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Patient-Reported Outcomes in Prostate Cancer: Prospective Changes Analysis for Prognosis Prediction

Journal of Cancer Therapy 2015年第15期6卷 1238-1248页

作者： Teresa Sequeira Pedro Lopes Ferreira joana Teixeira Isabel Peres Jorge Oliveira Augusta Silveira Fernando Pessoa University (UFP) Porto Portugal Centro de Estudos e Investigacao em Saúde da Universidade de Coimbra (CEISUC) Coimbra Portugal Coimbra University Coimbra Portugal Fernando Pessoa University Hospital School Porto Portugal Instituto Portugues de Oncologia do Porto (IPOP) Porto Portugal

Prostate cancer is affecting a higher proportion of male population. Health Related Quality of Life assessment can guide the development of an interdisciplinary and patient-centered care intervention. This study is aimed to assess Health Related Quality of Life in prostate cancer patients. Relationships between socio-demographic, clinical characteristics and patient-reported outcomes have been considered. Consecutive outpatients with prostate cancer, admitted at the Urology Clinic of the Instituto Português de Oncologia do Porto, were studied (n = 300). Health Related Quality of Life was assessed as part of the routine practice. The European Organisation for Research and Treatment of Cancer general questionnaire, QLQ-C30, and its specific module for prostate cancer patients, QLQ-PR25, were used. Evolution along time (elapsed since diagnosis, and up to 5 years) was considered in order to search for a prognosis prediction in prostate cancer patients. This study confirms the feasibility of a systematic Health Related Quality of Life assessment. Global Health Related Quality of Life was found to be higher 6 months after diagnosis, decreasing then until the second year after diagnosis and improving thereafter. A peak with better scores was identified at the fifth year after diagnosis. Social and physical dimensions revealed a similar pattern. Clinical significance was found 6 months and 5 years after diagnosis. The prospective analysis of Health Related Quality of Life changes is able to explore the patients’ outcomes in order to find patterns and relationships for prognosis prediction along the disease course. Such approach might promote patient confidence and thus a better cancer experience.

关键词： Oncology Prostate Cancer Health Related Quality of Life Patient-Reported Outcomes Prognosis Prediction

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Ammonia Sensing System Based on Wavelength Modulation Spectroscopy

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Photonic Sensors 2015年第2期5卷 109-115页

作者： Duarte VIVEIROS Joao FERREIRA Susana O. SILVA joana RIBEIRO Deolinda FLORES Jose L. SANTOS Orlando FRAZAO Jose M. BAPTISTA INESC Porto Rua do Campo Alegre 687 4169-007 Porto Portugal Geology Center of the University of Porto and Department of Geosciences Environment and Spatial Plannings Facultyof Science at University of Porto Rua do Campo Alegre 687 4169-007 Porto Portugal Department of Physics and Astronomy Faculty of Science at University of Porto Rua do Campo Alegre 687 4169-007 Porto Portugal Competence Center of Exact Sciences and Engineering University of Madeira Campus da Penteada 9000-390 Funchal Portugal

A sensing system in the near infrared region has been developed for ammonia sensing based on the wavelength modulation spectroscopy （WMS） principle. The WMS is a rather sensitive technique for detecting atomic/molecular species, presenting the advantage that it can be used in the near-infrared region by using the optical telecommunications technology. In this technique, the laser wavelength and intensity were modulated by applying a sine wave signal through the injection current, which allowed the shift of the detection bandwidth to higher frequencies where laser intensity noise was typically lower. Two multi-pass cells based on free space light propagation with 160 cm and 16 cm of optical path length were used, allowing the redundancy operation and technology validation. This system used a diode laser with an emission wavelength at 1512.21nm, where NH3 has a strong absorption line. The control of the NH3 gas sensing system, as well as acquisition, processing and data presentation was performed.

关键词： Ammonia sensing fiber optic system near infrared region wavelength modulation spectroscopy,environment

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Effect of Seed Size, Suspension Recycling and Substrate Pre-Treatment on the CVD Growth of Diamond Coatings

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Open Journal of Applied Sciences 2015年第12期5卷 747-763页

作者： Awadesh Kumar Mallik Sandip Bysakh Radhaballabh Bhar Shlomo Z. Rotter joana Catarina Mendes CSIR-Central Glass & Ceramic Research Institute Kolkata India Department of Instrumentation Science Jadavpur University Kolkata India Instituto de Telecomunicaç õ es Campus Universitário de Santiago Aveiro Portugal

CVD growth of uniform conformal polycrystalline diamond (PCD) coatings over complex three dimensional structures is very important material processing technique. It has been found that the nucleation and subsequent growth period is very critical for successful development of CVD diamond based technologies. There are many methods of enhancing diamond nucleation on foreign substrates-ultrasonic treatment with diamond seed suspension being the best among them. A combination of ultrasonic seeding (US) technique with prior treatment (PT) of the substrate under CVD diamond growth conditions for brief period of time, has found to be very effective in enhancing the diamond nucleation during CVD growth—together they are known as NNP. But successive usage of the same seeding suspension up to ten cycles deteriorates the seeding efficiency. 6th seeding cycle onwards the silicon substrates are barely get covered by diamond crystallites. Five different diamond micron grits were used for seeding the silicon substrates and it is observed that US with the sub-micron particles (0.25 μm) is very effective in efficient nucleation of PCD on Si substrates. PT of the substrate somewhat negates the effect of successive use of the same seeding slurry but it is best to avoid recycling of the same seeding suspension using micron size diamond grits.

