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CXCL9 and CXCL10 display an agedependent profile in Chagas patients:a cohort study of aging in Bambui,Brazil

Infectious Diseases of Poverty 2020年第3期9卷 132-132页

作者： Fernanda Fortes de Araújo Karen Cecília Lima Torres Sérgio Viana Peixoto Antonio Luiz Pinho Ribeiro Juliana Vaz Melo Mambrini Vitor Bortolo Rezende Maria Luiza Lima Silva Antônio Ignácio Loyola Filho Andréa Teixeira-Carvalho Maria Fernanda Lima-costa olindo Assis Martins-Filho Integrated Research Group in Biomarkers Rene Rachou InstituteOswaldo Cruz FoundationAvenida Augusto de Lima1715–Barro Preto–Belo HorizonteMinas Gerais 30190-002Brazil 不详

Background:Chagas disease is endemic in Latin America and still represents an important public health problem in the *** cardiomyopathy is the most significant chronic form due to its association with morbidity and *** last decade has seen increasing evidence that inflammatory cytokines and chemokines are responsible for the generation of inflammatory infiltrate and tissue damage,with chronic chagasic cardiomyopathy patients presenting a pro-inflammatory immune *** studies have evaluated the role of chemokines in experimental *** infection,few have addressed their systemic profile,especially for human infection and in aging *** present work aimed to use the data from a large population based study of older adults,conducted in an endemic area for Chagas disease,to examine the association between serum levels of cytokines and chemokines,*** infection and electrocardiogram(ECG)***:The present work evaluated serum levels of CCL2,CXCL9,CXCL10,CCL5,CXCL8,IL-1β,IL-6,TNF,IL-12 and IL-10 by Flow Cytometric Bead Array assay(CBA)and the results expressed in pg/*** baseline survey started in January 1st 1997,with 1284 participants of an aged population-based *** signed an informed consent at baseline and at each subsequent visit and authorized death certificate and medical records ***:our results demonstrated that Chagas disease patients had higher serum levels of CXCL9,CXCL10 and IL-1βand lower serum levels of CCL5 than non-infected ***,our data demonstrated that CXCL9 and CXCL10 increased in an age-dependent profile in Chagas disease ***:Together,this study provided evidences that serum biomarkers increase along the age continuum and may have potential implications for establishing clinical management protocols and therapeutic intervention in Chagas disease patients.

关键词： Chagas disease Immune biomarkers Chemokines Cytokines Cohort

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<i>Kappaphycus alvarezii</i>(Rhodophyta): New Record of an Exotic Species for the Caribbean Coast of costa Rica

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American journal of Plant Sciences 2019年第10期10卷 1888-1902页

作者： Rubén Cabrera Schery Umanzor Jhoana Díaz-Larrea Patricia G. Araújo Gabinete de Arqueologia Oficina del Historiador de la Ciudad Habana Vieja Cuba Department of Ecology & Evolutionary Biology University of Connecticut Stamford CT USA Departamento de Hidrobiología Universidad Autónoma Metropolitana-Iztapalapa Ciudad de México México Instituto de Biociências Universidad Sao Paulo Sao Paulo Brazil

Kappaphycus alvarezii, a red macroalgal species native to South-East Asia, has been introduced for commercial purposes to more than 20 tropical countries. In 2000, Panama became the first Central American country to develop its cultivation following a pilot-commercial approach. Twelve years after his introduction to Panama, the species was found to the south Caribbean coast. In the present study, we report the first record of K. alvarezii collected in costa Rican waters. Genetic identification of the sample was performed with the mitochondrial marker cox2-cox3 intergenic spacer, and phylogenetic analyses showed that the sample collected grouped into a monophyletic clade with GenBank sequences from Vietnam, Indonesia, the Philippines, Brazil and Venezuela. Here we provide further description of its position with respect to other strains of K. alvarezii collected globally. Its possible route of entry to the Caribbean coast of costa Rica is discussed. To date, it is possible to locate K. alvarezii in different areas away from the production fields which show its dispersion, and that the species is expanding;but more studies are needed to know the phase of colonization in which it is located because it is a combination of natural factors and human exploitation that determines the invasive potential of the species.

