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Integrated causal inference modeling uncovers novel causal factors and potential therapeutic targets of Qingjin Yiqi granules for chronic fatigue syndrome

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Acupuncture and Herbal Medicine 2024年第1期4卷 122-133页

作者： Junrong Li Xiaobing Zhai jixing liu Chi Kin Lam Weiyu Meng Yuefei Wang Shu Li Yapeng Wang Kefeng Li Faculty of Applied Sciences Macao Polytechnic UniversityMacao SARChina Center for Artificial Intelligence Driven Drug Discovery Faculty of Applied SciencesMacao Polytechnic UniversityMacao SARChina National Key Laboratory of Chinese Medicine Modernization Tianjin Key Laboratory of TCM Chemistry and AnalysisTianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine TianjinChina

Objective:Chronic fatigue syndrome(CFS)is a prevalent symptom of post-coronavirus disease 2019(COVID-19)and is associated with unclear disease *** herbal medicine Qingjin Yiqi granules(QJYQ)constitute a clinically approved formula for treating post-COVID-19;however,its potential as a drug target for treating CFS remains largely *** study aimed to identify novel causal factors for CFS and elucidate the potential targets and pharmacological mechanisms of action of QJYQ in treating ***:This prospective cohort analysis included 4,212 adults aged≥65 years who were followed up for 7 years with 435 incident CFS *** modeling and multivariate logistic regression analysis were performed to identify the potential causal determinants of CFS.A proteome-wide,two-sample Mendelian randomization(MR)analysis was employed to explore the proteins associated with the identified causal factors of CFS,which may serve as potential drug ***,we performed a virtual screening analysis to assess the binding affinity between the bioactive compounds in QJYQ and CFS-associated ***:Among 4,212 participants(47.5%men)with a median age of 69 years(interquartile range:69–70 years)enrolled in 2004,435 developed CFS by *** graph analysis with multivariate logistic regression identified frequent cough(odds ratio:1.74,95%confidence interval[CI]:1.15–2.63)and insomnia(odds ratio:2.59,95%CI:1.77–3.79)as novel causal factors of ***-wide MR analysis revealed that the upregulation of endothelial cell-selective adhesion molecule(ESAM)was causally linked to both chronic cough(odds ratio:1.019,95%CI:1.012–1.026,P=2.75 e^(−05))and insomnia(odds ratio:1.015,95%CI:1.008–1.022,P=4.40 e^(−08))in *** major bioactive compounds of QJYQ,ginsenoside Rb2(docking score:−6.03)and RG4(docking score:−6.15),bound to ESAM with high affinity based on virtual ***:Our integrated analytical framework combining epidemiological,genet

关键词： Causal factors Causal graph analysis Chronic fatigue syndrome Drug targets Mendelian randomization Qingjin Yiqi

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11体系铁基超导材料实用化研究进展

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稀有金属材料与工程 2024年第7期53卷 2059-2066页

作者：晏晨杨芳刘吉星贺一轩张胜楠王大友闫果张平祥西北工业大学超导材料与应用技术研究院陕西西安710072 西北有色金属研究院陕西西安710016 西安聚能医工科技有限公司陕西西安710028

自被发现以来,铁基超导体因其较高的临界电流密度、较低的各向异性以及极高的上临界磁场而受到科学家们的广泛关注,具有极好的应用前景,同时也是研究高温超导机制的重要抓手。“11”体系作为结构最简单的铁基超导材料,其不含有毒元素As... 详细信息

自被发现以来,铁基超导体因其较高的临界电流密度、较低的各向异性以及极高的上临界磁场而受到科学家们的广泛关注,具有极好的应用前景,同时也是研究高温超导机制的重要抓手。“11”体系作为结构最简单的铁基超导材料,其不含有毒元素As以及对掺杂敏感等特点使其成为领域内的研究热点。本文从线带材、涂层导体和薄膜2个角度综述了“11”体系铁基超导材料实用化的研究进展。

关键词：铁基超导线带材薄膜材料

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122体系铁基超导单晶的制备及其化学掺杂研究进展

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材料研究学报 2024年第5期38卷 321-329页

作者：余启航杨芳刘吉星贺一轩张胜楠闫果张平祥西北工业大学超导材料与应用技术研究院西安710072 西北有色金属研究院西安710016 西安聚能医工科技有限公司西安710028

