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促进慢性阻塞性肺疾病哮喘患者自我监控空气质量的护理干预措施:整合性综述（英文）

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International Journal of Nursing Sciences 2024年第1期 46-56页

作者： Bruna F.Sebasti?o raquel M.Hortel?o Sara S.Granadas José M.Faria joana r.pinto Helga rafael Henriques Nursing School of Lisbon Hospital Center of Central Lisbon CUF Tejo Hospital University Hospital Center of Northern Lisbon Nursing research Innovation and Development Centre of Lisbon (CIDNUR)

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronic obstructive pulmonary disease overlap,ACO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过... 详细信息

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronic obstructive pulmonary disease overlap,ACO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过系统性综述,寻找证据,以指导制订护理干预措施,促进ACO患者对空气质量的自我管理。方法 2023年3月,系统检索CINAHL、Medline、Academic Search Complete、Scopus、Web of Science、Cochrane图书馆、乔安娜布里格斯研究所(Joanna Briggs Institute,JBI)循证实践数据库,以及Google Scholar。对纳入研究进行数据提取和综合,并对护理干预措施进行分类。采用JBI研究质量评估工具进行方法学质量评估。结果共纳入5篇来自不同国家的研究。促进ACO患者自我监控空气质量的干预措施包括:警觉性干预措施(医务人员定期巡诊、进行症状评估),监测干预措施(监测室内外诱发因素),教育干预措施(空气质量警报、避免接触过敏原),以及相关政策的影响,如无烟政策和改善空气质量的综合战略。尽管这些研究报告了不同的干预措施,方法质量也存在差异,但这些干预措施显示了预防患者病情恶化、尽量减少急诊就诊和住院治疗的潜力。这些关键点可作为护理干预措施的关键组成部分。结论有必要采取全面措施,让护士参与促进患者自我监控空气质量的多学科团队、提高认识、制订和实施护理干预,从而使ACO患者受益。同时,需要进一步开展研究,以扩大证据基础并完善这些干预措施。

关键词：空气质量哮喘哮喘-慢阻肺重叠慢性病慢性阻塞性肺疾病护理自我管理

The role of endosomal cholesterol trafficking protein, StAr-related lipid transfer domain 3 （StarD3/MLN64）, in BrIN-BD11 insulinoma cells

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Protein & Cell 2016年第11期7卷 833-838页

作者： joana Borges pinto Annette Graham Department of Life Sciences School of Health and Life Sciences Glasgow Caledonian University Glasgow G4 0BA UK WolfsonWohl Cancer research Centre Institute of Cancer Sciences University of Glasgow Switchback Road Bearsden Glasgow G61 1QH UK

Dear Editor, Insulin secretion by pancreatic β-cells is modulated by altering the cellular content and distribution of cholesterol, which is tightly regulated by a network of transcription factors, enzymes, receptors, transporters and cholesterol trafficking proteins. Inhibition of cellular biosynthesis by ＇statin＇ drugs, or depletion of plasma membrane cholesterol by methyl-β-cyclodextrin （MCD）, reduce glucose-stimulated insulin secretion （GSIS） and content in β-cells and islets;

关键词： Cholesterol Lutein Insulin release Cholesterol Efflux Cholesterol Depletion

Fecal marker levels as predictors of need for endoscopic balloon dilation in Crohn's disease patients with anastomotic strictures

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World Journal of Gastroenterology 2017年第35期23卷 6482-6490页

作者： Susana Lopes Patrícia Andrade Eduardo rodrigues-pinto joana Afonso Guilherme Macedo Fernando Magro Gastroenterology Department Faculty of MedicineHospital de Sao Joao Department of Pharmacology and Therapeutics University of Porto

