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journal of Science in Sport and Exercise 2023年第1期5卷 53-61页

作者： joão paulo lopes-silva Dillon Richardson Emerson Franchini Applied Research Group Performance and Health CESMAC University CenterMaceióAlagoasBrazil International Paralympic Committee(IPC) BonnGermany Sport Department School of Physical Education and SportUniversity of Sao PauloSao PauloBrazil

Purpose We quantified the chronological age and performance of Paralympic powerlifters competing at the elite level in the World Championships(WC)and Paralympic Games(PG),and examined the age-related differences between sexes,weight categories,and competition *** This was a retrospective study involving 3107 athletes who took part in the last eight WC and six *** pow-erlifters were divided by sex,chronological age,weight category,and competition *** overall,males were older(33 years)and stronger(lifting 168 kg)than female(32 years and lifting 96 kg,respec-tively)para powerlifters(Powerlifters lifted heavier loads in the PG(174 and 103 kg,respectively)than in WC(163 and 93 kg,respectively)and medallists were younger(31 and 30 years for females and males,respectively)than non-medallists(33 and 32 years for females and males,respectively)(Powerlifters compet-ing in lighter categories were younger when compared to heavier categories(Poad was heavier compared to heavier competitors(Ponclusion our results show that medallists were younger(31 and 30 years)than non-medallists(33 and 32 years)for females and males,respectively.

关键词： Data analysis Para athletes Sports performance Gender

Determination of critical state line(CSL)for silty-sandy iron ore tailings subjected to low-high confining pressures

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journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1684-1695页

作者： Nilo Cesar Consoli joão Vítor de Azambuja Carvalho Alexia Cindy Wagner Hugo Carlos Scheuermann Filho Inácio Carvalho Pedro Pazzoto Cacciari joão paulo de Sousa silva Civil Engineering Universidade Federal do Rio Grande do SulPorto AlegreRS90035-190Brazil Exploration and Mineral Projects-Mineral Development Centre VALE S.A.Santa LuziaMG33040-900Brazil Department of Civil Geological and Mining EngineeringPolytechnique MontrealQuebecH3C 3A7Canada

The disposal of filtered tailings in high dry stacks can induce particle breakage,changing the material's behaviour during the structure's *** grading changes influence material properties at the critical state,and this is not mature for intermediate artificial soils(tailings)in a broad range of confining *** this paper,it aims to describe the behaviour of iron ore tailings in a spectrum of confining pressures broader than the reported in previous studies.A series of consolidated drained(CD)triaxial tests was carried out with confining pressures ranging from 0.075 MPa to 120 *** results show that the amount of breakage plays an essential role in the response of iron ore *** existence of curved critical state line(CSL)in both specific volume(ν)-logarithm of mean effective stress(p′)and deviatoric stress(q)-mean effective stress(p′)planes,and different responses in the deviatoric stress-axial strain-volumetric strain curves were *** inverse S-shaped equation was proposed to represent the silty-sandy tailings'behaviour up to high pressures onν-lnp′*** proposed equation provides a basis for enhancing constitutive models and considers the evolution of the grading up to severe loading *** adjustment considered three regions with different responses associated with particle breakage at different pressure levels.

关键词： Tailings Iron ore tailings dry stacking Silty-sandy material Critical state soil mechanics High confining pressures Particle breakage

Mechanical behavior of iron ore tailings under standard compression and extension triaxial stress paths

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journal of Rock Mechanics and Geotechnical Engineering 2023年第7期15卷 1883-1894页

作者： Alexia Cindy Wagner joão paulo de Sousa silva joão Vítor de Azambuja Carvalho Ana Luisa Cezar Rissoli Pedro Pazzoto Cacciari Helder Mansur Chaves Hugo Carlos Scheuermann Filho Nilo Cesar Consoli Universidade Federal do Rio Grande do Sul Porto Alegre90035-190Brazil Mineral Development Centre Vale S.A.Santa Luzia33040-900Brazil Department of Civil Geological and Mining EngineeringPolytechnique MontrealMontrealH3C 3A7Canada

The disposal of mining tailings has increasingly focused on the use of dry *** structures offer more security since they use filtered and compacted *** of the construction method and the heights achieved,the material that compounds the structure can be subjected to different stress paths along the failure *** theoretical framework considered in the design of these structures generally is the critical state soil mechanics(CSSM).However,the data in the literature concerning the uniqueness of critical state line(CSL)is still controversial as the soil is subjected to different stress *** respect to tailings,this question is even more *** paper studies two tailings with different gradings due to the beneficial processes over extension and compression paths.A series of drained and undrained triaxial tests was conducted over a range of initial densities and stress *** the q-p'plane,different critical stress ratio(M)values were obtained for compression and extension stress ***,the critical state friction angle is very similar with a slightly higher critical state friction angle for extension *** stress path dependent CSLs were obtained in the n-lnp0 plane with the extension tests below the CSL defined in *** the fines content,the studied tailings presented very similar M and critical state friction angle ***,the fines content af-fects the volumetric behavior of the studied tailings and the CSLs on the n-lnp0 plane shift downwards with the increasing fines content for compression and extension *** relation to dilatancy analysis,the fines content did not present an evident influence on the dilatancy of the ***,different values of mean stress ratio N were obtained between compression and extension tests and can corroborate the existence of non-unique CSLs for these materials.

