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Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer:A case report

World Journal of Gastrointestinal Oncology 2024年第1期16卷 234-243页

作者： João Gramaça Isabel Gomes Fernandes Carolina Trabulo joana Gonçalves Rita Gameiro dos Santos Adriano Baptista Idília Pina Centro Hospitalar Barreiro Montijo Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal Medical Oncology Unit Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal

BACKGROUND In patients with metastatic colorectal cancer(mCRC),the treatment options are limited and have been proved to be affected by rat sarcoma virus(RAS)mutational *** RAS wild-type(wt)patients,the combination of antiepidermal growth factor receptor(EGFR)monoclonal antibodies with chemotherapy(CT)is more effective than CT *** the other hand,RAS-mutated patients are not eligible for treatment with anti-EGFR *** SUMMARY Eleven patients with initially RAS-mutated mCRC were followed from diagnosis to May *** the time of cell-free DNA determination,five patients had undergone one CT line,five patients had undergone two CT lines,and one patient had undergone three CT lines(all in combination with bevacizumab).At the second and third treatment lines[second line(2L),third line(3L)],patients with neo-RAS wt received a combination of CT and *** neo-RAS wt patients treated with anti-EGFR,our findings indicated an increase in progression-free survival for both 2L and 3L(14.5 mo,P=0.119 and 3.9 mo,P=0.882,respectively).Regarding 2L overall survival,we registered a slight increase in neo-RAS wt patients treated with anti-EGFR(33.6 mo vs 32.4 mo,P=0.385).At data cut-off,two patients were still alive:A RAS-mutated patient undergoing 3L treatment and a neo-RAS wt patient who received 2L treatment with anti-EGFR(ongoing).CONCLUSION Our case series demonstrated that monitoring RAS mutations in mCRC by liquid biopsy may provide an additional treatment line for neo-RAS wt patients.

关键词： Metastatic colorectal cancer Rat sarcoma virus mutational status Liquid biopsy Rat sarcoma virus wild-type Neo-rat sarcoma virus wild-type Anti-epidermal growth factor receptor therapy Case report

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Red deer as a disperser of native,but not invasive plants’seeds

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Integrative Zoology 2023年第5期18卷 859-866页

作者： Fernanda GARCIA António alves DA SILVA Ruben HELENO JoséPaulo SOUSA joana alves Centre for Functional Ecology(CFE) TERRA Associate LaboratoryDepartment of Life SciencesUniversity of CoimbraCoimbraPortugal

INTRODUCTION Seed dispersal is a key process in the life cycle of most plants,with ecological and evolutionary consequences that go beyond vegetation dynamics and cascade to entire ecosystem functioning and stability(Traveset et al.2014).Seed dispersal largely constrains plant recruitment and the distribution of future plant cohorts,thus playing a critical role in the restoration of disturbed sites(Cain et al.2000;Higgins et al.2003).It can also threaten plant diversity by facilitating plant invasions(Vavra et al.2007;Heleno 2020).

关键词： consequences disperse disturbed

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Unveiling DNA methylation in Alzheimer’s disease:a review of array-based human brain studies

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Neural Regeneration Research 2024年第11期19卷 2365-2376页

作者： Victoria Cunha alves Eva Carro joana Figueiro-Silva Neurodegenerative Diseases Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain Network Center for Biomedical Research Neurodegenerative Diseases(CIBERNED)MadridSpain PhD Program in Neuroscience Autonoma de Madrid UniversityMadridSpain Neurotraumatology and Subarachnoid Hemorrhage Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain Neurobiology of Alzheimer’s Disease Unit Functional Unit for Research Into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpain Institute of Medical Genetics University of ZurichZurichSwitzerland Department of Molecular Life Science University of ZurichZurichSwitzerland

The intricacies of Alzheimer’s disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms,particularly DNA *** review comprehensively surveys recent human-centered studies that investigate whole genome DNA methylation in Alzheimer’s disease *** examination of various brain regions reveals distinctive DNA methylation patterns that associate with the Braak stage and Alzheimer’s disease *** entorhinal cortex emerges as a focal point due to its early histological alterations and subsequent impact on downstream regions like the ***,ANK1 hypermethylation,a protein implicated in neurofibrillary tangle formation,was recurrently identified in the entorhinal ***,the middle temporal gyrus and prefrontal cortex were shown to exhibit significant hypermethylation of genes like HOXA3,RHBDF2,and MCF2L,potentially influencing neuroinflammatory *** complex role of BIN1 in late-onset Alzheimer’s disease is underscored by its association with altered methylation *** the disparities across studies,these findings highlight the intricate interplay between epigenetic modifications and Alzheimer’s disease *** research efforts should address methodological variations,incorporate diverse cohorts,and consider environmental factors to unravel the nuanced epigenetic landscape underlying Alzheimer’s disease progression.