AIM To evaluate the accuracy and best cut-off value of fecal calprotectin(FC) and fecal lactoferrin(FL) to predict disease recurrence in asymptomatic patients presenting with anastomotic strictures. METHODS This was a longitudinal single tertiary center study based on prospectively collected data(recorded in a clinical database created for this purpose) performed between March 2010 and November 2014. Crohn's disease(CD) patients with anastomotic stricture who submitted to postoperative endoscopic evaluation were included. Stools were collected on the day before bowel cleaning for FC and FL. Endoscopic balloon dilation(EBD) was performed if the patient presented an anastomotic stricture not traversed by the colonoscope, regardless of patients' symptoms. Successful dilation was defined as passage of the colonoscope through the dilated stricture into the neotermimal *** recurrence was defined as a modified rutgeerts score of ≥ i2 b. rESULTS In a total of 178 patients who underwent colonoscopy, 58 presented an anastomotic stricture, 86% were asymptomatic, and 48(54% male; median age of 46.5 years) were successfully dilated. Immediate success rate was 92% and no complications were recorded. FC and FL levels correlated significantly with endoscopic recurrence(P redictive value(PPV) of 72.4%, negative predictive value(NPV) of 94.7% and accuracy of 81%] for FC and of 5.6 μg/g(sensitivity of 77.3%, specificity of 69.2%, PPV of 68%, NPV of 78.4% and accuracy of 72.9%) for *** Fecal markers are good predictors of CD endoscopic recurrence in patients with asymptomatic anastomotic stricture. FC and FL may guide the need for EBD in this context.

关键词： Crohn's disease Anastomotic strictures Endoscopic balloon dilation Fecal markers Po stoperative recurrence

Endoscopic balloon dilation of crohn's disease stricturessafety,efficacy and clinical impact

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World Journal of Gastroenterology 2017年第41期23卷 7397-7406页

作者： Susana Lopes Eduardo rodrigues-pinto Patrícia Andrade joana Afonso Todd H Baron Fernando Magro Guilherme Macedo Gastroenterology Department Faculty of MedicineHospital de Sao Joao Department of Pharmacology and Therapeutics University of Porto Division of Gastroenterology and Hepatology University of North Carolina

AIM To evaluate the incidence of anastomotic strictures after intestinal resection in Crohn's disease(CD), demonstrate long-term efficacy and safety of endoscopic balloon dilation(EBD) in CD strictures and its impact on the diagnosis of subclinical postoperative endoscopic recurrence. METHODS retrospective single tertiary center study based on prospectively collected data between 2010 and 2015including anastomotic and non-anastomotic strictures. rESULTS29% of 162 CD patients included developed an anastomotic stricture. 43 patients with anastomotic strictures and 37 with non-anastomotic strictures underwent EBD; technical success was 97.7% and 100%, respectively, however, 63% and 41% needed repeat dilation during the 4.4-year follow-up. Longer periods between surgery and index colonoscopy and higher lactoferrin levels were associated with the presence of stricture after surgery. Calprotectin levels > 83.35 μg/g and current or past history of smoking were associated with a shorter time until need for dilation(Hr = 3.877, 95%CI: 1.480-10.152 and Hr = 3.041, 95%CI: 1.213-7.627). Anastomotic strictures had a greater need for repeat dilation(63% vs 41%, P = 0.047). No differences were found between asymptomatic and symptomatic cohorts. Disease recurrence diagnosis was only possible after EBD in a third of patients. CONCLUSION EBD is an effective and safe alternative to surgery, with a good short and long-term outcome, postponing or even avoiding further surgery. EBD may allow to diagnose disease recurrence in patients with no clinical signs/biomarkers of disease activity.

关键词： Crohn’s disease Endoscopic recurrence Anastomotic strictures Non-anastomotic strictures Endoscopic balloon dilation

Evaluation of Novel 3D Architectures Based on Knitting Technologies for Engineering Biological Tissues

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Journal of Donghua University(English Edition) 2013年第5期30卷 421-426页

作者： rIBEIrO Viviana pinto rIBEIrO Ana Soares SILVA Carla joana DUrES Nelson Feio BONIFCIO Graa COrrELO Vitor Manuel MArQUES Alexandra pinto SOUSA rui Amandi OLIVEIrA Ana Leite rEIS rui Luís 3B's research G roup-Biomaterials Biodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine ICVS /3B's-PT G overnment Associated Laboratory University of Minho CeNTI Centre for Nanotechnology and Smart MaterialsV. N. CITEVE Technological Centre for Textile and Clothing IndustryV. N. CBQF-School of Biotechnology Portuguese Catholic University

