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PNPLA3 and TM6SF2 polymorphisms in Brazilian patients with nonalcoholic fatty liver disease

World journal of Hepatology 2020年第10期12卷 792-806页

作者： Quelson Coelho Lisboa Mateus jorge Nardelli Patrícia de Araújo Pereira Débora Marques Miranda Stephanie Nunes Ribeiro Raissa Soares Neves costa Camila Azevedo Versiani Paula Vieira Teixeira Vidigal Teresa Cristina de Abreu Ferrari Claudia Alves Couto Departament de Clínica Médica Faculty of MedicineUniversidade Federal de Minas GeraisBelo Horizonte 30130100Brazil

BACKGRoUND Nonalcoholic fatty liver disease(NAFLD)is becoming the most common chronic liver disease worldwide,with significant morbidity associated with nonalcoholic steatohepatitis(NASH).Genome-wide association studies demonstrated that the variants rs738409 C/G in the PNPLA3 and rs58542926 C/T in the TM6SF2 genes are determinants of inter-individual and ethnicity-related differences in hepatic fat content and NAFLD *** To investigate PNPLA3 and TM6SF2 genotype frequency and their association with NAFLD development and progression in Brazilian *** This cross-sectional case-control study enrolled 285 individuals from the Gastroenterology and Hepatology clinics at a university hospital in *** case patients(n=148)were confirmed to have NAFLD by the identification of hepatic steatosis on ultrasonography and exclusion of other causes of liver *** to the clinical protocol,patients underwent liver biopsy when at high risk for NASH and/or advanced fibrosis(n=65).Steatohepatitis was confirmed in 54 *** who did not have biopsy indication or NASH on histology were considered to have simple steatosis(n=94).The control group(n=137)was selected among patients that attended the Intestinal Disease clinic and was composed of subjects without abnormalities on abdominal ultrasonography and normal liver biochemical *** individuals underwent PNPLA3 and TM6SF2 genotype *** PNPLA3 CC,CG and GG genotype frequencies were 37%,44%and 19%,respectively,in NAFLD patients and were 58%,31%and 10%in controls(Podel adjusted for gender,age,body mass index and type 2 diabetes mellitus,the G allele increased the chance of NAFLD(oR=1.69,95%CI:1.21-2.36,P=0.002)and NASH(oR=3.50,95%CI:1.84-6.64,Pof NASH was even higher with GG homozygosis(oR=5.53,95%CI:2.04-14.92,P=0.001).No association was found between G allele and the features of metabolic *** histological assessment,PNPLA3 genoty

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Genetic variation Single nucleotide polymorphism Genotype Brazil Fibrosis

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State’s Technical Cartography and Social Cartography’s Participatory Mapping: Contributions to a Contemporary Reflection on the Use of Maps

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journal of Geographic Information System 2020年第4期12卷 319-333页

作者： Christian Nunes Da Silva Vicka De Nazaré Magalhães Marinho Gracilene De Castro Ferreira Yasmin Alves Dos Santos Roberto Magno Reis Netto Aline Reis De oliveira Araújo Rafael Dantas Dias Adolfo Da costa oliveira Neto Rodolpho Zahluth Bastos joão Marcio Palheta Da Silva Leonardo De Sousa Santos Federal University of Pará Belém Pará Brazil

The use of cartography in geographical approaches, notably in those focused on territorial discussions, is gaining more and more importance. However, the use of technical maps still prevails, which often act to hinder its use and appropriation by traditional communities. Based on this assumption, this article seeks to show that, in addition to technical cartography, there are other methodologies, which should also be used, in both elaboration and representation of territories, such as the participatory mapping. For that, some recommendations and suggestions are presented in this paper, aiming to subsidize the application and the collaboration of maps, through the mentioned methodology. These suggestions and contributions are the result of both theoretical debates and in loci observations, in workshops held in traditional communities of Brazilian Amazonia. From these discussions, it is concluded that the adoption of participatory mapping in the process of valuing and understanding the knowledge of traditional communities is of great value, in addition to serving as a subsidy for the claims of rights of both appropriation and possession of the territory.

