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A multi-scale modelling framework to guide management of plant invasions in a transboundary context

Forest Ecosystems 2016年第4期3卷 297-310页

作者： Joao Martins David M.richardson renato Henriques Elizabete Marchante Hélia Marchante Paulo Alves Mirijam Gaertner Joao P.Honrado joana r.vicente InBIO/CIBIO-Centro de Investigacao em Biodiversidade e recursos Geneticos Universidade do Porto-Campus Agrario de VairaoRua Padre Armando Quintasn°74485-661 VairaoPortugal Centre for Invasion Biology Department of Botany and ZoologyStellenbosch UniversityMatieland 7602South Africa Institute of Earth Sciences(ICT/University of Minho/CCT) MinhoPortugal Centre for Functional Ecology Department of Life SciencesUniversity of Coimbra3000-456 CoimbraPortugal Departamento de Ambiente Escola Superior Agraria de CoimbraInstituto Politecnico de CoimbraBencanta3045-601 CoimbraPortugal Faculdade de Ciencias da Universidade do Porto Ediffcio FC4(Biologia)Rua do Campo Alegres/n4169-007 PortoPortugal Environmental resource Management Department Westlake Conservation OfficeOu Kaapse WegTokai7966 City of Cape TownSouth Africa

Background：Attention has recently been drawn to the issue of transboundary invasions,where species introduced and naturalized in one country cross international borders and become problematic in neighbouring *** modelling frameworks,able to identify the environmental drivers of invasion and forecast the current and future potential distribution of invasive species,are needed to study and manage *** due to the lack of species distribution and environmental data,or assumptions of modelling tools,often constrain the reliability of model ***：We present a multiscale spatial modelling framework for transboundary invasions,incorporating robust modelling frameworks（Multimodel Inference and Ensemble Modelling） to overcome some of the *** framework is illustrated using Hakea sericea Schrad.（Proteaceae）,a shrub or small tree native to Australia and invasive in several regions of the world,including the Iberian *** study scales were considered：regional scale（western Iberia,including mainland Portugal and Galicia） and local scale（northwest Portugal）.At the regional scale,the relative importance of environmental predictors sets was evaluated and ranked to determine the main general drivers for the species distribution,while the importance of each environmental predictor was assessed at the local *** potential distribution of *** was spatially projected for both scale ***：Model projections for western Iberia suggest that a large area is environmentally suitable in both Portugal and *** and landscape composition sets were the most important determinants of this regional distribution of the ***,a geological predictor（schist lithology） was more important in explaining its local-scale ***：After being introduced to Portugal,*** has become a transboundary invader by expanding in parts of Galicia（Spain）.The fact that a larger area is predicted as

关键词： Drivers of invasion Hakea sericea Multimodel inference Transboundary invasion management Species distribution models

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Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer

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World Journal of Gastrointestinal Oncology 2022年第7期14卷 1307-1323页

作者： Tiago Cruz Tomás Ines Eiriz Marina Vitorino rodrigo vicente Joao Gramaca Alicia Guadalupe Oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle Silva Teresa Fiúza Department of Medical Oncology Hospital Professor Doutor Fernando Fonseca EPEAmadora 2720-276Portugal Department of Medical Oncology Centro Hospitalar Barreiro-Montijo EPEBarreiro 2830-003Portugal Department of Medical Oncology Hospital do Espírito Santo deÉvora EPEÉvora 7000-811Portugal Department of Medical Oncology Centro Hospitalar Universitário do Algarve EPEAlgarve 8000-386Portugal Department of Medical Oncology Hospital São Francisco XavierCentro Hospitalar Lisboa Ocidental EPELisboa 1449-005Portugal Department of Medical Oncology Hospital Santo António dos CapuchosCentro Hospital Lisboa Central EPELisboa 1169-050Portugal Department of Medical Oncology Hospital BeatrizÂngeloLoures 2674-514Portugal Department of Medical Oncology Centro Hospitalar de Trás-os-Montes e Alto Douro EPEVila Real 5000-508Portugal Department of Medical Oncology Hospital da Senhora da Oliveira EPEGuimarães 4835-044Portugal Department of Medical Oncology Hospital Garcia de Orta EPEAlmada 2805-267Portugal Department of Medical Oncology Hospital da LuzLisboa 1500-650Portugal Department of Medical Oncology Hospital Distrital de Santarém EPESantarém 2005-177Portugal

BACKGrOUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLr),lymphocyte-tomonocyte(LMr),and platelet-to-lymphocyte(PLr)ratios are prognostic biomarkers but not predictive *** To assess blood ratios’(NLr,LMr and PLr)potential predictive response to FLOT and survival outcomes in resectable LAGC *** This was a multicentric retrospective study investigating the clinical potential of NLr,LMr,and PLr in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese *** were compared through non-parametric Mann-Whitney *** operating characteristic curve analysis defined the cut-off values as:High PLr>141 for progression and>144 for mortality;high LMr>3.56 for T stage regression(TSr).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLr,pathologic complete response,TSr,and tumor regression grade(TrG)as independent variables,and overall survival(OS)as the dependent *** This study included 295 patients(mean age,63.7 years;59.7% males).NLr was correlated with survival time(r=0.143,P=0.014).PLr was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLr patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMr was associated with TSr,and high LMr patients had a 1.4-times higher risk of achieving TSr(95%CI:1.01-1.99).OS benefit was found with TSr(P=0.015)and partial/complete TrG(Pr and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of *** Higher NLr is correlated with longer survival *** LMr patients have a higher risk of decreasing T stage,whereas high PLr patients have higher odds of progressing under FLOT a

关键词： Gastric cancer Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel Neutrophil-to-lymphocyte Lymphocyte-to-monocyte Platelet-to-lymphocyte Tumor regression grade

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Effects of exercise-based cardiac rehabilitation on inflammatory biomarkers in patients with cardiovascular disease:a systematic review with meta-analysis

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TMr Non-Drug Therapy 2022年第4期5卷 17-34页

作者： Agustin Manresa-rocamora Susana Lopes Ana Fernandez joana Martins vicente Climent-Paya Jose Manuel Sarabia Fernando ribeiro Department of Sport Sciences Sports Research CentreMiguel Hernández University of ElcheElche 03202Spain Institute for Health and Biomedical research of Alicante(ISABIAL) Alicante 03010Spain Institute of Biomedicine-iBiMED and School of Health Sciences University of AveiroAveiro 3810-193Portugal Cardiology Department Alicante General University Hospital(HGUA)Alicante 03010Spain

Background:Evidence supports the anti-inflammatory effect of exercise-based cardiac rehabilitation(Cr)in patients with cardiovascular disease(CVD).Nonetheless,the influence of training variables on the effects of exercise training is ***,this systematic review with meta-analysis aims to i)estimate the effects of exercise-based Cr on the circulating levels of inflammatory biomarkers in patients with CVD based on the type of exercise,and ii)analyse the influence of other potential moderator ***:Electronic searches were performed in PubMed,Scopus,and Web of Science databases up to October 2022.A random-effects models of standardised mean difference(SMD)were *** analyses and meta-regressions were used to carry out heterogeneity ***:Aerobic exercise diminished the levels of C-reactive protein compared with the control group in patients with CVD(SMD+=-0.33[95%CI=-0.47,-0.20),as well as the levels of tumor necrosis factor-alfa exclusively in patients with chronic heart failure(SMD+=-0.38[95%CI=-0.59,-0.17]).Moreover,heterogeneity analyses showed that the effect of aerobic exercise on vascular cell adhesion molecule-1 is higher in studies that carried out a Cr programme based exclusively on exercise,as well as in studies that performed a shorter intervention period or carried out a lower number of exercise sessions(P≤0.05).Conclusion:Our findings support the anti-inflammatory effect of aerobic exercise in patients with *** low number of studies testing interventions using resistance or combined exercise precludes a definitive answer about their anti-inflammatory effects in this patient population.

关键词： coronary artery disease cytokines cell adhesion molecules exercise

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