制备铁基超导体122体系的高质量、大尺寸单晶较为容易,对于研究铁基超导机理有重要的意义。122铁砷超导体母相没有超导性,进行化学掺杂在体系中引入电子、空穴或加化学压力,可诱导出超导性。本文总结了助熔剂法、布里奇曼法和光学浮区... 详细信息

制备铁基超导体122体系的高质量、大尺寸单晶较为容易,对于研究铁基超导机理有重要的意义。122铁砷超导体母相没有超导性,进行化学掺杂在体系中引入电子、空穴或加化学压力,可诱导出超导性。本文总结了助熔剂法、布里奇曼法和光学浮区法等几种122体系铁基超导单晶的制备方法,并介绍了相关方法和研究进展。本文还概述了电子掺杂、空穴掺杂、等价掺杂等几种122铁砷超导体的化学掺杂以及相关研究进展。

关键词：评述铁基超导体单晶制备方法化学掺杂

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Variational Analysis of Shape Equations for Axisymmetric Vesicles

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Chinese Physics Letters 1994年第4期11卷 227-230页

作者： ZHENG Weimou liu jixing HU Jianguo Institute of Theoretical Physics Academia SinicaBeijing 100080

In derivation of the shape equation for axisymmetric vesicles from the Helfrich free energy the variation must be taken with respect to the *** is pointed out that the widely used Helfrich shape equation and the one proposed by Peterson were derived by improper variations,hence both equations are generally *** validity of the two equations is analyzed.

关键词： equation hence equations

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Fabrication of La1-xCaxFeO3 perovskite-type oxides with macro-mesoporous structure via a dual-template method for highly efficient soot combustion

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Journal of Rare Earths 2020年第4期38卷 369-375页

作者： Minjie Zhao jixing liu Jian liu Junfeng Xu Zhen Zhao Yuechang Wei Weiyu Song State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China

A series of three-dimensionally ordered macro-mesoporous(3DOMM)La1-xCaxFeO3(x=0-0.3)perovskite-type oxides were designed and successfully fabricated for the first time via a dual-template *** which,PMMA and Brij-56 were employed as the hard template and soft template,*** is found that 3 DOMM La1-xCaxFeO3 exhibits abundant wormlike mesoporous channels about 3 nm in diameter on macroporous skeleton *** excellent catalytic activity of soot combustion benefits from not only the well-designed hierarchical porous structure of catalyst,but also the redox electron pair of Fe3+/Fe4+induced by the doping of low-valent alkaline earth metal Ca to A-site of LaFeO3.3DOMM La0.8Ca0.2FeO3 exhibits superior catalytic performance for soot combustion,which shows T50 of396℃.It is 189℃lower than that without catalyst.A combination of structure and composition in the design of catalyst can be widely extended to other catalytic systems.

关键词： Three-dimensionally ordered macro-mesoporous structure Perovskite-type oxides Lanthanum ferrite Soot combustion Rare earths

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Synthesis and kinetics investigation of meso-microporous Cu-SAPO-34 catalysts for the selective catalytic reduction of NO with ammonia

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Journal of Environmental Sciences 2016年第10期28卷 45-58页

作者： jixing liu Fuhong Yu Jian liu Lifeng Cui Zhen Zhao Yuechang Wei Qianyao Sun State Key Laboratory of Heavy Oil Processing and Beijing Key Lab of Oil & Gas Pollution Control China University of Petroleum Shandong Hengsheng Chemical Co. Ltd.

