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转移的分子基础——癌症的分子起源

中华肺部疾病杂志（电子版） 2009年第2期2卷 93-99页

作者： Anne C. Chiang joan massagué 钟晓琴（译）李玉英（校） From the Department of Medicine the Cancer Biology and Genetics Program Howard Hughes Medical Institute 不详

转移（metastasis）是进化过程的最终产物，癌细胞与其微环境之间复杂的相互作用产生各种变化，使癌细胞出现不受控制的行为。因此肿瘤细胞充斥于新的组织，并最终导致器官功能障碍（organ dysfunction）或死亡。了解转移中的分子作用... 详细信息

转移（metastasis）是进化过程的最终产物，癌细胞与其微环境之间复杂的相互作用产生各种变化，使癌细胞出现不受控制的行为。因此肿瘤细胞充斥于新的组织，并最终导致器官功能障碍（organ dysfunction）或死亡。了解转移中的分子作用及过程可更加有效并能靶向性地预防和治疗癌转移。

关键词：癌转移分子基础癌症器官功能障碍相互作用肿瘤细胞分子作用癌细胞

Effect of the Density of Molten Metal on the Raining Phenomenon in Horizontal Centrifugal Casting

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Open Journal of Applied Sciences 2024年第7期14卷 1918-1926页

作者： Miguel A. Barron joan Reyes Departamento de Materiales Universidad Autonoma Metropolitana Azcapotzalco Ciudad de Mexico Mexico

In this work the influence of the density of the molten metal on the emergence of the raining phenomenon in the horizontal centrifugal casting process is numerically studied. Transient 2D numerical simulations were carried out using Computational Fluid Dynamics software. Three molten metals with different density, namely aluminum, iron and lead, and three angular frequencies, namely 50, 66 and 77 rad/s were considered. It is found that the density of the molten metal significantly affects the emergence, transient or permanent, of the rain phenomenon. However, the magnitude and duration of the rain phenomenon depend on the angular frequency of the rotating mold. Likewise, since gravitational forces affect the metal according to its density, the value of the critical rotation speed of the mold is also affected.

关键词： Angular Frequency Centrifugal Force Computational Fluid Dynamics Critical Rotation Speed G Factor Horizontal Centrifugal Casting Molten Metal Density

Lack of evidence for germline WWP1 pathogenic variants in gastrointestinal polyposis and other phenotypes suggestive of PTEN-hamartoma-tumor syndrome

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Genes & Diseases 2024年第2期11卷 524-527页

作者： Noemi Gonzalez-Abuin Tirso Pons Teresa Fuster Isabel Quintana Mariona Terradas Gemma Aiza joan Brunet Gabriel Capellá Heather Hampel Laura Valle Hereditary Cancer Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain Department of Immunology and Oncology National Center for BiotechnologySpanish National Research Council (CNB-CSIC)Madrid 28049Spain Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) Madrid 28029Spain Catalan Institute of Oncology IDIBGiGirona 17007Spain Division of Clinical Cancer Genomics Department of Medical Oncology & Therapeutic ResearchCity of Hope National Cancer CenterDuarteCA 91010USA

Germline activating variants in WWP1,which encodes an E3 ubiquitin ligase that antagonizes PTEN tumor suppressive function,have been proposed as an alternative mechanism of PTEN inactivation in PTEN-hamartoma-tumor syndrome(PHTS)-like patients with wildtype PTEN.1 More specifically,heterozygous,potentially activating wwP1 variants were first identified by Lee et al in patients affected with gastrointestinal oligopolyposis,including adenomatous,hyperplastic/serrated,and hamartomatous polyps,and occasionally with colorectal cancer(Table 1).Subsequently,based on the PHTS phenotypic features,wWP1 mutational screening was performed in patients with thyroid nodules,2 or normocephalic autism spectrum disorder(ASD),3 where germline WWP1 variants were also identified(Table S1).

关键词： WWP1 gastrointestinal polyposis

Rumen microbial degradation of bromoform from red seaweed(Asparagopsis taxiformis)and the impact on rumen fermentation and methanogenic archaea

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Journal of Animal Science and Biotechnology 2024年第1期15卷 412-426页

作者： Pedro Romero Alejandro Belanche Elisabeth Jiménez Rafael Hueso Eva Ramos-Morales joan King Salwen Ermias Kebreab David R.Yáñez-Ruiz Estacion Experimental del Zaidin Consejo Superior de Investigaciones Cientificas(CSIC)Profesor Albareda 1Granada 18008Spain Department of Animal Production and Food Sciences University of ZaragozaMiguel Servet 177Saragossa 50013Spain Blue Ocean Barns Inc. Redwood CityCAUSA Department of Animal Science University of CaliforniaDavisCA 95618USA