关键词： Carrageenophytes Cultivation costa Rica Dispersion Exotic Introduction

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Resolutive Results with oral Corticosteroids for Patients with CoVID-19 in Pulmonary Inflammatory Phase. Successful outpatient Experience during the Collapse of Belem Do Para Health System—Brazil

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Health 2021年第8期13卷 830-838页

作者： Roberto S. Zeballos Luciana N. L. Cruz Vânia C. R. Brilhante Adriana V. Lima Carlliane L. L. P. Martins Karla N. A. Lima Michele C. G. L. Leão Belinete L. Cruz Alessandra B. Dysarz Paulo C. B. Lobato Erika S. Almeida Rute A. P. costa Klevison C. Araújo Augusto C. C. Almeida Leônidas B. D. Junior Kathia o. Harada Rita H. V. S. Araújo Elaine X. Prestes Ivete M. S. Souza Avany M. P. Pereira Antônio B. M. A. Rocha Iracema A. Estevão Fagnei I. C. Carvalho Paulo M. P. Melo Clinical Care Sao Paulo Brazil Instituto de Ciencias da Saude Faculdade de Medicina Universidade Federal do Para Belem Brazil Fundacao Publica Estadual Hospital de Clinicas Gaspar Vianna Belem Brazil Hospital da Policia Militar do Para Belem Brazil Imunoclinic Belem Brazil Universidade Estadual do Para Fundacao Santa Casa de Misericordia do Para Belem Brazil Clinica Barros Cirurgia Plastica Belem Brazil Secretaria de Estado de Saude Publica Castanhal Brazil Centro de Tratamento oncologico Belem Brazil Sociedade Brasileira de Valorizaç ã o das Sociedades Medicas—SoBEMED S&#227 o Paulo Brazil Clinica de Nutrologia Sao Luiz Brazil Hospital Nipo Brasileiro de olhos Belem Brazil Centro de Ciencias Biologicas e da Saude Universidade do Estado do Para Belem Brazil Hospital Regional do Baixo Amazonas Santarem Brazil Clinica Vallinoto Secretaria de Saude de Barcarena Barcarena Brazil Estrategia Saude da Familia Secretaria Municipal de Saude de Ananindeua Centro Universitario do Estado do Para Belem Brazil A. M. P. Endocrinologia Belem Brazil Instituto Avertano Rocha Belem Brazil Departamento de Neurocirurgia Hospital Militar de Area De Sao Paulo Sao Paulo Brazil

In the face of new diseases, medicine needs to reinvent itself in order to contain and control epidemics, such as the one we have recently faced, CoVID-19, a disease with a wide spectrum of clinical severity. A new moment has been established, since the application of well-known, effective and safe medications for other diseases, has shown high success rates in the treatment of CoVID-19. Thereunto, studies with early intervention are needed, which can change the unfavorable outcome of patients. In this article, we report the successful experience using an oral strategy during the collapse of Belem (Para, Brazil) Health System. Two hundred and ten patients were diagnosed with respiratory failure due to CoVID-19, with no option of hospital treatment due to lack of beds and resources. These patients were then started on therapeutic regimen consisting of 40 mg prednisolone, 40 mg enoxaparin and macrolides (500 mg clarithromycin, 500 mg axetylcefuroxime) associated and followed in outpatient facilities. Two hundred and eight patients had an excellent therapeutic response and there were only two fatalities. These results push research boundaries, valuing outpatient treatment with early use of prednisolone in the initial pulmonary phase, preventing severe CoVID-19 pneumonitis. Adoption of the proposed treatment intends to reduce the need for hospitalization, as well as lethality, with social robust benefits and incalculable economic savings since involves the use of accessible, safe and not expensive medications.

关键词： CoVID-19 Corticosteroids Pulmonary Inflammatory Phase Collapse Brazil

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Biotechnological Potential of Endophytic Bacteria to Improve the Micropropagated Seedling of Variety RB92579 Sugarcane(Saccharum officinarum L.)

