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Anti-Anaemic Activity and Potential Toxicity of Extracts of Four Tinctorial Plants Used in the Treatment of Anemia in Benin: Gossypium barbadense, Sorghum bicolor, Hibiscus sabdariffa and Justicia secunda

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American Journal of Plant Sciences 2022年第12期13卷 1460-1477页

作者： Louis Fagbohoun gbènagnon C. Nonvidé Aziz Sina Orou Alban Houngbèmè Amoussatou Sakirigui Felix Gunin joachim Djimon gbénou Kaba Research Laboratory in Chemistry and Applications (LaKReCA) National University of Sciences Technologies Engineering and Mathematics Abomey Benin Laboratory of Biologie and Molecular Typing in Microbiology Department of Biochemistry and Cell Biology Univessity of Abomey-Calavi Abomey-Calavi Benin Laboratory of Pharmacognosy and Essential Oils Department of Chemistry University of Abomey-Calavi Abomey-Calavi Benin

Justicia secunda, Sorghum bicolor, Gossypiun barbadense and Hibiscus sabdariffa are dye plants traditionally used in Benin for the treatment of anemia. This work is part of the therapeutic valorization of dyes from these plants. Its objective is to characterize their composition in chemical groups and evaluate their harmlessness and their anti-anaemic property in laboratory rats. Anemia was induced in Wistar rats by phenylhydrazine hydrochloride followed by treatment by gavage with hydroethanolic extracts of the plants studied. Phytochemical screening of these extracts made it possible to characterize the major chemical groups, in particular alkaloids, polyphenols including tannins, flavonoids and leucoanthocyanins, as well as reducing compounds and saponosides in the plants studied. Cytotoxic analysis of these extracts on Artemia salina shrimp larvae revealed globally high LC50 values of between 3.14 and 4.64 mg/mL, which testify a priori to the harmlessness of these extracts. The administration of the hydroethanolic extract of each plant to anaemic rats at doses of 2000 mg/kg/d promoted, after 15 days, an increase in hemoglobin levels, the number of red blood cells and hematocrit, going to more than 90% recovery of the hematological parameters involved. The highest rate, 99.06% being that of the species Justicia secunda followed closely by Sorghum bicolor (96.80%) compared to 93.93% obtained by treatment with the Ranferon-12 positive control used. Indeed, these results confirm the therapeutic indication of these plants in the resorption of anemia in traditional medicine.

关键词： Anemia Resorption Tinctorial Plants Phytochemistry Benin

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Physical and Technological Parameters of Maize Varieties (Zea mays L.) Grown in the Southern Parts of Benin and the Influence of Chemical Composition

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Food and Nutrition Sciences 2016年第14期7卷 1386-1400页

作者： Josiane Adjobignon Semassa Victor Bienvenu Anihouvi Adolphe Adjanohoun Wilfrid Padonou joachim gbénou Lamine Baba-Moussa Laboratoire des Sciences des Aliments Faculté des Sciences Agronomiques Université d’Abomey-Calavi Cotonou Bénin Laboratoire de Biologie et de Typage Moléculaire en Microbiologie Département de Biochimie et de Biologie Cellulaire Université d’Abomey-Calavi Cotonou Bénin Centre de Recherches Agricoles Sud Institut National des Recherches Agricoles du Bénin Attogon Bénin Programme Technologie Agricole et Alimentaire Centre de Recherches Agricoles d’Agonkanmey Institut National des Recherches Agricoles du Bénin Abomey-Calavi Bénin Laboratoire de Pharmacognosie et des huiles essentielles Faculté des Sciences et Techniques Université d’Abomey-Calavi Cotonou Bénin

