with SCI often occurring in adults during their peak earning ***,there are no approved drugs that improve functional outcomes for people with ***,SCI commonly leads to a lifetime of disability,and new therapeutic approaches are urgently needed.

关键词： injury modal consequences

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Exorcising memories of internalised stigma: The demons of lived experience

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World Journal of Psychiatry 2021年第3期11卷 63-72页

作者： joanna Ruth Fox School of Education and Social Care Anglia Ruskin UniversityCambridge CB11PTUnited Kingdom

Public stigma and self-stigma impact negatively on the lives of people with mental health *** people in society stereotype and discriminate against people with mental ill-health,and often this negative process of marginalisation is internalised by people with lived ***,this negative internalisation leads to the development of *** this article,I reflect on my own experiences of shame and self-stigma as a person with mental ill-health socially bullied by peers from my community and social groups.I present a personal narrative of both public and self-stigmatisation which I hope will enable me to exorcise memories of internalised stigma,which are encountered as my demons of lived *** reflexivity,a process used widely in health and social care fields,I consider how social bullying shattered my fragile confidence,selfesteem,and self-efficacy in the early days of my recovery;the impact of associative stigma on family members is also *** this,the potential to empower people who experience shame and stigma is explored alongside effective anti-stigma processes which challenge discrimination.I connect the concept of recovery with the notion of empowerment,both of which emphasise the importance of agency and self-efficacy for people with mental ***,I consider how the concepts of empowerment and recovery can challenge both the public stigma held by peers in the community and the selfstigma of those with lived experiences.

关键词： Stigma User-led narrative Reflexivity Empowerment Recovery Mental health

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The Influence of Poly(Vinyl Alcohol)on Oil Release Behavior of Polylactide-Based Composites Filled with Linseed Cake

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Journal of Renewable Materials 2020年第4期8卷 347-363页

作者： Olga Mysiukiewicz Mateusz Barczewski joanna Szulc Division of Polymer Processing Institute of Material TechnologyPoznan University of TechnologyPoznan61-138Poland Departament of Food Industry Technology and Engineering Faculty of Chemical Technology and EngineeringUTP University of Science and TechnologyBydgoszcz85-326Poland

In order to limit the negative impact of industry on natural environment,ecological alternatives to conventional polymers are being *** of the most popular“green”polymers is polylactide,which can also be successfully applied as a matrix of *** application of ground linseed cake as a filler for polylactide-based composites is in line with the idea of Circular Economy,and moreover it provides a modifying effect on the polymer by increasing its crystallinity and reducing its *** effect is caused by the presence of linseed oil which can be released to the polymeric matrix in a non-controlled *** order to control the miscibility of the oil and the polymer,we modified the filler particles with poly(vinyl alcohol)before introducing it to the *** concluded that poly(vinyl alcohol),which does not mix with oil,encapsulated the active ingredients inside the filler *** evaluated the mechanical properties of the composites containing 5,10,20 and 30 wt%of the filler in a static tensile stress and by means of dynamic mechanical thermal *** and thermal properties were tested using differential scanning calorimetry as well as thermogravimetric ***’microstructure was evaluated by Scanning Electron *** was found that modifying the oil-rich filler with poly(vinyl alcohol)helps to reduce its release to the matrix and thus limits the plasticizing effect of linseed *** result was in accordance with our hypothesis.

关键词： Polylactide poly(vinyl alcohol) waste filler oil release

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Micromorphological features of soils formed on calcium carbonate–rich slope deposits in the Polish Carpathians

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Journal of Mountain Science 2020年第6期17卷 1310-1332页

作者： joanna Beata KOWALSKA Tomasz ZALESKI Ryszard MAZUREK Department of Soil Science and Agrophysics University of AgricultureAl.Mickiewicza 2131-120 KrakowPoland

