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Global burden and drivers of hyperglycemia:Estimates and predictions from 1990 to 2050

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The Innovation 2023年第4期4卷 29-38页

作者： Hui-Ling Qiu Shujun Fan Kaixin Zhou Zhini He Matthew H.E.M.Browning Luke D.Knibbs Tianyu Zhao Ya-Na Luo Xiao-Xuan Liu Li-Xin Hu Jia-Xin Li Yi-Dan Zhang Yu-Ting Xie joachim heinrich Guang-Hui Dong Bo-Yi Yang Department of Occupational and Environmental Health School of Public HealthSun Yat-sen UniversityGuangzhou 510080China Guangzhou Joint Research Center for Disease Surveillance and Risk Assessment Guangzhou Center for Disease Control and PreventionGuangzhou 510440China Institute of Public Health Guangzhou Medical University&Guangzhou Center for Disease Control and PreventionGuangzhou 511436China College of Life Sciences University of Chinese Academy of SciencesBeijing 101408China Food Safety and Health Research Center Guangdong Provincial Key Laboratory of Tropical Disease ResearchGuangzhouGuangdongChina School of Public Health Southern Medical UniversityGuangzhou 510515China Department of Parks Recreation and Tourism ManagementClemson UniversityClemsonSC 29634USA School of Public Health The University of SydneyCamperdownNSW 2006Australia Institute of Epidemiology Helmholtz Zentrum M€unchen85764 NeuherbergGermany Institute of Epidemiology Helmholtz Zentrum Müunchen-German Research Centre for Environmental Health85764 NeuherbergGermany Institute and Clinic for Occupational Social and Environmental MedicineUniversity HospitalLudwig Maximilians University of MunichMunichGermany Allergy and Lung Health Unit Centre for Epidemiology and BiostatisticsSchool of Population and Global HealthThe University of MelbourneMelbourneVIC 3010Australia

Hyperglycemia is a key risk factor for death and disability *** better inform prevention strategies,we aimed to delineate and predict the temporal,spatial,and demographic patterns in mean fasting plasma glucose(FPG)levels and their related disease burden *** on the Global Burden of Disease Study 2019,we estimated the distributions of mean FPG levels and high FPG-related disease burden by age,sex,year,socioeconomic status(SES),and geographical region from 1990 to 2050.

关键词： prevention FPG death

Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al-Hasani joachim Altschmied Katharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

The ultimate goal of modeling—Simulation of system and plant performance

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Particuology 2011年第4期9卷 320-329页

作者： joachim Werther Stefan heinrich Maksym Dosta Ernst-Ulrich Hartge Institute of Solids Process Engineering and Particle Technology Hamburg University of Technology

Modern production processes in chemical, pharmaceutical and biological industries are characterized by complex process structures, which consist of different apparatuses and process steps. Modeling the entire process requires simulating all units altogether, while taking into account interconnections between them, Nevertheless, in the area of solids processing, there is nowadays an unfilled gap from the side of computer support of process modeling in allowing effective optimization and prediction of the behavior of the whole plant, This paper presents a tool for flowsheet simulation which allows the simulation of the stationary behavior of complex processes dealing with solids and its extension towards dynamic modeling, Also, a new simulation concept is proposed on the basis of the multiscale approach. On the macroscale, fiowsheet simulation is performed with the help of the SolidSim system. Parameters for the macromodels in Solid-Sim are predicted by microscale simulation. The models for the two scales are then coupled by inter-scale communication laws. Application of the proposed modeling concept is shown by an example of fluidized bed granulation.