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Advances in Microbiology 2018年第11期8卷 859-873页

作者： Maria do Carmo Silva Barreto Márcia do Vale Barreto Figueiredo Márcia Vanusa da Silva Arnóbio Gon?alves de Andrade josé de Paula de oliveira Clébia Maria Alves Almeida Livia Caroline Alexandre de Araújo odemar Vicente dos Reis Junior Manoel Urbano Ferreira Junior Antonio Félix da costa Vera Lucia de Menezes Lima Departamento de Bioquímica Centro de Biociências Universidade Federal de Pernambuco Recife Brazil Laboratório de Biologia do Solo Instituto Agron&#244 mico de Pernambuco Recife Brazil Departamento de Química Universidade Federal Rural de Pernambuco Recife Brazil Centro de Tecnologias Estratégicas do Nordeste Recife Brazil

Endophytic bacteria may influence agricultural production in several ways, including promoting plant growth. Two experiments were conducted in order to evaluate the combination of endophytic bacteria from the Brazilian Northeast region aims at the commercial introduction of the inoculation of these bacteria in micropropagated sugarcane plants using a temporary immersion bioreactor. one experiment was done in tubes with sterile commercial substrate, and the other was done in pots with soil;both were installed in a greenhouse. A mixed inoculation was performed in six inoculated endophytic diazotrophic bacteria in micropropagated sugarcane plants, variety RB92579. In the experiment with soil, the mixed inoculation significantly increased the shoot dry matter of plants without the addition of nitrogen fertilizer. However, the accumulation of total-N in the tissues showed no significant differences between treatments with and without nitrogen fertilization. The evaluation of micropropagated seedlings showed no increases in the parameters tested. The results showed that the response of inoculation in temporary immersion bioreactor micropropagation is possible, and that the application of homologous strains may have contributed to a better response by the interaction of endophytic bacteria with sugarcane RB92579. Further studies should be conducted to improve the methodology, which indicates a great potential to optimize this process on a commercial scale.

关键词： Biological Nitrogen Fixation Meristem Culture Diazotrophic Bacteria Endophytes Micropropagation

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Enriched Artemia Nauplii with Commercial Probiotic in the Larviculture of Angelfish Pterophyllum scalare Lichtenstein (1823)

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journal of Fisheries Science 2020年第1期2卷 17-21页

作者： Natalino da costa Sousa josé Araújo da Silva Emilly Monteiro Lopes Arthur Felipe Lima dos Santos Francisco Alex Lima Barros Carlos Alberto Martins Cordeiro Peterson Emmanuel Guimarães Paixão Estela dos Santos Medeiros joão Carlos Nunes de Souza Márcia Valéria Silva do Couto Federal University of Pará(UFPA) Campus BragançaAlameda Leandro RibeiroBragança68600-000PABrazil Tiradentes University(UNIT)-Av.Murilo Dantas 300-FarolândiaCEP 49032-490AracajuSergipeBrazil Faculdade Pio Décimo Av.Pres.Tancredo Neves 5655-Jabotiana49095-000Aracaju-SE.Brazil

This study evaluated the effect of enriched artemia nauplii with commercial probiotic for angelfish larvae determining growth perfomance,survival and modulation of the intestinal ***,it experiment occurred in completely randomized design with five treatments(T1-0.0,T2-1.5,T3-3.0,T4-4.5 and T5-6.0g of commercial probiotic)and four replaces during 20 *** larvaculture,post larvae passed by biometric procedures to determine productive performance and then microbiological *** reduction of total heterotrophic bacteria while increased lactic acid bacteria in the intestinal tract from the post larvae for treatments T3,T4 and *** commercial probiotic also increased the survival and performance as final weight,weight gain and specific growth *** these reasons,the use of 3g of commercial probiotic promotes greater performance and intestinal modulation for angelfish larvae.

关键词： ornamental fish Probiotic Larvaculture

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社会经济地位,而不是非洲血统的基因组,与血压相关:Bambui-Epigen(巴西)老龄化队列研究

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中华高血压杂志 2016年第2期24卷 109-109页

作者：刘莉叶鹏 Lima-costa MF Mello Mambrini JV Leite ML Peixoto SV Firmo jo Loyola Filho AI Gouveia MH Leal TP Pereira AC Macinko J Tarazona-Santos E

该研究旨在确定非洲基因组起源对巴西以社区为基础的多种族老年人群基线和11年血压变化的作用。方法：纳入随访11年的Bambui-Epigen（巴西）老龄化队列研究中的≥60岁受试者1272人的资料,观察指标为收缩压、舒张压和高血压控制率。潜在... 详细信息