关键词： Alzheimer’s disease ANK1 BIN1 DNA methylation epigenome-wide association studies HOXA3 MCF2L RHBDF2

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Ultra-broadband near-infrared NOPAs based on the nonlinear crystals Bi BO and YCOB

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High Power Laser Science and Engineering 2020年第3期8卷 6-15页

作者： Mario Galletti Hugo Pires Victor Hariton joana alves Pedro Oliveira Marco Galimberti Goncalo Figueira GoLP/Instituto de Plasmas e Fusao Nuclear Instituto Superior TecnicoUniversidade de Lisboa1049-001 LisboaPortugal Central Laser Facility Science and Technology Facilities CouncilRutherford Appleton LaboratoryHarwell Science and Innovation CampusDidcotUK INFN-LNF Via Enrico Fermi 5400044 FrascatiItaly

We evaluate and demonstrate ultra-broadband near-infrared noncollinear optical parametric amplification in two nonlinear crystals,bismuth borate(Bi BO)and yttrium calcium oxyborate(YCOB),which are not commonly used for this *** spectral bandwidth is of the microjoule level;the amplified signal is≥200 nm,capable of supporting sub-10 fs *** results,supported by numerical simulations,show that these crystals have a great potential as nonlinear media in both low-energy,few-cycle systems and high peak power amplifiers for terawatt to petawatt systems based on noncollinear optical parametric chirped pulse amplification(NOPCPA)or a hybrid.

关键词： ultrafast laser high power laser nonlinear optics ultra-broadband noncollinear OPA YCOB and Bi BO nonlinear crystal

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腺苷受体是调节大脑内侧前额叶皮质星形胶质细胞大麻素1型(CB1)受体对突触可塑性作用的开关

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神经损伤与功能重建 2024年第4期19卷 250-250页

作者： joana Gon?alves-Ribeiro Oksana K Savchak Sara Costa-Pinto joana I Gomes Rafael Rivas-Santisteban Alejandro Lillo Javier Sánchez Romero Ana M Sebasti?o Marta Navarrete Gemma Navarro Rafael Franco Sandra H Vaz Instituto de Farmacologia e Neurociencias Faculdade de MedicinaUniversidade de Lisboa Instituto de Medicina Molecular Joao Lobo Antunes Faculdade de MedicinaUniversidade de Lisboa Department of Biochemistry and Physiology School of Pharmacy and Food ScienceUniversitat de Barcelona CiberNed Network Center for Neurodegenerative DiseasesNational Spanish Health Institute Carlos Ⅲ 5. Instituto CajalCSIC PhD Program in Neuroscience Universidad Autonoma de Madrid-Instituto Cajal Institut de Neurociencies Universitat de Barcelona Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFaculty of Biology School of Chemistry Universitat de Barcelona

内侧前额叶皮质(mPFC)参与诸如工作记忆等认知功能。星形胶质细胞大麻素1型受体(CB1R)诱导细胞质内钙离子(Ca2+)浓度变化,对神经元功能产生影响。mPFC的星形胶质细胞也表达腺苷A1和A2A受体(A1R,A2AR),但目前尚不清楚这些细胞中的CB1R与... 详细信息

内侧前额叶皮质(mPFC)参与诸如工作记忆等认知功能。星形胶质细胞大麻素1型受体(CB1R)诱导细胞质内钙离子(Ca2+)浓度变化,对神经元功能产生影响。mPFC的星形胶质细胞也表达腺苷A1和A2A受体(A1R,A2AR),但目前尚不清楚这些细胞中的CB1R与腺苷受体之间的交流。我们在这里展示,通过CB1R-A2AR或CB1R-A1R异源二聚体,星形胶质细胞Ca2+信号传递发生了进一步的调节,最终影响mPFC突触可塑性。当A1R和A2AR被激活时,CB1R介导的Ca2+瞬变出现增加或减少,揭示了腺苷受体可能是星形胶质细胞CB1R的调节器。CB1R的激活导致mPFC的长时程增强(LTP)增强,受A1R控制,但不受A2AR控制。值得注意的是,在IP3R2KO小鼠中,由于没有显示出星形胶质细胞Ca2+水平升高,CB1R的激活减少了LTP,这种效果不受A1R或A2AR的调节。本研究表明,CB1R在mPFC LTP上具有稳态作用,受到A1R的控制,可能是由于这些受体在星形胶质细胞中的交流,最终改变了CB1R Ca2+信号传递。

关键词： CB1受体腺苷受体星形胶质细胞内侧前额叶皮质突触可塑性

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Novel synthetic opioids-toxicological aspects and analysis