Objective: The study aims to investigate some physical and technological parameters of varieties of maize collected from the most representative areas of maize production in the southern part of Benin, and mainly used by the populations of those areas. Method: The chemical composition, physical and technological characteristics of the grains were determined using standard methods. Results: The results showed that the weight of 1000 grains ranges from 158.01 to 305.12 g, the length from 0.79 to 1.81 cm, the average width from 0.74 to 1.51 cm, thickness from 0.36 to 0.85 cm and density from 1.07 to 1.25. Regarding the technological parameters, the hardness of the grains before and after cooking was between 16.78 and 47.20 kgf, and 0.23 and 0.71 kgf respectively, while the cooking time varies from 71.00 and 158.33 mn. There was a positive and significant correlation (r = 0.405;p < 0.026) between the hardness after cooking and the weight of 1000 grains, between the hardness after cooking and grain width (r = 0.460;p < 0.011). A positive and highly significant correlation (r = 0.527, p < 0.003) was also observed between the hardness after cooking and the grain length, between the hardness after cooking and the thickness of grain (r = 0.476, p < 0.008), and between the grain density and the weight of 1000 grains (r = 0.481, p < 0.007). A positive and highly significant correlation (r = 0.923, p < 0.000) was also observed between maize grain length and width, and between grain length and grain thickness (r = 0.764, p < 0.000) and between the width and thickness (r = 0.764, p < 0.000). On the other hand, a significant negative correlation (r = -0.394, p < 0.031) was found between the hardness before cooking and the thickness and between the hardness before cooking and sphericity index (r = -0465*, p Conclusion: Through its chemical and technological characteristics the maize constitutes an important raw material for many culinary recipes in West African region.

关键词： Maize Physical Characteristics Technological Parameters Chemical Parameters

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Phytochemical Screening, Nutritional and Toxicological Analyses of Leaves and Fruits of <i>Solanum macrocarpon</i>Linn (Solanaceae) in Cotonou (Benin)

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Food and Nutrition Sciences 2012年第11期3卷 1595-1603页

作者： Tamègnon Victorien Dougnon Honoré Sourou Bankolé Roch Christian Johnson Jean Robert Klotoé Godfried Dougnon Fernand gbaguidi Fidèle Assogba joachim gbénou Salifou Sahidou Jean-Marc Atègbo Bertrand Henri Rhin Frédéric Loko Michel Boko Aléodjrodo Patrick Edorh Department of Animal Physiology Faculty of Science and Technology University of Abomey-Calavi (UAC) Cotonou Benin Laboratory of Pharmacognosy and Essentials Oils Institute of Applied Biomedical Sciences Champ de Foire Cotonou Benin Laboratory of Toxicology and Environmental Health Interfaculty Center of Formation and Research in Environment for the Sustainable Development University of Abomey-Calavi (UAC) Cotonou Benin National Laboratory of Pharmacognosy Benin Center of Scientific and Technical Research and Essential Oils Porto-Novo Benin Research Laboratory in Applied Biology Polytechnic School of Abomey-Calavi University of Abomey-Calavi Cotonou Benin Unit Inserm U525 Faculty of Pharmacy Nancy France Unit of Training and Research in Pharmacy Faculty of Health Sciences Champ de Foire Cotonou Benin

Vegetables are very important sources of protein and minerals. Some of them even have medicinal properties recognized traditionally. Despite the large number of studies carried out on various vegetables and vegetable crops, very few have scientifically explored the usefulness of S. macrocarpon. This study identified the main groups of chemicals and mineral elements to explain any medicinal or nutritional value. It has also identified some toxic elements contained in this vegetable. Phytochemical screening was carried out on the leaves and fruits of S. macrocarpon. Some mineral elements were determined by Atomic Absorption Spectrophotometry (sodium, potassium, calcium, magnesium) while protein, phosphorous, iron, copper, zinc and toxic metals (lead, cadmium) were determined by Molecular Absorption Spectrophotometry. Fat, ash, moisture and vitamins were sought. The study showed that the leaves of S. macrocarpon were more nutritious than fruits (P macrocarpon require that the consumption of vegetables should be as varied as possible and that the fruit may be consumed with caution. In addition, constraints about vegetable cultivation in Cotonou could lead to research findings that could help provide techniques for producing healthy *** A and K1 were found in both parts of this vegetable very rich in water while vitamin E has not been detected. S. macrocarpon also contains lipids at various levels.

关键词： S. macrocarpon Nutrients Minerals Lead Cadmium Cotonou

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Anti-Anaemic Activity and Potential Toxicity of Extracts of Four Tinctorial Plants Used in the Treatment of Anemia in Benin: Gossypium barbadense , Sorghum bicolor ,Hibiscus sabdariffa and Justicia secunda

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American Journal of Plant Sciences（美国植物学期刊） 2022年第12期

作者： Louis Fagbohoun gbènagnonC.Nonvidé Aziz Sina Orou AlbanHoungbèmè Amoussatou Sakirigui Felix Gunin joachim Djimon gbénou

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Apoer2/Lrp8:the undercover cop of synaptic homeostasis

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Neural Regeneration Research 2024年第12期19卷 2563-2564页

