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Understanding the corrosion of Mg alloys in in vitro urinary tract conditions: A step forward towards a biodegradable metallic ureteral stent

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Journal of Magnesium and Alloys 2023年第11期11卷 4301-4324页

作者： Margarida Pacheco Ivo M.Aroso joana M.Silva Sviatlana V.Lamaka Jan Bohlen Maria Nienaber Dietmar Letzig Estêvão Lima Alexandre A.Barros Rui L.Reis 3B’s Research Group-Research Institute on Biomaterials Biodegradables and BiomimeticsUniversity of MinhoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal Institute of Surface Science Helmholtz-Zentrum hereon GmbHGermany Institute of Material and Process Design Helmholtz-Zentrum hereon GmbHGermany School of Health Sciences Life and Health Sciences Research Institute(ICVS)University of MinhoBragaPortugal

Ureteral stents play a fundamental role in modern time urology. However, following the deployment, stent-related symptoms are frequent and affect patient health and quality of life. Using biodegradable metals as ureteral stent materials have emerged as a promising strategy, mainly due to the improved radial force and slower degradation rate expected. Therefore, this study aimed to characterize different biodegradable metals in urinary tract environment to understand their propensity for future utilization as base materials for ureteral stents. The corrosion of 5 Mg alloys - AZ31, Mg-1Zn, Mg-1Y, pure Mg, and Mg-4Ag - under simulated urinary tract conditions was accessed. The corrosion layer of the different alloys presented common elements, such as Mg(OH)_(2), MgO, and phosphate-containing products, but slight variations in their chemical compositions were detected. The corrosion rate of the different metals varied, which was expected given the differences in the corrosion layers. On top of this, the findings of this study highlighted the significant differences in the samples' corrosion and corrosion layers when in stagnant and flowing conditions. With the results of this study, we concluded that Mg-1Zn and Mg-4Ag presented a higher propensity for localized corrosion, probably due to a less protective corrosion layer;Mg-4Ag corroded faster than all the other four alloys,and Mg-1Y stood out due to its distinct corrosion pattern, that showed to be more homogeneous than all the other four samples, making this one more attractive for the future studies on biodegradable metals.

关键词： Biodegradable metals Magnesium alloys Localized corrosion Biodegradable metallic ureteral stent

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Does Surgery Have a Relevant Role in the Primary Treatment of Locoregionally Advanced Oropharyngeal Carcinomas?

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International Journal of Otolaryngology and Head & Neck Surgery 2013年第6期2卷 263-270页

作者： joana Guimaraes Sara Cruz Eduardo Breda Eurico Monteiro Department of Otorhinolaryngology and Head and Neck Surgery Portuguese Institute of Oncology—Francisco GentilOportoPortugal

Background: Treatment concepts for oropharyngeal squamous cell carcinomas are controversial. This review compares the results obtained by distinct treatment options in locoregionally oropharyngeal advanced carcinomas: primary surgical resection followed by concurrent chemoradiotherapy and concurrent chemoradiotherapy alone. Methods: 57 patients with stage III and IV oropharyngeal squamous cell carcinoma were selected. 17 patients were treated with primary surgical resection followed by concurrent chemoradiotherapy and 40 patients were treated only with concurrent chemoradiotherapy. Statistical analysis was performed regarding survival rates according to tumor location, stage, treatment regimen and recurrence. Results: Two-year loco-regional control rates were 94% after surgery plus chemoradiotherapy and 55% after chemoradiotherapy (p = 0.016). Progression free survival rates were 88% and 27%, respectively (p 0.001). Overall survival rates were 88% and 45%, respectively (p = 0.002). Conclusions: In this study, primary surgical resection followed by concurrent chemoradiotherapy showed better clinical outcomes with a lower risk of death associated with tumor and tumor progression.