Background The red macroalgae Asparagopsis is an effective methanogenesis inhibitor due to the presence of halogenated methane(CH_(4))analogues,primarily bromoform(CHBr_(3)).This study aimed to investigate the degradation process of CHBr3 from A taxiformis in the rumen and whether this process is *** in vitro batch culture system was used according to a 2×2 factorial design,assessing two A taxiformis inclusion rates[0(CTL)and 2%DM diet(AT)]and two diets[high-concentrate(HC)and high-forage diet(HF)].Incubations lasted for 72 h and samples of headspace and fermentation liquid were taken at 0,0.5,1,3,6,8,12,16,24,48 and 72 h to assess the pattern of degradation of CHBr_(3) into dibromomethane(CH_(2)Br_(2))and fermentation ***,an in vitro experiment with pure cultures of seven methanogens strains(Methanobrevibacter smithii,Methanobrevibacter ruminantium,Methanosphaera stadtmanae,Methanosarcina barkeri,Methanobrevibacter millerae,Methanorhermobacter wolfei and Methanobacterium mobile)was conducted to test the effects of increasing concentrations of CHBr3(0.4,2,10and 50μmol/L).Results The addition of AT significantly decreased CH_(4) production(P=0.002)and the acetate:propionate ratio(P=0.003)during a 72-h *** concentrations of CHBr_(3) showed a rapid decrease with nearly 90%degraded within the first 3 h of *** the contrary,CH_(2)Br_(2) concentration quickly increased during the first 6 h and then gradually decreased towards the end of the *** CHBr_(3) degradation nor CH_(2)Br_(2) synthesis were affected by the type of diet used as substrate,suggesting that the fermentation rate is not a driving factor involved in CHBr_(3)*** in vitro culture of methanogens showed a dose-response effect of CHBr3 by inhibiting the growth of ***,***,***,***,***,***,and *** The present work demonstrated that CHBr_(3) from *** is quickly degrad

关键词： Bromoform metabolism Dibromomethane metabolism Methane mitigation Methanogens Rumen microbiota Seaweed

The Influence of Social Media on College Choice among Undergraduates Majoring in Big Data Management and Application in China:Taking Guilin University of Electronic Technology as an Example

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Journal of Contemporary Educational Research 2024年第10期8卷 128-138页

作者： Junchao Dong joan P.Lazaro Graduate School University of the EastManilaPhilippines

This study aims to investigate the influence of social media on college choice among undergraduates majoring in Big Data Management and Application in *** study attempts to reveal how information on social media platforms such as Weibo,WeChat,and Zhihu influences the cognition and choice process of prospective *** employing an online quantitative survey questionnaire,data were collected from the 2022 and 2023 classes of new students majoring in Big Data Management and Application at Guilin University of Electronic *** aim was to evaluate the role of social media in their college choice process and understand the features and information that most attract prospective *** media has become a key factor influencing the college choice decision-making of undergraduates majoring in Big Data Management and Application in *** tend to obtain school information through social media platforms and use this information as an important reference in their decision-making *** education institutions should strengthen their social media information dissemination,providing accurate,timely,and attractive *** is also necessary to ensure effective management of social media platforms,maintain a positive reputation for the school on social media,and increase the interest and trust of prospective ***,educational decision-makers should consider incorporating social media analysis into their recruitment strategies to better attract new student *** study provides a new perspective for understanding higher education choice behavior in the digital age,particularly by revealing the importance of social media in the educational decision-making *** has important practical and theoretical implications for higher education institutions,policymakers,and social media platform operators.

关键词： Social media Big Data Management and Application Undergraduate college choice Student decision-making behavior Chinese higher education

Temperature Drop of Molten Metals in Open Channels

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World Journal of Engineering and Technology 2024年第3期12卷 493-500页

作者： Miguel A. Barron-Meza joan Reyes-Miranda Departamento de Materiales Universidad Autonoma Metropolitana Azcapotzalco Ciudad de Mexico Mexico

The temperature drop of molten metal flowing in open channels is numerically determined. Rectangular, trapezoidal and triangular geometries are considered. The overall heat transfer coefficients for the bottom, side walls and free surface of the channel have been taken from the literature. For each geometry, the volumetric flow rate, mean residence time and temperature drop as a function of the channel inclination angle were determined. The rectangular and trapezoidal geometries present the smallest temperature drops, while the triangular geometry presents the greatest temperature drop. The factors that most affect this drop are the value of the free surface area of the channel, and the average residence time of the molten metal in the channel.

