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Expression of c-kit receptor in human cholangiocarcinoma and in vivo treatment with imatinib mesilate in chimeric mice

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World Journal of Gastroenterology 2006年第10期12卷 1583-1590页

作者： Thomas Kamenz Karel Caca Thilo Blüthner Andrea Tannapfel joachim mssner marcus Wiedmann Department of Internal medicine Ⅱ University of Leipzig Philipp-Rosenthal-Str.2704103 LeipzigGermany Institute of Pathology University of Leipzig Liebigstr.2604103 LeipzigGermany

AIm： To investigate the c-kit expression in biliary tract cancer cell lines and histological sections from patients with extrahepatic cholangiocarcinoma （CC） and to evaluate the efficacy of in vitro and in vitro treatment with imatinib mesilate. mETHODS： The protein expression of c-kit in the human biliary tract cancer cell lines mz-ChA-2 and EGI-1 and histological sections from 19 patients with extrahepatic CC was assessed by immunoblotting, immunocytochemistry, and immunohistochemistry. The anti-proliferative effect of imatinib mesilate on biliary tract cancer cell lines mz-ChA-2 and EGI-1 was studied in vitro by automated cell counting. In addition, immunodeficient NmRI mice （Taconic^Tm） were subcutaneously injected with 5 × 10^6 cells of cell lines mzChA-2 and EGI-1. After having reached a tumour volume of 200 mm^3, daily treatment was started intraperitoneally with imatinib mesilate at a dose of 50 mgikg or normal saline （NS）. Tumor volume was calculated with a Vernier caliper. After 14 d, mice were sacrificed with tumors excised and tumor mass determined.RESULTS： Immunoblotting revealed presence of c-kit in mz-ChA-2 and absence in EGI-1 cells. Immunocytochemistry with c-kit antibodies displayed a cytoplasmatic and membraneous localization of receptor protein in mz-ChA-2 cells and absence of c-kit in EGI-1 cells, c-kit was expressed in 7 of 19 （37%） extrahepatic humanCC tissue samples, 2 showed a moderate and 5 a rather weak immunostaining. Imatinib mesilate at a low concentration of 5 μmoliL caused a significant growth inhibition in the c-kit positive cell line mz-ChA-2 （31%）, but not in the c-kit negative cell line EGI-1 （0%）（P〈0.05）. Imatinib mesilate at an intermediate concentration of 10 μmoliL inhibited cellular growth of both cell lines （51% vs 57%）. Imatinib mesilate at a higher concentration of 20 μmoliL seemed to have a general toxic effect on both cell lines. The IC50 values were 9.7 μmoliL and 11 μmoliL, respectively. After 14 d of in vitro treat

关键词： Cholangiocarcinoma Imatinib Tyrosine kinase inhibitor c-kit Chimeric mice

Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis

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World Journal of Gastroenterology 2005年第44期11卷 7001-7006页

作者： Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia morgenstern joachim m(o|¨)ssner Stephan Schreiber maurizio Vecchi Alberto malesci max Reinshagen Robert L(o|¨)fberg Evangelisches Krankenhaus Kalk medizinische Klinik für Hepatologie und Gastroenterologie medizinische Klinik und Poliklinik Ⅱ medizinische Klinik Dep of Int medicine IRCCS Ospedale Policlinico Istituto Clinico Humanitas Innere medizin Karolinska Institute at the IBD unit

AIm： To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy. mETHODS： An open label multicenter study was carried out in 39 patients with active ulcerative colitis （CAI 6-8） despite continuous use of steroids （a minimum total dose of 400 mg prednisone within the last 4 wk）. Patients received a total of five aphereses using a granulocyte adsorptive technique （Adacolumn, Otsuka Pharmaceutical Europe, UK）. Assessments at wk 6 and during follow-up until 4 mo comprised clinical （CAI） and endoscopic （EI） activity index, histology, quality of life （IBDQ）, and laboratory tests. RESULTS： Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 （37.1%） patients achieved clinical remission and 10/35 （28.6%） patients had endoscopic remission （CAI〈4, EI〈4）. Quality of life （IBDQ） increased significantly （24 points, P〈0.01） at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia. CONCLUSION： In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/ monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent.