关键词： Oropharyngeal Carcinoma Treatment Concurrent Chemoradiotherapy Primary Surgical Resection Survival Rates

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Green Tea(Camellia sinensis):Hypocholesterolemic Effects in Humans and Anti-Inflammatory Effects in Animals

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Food and Nutrition Sciences 2014年第22期5卷 2185-2194页

作者： Márcia Reto Cristina Almeida Joao Rocha Bruno Sepodes Maria-Eduardo figueira Research Institute for Medicines(iMed.ULisboa) Faculty of PharmacyUniversity of LisbonLisbonPortugal

In its essence, tea is an infusion of Camellia sinensis leaves and it is the most widely consumed beverage in the world, aside water. Animal and epidemiological studies have associated green tea consumption with several health benefits, which include hypocholesterolemic effect and anti-in-flammatory activity. In this study catechins levels of green tea and its effect on the lipid profile of humans were evaluated as well as the protective effects against H2O2-mediated damage in human fibroblasts and anti-inflammatory activity of (–)-epigallocatechingallate (EGCG). The daily consumption of 1200 mL of green tea for 30 days by 15 human volunteers promoted the decrease of cholesterol and LDL levels after 15 days, but this effect was not persistent after 30 days. No changes were observed in lipid profile after the consumption of green tea capsules. EGCG, a major green tea catechin, demonstrated an anti-inflammatory action in rats and an antioxidant effect in cultured human fibroblasts.

关键词： Green Tea Infusions Hypocholesterolemic Effect Anti-Inflammatory Activity Antioxidant Activity

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Spinal Epidural Abscess: When a Fast Diagnosis Is Necessary

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Case Reports in Clinical Medicine 2014年第12期3卷 664-668页

作者： joana Cosme joana Branco Hermana Carneiro Gheorghe Diviza Carlos Chagas Emília Velhinho Glória Silva Serviço Medicina III Hospital Pulido Valente Centro Hospitalar Lisboa Norte Lisboa Portugal

A 61 years old man with fatty liver disease and history of recent urinary infection was admitted to the Department of Internal Medicine for severe back pain and fever. The blood culture exams were positive for methicillin-resistant Staphylococcus aureus and later the cervical spine MRI showed an anterior epidural abscess associated with medullary compression. The patient was kept under antibiotic therapy and a decompressive surgery was required. Spinal epidural abscess presentation can be subtle with its presenting complaints ranging in severity from nonspecific back pain to marked weakness. This case report highlights the importance of an early diagnosis in order to avoid a devastating outcome.

关键词： Spinal Epidural Abscess Magnetic Resonance Imaging Early Diagnosis

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Sanitary Landfill Site Selection Using Multi-criteria Analysis Evaluation:Case Study of Dibra Region,Albania

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Journal of Environmental Science and Engineering(A) 2022年第3期11卷 87-94页

作者： Neritan Shkodrani Oltion Marko Konalsi Gjoka joana Gjipalaj Department of Civil Engineering Faculty of Civil EngineeringPolytechnic University of Tirana1023TiranaAlbania Department of Environmental Engineering Faculty of Civil EngineeringPolytechnic University of Tirana1023TiranaAlbania

Landfill is a common solution for the final disposal of MSW(Municipal Solid Waste)in *** sitting is an extremely difficult task to accomplish because the site selection process depends on different factors and *** ensure that an appropriate site is chosen,a systematic process should be developed and *** this study,10 candidate sites for an appropriate landfill area in Dibra Region are determined by using the MCE(Multi-criteria Evaluation).From the application of the exclusion criteria provided in the study methodology,it was able to find the best three *** statistical processing for the determination of the best place was accomplished through MCA(Multi-criteria Analysis)and Environmental Management,for three scenarios with different weights of *** application of this method has led to the identification of the most suitable site for the construction of sanitary landfill in the Dibra Region.