关键词： Free Surface Heat Transfer Molten Metal Open Channel Geometry Residence Time Temperature Drop

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Open Journal of Civil Engineering 2024年第2期14卷 214-224页

作者： joan Anyika Otike Charles Kabubo Victoria Okumu Kenya National Highways Authority Nairobi Kenya Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya

The performance of bridge projects in Kenya is poor in terms of completion by schedule, cost, and quality (scope). Yet, there is less evidence of empirical research on what factors contribute to this outcome. This study aimed to bridge this gap by examining the effects of contractor-related factors on the performance of bridge construction projects in Kenya through a case study of the Bridge projects Implemented by the Kenya National Highway Agency (KeNHA). The theory of constraints (TOC) was adopted as its theoretical framework. Descriptive research was used, and the target population was 18 bridge construction projects, which were the units of analysis from 2012 to 2022. In each of these projects, 18 respondents, namely clients, consultants, contractors, engineers, environment and social guards, project managers, stakeholders, subcontractors, technical advisors, and inspectors, were included in a target population of 144 respondents. A census was conducted and a structured questionnaire was administered from which a response rate of 68% was achieved. The information was analyzed using descriptive, correlation, and multiple linear regression analysis. The contractor-related factors considered in the study were staff and management factors. The findings indicated that staff and management factors had a positive and significant outcome on performance of bridge construction projects. The study recommends continuous training and a safe learning environment for staff to improve their skills and performance in future projects. The study also recommends that a special category for bridge contractors be created in Kenya’s National Construction Authority rankings to ensure that only qualified contractors implement the Bridge projects.

关键词： Staff Factors Management Factors Performance Bridge Projects KeNHA

Low-power SiPM readout BETA ASIC for space applications

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Nuclear Science and Techniques 2024年第3期35卷 153-169页

作者： Anand Sanmukh Sergio Gómez Albert Comerma joan Mauricio Rafel Manera Andreu Sanuy Daniel Guberman Roger Catala Albert Espinya Marina Orta Oscar de la Torre David Gascon Departament de Física Quàntica i Astrofísica(FQA) Institut de Ciències del Cosmos(ICCUB)Universitat de Barcelona(UB)08028 BarcelonaSpain Institut d’Estudis Espacials de Catalunya(IEEC) 08034 BarcelonaSpain Electronics Department Serra Hunter fellow at Polytechnic University of Catalonia(UPC)08019 BarcelonaSpain

The BETA application-specific integrated circuit(ASIC)is a fully programmable chip designed to amplify,shape and digitize the signal of up to 64 Silicon photomultiplier(SiPM)channels,with a power consumption of approximately~1 mW/*** to its dual-path gain,the BETA chip is capable of resolving single photoelectrons(phes)with a signal-to-noise ratio(SNR)>5 while simultaneously achieving a dynamic range of~4000 ***,BETA can provide a cost-effective solution for the readout of SiPMs in space missions and other applications with a maximum rate below 10 *** this study,we describe the key characteristics of the BETA ASIC and present an evaluation of the performance of its 16-channel version,which is implemented using 130 nm *** ASIC also contains two discriminators that can provide trigger signals with a time jitter down to 400 ps FWHM for 10 *** linearity error of the charge gain measurement was less than 2%for a dynamic range as large as 15 bits.

关键词： Radiation detectors Silicon photomultipliers Photon sensors Front-end electronics Mixed-mode ASICs Space technology

Severe respiratory syncytial virus disease

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Journal of Intensive Medicine 2024年第4期4卷 405-416页

作者： Yolanda Pena-López joan Sabater-Riera Prithvi Raj Microbiome Research Laboratory(MRL) Department of ImmunologyUniversity of Texas Southwestern Medical CenterDallasTXUSA Pediatric Critical Care Department Hospital Universitari Vall d’HebronBarcelonaSpain Global Health eCore Vall d’Hebron Institute of ResearchBarcelonaSpain Intensive Care Department Servei de Medicina IntensivaIDIBELL-Hospital Universitari de BellvitgeL´Hospitalet de LlobregatBarcelonaSpain Bellvitge Biomedical Research Institute(IDIBELL) L’Hospitalet de LlobregatBarcelonaSpain

The burden of respiratory syncytial virus(RSV)disease is widely *** risk factors for severe disease,such as extreme ages,chronic cardiopulmonary conditions,and immunosuppression,typically coincide withpoorer *** the majority of RSV hospitalizations involve healthy children,a higher proportion ofhospitalized adults with underlying conditions need intensive ***,treatment primarily consists ofsupportive ***-induced wheezing should be distinguished from respiratory tract thickening,withoutresponse to *** RSV disease frequently overlaps with viral ***-invasivemechanical ventilation and high-flow oxygen therapy represented significant advancements in the managementof severe RSV disease in children and may also hold considerable importance in specific phenotypes of RSV diseasein *** severe infections manifest with refractory hypoxemia necessitating more advanced ventilatorysupport and/or extracorporeal membrane oxygenation *** bacterial co-infection rates are low,they have been associated with worse *** prescription rates are *** diagnosingbacterial co-infections remains a *** evidence and antibiotic stewardship policies advise againstindiscriminate antibiotic usage,even in severe *** role of currently developing antiviral therapies in severeRSV disease will be elucidated in the coming years,contingent upon the success of new vaccines and immunepassive strategies involving nirsevimab.

关键词： RSV Bronchiolitis Co-infection Pneumonia ARDS Respiratory failure