Seven soil profiles developed on calcium carbonate–rich slope deposits in the Polish Carpathians were studied in order to:i)determine the micromorphological features of heterogeneous soils formed in a carbonate depositional environment,and ii)track primary and secondary calcium carbonate forms and their distribution in such stratified *** cases of soils with different arrangements of calcium carbonate were distinguished,controlled mostly by slope *** instance,the increasing content and random distribution of angular and subangular rock fragments found in the overall soil matrix and the irregular coarse:fine size limit suggested different intensities of accumulation and mixing of soil material transported along the *** processes,together with the calcium carbonate content,mineralogical characteristics and texture influenced the type and arrangement of the bfabric *** calcium carbonate distribution within the soils,besides the obvious inheritance from parent material,was governed by the translocation and mixing of deposits on *** climatic conditions prevailing in the area favour the development of secondary forms of calcium ***,only three of the seven studied profiles contained pedogenic forms of calcium carbonate,yet they were distributed *** occurrence,distribution and preservation of secondary carbonates depended on the content of primary calcium carbonate and soil features such as *** transported material down the slope may indicate a very low content of primary calcium or lack thereof,hence its pedogenic forms could not be created.

关键词： Heterogeneous soils Microfacies Secondary calcium carbonate Pedofeatures Soil profile

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β-Carotene-properties and production methods

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Food Quality and Safety 2018年第2期2卷 69-74页

作者： Ludmila Bogacz-Radomska joanna Harasym Department of Biotechnology and Food Analysis Faculty of Engineering and EconomicsWroclaw University of EconomicsWroclawPoland epartment of Agriculture and Forestry Engineering College of Agricultural and Forestry EngineeringUniversity of ValladolidValladolidSpain

β-Carotene belongs to a group of more than 600 compounds,jointly called as *** has numerous biological functions in the human body and because human is not able to synthesize any of them,it is necessary to supply these valuable compounds with food or ***,therefore,market demand stimulates the development of its diverse production ***β-carotene was recovered from plants by physicochemical extraction and mainly from ***β-carotene is mainly produced through chemical *** quite recently biotechnology makes a great approach towardβ-carotene production as bioactive compounds of natural origin reveal higher bioaccessibility and higher consumer trust on market.

关键词： β-carotene properties production methods

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Update on cerebral small vessel disease: a dynamic whole-brain disease

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Stroke & Vascular Neurology 2016年第3期1卷 83-92页

作者： Yulu Shi joanna M Wardlaw Centre for Clinical Brain Sciences University of EdinburghEdinburghUK Department of Neurology Zhongnan HospitalWuhan UniversityWuhanChina

Cerebral small vessel disease(CSVD)is a very common neurological disease in older *** causes stroke and dementia,mood disturbance and gait *** it is difficult to visualise CSVD pathologies in vivo,the diagnosis of CSVD has relied on imaging findings including white matter hyperintensities,lacunar ischaemic stroke,lacunes,microbleeds,visible perivascular spaces and many haemorrhagic ***,variations in the use of definition and terms of these features have probably caused confusion and difficulties in interpreting results of previous studies.A standardised use of terms should be encouraged in CSVD *** CSVD features have long been regarded as different lesions,but emerging evidence has indicated that they might share some common intrinsic microvascular pathologies and therefore,owing to its diffuse nature,CSVD should be regarded as a‘whole-brain disease’.Single antiplatelet(for acute lacunar ischaemic stroke)and management of traditional risk factors still remain the most important therapeutic and preventive approach,due to limited understanding of pathophysiology in *** evidence suggests that new studies should consider drugs that target endothelium and blood–brain barrier to prevent and treat *** of CSVD might differ in Asian compared with Western populations(where most results and guidelines about CSVD and stroke originate),but more community-based data and clear stratification of stroke types are required to address this.

关键词： diagnosis drugs cerebral

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Decreased serum prohepcidin concentration in patients with polycythemia vera

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第11期10卷 791-795页

作者： Justyna KWAPISZ Ewa ■EKANowska joanna JASINIEWSKA Department of Pathophysiology Nicolaus Copernicus University in ToruńCollegium Medicum in Bydgoszcz