关键词： MCDA(Multi-criteria Decision Analysis) landfill waste management site selection Albania

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Impact of the residues of detergents and disinfectants used in dairy farms on the results of inhibitor tests for raw milk

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Advances in Bioscience and Biotechnology 2013年第2期4卷 266-272页

作者： joana Salomskiene Irena Macioniene Renata Zvirdauskiene Dovile Jonkuviene Kaunas University of Technology Food instituteKaunasLithuania

The aim of the study was to determine the impact of residues of detergents and disinfectants on the results of most commonly used inhibitor tests for raw milk. Microbiological test (Delvotest SP-NT) and three rapid tests (Charm 3 MRL BL/TET2, Charm ROSA MRL BL/TET and Penzym) were used in the study. Three concentrations (recommended by the manufacturer, 10 times lower and twice higher) of 36 detergents and disinfectants in raw milk were investigated. All methods did not detect concentrations of detergents and disinfectants of alkaline and acid origin 10 times lower than recommended by the manufacturer. 39% of the investigated substances of alkaline origin were detected by Delvotest SP-NT and Penzym;Charm tests showed non-typical results only. Delvotest SP-NT did not detect substances of acid origin;Penzym detected 50% of these substances, Charm tests showed only non-typical results. Delvotest SP-NT and Penzym appeared to be more sensitive to the substances used for teat hygiene and disinfection. The scope of rapid tests (receptor or enzymatic) does not cover the detection of detergent and disinfectant re- sidues in milk. However, according to the non-typical results of the test, it is possible to suspect the presence of these substances in milk. McNemar’s and Cochran’s Q tests were used for statistical analysis of the data.

关键词： Detergents Disinfectants Residues Sensitivity Inhibitor Tests Raw Milk

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腺苷受体是调节大脑内侧前额叶皮质星形胶质细胞大麻素1型(CB1)受体对突触可塑性作用的开关

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神经损伤与功能重建 2024年第4期19卷 250-250页

作者： joana Gon?alves-Ribeiro Oksana K Savchak Sara Costa-Pinto joana I Gomes Rafael Rivas-Santisteban Alejandro Lillo Javier Sánchez Romero Ana M Sebasti?o Marta Navarrete Gemma Navarro Rafael Franco Sandra H Vaz Instituto de Farmacologia e Neurociencias Faculdade de MedicinaUniversidade de Lisboa Instituto de Medicina Molecular Joao Lobo Antunes Faculdade de MedicinaUniversidade de Lisboa Department of Biochemistry and Physiology School of Pharmacy and Food ScienceUniversitat de Barcelona CiberNed Network Center for Neurodegenerative DiseasesNational Spanish Health Institute Carlos Ⅲ 5. Instituto CajalCSIC PhD Program in Neuroscience Universidad Autonoma de Madrid-Instituto Cajal Institut de Neurociencies Universitat de Barcelona Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFaculty of Biology School of Chemistry Universitat de Barcelona

内侧前额叶皮质(mPFC)参与诸如工作记忆等认知功能。星形胶质细胞大麻素1型受体(CB1R)诱导细胞质内钙离子(Ca2+)浓度变化,对神经元功能产生影响。mPFC的星形胶质细胞也表达腺苷A1和A2A受体(A1R,A2AR),但目前尚不清楚这些细胞中的CB1R与... 详细信息

内侧前额叶皮质(mPFC)参与诸如工作记忆等认知功能。星形胶质细胞大麻素1型受体(CB1R)诱导细胞质内钙离子(Ca2+)浓度变化,对神经元功能产生影响。mPFC的星形胶质细胞也表达腺苷A1和A2A受体(A1R,A2AR),但目前尚不清楚这些细胞中的CB1R与腺苷受体之间的交流。我们在这里展示,通过CB1R-A2AR或CB1R-A1R异源二聚体,星形胶质细胞Ca2+信号传递发生了进一步的调节,最终影响mPFC突触可塑性。当A1R和A2AR被激活时,CB1R介导的Ca2+瞬变出现增加或减少,揭示了腺苷受体可能是星形胶质细胞CB1R的调节器。CB1R的激活导致mPFC的长时程增强(LTP)增强,受A1R控制,但不受A2AR控制。值得注意的是,在IP3R2KO小鼠中,由于没有显示出星形胶质细胞Ca2+水平升高,CB1R的激活减少了LTP,这种效果不受A1R或A2AR的调节。本研究表明,CB1R在mPFC LTP上具有稳态作用,受到A1R的控制,可能是由于这些受体在星形胶质细胞中的交流,最终改变了CB1R Ca2+信号传递。