关键词： Steroid Refractory colitis Ulcerative colitis Granulocyte Apheresis

Prevalence and intensity of urinary schistosomiasis and soil-transmitted helminths among women of reproductive age in mwaluphamba,Kwale

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Asian Pacific Journal of Tropical medicine 2024年第2期17卷 71-83页

作者： Samuel m.Ngui Joseph m.mwangangi joachim Richter Josephine W.Ngunjiri Department of Biological Sciences University of EmbuKenya medical Entomology Kenya Medical Research Institute(KEMRI)Center for Geographic Medicine Research Coast KilifiKenya Institute of International Health Global Health CenterCharitéUniversity MedicineBerlinCorporate Member of Free University and Humboldt University and Berlin Institute of HealthBerlinGermany Swiss Tropical and Public Health Institute BaselSwitzerland Tropical and Infectious Diseases Department of Biological sciencesUniversity of EmbuKenya

Objective:To assess the epidemiology of urinary schistosomiasis and soil-transmitted helminthiasis among women of reproductive age in mwaluphamba,Kwale County,***:A community-based cross-sectional study design was employed to randomly sample 422 women of reproductive age(15-m four villages in mwaluphamba *** specimens were collected and examined using the Kato-Katz method,while filtration technique was used to analyze urine ***’sociodemographic details were obtained using a standardized ***:Urinary schistosomiasis prevalence was at 4.7%(20/422,95%CI 2.8%-6.9%)while the prevalence of soil-transmitted helminthiasis infection was 4.5%(19/422,95%CI 2.6%-6.7%).The infection intensities of urinary schistosomiasis among the study participants ranged from 1 to 120 eggs/10 mL of urine with median egg count of 18.45 eggs/10 *** patients were diagnosed with light infection,of 56.16 egg/gram and 48.48 egg/gram for Trichuris trichiura and hookworms,*** without latrines had 15.7 times higher risk of having urinary schistosomiasis compared to those with a ***,use of surface water(aOR=1.0,95%CI 0.2-1.4,P=0.010)and crossing the river to go to a place(aOR=1.1,95%CI 0.3-1.6,P=0.009)were statistically significant risk factors for getting urinary *** bivariable regression analysis,defecating around the water source(OR=4.3,95%CI 1.5-12.9)had a statistically significant association with the prevalence of soil-transmitted helminthiasis(P=0.008).Conclusions:This study has given an insight on the prevalence and intensity of urinary schistosomiasis and soil-transmitted helminthiasis in mwaluphamba location that form a basis for strengthening the control and elimination programmes for these neglected tropical diseases.

关键词： Urinary schistosomiasis Prevalence Soiltransmitted helminths mwaluphamba

Apoer2/Lrp8:the undercover cop of synaptic homeostasis

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Neural Regeneration Research 2024年第12期19卷 2563-2564页

作者： Gordon C.Werthmann joachim Herz Department of molecular Genetics and Center for Translational Neurodegeneration Research University of Texas Southwestern Medical Center at DallasDallasTXUSA Department of Neuroscience Department of Neurology University of Texas Southwestern medical Center at Dallas DallasTXUSA

Apolipoprotein E receptor 2(ApoER2)is a receptor for the protein ApoE,the most common genetic risk factor for late-onset Alzheimer's disease(AD).It is also a key modulator of syna ptic homeostasis,in part through its effect on the expression of neuronal genes including those implicated in AD and other neuropsychiatric *** this perspective,we highlight several genes affected by ApoER2 and its alternatively spliced forms and how aberrant expression can be rescued by the reintroduction of the ApoER2 intracellular domain in the mouse hippocampus.

关键词： homeostasis ApoE Alzheimer

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Does HSP27 injection induce glaucoma damage in mice?

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Neural Regeneration Research 2024年第11期19卷 2347-2348页

作者： Stephanie C.joachim Sabrina Reinehr Experimental Eye Research Institute University Eye HospitalRuhr-University BochumBochumGermany

In a further aging society,excellent eyesight is an integral part of overall well-being and quality of *** good vision is crucial to maintaining mobility,independence,and mental *** can be several reasons for visual impairment in elderly people,these include age-related macular degeneration,the leading cause of vision loss among older adults,cataract,glaucoma,diabetic retinopathy,retinal detachment,and others.

关键词： HSP27 injection damage

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The whole and its parts: Visualizing Gaussian mixture models

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Visual Informatics 2024年第2期8卷 67-79页

作者： joachim Giesen Philipp Lucas Linda Pfeiffer Laines Schmalwasser Kai Lawonn Friedrich-Schiller-University Jena Germany German Aerospace Center DLR-Institute of Data Science Jena Germany

Gaussian mixture models are classical but still popular machine learning *** appealing feature of Gaussian mixture models is their tractability,that is,they can be learned efficiently and exactly from data,and also support efficient exact inference queries like soft clustering data *** seemingly simple,Gaussian mixture models can be hard to *** are at least four aspects to understanding Gaussian mixture models,namely,understanding the whole distribution,its individual parts(mixture components),the relationships between the parts,and the interplay of the whole and its *** a structured literature review of applications of Gaussian mixture models,we found the need for supporting all four *** identify candidate visualizations that effectively aid the user needs,we structure the available design space along three different representations of Gaussian mixture models,namely as functions,sets of parameters,and sampling *** the design space,we implemented three design concepts that visualize the overall distribution together with its ***,we assessed the practical usefulness of the design concepts with respect to the different user needs in expert interviews and an insight-based user study.