关键词： Participatory Mapping Social Cartography Territory Traditional Communities

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Growth and Photosynthetic Pigments of Cotton Cultivars Irrigated with Saline Water

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Agricultural Sciences 2019年第1期10卷 81-91页

作者： Elka costa Santos Nascimento Ronaldo do Nascimento André Alisson Rodrigues da Silva Carlos Vailan de Castro Bezerra Mateus costa Batista Luana Lucas de Sá Almeida Veloso Márcia Cristina de Araújo Pereira Hallyson oliveira Federal University of Campina Grande Campina Grande Brazil

The cultivation of cotton is a relevant socioeconomic activity in the Brazilian agricultural scenario. In the Brazilian Northeast, however, production is limited by low rainfall, requiring water supplementation, a problem for the cotton cultivation practiced in the semi-arid region, due to the presence of saline ions in several water sources, from where the water is used for irrigation. It is necessary to identify cultivars that better tolerate saline stress in order to provide subsidies for their cultivation under such conditions. In this sense, the objective was to evaluate the tolerance of cotton cultivars to salinity. The experiment was conducted in a greenhouse, belonging to the Natural Resource Technology Center of the Federal University of Campina Grande, Campus I, Campina Grande, Brazil, in a completely randomized design in a 2 × 5 factorial scheme, with four replications, totaling 40 experimental units (BRS 368 RF and BRS SAFIRA) submitted to five saline levels (1.5, 3.0, 4.5, 6.0 and 7.5 dS·mˉ1). Irrigation with water saline of EC from 1.5 dS·mˉ1 affects adversely the growth of cotton cultivars, causing reductions in plant height, stem diameter, leaf area and number of leaves. Saline stress reduced the levels of the photosynthetic pigments of the cotton plants studied.

关键词： Gossypium hirsutum L. Salinity Chlorophyll

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Stability and Sensory Quality of Dried Papaya

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Food and Nutrition Sciences 2018年第5期9卷 489-501页

作者： Ronielli Cardoso Reis Eliseth de Souza Viana Siomara costa Santana da Silva Maria Eugê nia de oliveira Mamede Í dila Maria da Silva Araú jo National Cassava & amp Fruits Research Center Brazilian Agricultural Research Corporation (EMBRAPA) Cruz das Almas Brazil Federal University of Bahia (UFBA) Salvador Brazil State University of Feira de Santana (UEFS) Feira de Santana Brazil Tropical Agroindustry Center Brazilian Agricultural Research Corporation (EMBRAPA) Fortaleza Brazil

Fruit dehydration is a way of supplying the population with healthy and nutritious foods. The shelf life of dried fruit can be defined by the evaluation of changes occurred in chemical characteristics during storage. This study aims to evaluate the sensory quality and the stability of papaya cv. Tainung n° 1 dehydrated by convective drying. Fresh and dried papaya were evaluated for color, moisture, pH, acidity, water activity, soluble solids, vitamin C, carotenoids, total extractable polyphenols (TEP) and antioxidant activity (ABTS). The sensorial acceptance of the dried papaya was evaluated using a structured nine-point hedonic scale. For the stability study, the analysis of moisture, pH, titratable acidity, water activity, total carotenoids and vitamin C were carried out every 30 days of storage until 120 days. During storage, the moisture content of dried papaya remained constant, but there were undesirable changes in color, increase of acidity and reduction of soluble solids. The degradation of total carotenoids and vitamin C followed the first order reaction, and the half-life time was 346 days for carotenoids, whereas for vitamin C it was only 29 days. In the sensory analysis, the dried papaya received grades between 5.0 and 6.0 for all evaluated attributes. Dried papaya is recommended to be consumed up to 30 days, since within this period a product with higher total carotenoids content, vitamin C and with satisfactory physicochemical and sensorial characteristics were obtained.

关键词： Carica papaya Carotenoids Color Dehydrated Fruit Drying Vitamin C

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Correction of Acidity of a Brazilian Cerrado oxisol with Limestone and Wood Ash on the Initial Growth of Cowpea

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Agricultural Sciences 2019年第7期10卷 841-851页

作者： Edna Maria Bonfim-Silva Alisson Silva costa Jefferson Vieira josé André Pereira Freire Ferraz Ana Paula Alves Barreto Damasceno Tonny josé Araújo da Silva Department of Agricultural and Environmental Engineering Institute of Agricultural Sciences and Technology Federal University of Mato Grosso Rondonópolis Brazil