作者： Gordon C.Werthmann joachim Herz Department of Molecular Genetics and Center for Translational Neurodegeneration Research University of Texas Southwestern Medical Center at DallasDallasTXUSA Department of Neuroscience Department of Neurology University of Texas Southwestern Medical Center at Dallas DallasTXUSA

Apolipoprotein E receptor 2(ApoER2)is a receptor for the protein ApoE,the most common genetic risk factor for late-onset Alzheimer's disease(AD).It is also a key modulator of syna ptic homeostasis,in part through its effect on the expression of neuronal genes including those implicated in AD and other neuropsychiatric *** this perspective,we highlight several genes affected by ApoER2 and its alternatively spliced forms and how aberrant expression can be rescued by the reintroduction of the ApoER2 intracellular domain in the mouse hippocampus.

关键词： homeostasis ApoE Alzheimer

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Does HSP27 injection induce glaucoma damage in mice?

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Neural Regeneration Research 2024年第11期19卷 2347-2348页

作者： Stephanie C.joachim Sabrina Reinehr Experimental Eye Research Institute University Eye HospitalRuhr-University BochumBochumGermany

In a further aging society,excellent eyesight is an integral part of overall well-being and quality of *** good vision is crucial to maintaining mobility,independence,and mental *** can be several reasons for visual impairment in elderly people,these include age-related macular degeneration,the leading cause of vision loss among older adults,cataract,glaucoma,diabetic retinopathy,retinal detachment,and others.

关键词： HSP27 injection damage

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Prevalence and intensity of urinary schistosomiasis and soil-transmitted helminths among women of reproductive age in Mwaluphamba,Kwale

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 71-83页

作者： Samuel M.Ngui Joseph M.Mwangangi joachim Richter Josephine W.Ngunjiri Department of Biological Sciences University of EmbuKenya Medical Entomology Kenya Medical Research Institute(KEMRI)Center for Geographic Medicine Research Coast KilifiKenya Institute of International Health Global Health CenterCharitéUniversity MedicineBerlinCorporate Member of Free University and Humboldt University and Berlin Institute of HealthBerlinGermany Swiss Tropical and Public Health Institute BaselSwitzerland Tropical and Infectious Diseases Department of Biological sciencesUniversity of EmbuKenya

Objective:To assess the epidemiology of urinary schistosomiasis and soil-transmitted helminthiasis among women of reproductive age in Mwaluphamba,Kwale County,***:A community-based cross-sectional study design was employed to randomly sample 422 women of reproductive age(15-<50 years)from four villages in Mwaluphamba *** specimens were collected and examined using the Kato-Katz method,while filtration technique was used to analyze urine ***’sociodemographic details were obtained using a standardized ***:Urinary schistosomiasis prevalence was at 4.7%(20/422,95%CI 2.8%-6.9%)while the prevalence of soil-transmitted helminthiasis infection was 4.5%(19/422,95%CI 2.6%-6.7%).The infection intensities of urinary schistosomiasis among the study participants ranged from 1 to 120 eggs/10 mL of urine with median egg count of 18.45 eggs/10 *** patients were diagnosed with light infection,of 56.16 egg/gram and 48.48 egg/gram for Trichuris trichiura and hookworms,*** without latrines had 15.7 times higher risk of having urinary schistosomiasis compared to those with a ***,use of surface water(aOR=1.0,95%CI 0.2-1.4,P=0.010)and crossing the river to go to a place(aOR=1.1,95%CI 0.3-1.6,P=0.009)were statistically significant risk factors for getting urinary *** bivariable regression analysis,defecating around the water source(OR=4.3,95%CI 1.5-12.9)had a statistically significant association with the prevalence of soil-transmitted helminthiasis(P=0.008).Conclusions:This study has given an insight on the prevalence and intensity of urinary schistosomiasis and soil-transmitted helminthiasis in Mwaluphamba location that form a basis for strengthening the control and elimination programmes for these neglected tropical diseases.

关键词： Urinary schistosomiasis Prevalence Soiltransmitted helminths Mwaluphamba

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Building Blocks of Nature

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第3期10卷 1226-1303页

作者： Hans joachim Dudek Retired Auf dem Komp Germany

By means of a representation of the elementary objects by the Lagrange density and by the commutators of the communication relations, correlations can be formed using the Fourier transform, which under the conditions of the Hamilton principle, describes correlation structures of the elementary objects with oscillator properties. The correlation structures obtained in this way are characterized by physical information, the essential component of which is the action. The correlation structures describe the physical properties and their interactions under the sole condition of the Hamilton’s principle. The structure, the properties and the interactions of elementary objects can be led back in this way to a fundamental four dimensional structure, which is therefore in their different modifications the building block of nature. With the presented method, an alternative interpretation of elementary physical effects to quantum mechanics is obtained. This report provides an overview of the fundamentals and statements of physical information theory and its consequences for understanding the nature of elementary objects.