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Forensic Sciences Research 2019年第2期4卷 111-140页

作者： Inês Tabarra Sofia Soares Tiago Rosado joana Gonçalves Àngelo Luís Sara Malaca Mário Barroso Thomas Keller José Restolho Eugenia Gallardo Centro de Investigação em Ciências da Saude(CICS-UBI) Universidade da Beira InteriorCovilhãPortugal Laboratorio de Fármaco-Toxicologia-UBIMedical Universidade da Beira InteriorCovilhãPortugal Serviço de Química e Toxicologia Forenses Instituto Nacional de Medicina Legal e Ciências ForensesDelegac¸ão do SulLisboaPortugal Departament of Toxicology Institute of Forensic MedicineSalzburgAustria nal von minden GmbH RegensburgGermany

Over the past few years,there has been an emerging number of new psychoactive *** drugs are frequently mentioned as“legal highs”,“herbal highs”,“bath salts”and“research chemicals”.They are mostly sold and advertised on online forums and on the dark *** emerging new psychoactive substances are designed to mimic the effects of psychoactive groups,which are often abused *** synthetic opioids are a new trend in this context and represent an alarming threat to public *** the wide number of fatalities related to these compounds reported within the last few years,it is an important task to accurately identify these compounds in biologic matrices in order to administer an effective treatment and reverse the respiratory depression caused by opioid related *** dealing with fentanyl intoxication cases should consider that it could,in fact,be a fentanyl *** this reason,it is a helpful recommendation to include synthetic opioids in the routine toxicological screening procedures,including analysis in alternative matrices,if available,to investigate poly-drug use and possible tolerance to *** address this public health problem,better international collaboration,effective legislation,effective investigation,control of suspicious“research chemicals”online forums and continuous community alertness are *** article aims to review diverse reported fatalities associated with new synthetic opioids describing them in terms of pharmacology,metabolism,posology,available forms,as well as their toxic effects,highlighting the sample procedures and analytical techniques available for their detection and quantification in biological matrices.

关键词： Forensic sciences forensic toxicology new synthetic opioids biological specimens toxicity analysis

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Ultrashort pulse capability at the L2I high intensity laser facility

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High Power Laser Science and Engineering 2017年第1期5卷 7-11页

作者： Gonqalo Figueira joana alves Joao M.Dias Marta Fajardo Nuno Gomes Victor Hariton Tayyab Imran Celso P.Joao Jayanath Koliyadu Swen Kunzel Nelson C.Lopes Hugo Pires Filipe Ruao Gareth Williams GoLP/Instituto de Plasmas e Fusao Nuclear lnstituto Superior TecnieoUniversidade de LisboaLisbonPortugal Faculdade de Ciências e Tecnologia Universidade Nova de LisboaCaparicaPortugal Department of Physics&Astronomy College of ScienceKing Saud UniversityRiyadhSaudi Arabia

The Laboratory for Intense Lasers(L2I) is a research centre in optics and lasers dedicated to experimental research in high intensity laser science and technology and laser plasma interaction. Currently the laboratory is undergoing an upgrade with the goal of increasing the versatility of the laser systems available to the users, as well as increasing the pulse repetition rate. In this paper we review the current status of the laser research and development programme of this facility, namely the upgraded capability and the recent progress towards the installation of an ultrashort, diode-pumped OPCPA laser system.

关键词： diode-pumped solid-state laser and applications femtosecond laser and applications frequency conversion laser amplifiers nonlinear optics

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边境围栏影响帕米尔高原马可波罗盘羊的跨境迁移

边境围栏影响帕米尔高原马可波罗盘羊的跨境迁移

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第十六届全国野生动物生态与资源保护学术研讨会

作者：卓莹莹汪沐阳刘忠军徐文轩 Abdulnazarov Abdulnazar Ali Madad Rajabi Askar Davletbakov Jibran Haider Muhammad Zafar Khan Nabiev Loik Sorosh Poya Faryabi Stefan Michel Stephane Ostrowski Zalmai Moheb Kathreen Ruckstuhl Anto?nio alves da Silva joana alves 杨维康中国科学院新疆生态与地理研究所荒漠与绿洲生态国家重点实验室干旱区生态安全与可持续发展重点实验室中国-塔吉克斯坦生物资源保护与利用联合实验室中国科学院新疆生态与地理研究所生物标本馆中国科学院新疆生态与地理研究所木垒野生动物生态监测实验站中国科学院大学新疆维吾尔自治区林业和草原局世界自然保护联盟(IUCN) 加拿大卡尔加里大学葡萄牙科英布拉大学