关键词： Microwave Plasma CVD Seeding Diamond Micron Grits Novel Nucleation Process (NNP) Polycrystalline Diamond

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HPV Vaccination in Young Girls from Developing Countries: What Are the Barriers for Its Implementation? A Systematic Review

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Health 2020年第6期12卷 671-693页

作者： Inês Maria Brito Gonçalves joana Rafaela Magalhães Fernandes Filipa Ribeiro Adhemar Longatto-Filho School of Medicine University of Minho Braga Portugal Life and Health Sciences Research Institute (ICVS) School of Medicine University of Minho Braga Portugal ICVS/3B’s-PT Government Associate Laboratory Braga/Guimar&#227 es Portugal Molecular Oncology Research Center Barretos Cancer Hospital Barretos S&#227 o Paulo Brazil Medical Laboratory of Medical Investigation (LIM) 14 Department of Pathology Medical School University of S&#227 o Paulo S&#227 o Paulo Brazil

Cervical cancer is the second most common cancer in women living in developing countries that account high HPV incidence and mortality rates. Vaccinating girls between 9 and 14 years old is supposed to be the most cost-effective public health approach against cervical cancer. This systematic review aims to assess the application and coverage of the HPV vaccine in developing countries and identify the main challenges for the introduction of the vaccine in these settings. Eligible studies were selected according to the defined inclusion and exclusion criteria. To determine the quality of the studies was employed the STROBE checklist. This review included seven studies, encompassing the analysis of 19 countries and 112,116 girls aged from 9 to 18 years old. The coverage of HPV vaccination ranged from 13.8% to 107.4%, with most of the programs having more than 60% of coverage, which reflects a high percentage of vaccinated girls. The main challenges were lack of knowledge and worries about the vaccine, insufficient financial resources and staff workers, lack of community involvement and dissemination of important information about HPV. In developing countries that implemented the HPV vaccine, high coverage rates were achieved, despite sociocultural, economic and political challenges. In the future, studies that analyze the coverage rates after the elimination of the barriers and the repercussions on the mortality rates should be conducted, so that more developing countries have the opportunity to efficiently implement the vaccine.

关键词： HPV Vaccine HPV Knowledge and Education HPV-Induced Cancer Papillomavirus Vaccine Awareness Cervical Cancer Mortality HPV Incidence HPV in Developing Countries

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Structural Characterization of Ulvan Polysaccharide from Cultivated and Collected <i>Ulva fasciata</i>(Chlorophyta)

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Advances in Bioscience and Biotechnology 2020年第5期11卷 206-216页

作者： Tiphane Andrade figueira Antonio Jorge Ribeiro da Silva Alex Enrich-Prast Yocie Yoneshigue-Valentin Vinícius Peruzzi de Oliveira Multiuser Unit of Environmental Analysis Institute of Biology Federal University of Rio de Janeiro Rio de Janeiro Brazil Institute for Research on Natural Products Federal University of Rio de Janeiro Rio de Janeiro Brazil Department of Thematic Studies—Environmental Change Link?ping University Link?ping Sweden Marine Macroalgae Laboratory Department of Botany Federal University of Rio de Janeiro Rio de Janeiro Brazil

Ulvan is a sulfated heteropolysaccharide present in the cell wall of Ulva species with unique structural properties and technological potential. Here we characterized by FTIR and NMR analysis the structure of ulvan from Ulva fasciata collected in natural environment (SEA) and after in vitro biomass cultivation in nutrient enriched water (CULT). FTIR spectrum of CULT ulvan presented stronger signals of sulfate groups than SEA. 1H and 13C NMR showed that both ulvan are composed mainly of ulvanobiuronic acid 3-sulfate type A and type B. SEA ulvan presented signals characteristics of xylose, suggesting the presence of ulvanobiose in its structure, while CULT presented most signals of type A disaccharide. The cultivation of Ulva could be an alternative to suffice the emerging demand for ulvan meeting requirements of quality and quantity.

关键词： Sulfated Polysaccharide Aquaculture FTIR Analysis NMR Analysis Biotechnology

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Abdominal Muscular Metastases of a Pulmonar Adenocarcinoma

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Advances in Lung Cancer 2015年第2期4卷 25-27页

作者： joana de Castro Rocha Pedro Nuno Brandao Ana Rita Cruz Vítor Valente Internal Medicine Department Centro Hospitalar do PortoPortoPortugal General Surgery Department Centro Hospitalar do PortoPortoPortugal

Metastases are synonymous of malignant neoplasm in advanced stage and so associated with a poor prognosis. As the first manifestation of cancer disease, the muscle metastasis is very rare. The definitive diagnosis of its presence is made based on histology. The authors presented the case of a patient with a lung adenocarcinoma, being with first manifestation of it, a muscle metastasis only about a month later there were clinical manifestations with imaging appearance that led to the diagnosis of a primary neoplasm. The rare manifestation of the disease motivated the study and surveillance of the patient and lead to the diagnosis.