Objective： Iron deficiency is a common complication in patients with polycythemia vera （PV）. Hepcidin is a principal regulator of iron homeostasis. The aim of our study was to assess prohepcidin, a hepcidin precursor, and other iron status pa- rameters in the serum of PV patients. Methods： The study was performed in 60 patients （F/M 26/34） aged 38-84 （66＋ 10） years. The control group consisted of 20 healthy volunteers, age and sex matched. The following parameters were determined in blood serum samples： prohepcidin concentration, iron content, unsaturated iron binding capacity （UIBC）, total iron binding capacity （TIBC）, transferrin saturation （TfS）, and concentrations of ferritin and soluble transferrin receptor （sTfR）. Results： All PV patients showed significantly lower levels of prohepcidin, higher levels of sTIR and TIBC compared to the control group. 40% of the patients from the study group showed concentrations of ferritin below the normal range and significantly lower levels of serum iron and TfS, and significantly higher levels of sTIR, UIBC and TIBC in comparison with the rest of the study group. In this group of patients, prohepcidin concentrations were significantly lower than those in other patients. Conclusion： The results indicate that PV patients suffer from iron metabolism disorders. The decreased serum level ofprohepcidin in PV patients may be a result of iron deficiency.

关键词： Polycythemia vera (PV) Iron metabolism Prohepcidin Hepcidin

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The Spatiality of Cognition in the Zhuangzi

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Frontiers of Philosophy in China 2015年第3期10卷 415-429页

作者： joanna Guzowska Institute of Philosophy University of Warsaw Krakowskie Przedmie~cie 3 00-047 WarsawPoland

In this paper I explore the conception of cognition and action found in the Inner Chapters of the Zhuangzi. More specifically, I focus on the role of explicit and implicit spatial imagery in the context of this complex problem. Spatial imagery suggests that cognition is understood as fundamentally bimodal in the text：（1） the default modality, which is informed by an entrenched distinction pattern, is cast in terms of fullness and bulk; and （2） the auxiliary modality, which is free from this kind of constraint, is imagined in terms of emptiness and lack of bulk, as an axis or point. The latter is the preferred mode of engagement with the environment, according to the Zhuangzi. Spatial imagery brings out the crucial characteristics of this cognitive modality： its radical openness and infinite fecundity in the context of distinction-drawing and action. It also connects with other metaphorical schemata at work in the text, including organic imagery. Interestingly, the notion of emptiness and the figure of an axis do not mark an experience of undifferentiated oneness but the state of heightened sensitivity to the makeup of one＇s environment. Such sensitivity allows the agent to entertain the situation at hand without bias and to move around （relatively） conflict-free.

关键词： Zhuangzi cognition spatiality axis emptiness heartmind body,distinction-making action

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Lithological indicators of discontinuities in mountain soils rich in calcium carbonate in the Polish Carpathians

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Journal of Mountain Science 2020年第5期17卷 1058-1083页

作者： joanna Beata KOWALSKA Bartlomiej KAJDAS Tomasz ZALESKI Depatment of Soil Science and Agrophysics University of AgricultureAl.Mickiewicza 2131-120 KrakowPoland Natural Science Education Centre Jagiellonian UniversityGronostajowa 530-387 KrakowPoland

Six soils located within the Polish Carpathians,developed on calcium carbonate–rich sedimentary parent materials and representing various reference groups,were investigated in order to detect the lithic *** propose using a multidirectional approach to assess the lithic discontinuity in these soils,one that includes grain size distribution,geochemical composition,heavy mineral content and micromorphology,supported by a traditional soil survey.A further aim of this process was to identify the possible admixture of allochthonous material of aeolian *** studied soils presented lithic discontinuities mostly at the contact of underlying calcium carbonate–rich coarsegrained slope deposits with the overlaying colluvium layer having a lower content of rock *** significant changes in grain size distribution,especially in the silt and sand content,as well as high Uniformity Values and partially,high Lithological Discontinuity Index values,confirmed the occurrence of a lithic discontinuity in all studied *** heterogeneity in the soil profiles was also confirmed by the distribution of the major oxides;however,their distribution did not clearly indicate the lithic *** most visible distinctions were noted from CaO content,which resulted from the deposition of carbonate-free materials(aeolian silts)and their mixing with the calcium carbonate–rich parent ***,the analysis of heavy mineral content confirmed the allochthonous origin of the upper(and in some cases also the middle)parts of all profiles,which was manifested by the presence of highly weathering-resistant minerals such as zircon,epidote and various types of *** micromorphological features of some of the studied soils showed distinctiveness within the soil profile,manifested by changes in b-fabric pattern,the occurrence and distribution of secondary carbonate and the coarse and fine coarse and fine *** on the high content of silt within the u

关键词： Lithic discontinuities Heavy minerals Geochemistry Slope processes Micromorphology Uniformity Values

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