关键词： Gaussian mixture models

Building Blocks of Nature

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第3期10卷 1226-1303页

作者： Hans joachim Dudek Retired Auf dem Komp Germany

By means of a representation of the elementary objects by the Lagrange density and by the commutators of the communication relations, correlations can be formed using the Fourier transform, which under the conditions of the Hamilton principle, describes correlation structures of the elementary objects with oscillator properties. The correlation structures obtained in this way are characterized by physical information, the essential component of which is the action. The correlation structures describe the physical properties and their interactions under the sole condition of the Hamilton’s principle. The structure, the properties and the interactions of elementary objects can be led back in this way to a fundamental four dimensional structure, which is therefore in their different modifications the building block of nature. With the presented method, an alternative interpretation of elementary physical effects to quantum mechanics is obtained. This report provides an overview of the fundamentals and statements of physical information theory and its consequences for understanding the nature of elementary objects.

关键词： Hamilton Principle as Global Law in Physics Physical Information Generated by Action Correlation Space mass and Charge Formation Interpretation of Physical Effects

矩形边界限定形式的感应电机低开关频率预测控制研究

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中国电机工程学报 2024年第8期44卷 3278-3286,I0029页

作者：齐昕张家宁 HOLTZ joachim 田柏轩任佳仕王辰宇周珂北京科技大学机械工程学院北京市海淀区100083 伍珀塔尔大学电机与驱动实验室德国伍伯塔尔42119 北京科技大学顺德研究生院广东省佛山市528399 北京科技大学高等工程师学院北京市海淀区100083

圆形边界限定形式预测控制对电流畸变的限定在各方向均相同,无法通过增大边界圆半径进一步降低开关频率。因此,该文提出一种矩形边界限定形式的预测控制方法。首先,深入分析感应电机数学模型,发现感应电机转子子系统的低通物理特性,以... 详细信息

圆形边界限定形式预测控制对电流畸变的限定在各方向均相同,无法通过增大边界圆半径进一步降低开关频率。因此,该文提出一种矩形边界限定形式的预测控制方法。首先,深入分析感应电机数学模型,发现感应电机转子子系统的低通物理特性,以及励磁电流波动对电磁转矩的影响不显著;其次,利用该特性,将限定边界改为矩形,对转矩电流与励磁电流进行独立约束,适度增加励磁电流畸变允许限值,扩大电流轨迹运动范围,延长开关状态切换时长;再次,探究电流矢量梯度同边界约束间的数学关系,提出该方法下电压矢量筛选与寻优准则,筛选出最优矢量;最终,进行实验对比。实验结果证明,在相同系统动态特性和转矩波动下,相较于圆形边界限定策略,矩形边界限定策略可以进一步降低开关频率。

关键词：矩形边界低开关频率预测控制感应电机

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The effect of Laves phases and nano-precipitates on the electrochemical corrosion resistance of mg-Al-Ca alloys under alkaline conditions

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Journal of magnesium and Alloys 2024年第6期12卷 2447-2461页

作者： markus Felten Veronika Chaineux Siyuan Zhang Ali Tehranchi Tilmann Hickel Christina Scheu Joshua Spille marta Lipińska-Chwałek joachim mayer Benjamin Berkels marcus Hans Imke Greving Silja Flenner Sandra Sefa Daniela Zander Chair of Corrosion and Corrosion Protection RWTH Aachen UniversityAachen 52072 Germany max-Planck-Institut für Eisenforschung GmbH Düsseldorf 40237 Germany Central Facility for Electron microscopy RWTH Aachen UniversityAachen 52074 Germany Ernst Ruska-Centre for microscopy and Spectroscopy with Electrons Forschungszentrum Jülich GmbHJülich 52428Germany mathematical Image and Signal Processing Aachen Institute for Advanced Study in Computational Engineering ScienceRWTH Aachen UniversityAachen 52062 Germany materials Chemistry RWTH Aachen UniversityAachen 52074 Germany Institute of materials Physics Helmholtz-Zentrum HereonGeesthacht 21502 Germany

The electrochemical corrosion mechanisms of mg alloys were extensively studied in previous investigations of different chemical com-positions,modified surface states and various electrolyte ***,recent research focused on the active state of mg dissolution,leading to unresolved effects of secondary phases adjacent to a stableα-solid solution passive *** present study investigates the fundamental electrochemical corrosion mechanisms of three different Laves phases with varying phase morphologies and phase fractions in the passive state of mg-Al-Ca *** microstructure was characterized by(transmission-)electron microscopy and synchrotron-based transmission X-ray *** electrochemical corrosion resistance was determined with a standard three-electrode setup and advanced in-situ flow cell measurements.A new electrochemical activity sequence(C15>C36>α-mg>C14)was obtained,as a result of a stable passive layer formation on theα-solid ***,nm-scale mg-rich precipitates were identified within the Laves phases,which tend to inhibit the corrosion kinetics.

关键词： Laves phase STEm magnesium Corrosion Passive layer

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