关键词： Iron ore tailings(IoTs) Dry stacking Critical state soil mechanics Extension tests Stress path

Continuous positive airway pressure acutely increases exercise duration in children with severe therapy-resistant asthma:a randomized crossover trial

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World journal of Pediatrics 2021年第2期17卷 189-196页

作者： Claudia silva Schindel Daniele Schiwe joao paulo Heinzmann-Filho Natalia Evangelista Campos paulo Marcio Pitrez Marcio Vinicius Fagundes Donadio Laboratory of Pediatric Physical Activity Centro Infant.Pontiffcia Universidade Catolica do Rio Grande do Sul(PUCRS)Av.Ipiranga6690.2°andarPorto AlegreRS CEP 90610-000.Brazil Hospital Moinhos de Vento Porto AlegreBrazil and Centro InfantPontiffcia Universidade Catolica do Rio Grande do Sul(PUCRS)Porto Alegre.Brazil

Background Lower exercise tolerance is an important component of asthma and the possible effects of non-invasive ven-tilation on exercise capacity in individuals with severe therapy-resistant asthma(STRA)are *** study aimed to evaluate the immediate effect of continuous positive airway pressure(CPAP)on exercise tolerance in children with *** We performed a controlled,randomized,crossover clinical trial including subjects aged 6 to 18 years old diagnosed with ***,anthropometric and lung function data were *** participants in the intervention group(IG)used CPAP(PEEP 10cmH2o and Fio20.21)for a period of 40 *** in the control group(CG)used CPAP with mini-mum PEEP at 1 cmH20 also for 40 ***,subjects from both groups underwent cardiopulmonary exercise testing(CPET).After a 15-day washout period,on a subsequent visit,subjects participated in the opposite group to the initial *** Thirteen subjects with a mean age of 12.30±1.7 years were *** variables of peak expiratory flow(PEF)and forced expiratory volume in the first second(FEV1)before using CPAP and after performing CPET did not show sig-nificant *** CPET results,there was no significant difference(P=0.59)between groups at peak exercise for oxygen consumption—Vo2(CG:33.4±6.3 and IG:34.5±5.9,mL kg^(-1)min^(-1)).However,the IG(12.4±2.1)presented a total test time(min)significantly(P=0.01)longer than the CG(11.5±1.3).Conclusion The results suggest that the use of CPAP before physical exercise increases exercise duration in children and adolescents with STRA.

关键词： Asthma Non-invasive ventilation oxygen consumption Exercise test Exercise tolerance Exercise-induced bronchospasm

Are dogs not susceptible to retroviral infections?

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Animal Diseases 2024年第3期4卷 217-223页

作者： jorge Casseb joão Henrique Campos Luciano Rodrigo lopes Laboratory of Investigation in Dermatology and Immunodefciencies Department of DermatologyUniversity of São Paulo Medical SchoolSão PauloSPBrazil Igen-Institute of Immunogenetics São PauloSPBrazil Bioinformatics and Biomedical Data Science Division Health Informatics DepartmentUniversidade Federal de São Paulo–UNIFESP.Rua Botucatu 862Prédio Leal PradotérreoVila ClementinoCEP 04023-062São PauloSPBrazil

Retroviruses have been proven to cause infections and diseases in a series of mammalian hosts but not in ***,this letter discussed the dog susceptibility to retrovirus infection,encompassing arguments to understand why dogs may have not been infected by retroviruses thus *** potential resistance of retrovirus in dogs enables this provocative short communication to discuss this question,looking at some evolutive *** lineage of canids has shown,throughout its evolutionary history,a smaller accumulation of retroviruses in canid genomes,classifed as endogenous *** this context,the genomes of canids seem to ofer obstacles,which have been evolutionarily conserved,in the face of retroviral infection.