Textile-based technologies are considered as potential routes for the production of 3D porous architectures for tissue engineering( TE) applications. We describe the use of two polymers,namely polybutylene succinate( PBS) and silk fibroin(SF) to produce fiber-based finely tuned porous architectures by weft and warp knittings. The obtained knitted constructs are described in terms of their morphology, mechanical properties,swelling ability,degradation behaviour,and cytotoxicity. Each type of polymer fibers allows for the processing of a very reproducible intra-architectural scaffold geometry,with distinct characteristics in terms of the surface physicochemistry,mechanical performance,and degradation capability,which has an impact on the resulting cell behaviour at the surface of the respective biotextiles. Preliminary cytotoxicity screening shows that both materials can support cell adhesion and proliferation. Furthermore, different surface modifications were performed( acid /alkaline treatment, UV radiation,and plasma) for modulating cell behavior. An increase of cell-material interactions were observed,indicating the important role of materials surface in the first hours of culturing. Human adipose-derived stem cells( hASCs) became an emerging possibility for regenerative medicine and tissue replacement therapies. The potential of the recently developed silk-based biotextile structures to promote hASCs adhesion,proliferation,and differentiation is also evaluated. The obtained results validate the developed constructs as viable matrices for TE applications. Given the processing efficacy and versatility of the knitting technology, and the interesting structural and surface properties of the proposed polymer fibers,it is foreseen that our developed systems can be attractive for the functional engineering of tissues such as bone,skin,ligaments or cartilage and also for develop more complex systems for further industrialization of TE products.

关键词： textile-based technologies silk polybutylene succinate(PBS) surface modifications human adipose-derived stem cells(hASCs) tissue engineering(TE)

Initial medication adherence in newly diagnosed glaucoma patients:three adherence measures

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 630-637页

作者： joana Menino Pedro Camacho AndréCoelho Escola Superior de Tecnologia da Saúde Instituto Politécnico de LisboaLisbon 1990-096Portugal H&TrC-Health&Technology research Center ESTeSLEscola Superior de Tecnologia da SaúdeInstituto Politécnico de LisboaLisbon 1990-096Portugal iNOVA4Health NOVA Medical SchoolFaculdade de Ciências MédicasNMSFCMUniversidade NOVA de LisboaLisbon 1150-82Portugal Instituto de Oftalmologia Dr.Gama pinto Lisbon 1150-255Portugal

AIM:To determine initial medication adherence in newly diagnosed glaucoma patients treated with anti-glaucoma ***:This retrospective and observational study included all patients diagnosed with glaucoma in the Primary Health Care units in Portugal during the years 2012 and 2013,which in consequence received a first prescription for anti-glaucoma *** was collected from electronic prescribing records of the primary care units and from pharmacy claims *** of glaucoma treatment and early discontinuation were measured,and the combination of(non)-initiation and early discontinuation accounted for initial medication(non)-***:A total of 3548 new glaucoma patients(40.1%male;59.9%female)were *** 1133(31.9%)patients were initially classified as non-users,since there was no pharmacy claim found for their first prescription for glaucoma ***,277(11.5%)patients early discontinued their treatment,acquiring only their first ***,the initial medication non-adherence rate was 39.7%since 1410 patients either didn’t initiate treatment or discontinued it ***:This study,reveals a major opportunity to improve glaucoma treatment and its control,since a large proportion of patients fail to engage with their prescribed therapy,which implies that implementation of individual or group strategies that enable patients with glaucoma to correctly perform their treatment is still needed.

关键词： glaucoma glaucoma treatment initiation early discontinuation initial medication adherence

腺苷受体是调节大脑内侧前额叶皮质星形胶质细胞大麻素1型(CB1)受体对突触可塑性作用的开关

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神经损伤与功能重建 2024年第4期19卷 250-250页

作者： joana Gon?alves-ribeiro Oksana K Savchak Sara Costa-pinto joana I Gomes rafael rivas-Santisteban Alejandro Lillo Javier Sánchez romero Ana M Sebasti?o Marta Navarrete Gemma Navarro rafael Franco Sandra H Vaz Instituto de Farmacologia e Neurociencias Faculdade de MedicinaUniversidade de Lisboa Instituto de Medicina Molecular Joao Lobo Antunes Faculdade de MedicinaUniversidade de Lisboa Department of Biochemistry and Physiology School of Pharmacy and Food ScienceUniversitat de Barcelona CiberNed Network Center for Neurodegenerative DiseasesNational Spanish Health Institute Carlos Ⅲ 5. Instituto CajalCSIC PhD Program in Neuroscience Universidad Autonoma de Madrid-Instituto Cajal Institut de Neurociencies Universitat de Barcelona Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFaculty of Biology School of Chemistry Universitat de Barcelona