A series of meso-microporous Cu-SAPO-34 catalysts were successfully synthesized by a one-pot hydrothermal crystallization method, and these catalysts exhibited excellent NH3-SCR performance at low temperature. Their structure and physic chemical properties were characterized by means of X-ray diffraction patterns （XRD）, Scanning electron microscopy （SEM）, Transmission electron microscopy （TEM）, N2 sorption-desorption, nuclear magnetic resonance （NMR）, Inductively Coupled Plasma-Atomic Emission spectrometer （ICP-AES）, X-ray absorption spectroscopy （XPS）, Temperature-programmed desorption of ammonia （NH3-TPD）, Ultraviolet visible diffuse reflectance spectroscopy （UV-Vis DRS） and Temperature programmed reduction （TPR）. The analysis results indicate that the high activities of Cu-SAPO-34 catalysts could be attributed to the enhancement of redox property, the formation of mesopores and the more acid sites. Furthermore, the kinetic results verify that the formation of mesopores remarkably reduces diffusion resistance and then improves the accessibility of reactants to catalytically active sites. The 1.0-Cu-SAPO-34 catalyst exhibited the high NO conversion （〉90%） among the wide activity temperature window in the range of 150- 425℃.

关键词： Cu-SAPO-34 NOx KineticDiffusion resistanceSelective catalytic reduction

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Immune response in cattle inoculated with the recombinant complete polyprotein of foot-and-mouth disease virus from Bombyx mori larvae

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Chinese Science Bulletin 2007年第20期52卷 2805-2810页

作者： LI ZhiYong YI YongZhu YIN XiangPing ZHANG ZhiFang liu jixing Key Laboratory of Animal Virology of Ministry of Agriculture State Key Laboratory of Veterinary Etiological Biology Lanzhou Vet- erinary Research Institute Chinese Academy of Agriculture Sciences Lanzhou 730046 China Biotechnology Research Institute Chinese Academy of Agricultural Sciences Beijing 100081 China

The intact open reading frame (ORF) of foot-and-mouth disease virus (FMDV) Asia I/XJ strain was am- plified by RT-PCR and inserted into the transfer vector pVL1393 to generate plasmid pVL-ORF. Bm-N cells were transfected with pVL-ORF and linearized Bm-BacPAK6 DNA, and the recombinant silkworm baculovirus Bm-ORF containing the full ORF of FMDV was obtained. The results of indirect im- munofluorescence assay (IFA) showed that Bm-ORF could be expressed efficiently in Bm-N cell. After inoculating the early 5th instar larvae of silkworm, the polyprotein of FMDV could be detected by sandwich ELISA and empty capsid-like particles could be observed under the electron microscope. Expression products from silkworm were used as the antigen to immunize the cattle. The specific an- tibody was induced in all vaccinated animals. The immunized cattle were challenged with the virulent FMDV Asia I/XJ strain, two of the four cattle were completely protected and clinical symptoms were alleviated and delayed in the others. The results suggest that this strategy might be used to develop the new subunit FMDV vaccine.

关键词：口蹄疫免疫系统基因表达免疫原性

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Engineering the electronic and geometric structure of VO_(x)/BN@TiO_(2)heterostructure for efficient aerobic oxidative desulfurization

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Frontiers of Chemical Science and Engineering 2023年第3期17卷 276-287页

作者： Lu Zhang jixing liu Deqi Huang Wenfeng Zhang Linjie Lu Mingqing Hua Hui liu Huifang Cheng Huaming Li Wenshuai Zhu School of Chemistry and Chemical Engineering Institution for Energy ResearchJiangsu UniversityZhenjiang 212013China College of Chemical Engineering Yangzhou Polytechnic InstituteYangzhou 225127China

Particle size governs the electronic and geometric structure of metal nanoparticles(NPs),shaping their catalytic performances in heterogeneous ***,precisely controlling the size of active metal NPs and thereafter their catalytic activities remain an affordable challenge in ultra-deep oxidative desulfurization(ODS)***,a series of highly-efficient VO_(x)/boron nitride nanosheets(BNNS)@TiO_(2)heterostructures,therein,cetyltrimethylammonium bromide cationic surfactants serving as intercalation agent,BNNS and MXene as precursors,with various VO_(x)NP sizes were designed and controllably constructed by a facile intercalation confinement *** properties and structures of the prepared catalysts were systematically characterized by different technical methods,and their catalytic activities were investigated for aerobic ODS of dibenzothiophene(DBT).The results show that the size of VO_(x)NPs and V^(5+)/V^(4+)play decisive roles in the catalytic aerobic ODS of VO_(x)/BNNS@TiO_(2)catalysts and that VO_(x)/BNNS@TiO_(2)-2 exhibits the highest ODS activity with 93.7%DBT conversion within 60 min under the reaction temperature of 130℃and oxygen flow rate of 200 mL·min-1,which is due to its optimal VO_(x)dispersion,excellent reducibility and abundant active ***,the finding here may contribute to the fundamental understanding of structure-activity in ultradeep ODS and inspire the advancement of highly-efficient catalyst.