关键词： Retrovirus dogs Endogenous retrovirus

Entropy model to assess sediment resuspension probability and trap efficiency of small dams

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International journal of Sediment Research 2022年第5期37卷 675-686页

作者： Francisco Jairo Soares Pereira Antonio Viana da silva Filho josé Wellington Batista lopes josé Carlos de Araújo Department of Agricultural Engineering Federal University of Ceará Campus Do Pici Rural Federal University of Pernambuco Federal University of Piauí

In the Brazilian drylands, there are tens of thousands of small dams. Despite their paramount importance to the rural population, they are rarely monitored. Water demand increases with time while, simultaneously, siltation reduces reservoir water capacity and availability. Reservoir siltation models are, therefore, mandatory to manage the numerous ungauged small dams in these *** objective of the current study is to improve sediment trap efficiency(TE) modeling by including resuspension as a key probabilistic process. The Shannon entropy was used to estimate the sediment resuspension probability, which was merged with the Camp model and generated the RETSED entropy model. To validate the RETSED model, an experimental check dam(ECD, 300 m3), located in the Gilbu es desertification site, Brazil, was monitored hourly during one hydrological year(July 2018-July 2019). Measurements show that the annual volumetric decline of the check dam was 12%; and that the average trap efficiency equaled 86%. only 9.5% of the hourly sediment concentration outflow exceeded the average plus one standard deviation, showing that the reservoir is well mixed; a fact which highlights the relevance of the resuspension process. Three empirical models failed to mimic the experimental results: Churchill(TE = 99%), Brune(TE = 75%), and Maryland(TE = 94%). According to the RETSED entropy model, the resuspension probability during the experiment was 10%and TE = 81%, a value only 6% below the measured one. The Camp model simulated TE = 89%, only 3%higher than the measured value, but confirmed the Camp model’s tendency to overestimate TE due to a disregard of resuspension. The deterministic model showed low sensitivity concerning the hydrodynamic effects, whereas the entropy formulation proved to be more consistent with physical behavior: the resuspension probability clearly increased and trap efficiency decreased with rising reservoir discharge.

关键词： Erosion Check dam Sedimentation Ungauged basins Camp model

Seaweeds’nutraceutical and biomedical potential in cancer therapy:a concise review

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journal of Cancer Metastasis and Treatment 2021年第1期7卷 189-212页

作者： joão Cotas Diana Pacheco Ana M.M.Gonçalves paulo silva Loïc G.Carvalho Leonel Pereira University of Coimbra MARE-Marine and Environmental Sciences CentreDepartment of Life SciencesCalçada Martim de FreitasCoimbra 3000-456Portugal Department of Biology and CESAM University of AveiroAveiro 3810-193Portugal UCIBIo-REQUIMTE Departamento de QuímicaFaculdade de Ciências e TecnologiaUniversidade Nova de LisboaCaparica 2829-516Portugal The James Hutton Institute Dundee DD25DAScotlandUK Heriot-Watt University Edinburgh EH144ASScotlandUK.

Seaweeds have been a food source since ancient times(600 BC)and are still widely used in Asia,mainly in traditional Chinese medicine and Japanese folk ***,seaweed compounds and extracts have been gaining interest from the biomedical and pharmaceutical market *** have been referenced as feasible solutions in finding new potential compounds and therapies in prevention,control,and reduction of cancer development due to the multirole of some bioactive components(e.g,phenolic compounds and sulphated polysaccharides).Moreover,seaweeds are rich in important health-promoting molecules[such as poly and highly unsaturated fatty acids(PUFAs and HUFAs),essential amino acids,vitamins,and dietary fibers]and minerals(calcium,iron,iodine,magnesium,phosphorus,potassium,zinc,copper,manganese,selenium,and fluoride).In this review,the potential therapeutic effects of seaweed in the prevention and treatment of cancer are approached,as well as nutraceutical properties of seaweed to promote cell homeostasis.

关键词： Seaweed compounds nutraceutical bioactive molecules cancer prevention cancer treatment

Extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum

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World journal of Gastroenterology 2009年第28期15卷 3565-3568页

作者： Fabiana Pirani Carneiro Maria de Nazareth Machado Sobreira Lívia Bravo Maia Alesso Cervantes Sartorelli Luiz Eduardo de Almeida Prado Franceschi Mauro Brito Brando Bárbara Wosnjuk Calaca Fernando silva Lustosa joo Vieira lopes Department of Pathology University Hospital of Brasília Department of Radiology University Hospital of Brasília Department of Hematology University Hospital of Brasília Department of Surgery University Hospital of Brasília

We report a rare case of extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum. A 72-year-old Japanese man was admitted to our hospital presenting with a 3-mo history of epigastric pain, vomiting and weight loss. on computed tomography （CT） a wall thickening of the fourth part of the duodenum was observed. Multiple biopsies obtained from the lesion showed infiltration of plasma cells and lymphocytes, but they were not conclusive. The patient underwent resection of the lesion and, on histopathological examination, the lesion consisted of a dense and diffuse infiltrate of plasma cells and a few admixed lymphocytes with reactive follicles extending to the muscular propria. An extensive deposition of amyloid was also observed. Immunohistochemical stains revealed that a few plasmacytoid cells showed λ light chain staining, though most were κ： light chain positive. These cells also were positive for CD138 and CD56 but negative for CD20 and CD79. The findings were consistent with extramedullary plasmocytoma associated with a massive deposit of amyloid in duodenum. A subsequent workup for multiple myeloma was completely negative. The patient showed no signs of local recurrence or dissemination of the disease after 12 mo follow-up. Because of the association of plasmocytoma and amyloidosis, the patient must be followed up because of the possible systemic involvement of the neoplasm and amyloidosis in future.