关键词： Muscular Metastasis Adenocarcinoma Lung

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Endoscopic ultrasonography-emerging applications in hepatology

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World Journal of Gastrointestinal Endoscopy 2017年第8期9卷 378-388页

作者： joana Magalhaes Sara Monteiro Sofia Xavier Sílvia Leite Francisca Dias de Castro JoséCotter Gastroenterology Department Hospital Senhora da Oliveira School of Medicine University of Minho Life and Health Sciences Research Institute/3B’s PT Government Associate Laboratory

The inspection of the liver is a valuable part of the upper endoscopic ultrasonography(EUS) studies,regardless of the primary indication for the *** detailed images of the liver segments provided by EUS allows the use of this technique in the study of parenchymal liver disease and even in the diagnosis and classification of focal liver *** has also emerged as an important tool in understanding the complex collateral circulation in patients with portal hypertension and their clinical and prognostic ***,EUS-guided portal vein catheterization has been performed for direct portal pressure measurement as an alternative method to evaluate portal *** this review,the authors summarize the available evidence regarding the application of EUS to patients with liver diseases and how we can apply it in our current clinical practice.

关键词： Endoscopic ultrasonography Portal hypertension Gastroesophageal varices Focal liver lesions Liver biopsy

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Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation

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World Journal of Gastroenterology 2021年第12期27卷 1161-1181页

作者： Karina Gordon Estela Regina Ramos figueira Joel Avancini Rocha-Filho Luiz Antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da Fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla Jose Otavio Costa Auler Jr Maria Jose Carvalho Carmona Luiz Augusto Carneiro D'Alburquerque Division of Anesthesiology Hospital das ClínicasUniversity of São Paulo School of MedicineSão Paulo 05403-000Brazil Department of Anesthesiology AC Camargo Cancer CenterSão Paulo 01509-010Brazil Department of Gastroenterology Discipline of Liver and Gastrointestinal TransplantationLaboratory of Medical Investigations LIM37 Hospital das ClinicasUniversity of São Paulo School of MedicineSão Paulo 05402-000Brazil Department of Liver Transplantation AC Camargo Cancer CenterSão Paulo 01525-901Brazil Department of Gastroenterology Division of Liver and Gastrointestinal TransplantHospital das ClinicasUniversity of São Paulo School of MedicineSão Paulo 05402-000Brazil

BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young *** and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver *** To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing *** We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative *** receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/***,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be *** High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up *** a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the *** a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection ***,Cox hazard regr

关键词： Liver transplantation Child Blood transfusion Outcome Liver cirrhosis Mortality

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Thermal lens analysis in a diode-pumped 10 Hz 100 mJ Yb:YAG amplifier

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High Power Laser Science and Engineering 2020年第2期8卷 24-31页

作者： Victor Hariton Celso Paiva Joao Hugo Pires Mario Galletti Goncalo figueira GoLP/Instituto de Plasmas e Fusao Nuclear Instituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais1049-001 LisbonPortugal Central Laser Facility Science and Technology Facilities CouncilRutherford Appleton LaboratoryHarwell Science and Innovation CampusDidcot OX110QXUK

We address the power scaling issue in end-pumped laser rod amplifiers by studying,experimentally and numerically,the magnitude of thermal lensing in a high-energy diode-pumped Yb:YAG *** spatio-temporal temperature profile of the gain medium and the focal length of the induced thermal lens are determined *** influence of the repetition rate and pumping power on the temperature distribution is *** measurements covered repetition rates between 1 and 10 Hz and up to 4 kW pumping power.

关键词： diode-pumped lasers high-energy laser amplifiers thermal effects in lasers ytterbium-doped laser media

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Carotid body tumours resection with ultrasound dissector

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Chinese Medical Journal 2013年第3期126卷 586-588页

作者： joana Ferreira Alexandra Canedo Sandrina Braga Jogo Vasconcelos Ricardo Gouveia Victor Martins Pedro Brandāo António Vaz Vascular Surgery Department Hospital Vila Nova de Gaia/Espinho Santa Maria da Feira Portugal (Ferreira J Canedo A Braga S Vasconcelos J Gouveia R Martins V Brandǎo P and Vaz A)不详

Carotid body tumour （CBT） is a rare neoplasm arising from para^an^lion cells of the carotid body.1 Sureical resection of the CBT is considered the primary treatment option, and the only one which can allow a definitive cure.^1-3 The resection is particularly difficult because the tumour is adherent to the carotid adventitia, is highly vascularized, often involves the cranial nerves, and is in a limited field for exposure, consequently, the intervention is associated with high morbidity due to risk of nervous injuries, stroke, was well as hemorrhage shock.^1-3

关键词： carotid body tumour ultrasound dissector advantages

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