关键词： oxidative desulfurization boron nitride vanadium MXene intercalation confinement

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Structure, synthesis, and catalytic properties of nanosize cerium-zirconium-based solid solutions in environmental catalysis

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Chinese Journal of Catalysis 2019年第10期40卷 1438-1487页

作者： jixing liu Zhen Zhao Chunming Xu Jian liu State Key Laboratory of Heavy Oil China University of PetroleumBeijing 102249China Institute of Catalysis for Energy and Environment Shenyang Normal UniversityShenyang 110034LiaoningChina

Nanosize cerium-zirconium solid solution(CZO)with a special fluorite structure has received an increasing research interest due to their remarkable advantages such as excellent oxygen storage capacity and great flexibility in their composition and *** partial metal(including rare earth,transition,alkaline earth or other metal)doping into CZO,the physicochemical properties of these catalytic materials can be controllable adjusted for the study of specific *** date,nanosize CZO has been prepared by co-precipitation,sol-gel,surfactant-assisted approach,solution combustion,micro-emulsion,high energy mechanical milling,*** advent of these methodologies has prompted researchers to construct well-defined networks with customized micromorphology and *** this review,we describe not only the basic structure and synthetic strategies of CZO,but also their relevant applications in environmental catalysis,such as the purification for CO,nitrogen oxides(NOx),volatile organic compounds(VOC),soot,hydrocarbon(HC),CO2 and solid particulate matters(PM),and some reaction mechanisms are also summarized.

关键词： Cerium-zirconium solid solution Synthesis Method Structure Environmental catalysis

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The earthquake precursor detected in a granular medium and a proposed model for the propagation of precursive stress-strain signal

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Chinese Science Bulletin 2011年第11期56卷 1071-1079页

作者： LU KunQuan HOU MeiYing WANG Qiang PENG Zheng SUN Wei SUN XiaoMing WANG YuYing TONG XiaoHui JIANG ZeHui liu jixing Beijing National Laboratory for Condensed Matter Physics Key Laboratory of Soft Matter Physics Institute of Physics Chinese Academy ofSciences Beijing 100190 China Beijing Precision Technology Co. Ltd Beijing 100089 China Earthquake Administration of Liaoning Province Shenyang 110034 China Department of Applied Physics Harbin Institute of Technology Harbin 150001 China' Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100190 China

A way to detect the seismic precursor in granular medium is described and a model of propagation for precursive stress-strain signals is proposed.A strain sensor buried in a sandpit is used to measure a seismic precursor *** signal has been investigated and confirmed to originate from a specific earthquake.A comparison of simulated and experimental signals indicates that the signal results from the strain in the earth's *** on the behavioral characteristics of granular materials,an analysis of why this method can be so sensitive to the seismic strain signal is undertaken and a model for the propagation of this stress-strain signal is *** Earth's lithosphere is formed of tectonic plates,faults and fault gouges at their *** the case of the quasi-static mechanics of seismic precursory stress-strain propagation,the crustal lithosphere should be treated as a large-scale granular *** a seismogenic event,accumulated force generates the stick-slip motion of adjacent tectonic plates and incrementally pushes blocks farther apart through stick-slip *** shear force released through this plate displacement causes soil compression *** discrete properties of the sand in the sandpit lead to the sensitive response of the sensor to the deformation signal which enables it to detect the seismic *** the analysis of the mechanism of the stress-strain propagation in the lithosphere,an explanation is found for the lack of signal detection by sensors installed in *** principles and method presented in this paper provide a new technique for investigating seismic precursors to shallow-source earthquakes.

关键词：地震前兆信号传播应力应变信号检测颗粒介质信号模型岩石圈板块应变信号

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