边境围栏严重阻碍了大型哺乳动物的跨境迁移,中亚是边境围栏建设最密集的区域之一。马可波罗盘羊(Ovis ammon polii)是帕米尔地区的旗舰物种,近年来由于其五个分布国之间的边界围栏不断增加,该物种的跨境迁移受到威胁。本研究通过建立... 详细信息

边境围栏严重阻碍了大型哺乳动物的跨境迁移,中亚是边境围栏建设最密集的区域之一。马可波罗盘羊(Ovis ammon polii)是帕米尔地区的旗舰物种,近年来由于其五个分布国之间的边界围栏不断增加,该物种的跨境迁移受到威胁。本研究通过建立集合物种分布模型发现塔吉克斯坦东部拥有最大的马可波罗盘羊适宜生境(约占总适宜生境的42%),其次是中国(约32%)。采用最小成本路径方法确定了51条生态廊道,其中包括5条跨境生态廊道,这些生态廊道对维持各国国内和跨境核心生境斑块之间的连通性具有重要意义。受地形影响,在过于陡峭的区域无法建设围栏,因此边境围栏存在一些"缺口",它们可以被盘羊利用穿越边境,被定义为自然通道。为量化评估边境围栏的潜在影响,基于马可波罗盘羊坡度选择偏好和围栏建设,本研究评估了情景30、情景40、情景50和情景60四种情景,分别对应围栏建设的坡度上限为30°,40°,50°和60°。在最悲观的情景60中,沿着边界围栏只发现了25条自然通道,而在最乐观的情景(情景30)中则发现了997条,这表明高强度的边界围栏建设将对马可波罗盘羊的跨境迁移具有强烈的负面影响。我们建议通过跨国合作,建立跨境自然保护区,降低边境围栏对马可波罗盘羊等大型哺乳动物的跨境迁移的影响,加强各国马可波罗盘羊种群的连通性,有助于该物种的持续生存。本研究也为其他跨境地区的大型迁徙哺乳动物的保护管理提供宝贵经验。

关键词：帕米尔高原边界围栏自然通道迁徙通道跨国保护

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BCG Infection after Bladder Cancer Treatment—3 Clinical Case Reports

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Advances in Infectious Diseases 2015年第4期5卷 218-221页

作者： joana alves Angélica Ramos Teresa Carvalho Susana Silva Joao Tiago Guimaraes António Sarmento Infectious Diseases Department Faculty of MedicineUniversity of PortoCentro Hospitalar Sao Joao EPEPortoPortugal Clinical Pathology Department Centro Hospitalar Sao Joao EPEPortoPortugal EPI Unit Institute of Public Health of University of PortoPortoPortugal Biochemistry Department Faculty of MedicineUniversity of PortoPortoPortugal

Immunotherapy with Bacillus Calmette-Guérin (BCG) to treat non-muscle invasive bladder cancer has become an effective and superior alternative to chemotherapy. Intravesical treatment with BCG appears to be relatively safe;however, occasionally BCG infection complicates such treatment. In the present work we describe three patients in whom BCG infection occurred after intravesical BCG therapy. All patients had positive urine culture forMycobacterium tuberculosis complex, using AccuProbe culture identification and then Genotype Mycobacterium MTBC test identified Mycobacterium bovis BCG. The diagnosis is difficult and microbiologic study is usually negative, so high index of suspicion is essential.

关键词： Bacillus Calmette-Guérin Intravesical BCG Therapy BCG Infection Disseminated M.bovis BCG Infection

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社会行为和食性组成对北山羊同性聚群行为的作用

社会行为和食性组成对北山羊同性聚群行为的作用

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第十三届全国野生动物生态与资源保护学术研讨会暨第六届中...

作者：汪沐阳 joana alves António alvesda Silva 杨维康 Kathreen E.Ruckstuhl 中国科学院新疆生态与地理研究所中国科学院干旱区生物地理与生物资源实验室葡萄牙科英布拉大学加拿大卡尔加里大学

许多性别体二型物种雌雄个体的行为与生态特征具有显著差异,这些差异被认为是导致同性聚群现象产生的主要因素。为此,在制定物种保护策略时,必须考虑两性截然不同的生态需求,这也是濒危物种保护管理工作中面临的主要困难之一。近几十年...

许多性别体二型物种雌雄个体的行为与生态特征具有显著差异,这些差异被认为是导致同性聚群现象产生的主要因素。为此,在制定物种保护策略时,必须考虑两性截然不同的生态需求,这也是濒危物种保护管理工作中面临的主要困难之一。近几十年来,众多学者为阐释同性聚群的近因和远因提出并发展了多个假说,其中基于栖息地分离的食物选择(性别体二型)假说和捕食风险(繁殖策略)假说,以及基于社会分离的

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