关键词： Flowsheet simulation Multiscale modeling Plant performance Solids processes Granulation

儿童早期空气污染与呼吸道感染:ESCAPE项目中10个欧洲出生队列的分析

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环境与职业医学 2014年第3期31卷 202-202页

作者： Elaina A.MacIntyre Ulrike Gehring Anna Molter Elaine Fuertes Claudia Klümper Ursula Kramer Ulrich Quass Barbara Hoffmann Mireia Gascon Bert Brunekreef Gerard H.Koppelman Rob Beelen Gerard Hoek Matthias Birk Johan C.de Jongste H.A.Smit Josef Cyrys Olena Gruzieva Michal Korek Anna Bergstrom Raymond M.Agius Frank de Vocht Angela Simpson Daniela Porta Francesco Forastiere Chiara Badaloni Giulia Cesaroni Ana Esplugues Ana Fernández-Somoano Aitana Lerxundi Jordi Sunyer Marta Cirach Mark J.Nieuwenhuijsen Goran Pershagen joachim heinrich

[背景]将交通源空气污染作为幼儿期呼吸道感染的危险因素的研究很少。[目的]在10个欧洲出生队列——BAMSE（瑞典）、GASPⅡ（意大利）、GINIplus和LISAplus（德国）、MAAS（英国）、PIAMA（荷兰）和4个INMA队列（西班牙）——中研究空... 详细信息

[背景]将交通源空气污染作为幼儿期呼吸道感染的危险因素的研究很少。[目的]在10个欧洲出生队列——BAMSE（瑞典）、GASPⅡ（意大利）、GINIplus和LISAplus（德国）、MAAS（英国）、PIAMA（荷兰）和4个INMA队列（西班牙）——中研究空气污染与肺炎、哮喘及中耳炎之间的相关性，并使用meta分析得出综合效应估值。[方法]评价家长报告的医师诊断的儿童早期肺炎、中耳炎以及哮喘与全年平均污染物水平[二氧化氮（NO2）、氮氧化物（NOx）、≤2．5gm的颗粒物（PM2.5）、PM2.5吸光度、PM10、PM2.5-10（粗PM）]间的关联，污染物浓度的估计采用土地利用回归模型并根据孩子的出生住址分配。作为ESCAPE项目的一部分，每个研究区域都采用相同的方案建立回归模型。用logistic回归来计算每个研究校正后的效应估值，用随机效应meta分析来计算合并的估计值。[结果]除了PM2.5外的所有污染物，肺炎的合并校正优势比（OR）均升高（例如，N02每增加10μg／m3，OR=1．30，95％CI：1．02～1．65；PM10每增加10μg／m3的OR=1．76，95％CI：1．00—3．09）。对于中耳炎和哮喘，除了NO2与中耳炎问的关联（每10μg／m3对应的OR=1．09，95％CI：1．02～1．16），所有分析的结果均无显著性。[结论]对ESCAPE项目中10个欧洲出生队列进行的meta分析为空气污染和儿童早期肺炎之间的相关性找到一致性的证据，也为与中耳炎间的相关性找到了一些证据。

关键词：早期肺炎呼吸道感染出生队列空气污染欧洲儿童 meta分析 logistic

Human iPSC-derived iMSCs improve bone regeneration in mini-pigs

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Bone Research 2019年第4期7卷 399-409页

作者： Pascal Jungbluth Lucas-Sebastian Spitzhorn Jan Grassmann Stephan Tanner David Latz Md Shaifur Rahman Martina Bohndorf Wasco Wruck Martin Sager Vera Grotheer Patric Kropil Mohssen Hakimi joachim Windolf Johannes Schneppendahl James Adjaye Department of Trauma and Hand Surgery Heinrich Heine University Hospital DüsseldorfMoorenstr.540225 DüsseldorfGermany Institute for Stem Cell Research and Regenerative Medicine Medical FacultyHeinrich Heine UniversityDüsseldorfMoorenstr.540225 DüsseldorfGermany Animal Research Institute Heinrich Heine UniversityDüsseldorfMoorenstr.540225 DüsseldorfGermany Department of Diagnostic and Interventional Radiology Medical FacultyHeinrich Heine UniversityDüsseldorfMoorenstr.540225 DüsseldorfGermany Vivantes Klinikum Am Urban Dieffenbachstraβe 110967 BerlinGermany