关键词： Extramedullary plasmocytoma Amyloidosis Duodenum Plasma cell neoplasms Immunohistochemistry

Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

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Military Medical Research 2023年第5期10卷 699-725页

作者： Daniela lopes joana lopes Miguel Pereira-silva Diana Peixoto Navid Rabiee Francisco Veiga omid Moradi Zhan-Hu Guo Xiang-Dong Wang joao Conde Pooyan Makvandi Ana Claudia Paiva-Santos Department of Pharmaceutical Technology Faculty of Pharmacy of the University of CoimbraUniversity of Coimbra3000-548 CoimbraPortugal REQUIMTE/LAQV Group of Pharmaceutical TechnologyFaculty of Pharmacy of the University of CoimbraUniversity of Coimbra3000-548 CoimbraPortugal School of Engineering Macquarie UniversitySydneyNsW 2109Australia Centre for Molecular Medicine and Innovative Therapeutics Murdoch UniversityPerthWA 6150Australia Department of Chemistry Shahr-e-Qods BranchIslamic Azad UniversityTehran 374-37515Iran lntegrated Composites Laboratory(iCL) Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK Department of Pulmonary and Critical Care Medicine Zhongshan HospitalFudan University Shanghai Medical CollegeShanghai 200032China Faculdade de Ciencias Medicas NOVA Medical SchoolUniversidade Nova de Lisboa1169-056 LisbonPortugal Centre for Toxicogenomics and Human Health GeneticsOncology and Human ToxicologyFaculdade de Ciencias MedicasNOVA Medical SchoolUniversidade Nova de Lisboa1169-056 LisbonPortugal school of Engineering Institute for Bioengineeringthe University of EdinburghEdinburgh EH93JLUK.

A bio-inspired strategy has recently been developed for camouflaging nanocarriers with biomembranes,such as natural cell membranes or subcellular structure-derived *** strategy endows cloaked nanomaterials with improved interfacial properties,superior cell targeting,immune evasion potential,and prolonged duration of systemic ***,we summarize recent advances in the production and application of exosomal membrane-coated *** structure,properties,and manner in which exosomes communicate with cells are first *** is followed by a discussion of the types of exosomes and their fabrication *** then discuss the applications of biomimetic exosomes and membrane-cloaked nanocarriers in tissue engineering,regenerative medicine,imaging,and the treatment of neurodegenerative ***,we appraise the current challenges associated with the clinical translation of biomimetic exosomal membrane-surface-engineered nanovehicles and evaluate the future of this technology.

关键词： Biomimetic Cell membrane coating Exosome Exosomal-membrane-coated nanoparticle Extracellular vesicle(EV)

3D printed millireactors for process intensification

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Chinese journal of Chemical Engineering 2020年第1期28卷 180-190页

作者： Harrson S.Santana Alan C.Rodrigues Mariana G.M.lopes Felipe N.Russo joao L.silva Jr osvaldir P.Taranto School of Chemical Engineering University of CampinasBrazil Federal Institute of Education Science and Technology of South of Minas GeraisBrazil

The scope of the present research aims at demonstrating the 3D printing use in the manufacturing of microchannels for chemical process applications. A comparison among digital model processing applications for 3D print(slicers) and a print layer thickness analysis were performed. The 3D print fidelity was verified in several devices, including the microchannels’ printing with and without micromixer zones. In order to highlight the 3D print potential in Chemical Engineering, the biodiesel synthesis was also carried out in a millireactor manufactured by 3D printing. The millireactor operated under laminar flow regime with a total flow rate of 75.25 ml·min^-1(increment of about 130 times over traditional microdevices used for biodiesel production).The printed millireactor provided a maximum yield of Ethyl Esters of 73.51% at 40 ℃, ethanol:oil molar ratio of7 and catalyst concentration of 1.25 wt% and residence time about 10 s. As a result of flow rate increment attained in the millireactor, the number of required units for scaling-up the chemical processes is reduced. Using the approach described in the present research, anyone could produce their own millireactor for chemical process in a simple way with the aid of a 3D printer.

关键词： Process intensification 3D printer Millireactors Micromixers Microdevices Biodiesel