Among Brazilian soils orders, there are some of it classified as acid soils, which need correction to guarantee crop productivity. Currently, limestone is the most used soil corrective and wood ash has been a sustainable alternative to this process. Thus, the objective was to evaluate the effect of two correctives of soil acidity on an oxisol collected in the Brazilian Cerrado area using limestone and wood ash and the effect of soil correction on initial growth of cowpea. Two greenhouse experiments were carried out: 1) with limestone, using base saturation levels (V%) of 0, 20, 40, 60 and 80;and 2) wood ash, with doses of 0, 8, 16, 24 and 32 g⋅dm−3, both in five randomized blocks. At 40 days after sowing, it was verified that pH values were within the range considered ideal for soil (pH of 5 to 7), according to the increase of base saturation levels and wood ash doses, but limestone provided faster results. Initial growth of cowpea was positively influenced by soil correction with use of both correctives. Wood ash and limestone increased soil pH to adequate values and resulted in better initial crop development.

关键词： Vigna unguiculata Solid Waste Disposal Alternative Soil Corrective Soil pH

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波尔图Kinematix办公室

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现代装饰 2015年第6期 112-115页

作者： Diogo Aguiar Teresa otto joo Jesus Tània costa Coll lvaro Vila Iturbe Dinis Sottomayor 姜敏华 LIKE建筑事务所

项目地址葡萄牙项目面积180m^2竣工时间2014.05设计单位LIKE建筑事务所本案是LIKE建筑事务所的设计团队为一家专业致力于医疗保健技术和健身产品的IT公司Kinematix打造的研发总部。项目坐落于葡萄牙第二大城市——波尔图一栋具有象征意... 详细信息

项目地址葡萄牙项目面积180m^2竣工时间2014.05设计单位LIKE建筑事务所本案是LIKE建筑事务所的设计团队为一家专业致力于医疗保健技术和健身产品的IT公司Kinematix打造的研发总部。项目坐落于葡萄牙第二大城市——波尔图一栋具有象征意义的六十年代历史建筑内,其前身为卢米埃尔电影院。该建筑上层现存的空间安装有排列整齐的窗户,覆盖建筑物的整个立面,极具韵律感。

关键词：波尔建筑事务所 Kinematix 项目地址自然光线设计单位历史建筑韵律感象征意义项目面积

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Quality of Service to Users of Primary Health Care:A Study of Evaluation

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Health 2015年第2期7卷 201-206页

作者： Fábia Barbosa de Andrade Iris do Ceu Clara costa Tainara Lorena dos Santos Ferreira Dayane Caroliny Pereira Justino Luanni Rayssa de Medeiros Souza Cláudia Janiele Batista Fonseca Paula Thayse costa Fernandes Andréia Geíse Gomes de Araújo Faculty of Health Sciences of Trairi(FACISA) Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil Department of Dentistry Federal University of Rio Grande do Norte(UFRN)NatalBrazil

The quality of service to people in Primary Healthcare (PHC) is linked to the provision of quality service by professionals who integrate this service in the community. Accordingly, this study aims to evaluate the service given by health professionals in primary health care, from the user’s perception. This is an evaluative and quantitative study, conducted with people who use the PHC service. 180 adults are interviewed in the city of Santa Cruz, Rio Grande do Norte, Brazil. The results show that most respondents are women. The average age is of 36.65, median of 34.00 and standard deviation of 11,554. With regards to the quality of service, it ranges from fair to good. When performing correlation between the quality of service and time spent to reach the service, most people say that they spend between 0 and 15 minutes from their house to the healthcare service unit. About reception, respondents reported being satisfied and that the service has been responsible and quality for health monitoring. Thus, it is noted that the user classifies the quality of the service in primary healthcare as regular, showing weaknesses that need to be corrected to prevent damage in service provision in Primary Healthcare.