该研究旨在确定非洲基因组起源对巴西以社区为基础的多种族老年人群基线和11年血压变化的作用。方法：纳入随访11年的Bambui-Epigen（巴西）老龄化队列研究中的≥60岁受试者1272人的资料,观察指标为收缩压、舒张压和高血压控制率。潜在的混杂因素包括人口学特征、社会经济地位（教育和家庭收入）、健康指标（吸烟、久坐的生活方式、高密度脂蛋白胆固醇、腰围、糖尿病和心血管病等）、抗高血压药物的使用。

关键词：社会经济地位血压变化队列研究基因组老龄化巴西非洲高密度脂蛋白胆固醇

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Financial Analysis of Crop-Livestock-Forestry Systems in Goias,Brazil

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journal of Agricultural Science and Technology(B) 2019年第2期9卷 87-102页

作者： Juliana Baldan costa Neves Araújo Alvaro Nogueira de Souza Maísa Santos joaquim Ilvan Medeiros Lustosa Junior Maisa Isabela Rodrigues Lucas Francisco de Dominicis Department of Forest Engineering Faculty of TechnologyUniversity of BrasiliaBrasilia 70910-900DFBrazil Faculty of Agronomy and Veterinary Medicine University of BrasiliaBrasilia 70910-900DFBrazil Federal Institute of Brasília-Planaltina Campus DF-128 Highwaykm 21Planaltina 73380-900 DFBrazil

Integration system is used to denote practices that combine systematic use of the land and technologies,in which forest species are used in conjunction with herbaceous plants and/or animals respecting a spatial or temporal *** that this type of production seeks to balance ecological and economic factors,it is important to understand the financial benefits and risks involved in this *** analysis,therefore,acts as an important analysis tool to foster this type of *** paper aimed to conduct analysis of investment risk of a crop-livestock-forestry system deployed in Brazil,comparing two different production scenarios,scenario I with 17 ha and scenario II with 25 *** risk analysis was performed using the Monte Carlo method and sensitivity analysis(by varying the factors:the discount rate,productivity and price).A cash flow was elaborated based on annual cost and revenues data of the agricultural crops(corn and soybeans),livestock and eucalyptus,using an interest rate of 6%per *** results indicated that the optimal age for cutting the eucalyptus was at seven years on both scenarios;scenario I had better return on investment using deterministic and probabilistic methods;scenario I presents higher investments risks;there is a negative relation between discount rate and annualized net present value(ANPV);increased productivity of crops provides greater profitability to the system;there has been an increase in the economic viability of the system,as value has been added to the *** Carlo method and the sensitivity analysis showed to be an appropriate tool to analyze the risk of crop-livestock-forestry systems,making it possible to foresee how the project will respond to possible scenarios.

关键词： Agroforestry system risk Monte Carlo method and sensitivity analysis.

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Parasite Fauna of Lutjanus synagris Commercialized in the Fish Market from Bragança-PA,Brazil

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journal of Zoological Research 2019年第3期1卷 1-4页

作者： Natalino da costa Sousa Daiana Silva dos Santos Silmara Rosa Silva Alexandre Vaz da Silva Jucimauro de Araújo P.Junior joão Vitor Antunes Miranda Pedro Rodrigo Nery de Souza Matheus Carvalho de Melo Fagner de Melo Xavier Wellington Lima da Silva Junior Fabricio Ramos Menezes Márcia Valeria Silva do Couto Federal University of Pará(UFPA) Campus BragançaAlameda Leandro RibeiroBragança68600-000PABrazil Federal University of Pará(UFPA) Campus Tucuruí-ParáBrazil Federal University of Sergipe(UFS) Departamento de Pesca e Aquicultura.Aracaju-SergipeBrazil Instituto Federal do Pará(IFPA) Campus de Cametá-ParáBrazil

Studies about the parasite fauna of marine fish highlights as an important problem for public health with zoonotic parasites or affecting the fish ***,this study evaluated the parasite fauna of Lutjanus synagris commercialized in the fish market from Braganç*** laboratory,58 fish were measured,weighted and conducted to parasitological analysis to determine parasitological indexes and relative *** parasite was fixed and identified until to the lowest taxonomic *** the parasitological analysis,it found Cymothoidae,Digenea,Cucullanus *** Procamallanus(Spirocamallanus)sp.,with total prevalence 67.24%.Digenea showed the highest prevalence and mean intensity *** nematode,Cucullanus *** the greater prevalence and relative dominance,while Procamallanus(Spirocamallanus)*** the greater mean intensity and *** showed the lowest prevalence and mean intensity *** conclusion,the parasite fauna of *** has been noted with low diversity,reporting the nematode occurrence Procamallanus(Spirocamallanus).