内侧前额叶皮质(mPFC)参与诸如工作记忆等认知功能。星形胶质细胞大麻素1型受体(CB1r)诱导细胞质内钙离子(Ca2+)浓度变化,对神经元功能产生影响。mPFC的星形胶质细胞也表达腺苷A1和A2A受体(A1r,A2Ar),但目前尚不清楚这些细胞中的CB1r与... 详细信息

内侧前额叶皮质(mPFC)参与诸如工作记忆等认知功能。星形胶质细胞大麻素1型受体(CB1r)诱导细胞质内钙离子(Ca2+)浓度变化,对神经元功能产生影响。mPFC的星形胶质细胞也表达腺苷A1和A2A受体(A1r,A2Ar),但目前尚不清楚这些细胞中的CB1r与腺苷受体之间的交流。我们在这里展示,通过CB1r-A2Ar或CB1r-A1r异源二聚体,星形胶质细胞Ca2+信号传递发生了进一步的调节,最终影响mPFC突触可塑性。当A1r和A2Ar被激活时,CB1r介导的Ca2+瞬变出现增加或减少,揭示了腺苷受体可能是星形胶质细胞CB1r的调节器。CB1r的激活导致mPFC的长时程增强(LTP)增强,受A1r控制,但不受A2Ar控制。值得注意的是,在IP3r2KO小鼠中,由于没有显示出星形胶质细胞Ca2+水平升高,CB1r的激活减少了LTP,这种效果不受A1r或A2Ar的调节。本研究表明,CB1r在mPFC LTP上具有稳态作用,受到A1r的控制,可能是由于这些受体在星形胶质细胞中的交流,最终改变了CB1r Ca2+信号传递。

关键词： CB1受体腺苷受体星形胶质细胞内侧前额叶皮质突触可塑性

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壳聚糖基皮革抗菌涂层的研究

中国皮革 2014年第3期43卷 48-50页

作者： Isabel P.Fernandes joana S.Amaral Vera pinto Maria José Ferreira Maria Filomena Barreiro 分离与反应工程实验室(LSrE) 副实验室LSRE/LCM布拉干萨理工学院葡萄牙布拉干萨5301857 药剂学院波尔图大学葡萄牙波尔图4050313 布拉干萨理工学院葡萄牙布拉干萨5301857 葡萄牙制鞋技术中心葡萄牙圣若昂3700121

自抗菌类涂料在鞋材中应用以来,引起了制造商和消费者的极大兴趣。研究利用壳聚糖固有的抗菌活性和成膜性制备皮革抗菌材料。考虑到皮革鞣制的特殊性,采用不同的涂饰技术,如转鼓浸渍、辊涂和喷涂。结果表明,采用转鼓浸渍的方法效果最佳... 详细信息

自抗菌类涂料在鞋材中应用以来,引起了制造商和消费者的极大兴趣。研究利用壳聚糖固有的抗菌活性和成膜性制备皮革抗菌材料。考虑到皮革鞣制的特殊性,采用不同的涂饰技术,如转鼓浸渍、辊涂和喷涂。结果表明,采用转鼓浸渍的方法效果最佳。进一步研究了转鼓浸渍涂饰方法中壳聚糖的用量、增溶酸剂的类型和浸渍时间,对抗菌剂抗菌能力的影响。由于壳聚糖价格昂贵(成本原因)以及对最终试验结果(采用SEM考察了抗菌能力和成膜效果)的分析,得出最佳方案:壳聚糖用量为1%(w/v),溶剂为甲酸,转鼓浸渍时间为2h。

关键词：壳聚糖皮革鞋类抗菌涂料

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壳聚糖基皮革抗菌涂层的研究(续)

中国皮革 2014年第5期43卷 49-53页

作者： Isabel P. Fernandes joana S. Amaral Vera pinto Maria José Ferreira Maria Filomena Barreiro 陈小珂分离与反应工程实验室(LSrE)副实验室LSrE/LCM布拉干萨理工学院葡萄牙布拉干萨5301857 药剂学院波尔图大学葡萄牙波尔图4050313 布拉干萨理工学院葡萄牙布拉干萨5301857 葡萄牙制鞋技术中心葡萄牙圣若昂3700121

关键词：壳聚糖皮革鞋类抗菌涂料