关键词： CB1受体腺苷受体星形胶质细胞内侧前额叶皮质突触可塑性

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Novel synthetic opioids-toxicological aspects and analysis

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Forensic Sciences Research 2019年第2期4卷 111-140页

作者： Inês Tabarra Sofia Soares Tiago Rosado joana Gonçalves Àngelo Luís Sara Malaca Mário Barroso Thomas Keller José Restolho Eugenia Gallardo Centro de Investigação em Ciências da Saude(CICS-UBI) Universidade da Beira InteriorCovilhãPortugal Laboratorio de Fármaco-Toxicologia-UBIMedical Universidade da Beira InteriorCovilhãPortugal Serviço de Química e Toxicologia Forenses Instituto Nacional de Medicina Legal e Ciências ForensesDelegac¸ão do SulLisboaPortugal Departament of Toxicology Institute of Forensic MedicineSalzburgAustria nal von minden GmbH RegensburgGermany

Over the past few years,there has been an emerging number of new psychoactive *** drugs are frequently mentioned as“legal highs”,“herbal highs”,“bath salts”and“research chemicals”.They are mostly sold and advertised on online forums and on the dark *** emerging new psychoactive substances are designed to mimic the effects of psychoactive groups,which are often abused *** synthetic opioids are a new trend in this context and represent an alarming threat to public *** the wide number of fatalities related to these compounds reported within the last few years,it is an important task to accurately identify these compounds in biologic matrices in order to administer an effective treatment and reverse the respiratory depression caused by opioid related *** dealing with fentanyl intoxication cases should consider that it could,in fact,be a fentanyl *** this reason,it is a helpful recommendation to include synthetic opioids in the routine toxicological screening procedures,including analysis in alternative matrices,if available,to investigate poly-drug use and possible tolerance to *** address this public health problem,better international collaboration,effective legislation,effective investigation,control of suspicious“research chemicals”online forums and continuous community alertness are *** article aims to review diverse reported fatalities associated with new synthetic opioids describing them in terms of pharmacology,metabolism,posology,available forms,as well as their toxic effects,highlighting the sample procedures and analytical techniques available for their detection and quantification in biological matrices.

关键词： Forensic sciences forensic toxicology new synthetic opioids biological specimens toxicity analysis

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Clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in portugal

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World Journal of Gastroenterology 2017年第40期23卷 7292-7302页

作者： joana Ribeiro Andreia Oliveira Mariana Malta Claudia Oliveira Fernanda Silva Ana Galaghar Luís Pedro Afonso Maria Cassiano Neves Rui Medeiros Pedro Pimentel-Nunes Hugo Sousa Molecular Oncology and Viral Pathology Group Portuguese Oncology Institute of Porto Faculty of Medicine of Porto University Department of Pathology Portuguese Oncology Institute of Porto Medical Oncology Department Portuguese Oncology Institute of Porto Instituto CUF de Oncologia Virology Service Portuguese Oncology Institute of Porto Research Department-Portuguese League Against Cancer(Liga Portuguesa Contra o Cancro-Núcleo Regional do Norte) Gastroenterology Service Portuguese Oncology Institute of Porto CINTESIS-Center for Health Technology and Services Research(Centro de Investigacao Médica Faculdade de Medicina da Universidade do Porto)