关键词： Hamilton Principle as Global Law in Physics Physical Information Generated by Action Correlation Space Mass and Charge Formation Interpretation of Physical Effects

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矩形边界限定形式的感应电机低开关频率预测控制研究

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中国电机工程学报 2024年第8期44卷 3278-3286,I0029页

作者：齐昕张家宁 HOLTZ joachim 田柏轩任佳仕王辰宇周珂北京科技大学机械工程学院北京市海淀区100083 伍珀塔尔大学电机与驱动实验室德国伍伯塔尔42119 北京科技大学顺德研究生院广东省佛山市528399 北京科技大学高等工程师学院北京市海淀区100083

圆形边界限定形式预测控制对电流畸变的限定在各方向均相同,无法通过增大边界圆半径进一步降低开关频率。因此,该文提出一种矩形边界限定形式的预测控制方法。首先,深入分析感应电机数学模型,发现感应电机转子子系统的低通物理特性,以... 详细信息

圆形边界限定形式预测控制对电流畸变的限定在各方向均相同,无法通过增大边界圆半径进一步降低开关频率。因此,该文提出一种矩形边界限定形式的预测控制方法。首先,深入分析感应电机数学模型,发现感应电机转子子系统的低通物理特性,以及励磁电流波动对电磁转矩的影响不显著;其次,利用该特性,将限定边界改为矩形,对转矩电流与励磁电流进行独立约束,适度增加励磁电流畸变允许限值,扩大电流轨迹运动范围,延长开关状态切换时长;再次,探究电流矢量梯度同边界约束间的数学关系,提出该方法下电压矢量筛选与寻优准则,筛选出最优矢量;最终,进行实验对比。实验结果证明,在相同系统动态特性和转矩波动下,相较于圆形边界限定策略,矩形边界限定策略可以进一步降低开关频率。

关键词：矩形边界低开关频率预测控制感应电机

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The effect of Laves phases and nano-precipitates on the electrochemical corrosion resistance of Mg-Al-Ca alloys under alkaline conditions

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Journal of Magnesium and Alloys 2024年第6期12卷 2447-2461页

作者： Markus Felten Veronika Chaineux Siyuan Zhang Ali Tehranchi Tilmann Hickel Christina Scheu Joshua Spille Marta Lipińska-Chwałek joachim Mayer Benjamin Berkels Marcus Hans Imke Greving Silja Flenner Sandra Sefa Daniela Zander Chair of Corrosion and Corrosion Protection RWTH Aachen UniversityAachen 52072 Germany Max-Planck-Institut für Eisenforschung GmbH Düsseldorf 40237 Germany Central Facility for Electron Microscopy RWTH Aachen UniversityAachen 52074 Germany Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons Forschungszentrum Jülich GmbHJülich 52428Germany Mathematical Image and Signal Processing Aachen Institute for Advanced Study in Computational Engineering ScienceRWTH Aachen UniversityAachen 52062 Germany Materials Chemistry RWTH Aachen UniversityAachen 52074 Germany Institute of Materials Physics Helmholtz-Zentrum HereonGeesthacht 21502 Germany

The electrochemical corrosion mechanisms of Mg alloys were extensively studied in previous investigations of different chemical com-positions,modified surface states and various electrolyte ***,recent research focused on the active state of Mg dissolution,leading to unresolved effects of secondary phases adjacent to a stableα-solid solution passive *** present study investigates the fundamental electrochemical corrosion mechanisms of three different Laves phases with varying phase morphologies and phase fractions in the passive state of Mg-Al-Ca *** microstructure was characterized by(transmission-)electron microscopy and synchrotron-based transmission X-ray *** electrochemical corrosion resistance was determined with a standard three-electrode setup and advanced in-situ flow cell measurements.A new electrochemical activity sequence(C15>C36>α-Mg>C14)was obtained,as a result of a stable passive layer formation on theα-solid ***,nm-scale Mg-rich precipitates were identified within the Laves phases,which tend to inhibit the corrosion kinetics.

关键词： Laves phase STEM Magnesium Corrosion Passive layer

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