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Neuroinflammation revisited through the microglial lens

Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato joa.o b.relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell biology(IbMC) University of PortoPortoPortugal Department of biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

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Assessment of the bioaccessibility and bioavailability prediction of omega 3 and conjugated fatty acids by in vitro standardized digestion model (INFoGEST) and cell model

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FooD bIoSCIENCE 2023年第3期53卷 1678-1691页

作者： Salsinha, Ana Sofia Cunha, Sara A. Machado, Manuela Rodriguez-Alcala, Luis Miguel relvas, joao b. Pintado, Manuela Univ Catolica Portuguesa CBQF Ctr Biotecnol & Quim Fina Escola Super Biotecnol Lab Associado Rua Diogo Botelho 1327 P-4169005 Porto Portugal Univ Porto Inst Invest & Inovacao Saude Rua Alfredo Allen 208 P-4200135 Porto Portugal Univ Porto Inst Biol Mol & Celular IBMC Rua Alfredo Allen 208 P-4200135 Porto Portugal Fac Med Univ Porto FMUP Dept Biomed P-4200319 Porto Portugal

omega 3 EPA and DHA are polyunsaturated fatty acids with relevant health benefits. Conjugated linoleic and linolenic acids are known for their anti-carcinogenic effect, anti-inflammatory properties and body weight reduction. To achieve therapeutical doses, high amounts of these fatty acids' food sources must be consumed. Thus, the intake of enriched oils with a high concentration of these fatty acids is often used. but several factors influence their bioavailability. Here, by using the INFoGEST static in vitro protocol of gastrointestinal tract digestion it was studied the bioaccessibility of these fatty acids in different matrixes: Pomegranate and Fish oil and omega 3, CLA and CLNA soft-gel enriched capsules. After digestion, the Recovery Index for the major bioactive PUFAs are very low: Pomegranate oil is 2%, Fish oil 11-13%, CLNA 17%, CLA 6% and omega 3 capsules 3%. Higher initial concentrations of these PUFAs seem to be related to higher degrees of oxidation. In Pomegranate oil, CLNA and omega 3 capsules, the digestion process negatively influenced the antioxidant potential. The opposite was verified for the Fish oil and CLA capsules. Importantly, bioaccessibility studies of similar matrixes are very scarce and intestinal permeability is absent in most of the studies. Intestinal permeability studies were performed using a Caco-2/HT29-MTX co-culture: there is significative incorporation of the bioactive fatty acids into the intestinal cells, which may affect their permeability performance. Interestingly, most fatty acids remain in the non-bioaccessible fraction which may be relevant when designing oral routes of administration and in gut microbiota modulation.

关键词： Fish oil Pomegranate oil INFoGEST digestion Method bioaccessibility Intestinal permeability bioactive fatty acids

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Printable optical Filters for Visible optical Communications

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optics and Photonics Journal 2013年第2期3卷 136-138页

作者： P.S.André L.Nero Vania T.Freitas M.S.relvas R.A.S.Ferreira Instituto de Telecomunicacoes University of Aveiro3810-193 AveiroPortugal Physic Department University of Aveiro3810-193 AveiroPortugal Electronics and Telecommunications Department 3810-193 AveiroPortugal CICECo University of Aveiro3810-193 AveiroPortugal

The design, production and characterization of tailored printable optical filters for visible optical communications are demonstrated. As result, the average color difference between the specified and the produced fil... 详细信息

关键词： Free-space optical Communication Wavelength Filtering Devices

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Urban Air Quality Plans and Integrated Assessment Methodologies

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Journal of Environmental Science and Engineering(b) 2014年第2期3卷 70-78页

作者： Ana Isabel Miranda Helder relvas Enrico Turrini Diogo Lopes Carlos Silveira joana Ferreira Myriam Lopes Elisa Sa Carlos borrego Marialuisa Volta CESAM (Centre for Environmental and Marine Studies) and Department of Environmental and Planning University of Aveiro Aveiro 3810-193 Portugal Department of Mechanical and Industrial Engineering University of Brescia Brescia 25122 Italy

The air quality directive （2008/50/EC （of the European Parliament and of the Council of 21 May 2008）） requires European Member States to design appropriate AQPs （air quality plans） for zones and agglomerations where the air quality does not comply with the limit values and to assess possible emission reduction measures to decrease concentration levels. The Portuguese agglomeration of Porto Litoral is one of the several European Union urban areas that had to develop and implement AQPs to reduce particulate matter （PM10）. The AQPs were initially designed based on a scenario approach and using an air quality model, which was applied over the study region for the reference situation with the current PM10 emissions, and for a reduction scenario with PM10 emissions re-estimated considering the implementation of abatement measures. Aiming to cost-efficiently optimize Porto Litoral PM10 abatement measures, the assessment procedure was repeated using an optimization approach based on the RIAT ＋（regional integrated assessment tool ＋）. Porto Litoral urban area＇s technical and non-technical measures were characterized （including associated costs） and, through the application of the air quality model to 20 emissions abatement scenarios, S-R （source-receptor） relationships were created. This paper comparatively describes the air quality plans designed to improve PM10 levels in the Porto Litoral agglomeration based on both the scenario analysis and the optimization approach.