关键词： Cymothoidae Parasite Marine fish

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Effect of Adjunct Culture <i>Lactobacillus helveticus</i>(B02) on the Composition, Proteolysis, Free Amino Acids Release and Sensory Characteristics of Prato Cheese

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Food and Nutrition Sciences 2017年第5期8卷 512-525页

作者： Natália Chinellato de Azambuja Izildinha Moreno Darlila Aparecida Gallina Leila Maria Spadoti Eliana Maria Pettirossi Motta Maria Teresa Bertolodo Pacheco Angela Lima Menêses de Queiroz Adriane Elisabete costa Antunes Faculdade de Ciências Aplicadas Universidade Estadual de Campinas (FCA/UNICAMP) Limeira Brazil Centro de Tecnologia de Laticínios Instituto de Tecnologia de Alimentos (TECNOLAT/ITAL) Campinas Brazil Faculdade de Engenharia de Alimentos Universidade Estadual de Campinas (FEA/UNICAMP) Campinas Brazil Centro de Ciência e Qualidade de Alimentos Instituto de Tecnologia de Alimentos (CCQA/ITAL) Campinas Brazil Centro de Tecnologia Universidade Federal da Paraíba Jo&#227o Pessoa Brazil

At semi-industrial scale it was obtained two cheeses, one with aromatic culture (CHN) and the other with also L. helveticus (CHN + LH). Proteolysis during ripening was evaluated using proteolytic indices, electrophoretic profile Urea-PAGE and release of free amino acids. Sensory evaluation was performed by acceptability test. It was observed a 5-fold increase in the fraction corresponding to αs1-I-casein in the CHN cheese and 6.5 times in the CHN + LH cheese and 7.2 and 8.2 increase respectively, for total amino acids. Prato cheese with the adjunct culture showed higher acceptability in terms of overall aroma and flavor.

关键词： Amino Acids Cheese L. helveticus Ripening Sensory Analysis

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Pressure Ulcers in Institutionalized Elderly People:Association of Sociodemographic and Clinical Characteristics and Risk Factors

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open journal of Nursing 2017年第1期7卷 111-122页

作者： Suellen Duarte de oliveira Matos Iraktania Vitorino Diniz Adriana Lira Rufino de Lucena Smalyanna Sgren da costa Andrade Karen Krystine Goncalves de Brito Elizabeth Souza Silva de Aguiar Emanuelle Malzac Freire de Santana Mailson Marques de Sousa Ana Paula Marques Andrade de Souza Hemílio Fernandes Campos Coelho Mirian Alves da Silva Marta Miriam Lopes costa Maria Julia Guimaraes oliveira Soares Simone Helena dos Santos oliveira Graduate Program in Nursing Universidade Federal da ParaíbaJoao PessoaBrazil Departament of Statistics Universidade Federal da ParaíbaParaíbaBrazil

objective: To evaluate the association of socio-demographic and clinical characteristics, and risk factors with occurrence of pressure ulcers in institutionalized elderly people. Method: This cross-sectional, analytical study, in quantitative approach, performed from the database analysis linked to the project “Pressure Ulcer in institutionalized elderly people: Association of incidence with the risk factors to functional and nutritional assessment” developed in six long-stay institutions for the elderly people in joão Pessoa. Data were analyzed using the Statistical Package for Social Sciences (SPSS) version 20.0. Associations were made through chi square test and odds Ratio. Results: The clinical conditions of significant associations with the occurrence of pressure ulcers were the variables neurological disorders (p = 0.011) and visual impairment (p = 0.005). As for risk factors, the most important was fecal incontinence (p Conclusion: The analysis of the associations pointed out problems that require intervention in order to prevent health implications of the elderly people and to minimize the risk and occurrence of this injury.

关键词： Elderly People Institutions for the Elderly People Pressure Ulcer Health Profile Risk Factors

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