Autologous bone marrow concentrate(BMC)and mesenchymal stem cells(MSCs)have beneficial effects on the healing of bone *** address the shortcomings associated with the use of primary MSCs,induced pluripotent stem cell(iPSC)-derived MSCs(iMSCs)have been proposed as an *** aim of this study was to investigate the bone regeneration potential of human iMSCs combined with calcium phosphate granules(CPG)in critical-size defects in the proximal tibias of mini-pigs in the early phase of bone healing compared to that of a previously reported autograft treatment and treatment with a composite made of either a combination of autologous BMC and CPG or CPG *** were derived from iPSCs originating from human fetal foreskin fibroblasts(HFFs).They were able to differentiate into osteoblasts in vitro,express a plethora of bone morphogenic proteins(BMPs)and secrete paracrine signaling-associated cytokines such as PDGF-AA and *** and histomorphometrically,HFF-iMSC+CPG transplantation resulted in significantly better osseous consolidation than the transplantation of CPG alone and produced no significantly different outcomes compared to the transplantation of autologous BMC+CPG after 6 *** results of this translational study imply that iMSCs represent a valuable future treatment option for load-bearing bone defects in humans.

关键词： healing alone treatment

Phosphorus status, use and recycling in a Chinese peri-urban region with intensive animal husbandry and cropping systems Results from case study in a Sino-German applied research collaboration project

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Frontiers of Agricultural Science and Engineering 2019年第4期6卷 388-402页

作者： Marco ROELCKE Lisa HEIMANN Yong HOU Jianbin GUO Qiaoyun XUE Wei JIA Anne OSTERMANN Roxana Mendoza HUAITALLA Moritz ENGBERS Clemens OLBRICH Roland W.SCHOLZ joachim CLEMENS Frank SCHUCHARDT Rolf NIEDER Xuejun LIU Fusuo ZHANG Institute of Geoecology Technische Universitat Braunschweig38106 BraunschweigGermany Institute of Crop Science University of Hohenheim70599 StuttgartGermany College of Resources and Environmental Sciences China Agricultural UniversityBeijing 100193China College of Engineering China Agricultural UniversityBeijing 100094China Editorial Committee&Editorial Office of PEDOSPHERE Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China China Agricultural Science and Technology Press Chinese Academy of Agricultural SciencesBeijing 100081China Institute for Crop and Soil Science Julius Kuhn Institute(JKI)-Federal Research Centre for Cultivated Plants38116 BraunschweigGermany Institute of Agricultural Engineering University of Hohenheim70599 Institute of Ethics and Transdisciplinary Sustainability Research Leuphana University of Ltineburg21335 LiineburgGermany Department of Business Administration Economics and LawCarl von Ossietzky University of Oldenburg26129 OldenburgGermany Department for Knowledge and Communication Management Danube University Krems3500 KremsAustria SF-Soepenberg GmbH 46569 HiinxeGermany Institute of Agricultural Technology Johann Heinrich von Thiinen Institute(TI)-Federal Research Institute for Rural AreasForestry and Fisheries38116 BraunschweigGermany

The Sino-German research collaboration project,"Recycling of organic residues from agricultural and municipal origin in China"(2008–2012),comprising different interdisciplinary research groups,and also German small and medium-sized enterprises,aimed at developing integrated strategies and solutions for the recycling of organic residues in *** an intensive crop-livestock agricultural region in the Shunyi District of Beijing,five typical cropping systems were *** research was conducted in the form of analyses of phosphorus(P)in soil,plants,animal feed,animal products,manures,mineral and organic fertilizers and the derivation of the corresponding nutrient balances and P *** mean annual P balance surplus was492 kg·ha–1·yr–1 P for the vegetable production system,significantly higher(P30 mg·kg–1)that can lead to increased risk of P loss was exceeded in all five cropping *** feed additives,the"natural background value"(Chinese Environmental Quality Standard for Soils)of copper and zinc in topsoils was exceeded at several *** for several substances in the veterinary antibiotic classes of sulfonamides,tetracyclines,and fluoroquinolones revealed widespread topsoil *** livestock densities were 10.6 livestock units per ha arable land in *** husbandry is increasingly conducted in large operations,making traditional ways of reuse difficult to *** three management systems for treatment of organic

关键词： cropping systems life cycle assessment North China Plain balances and nutrient flows transdisciplinary approach