关键词： Primary Healthcare Adult’s Health Public Health Nursing

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Polyphenol oxidase Activity and Colour Changes of ‘Starking’ Apple Cubes Coated with Alginate and Dehydrated with Air

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Food and Nutrition Sciences 2011年第5期2卷 451-457页

作者： Susana Daniela Sousa Fernandes Catarina Araújo da Silva Ribeiro Maria Filomena de Jesus Raposo Rui Manuel Santos costa de Morais Alcina Maria Miranda Bernardo de Morais 不详

The objective was to study the effect of alginate coating on polyphenol oxidase (PPo) activity and colour of ‘Starking’ apple cubes during dehydration with hot air. Apple cubes were dehydrated at 20oC, 35oC, or 40oC, with a parallel airflow. Analysis of PPo activity, colour (L*, a*, b*) and dry matter were performed along the dehydration process at each temperature. All samples presented a peak in relative PPo activity in the beginning of the drying. Exponential models fitted well the experimental data after the peak. Cubes without coating presented lower PPo activity, suggesting lower browning, than coated samples throughout the dehydration process, for all temperatures. Better results for coated samples were obtained with a perpendicular airflow drying at 40oC, after dipping the whole apple in water at 60oC for 10 min. In order to prevent coated samples from browning, drying by perpendicular airflow preceded by a thermal treatment of the whole apple is required.

关键词： Alginate Coating Apple Cubes Colour Hot Air Drying Polyphenol oxidase

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Treatment of systemic lupus erythematosus with intravenous immunoglobulin （ivIg） and its impact on cellular subsets and immunoregulation

Treatment of systemic lupus erythematosus with intravenous i...

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The 8th International Congress on SLE

作者： Luiz Fernando Goulart Clara Pereira Ana Monica Gabriel Barbara Leal Maria Francisca Fontes Carlos Vasconcelos Carlos M.Ferreira jorge Martins joo Matos-costa Berta Martins António Marinho Margarida Lima jocelyne Demengeot Constantin Fesel Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPort

＜正＞Purpose:Intavenous immunoglobulin（ivIg）,which has well-demonstrated beneficial effects in various autoimmune diseases,is used as a therapeutic option for Systemic Lupus Erythematosus（SLE）patients,particularly for those with poor responses to standard *** studied immune homeostasis and regulation in patients undergoing this

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Biochar influences the cane fields’microbiota and the development of pre-sprouted sugarcane seedlings

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Waste Disposal and Sustainable Energy 2023年第1期5卷 75-88页

作者： Bruna Cristina Pinto Adriana Barboza Alves osania Emerenciano Ferreira Gustavo Henrique Gravatim costa Magno Andréde oliveira Augusto Cesar da Silva Bezerra Alan Rodrigues Teixeira Machado Postgraduate Program in Environmental Sciences State University of Minas GeraisFrutal UnityFrutalMinas Gerais38202-436Brazil Department of Agricultural and Biological Sciences State University of Minas GeraisFrutal UnityFrutalMinas Gerais38208-436Brazil Postgraduate Program in Geotechnical Engineering Federal University of Ouro PretoOuro PretoMinas Gerais35400-000Brazil Department of Transport Engineering Federal Center for Technological Education of Minas GeraisBelo HorizonteMinas Gerais30421-169Brazil Department of Exact Sciences State University of Minas GeraisJoão Monlevade UnityJoão MonlevadeMinas Gerais35930-314Brazil

This research investigates the soil conditioning effect of sugar cane fields with biochar produced from sugarcane *** influence on the physicochemical and microbiological conditions of the soil and the agronomic performance of sugarcane seedlings was *** this end,the biochar from sugarcane bagasse was produced by pyrolysis in a double drum oven and mixed with soil at rates of 0,1%,3%,and 5%(in weight).The experiment was installed in a greenhouse with two evaluation periods(30 days and 60 days)and five *** pot received a pre-sprouted cane seedling,and the analysis of colony-forming units(bacteria and fungi),physicochemical characteristics of the soil,and growth and development of sugarcane were performed per *** biochar showed a high fixed carbon content(72%)and a specific surface area estimated by the adsorption of methylene blue of 50 m2 g−***,its structure is porous and contains important nutrients(e.g.,Cao,K2o,and P2o5).In the periods evaluated,the applications of the 3%and 5%(in weight)rates of biochar reduced most of the soil fertility ***,the chemical analyses indicated that the sugarcane field soil collected already possessed high *** microbiota was influenced,but only the application of the 3%(in weight)rate at 60 days after planting showed a significant positive effect on the number of bacteria forming units,with an increase of approximately 385%.on the other hand,no significant positive effect on sugarcane development was ***,biochar application in high-fertility sugarcane plantation soil did not result in gains for sugarcane development in the periods evaluated.

关键词： Soil Biometry Microbiology Double drum oven Biochar

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