AIM To determine the prevalence of epstein-barr virus(eb V)-associated gastric carcinomas in the North Region of Portugal and to study its clinicopathological characteristics. METHODS We have performed a retrospective study including a total of 179 consecutive patients with gastric cancer(GC) submitted to gastrectomy during 2011 at the Portuguese Oncology Institute of Porto. Clinical and pathological data was collected from individual clinical records and inserted on a database with unique codification. Tumour tissues were collected from the institutional tumour bank. eb V was detected by in situ hybridization for the detection of eb V-encoded small RNAs(ebe Rs) and eb V latent proteins(LMP1 and LMP2 A) were detected by *** The analysis showed that eb V-associated gastric carcinomas(eb Va GC) represents 8.4%(15/179) of all GC cases, with a significant differential distribution among histological types(P < 0.001): 100%(3/3) of medullary carcinomas, 100%(1/1) of adenosquamous carcinoma, 8.7%(8/92) of tubular adenocarcinomas, 8.0%(2/25) of mixed carcinomas and 2%(1/51) in poorly cohesive carcinomas. The analysis revealed a higher predominance of eb Va GC in the upper third and middle(cardia, fundus and body) of the stomach(P = 0.041), a significant lower number of regional lymph nodes invasion(P = 0.025) and a tendency for better prognosis(P = 0.222). eb V latent protein expression revealed that all eb Va GC cases were LMP1-negative, nevertheless 6 cases(40%) expressed LPM2 A, which reveals that these cases show a distinct eb V-Latency profile(latency II-like).CONCLUSION eb Va GC represents 8.4% of all GC in the North Region of Portugal. The eb V-infected patients have specific clinic-pathological features that should be further explored to develop new strategies of management and treatment.

关键词： Gastric cancer Epstein-barr virus Prevalencel Epstein-barr virus-associated gastric carcinomas

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Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

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Military Medical Research 2023年第5期10卷 699-725页

作者： Daniela Lopes joana Lopes Miguel Pereira-Silva Diana Peixoto Navid Rabiee Francisco Veiga Omid Moradi Zhan-Hu Guo Xiang-Dong Wang Joao Conde Pooyan Makvandi Ana Claudia Paiva-Santos Department of Pharmaceutical Technology Faculty of Pharmacy of the University of CoimbraUniversity of Coimbra3000-548 CoimbraPortugal REQUIMTE/LAQV Group of Pharmaceutical TechnologyFaculty of Pharmacy of the University of CoimbraUniversity of Coimbra3000-548 CoimbraPortugal School of Engineering Macquarie UniversitySydneyNsW 2109Australia Centre for Molecular Medicine and Innovative Therapeutics Murdoch UniversityPerthWA 6150Australia Department of Chemistry Shahr-e-Qods BranchIslamic Azad UniversityTehran 374-37515Iran lntegrated Composites Laboratory(iCL) Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK Department of Pulmonary and Critical Care Medicine Zhongshan HospitalFudan University Shanghai Medical CollegeShanghai 200032China Faculdade de Ciencias Medicas NOVA Medical SchoolUniversidade Nova de Lisboa1169-056 LisbonPortugal Centre for Toxicogenomics and Human Health GeneticsOncology and Human ToxicologyFaculdade de Ciencias MedicasNOVA Medical SchoolUniversidade Nova de Lisboa1169-056 LisbonPortugal school of Engineering Institute for Bioengineeringthe University of EdinburghEdinburgh EH93JLUK.

A bio-inspired strategy has recently been developed for camouflaging nanocarriers with biomembranes,such as natural cell membranes or subcellular structure-derived *** strategy endows cloaked nanomaterials with improved interfacial properties,superior cell targeting,immune evasion potential,and prolonged duration of systemic ***,we summarize recent advances in the production and application of exosomal membrane-coated *** structure,properties,and manner in which exosomes communicate with cells are first *** is followed by a discussion of the types of exosomes and their fabrication *** then discuss the applications of biomimetic exosomes and membrane-cloaked nanocarriers in tissue engineering,regenerative medicine,imaging,and the treatment of neurodegenerative ***,we appraise the current challenges associated with the clinical translation of biomimetic exosomal membrane-surface-engineered nanovehicles and evaluate the future of this technology.

关键词： Biomimetic Cell membrane coating Exosome Exosomal-membrane-coated nanoparticle Extracellular vesicle(EV)

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