关键词： Urban air quality air quality plans integrated assessment methodologies modelling tools

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腰椎后路减压固定融合术联合针刺治疗督脉瘀阻型老年性腰椎管狭窄症的临床疗效

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医学综述 2018年第14期24卷 2865-2869页

作者：方志远李华李运海谭明生胡慧董笑克柏立群北京中医药大学东方医院骨科北京100078 北京中医药大学东方医院针灸科北京100078 中日友好医院骨科北京100029 北京中医药大学第二临床医学院北京100029

目的探讨腰椎后路减压固定融合术联合针刺治疗督脉瘀阻型老年性腰椎管狭窄症的临床疗效。方法回顾性分析2013年1月至2015年6月北京中医药大学东方医院骨科收治的57例督脉瘀阻型老年性腰椎管狭窄症患者的临床资料。依据治疗方法不同分为... 详细信息

目的探讨腰椎后路减压固定融合术联合针刺治疗督脉瘀阻型老年性腰椎管狭窄症的临床疗效。方法回顾性分析2013年1月至2015年6月北京中医药大学东方医院骨科收治的57例督脉瘀阻型老年性腰椎管狭窄症患者的临床资料。依据治疗方法不同分为两组:观察组36例,采用手术加针刺治疗;对照组21例,采用单纯手术治疗。术后随访2年,分别于术前、术后12 d(围术期)、术后2年(长期)行疼痛视觉模拟评分(VAS)、日本骨科协会评估治疗评分(joa)以及中医症状评分。结果术后12 d,观察组总有效率高于对照组[86.1%(31/36)比61.9%(13/21)](P0.05);两组患者术前VAS评分比较差异统计学意义(P>0.05),术后12 d和术后2年两组VAS评分、中医症状评分呈下降趋势,且观察组低于对照组,而joa评分呈上升趋势,且观察组高于对照组(P<0.05)。结论腰椎后路减压固定融合术治疗腰椎管狭窄症具有显著的临床疗效,针刺联合手术治疗可显著改善患者术后症状及功能,有助于患者术后康复。

关键词：椎管狭窄督脉瘀阻针刺减压术

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大推拿手法联合清湿利腰汤治疗湿热型腰椎间盘突出症的临床研究

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现代生物医学进展 2024年第22期24卷 4330-4332页

作者：孙健关宏刚胡容瑞区志楷黄宝晖广州中医药大学第八临床医学院/佛山市中医院骨一科广东佛山528000 广州中医药大学附属第八临床医学院/佛山市中医院骨科中心广东佛山528000 广州中医药大学附属第八临床医学院/佛山市中医院骨四科广东佛山528000 佛山市中医院禅城高新区医院外科广东佛山528000 佛山市普济医院综合骨科广东佛山528203

目的:探讨大推拿手法联合清湿利腰汤治疗湿热型腰椎间盘突出症(LDH)的临床研究。方法:选取LDH患者64例按照随机数字表法,分为对照组(n=32,清湿利腰汤治疗)和观察组(n=32,大推拿手法联合清湿利腰汤治疗)。对比两组临床疗效、中医证候评... 详细信息

目的:探讨大推拿手法联合清湿利腰汤治疗湿热型腰椎间盘突出症(LDH)的临床研究。方法:选取LDH患者64例按照随机数字表法,分为对照组(n=32,清湿利腰汤治疗)和观察组(n=32,大推拿手法联合清湿利腰汤治疗)。对比两组临床疗效、中医证候评分、相关量表评分和不良反应发生率。结果:观察组总有效率高于对照组(Poswestry功能障碍指数问卷表(oDI)评分下降,日本骨科学会下腰痛评分(joa)评分升高,且观察组的改善幅度更大(P0.05)。结论:大推拿手法联合清湿利腰汤治疗湿热型LDH患者,可提升临床疗效,改善临床症状,减轻疼痛程度,且治疗安全性良好。

关键词：大推拿手法清湿利腰汤湿热型腰椎间盘突出症疗效

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