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Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang Zhang Xia Sheng Quanju Ding Yujun Wang jiwei zhao Jingfa Zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

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Approximate Conditional Likelihood for Generalized Linear Models with General Missing Data Mechanism

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Journal of Systems Science & Complexity 2017年第1期30卷 139-153页

作者： zhao jiwei SHAO Jun Department of Biostatistics State University of New York at Buffalo School of Statistics East China Normal University

The generalized linear model is an indispensable tool for analyzing non-Gaussian response data, with both canonical and non-canonical link functions comprehensively used. When missing values are present, many existing methods in the literature heavily depend on an unverifiable assumption of the missing data mechanism, and they fail when the assumption is violated. This paper proposes a missing data mechanism that is as generally applicable as possible, which includes both ignorable and nonignorable missing data cases, as well as both scenarios of missing values in response and *** this general missing data mechanism, the authors adopt an approximate conditional likelihood method to estimate unknown parameters. The authors rigorously establish the regularity conditions under which the unknown parameters are identifiable under the approximate conditional likelihood approach. For parameters that are identifiable, the authors prove the asymptotic normality of the estimators obtained by maximizing the approximate conditional likelihood. Some simulation studies are conducted to evaluate finite sample performance of the proposed estimators as well as estimators from some existing methods. Finally, the authors present a biomarker analysis in prostate cancer study to illustrate the proposed method.

关键词： Asymptotic normality generalized linear model identifiability missing data mechanism,non-canonical link function nonignorable missingness.

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Statistical methods without estimating the missingness mechanism: adiscussion of ‘statistical inference for nonignorable missing data problems: aselective review’ by Niansheng Tang and Yuanyuan Ju

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Statistical Theory and Related Fields 2018年第2期2卷 143-145页

作者： jiwei zhao Department of Biostatistics State University of New York at BuffaloBuffaloNYUSA

First of all, I wholeheartedly congratulate Tang and Ju(referred to as TJ hereafter) on a well-written comprehensive review paper that surveys cutting-edge statistical theory and methodology relevant to estimation,inf... 详细信息

关键词： estimating hereafter estimation

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Interval estimation for minimal clinically important difference and its classification error via a bootstrap scheme

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Statistical Theory and Related Fields 2020年第2期4卷 135-145页

作者： Zehua Zhou jiwei zhao Melissa Kluczynski Department of Biostatistics School of Public Health and Health ProfessionsState University of New York at BuffaloBuffaloNYUSA Department of Orthopaedics Jacobs School of Medicine and Biomedical SciencesState University of New York at BuffaloBuffaloNYUSA

With the improved knowledge on clinical relevance and more convenient access to the patientreported outcome data,clinical researchers prefer to adopt minimal clinically important difference(MCID)rather than statistical significance as a testing standard to examine the effectiveness of certain intervention or treatment in clinical trials.A practical method to determining the MCID is based on the diagnostic *** using this approach,the MCID can be formulated as the solution of a large margin classification ***,this method only produces the point estimation,hence lacks ways to evaluate its *** this paper,we introduce an m-out-of-n bootstrap approach which provides the interval estimations for MCID and its classification error,an associated accuracy measure for performance assessment.A variety of extensive simulation studies are implemented to show the advantages of our proposed *** of the chondral lesions and meniscus procedures(ChAMP)trial is our motivating example and is used to illustrate our method.

关键词： Minimal clinically important difference classification error confidence interval non-convex optimisation bootstrap m-out-of-n bootstrap

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Channel-Feedback-Free Transmission for Downlink FD-RAN:A Radio Map Based Complex-Valued Precoding Network Approach

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China Communications 2024年第4期21卷 10-22页

作者： zhao jiwei Chen Jiacheng Sun Zeyu Shi Yuhang Zhou Haibo Xuemin(Sherman)Shen School of Electronic Science and Engineering Nanjing UniversityNanjing 210023China College of Information Science and Electronic Engineering Zhejiang UniversityHangzhou 310058China Department of Mathematics and Theories Peng Cheng LaboratoryShenzhen 518000China Department of Electrical and Computer Engineering University of WaterlooWaterlooOntarioN2L 3G1Canada

As the demand for high-quality services proliferates,an innovative network architecture,the fully-decoupled RAN(FD-RAN),has emerged for more flexible spectrum resource utilization and lower network ***,with the decoupling of uplink base stations and downlink base stations in FDRAN,the traditional transmission mechanism,which relies on real-time channel feedback,is not suitable as the receiver is not able to feedback accurate and timely channel state information to the *** paper proposes a novel transmission scheme without relying on physical layer channel ***,we design a radio map based complex-valued precoding network(RMCPNet)model,which outputs the base station precoding based on user *** comprises multiple subnets,with each subnet responsible for extracting unique modal features from diverse input ***,the multimodal embeddings derived from these distinct subnets are integrated within the information fusion layer,culminating in a unified *** also develop a specific RMCPNet training algorithm that employs the negative spectral efficiency as the loss *** evaluate the performance of the proposed scheme on the public DeepMIMO dataset and show that RMCPNet can achieve 16%and 76%performance improvements over the conventional real-valued neural network and statistical codebook approach,respectively.

关键词： beamforming complex neural networks deep learning FD-RAN

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Electrolyte and interphase engineering through solvation structure regulation for stable lithium metal batteries

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Chinese Chemical Letters 2023年第12期34卷 401-408页

作者： Hai Su Haikuo Zhang Zifeng Chen Mengjie Li jiwei zhao Haiyan Xun Jie Sun Yunhua Xu School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining Technology(Ministry of Education)and Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin 300072China State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Lithium metal batteries(LMBs)are considered to be one of the most promising high-energy-density battery ***,their practical application in carbonate electrolytes is hampered by lithium dendrite growth,resulting in short cycle ***,an electrolyte regulation strategy is developed to improve the cyclability of LMBs in carbonate electrolytes by introducing LiNO3 using trimethyl phosphate with a slightly higher donor number compared to NO_(3)^(-)as a *** not only allows the formaion of Li^(+)-coordinated NO3 but also achieves the regulation of electrolyte solvation structures,leading to the formation of robust and ion-conductive solid-electrolyte interphase films with inorganic-rich inner and organic-rich outer layers on the Li metal *** a result,high Coulombic efficiency of 99.1%and stable plating/stripping cycling of Li metal anode in LilCu cells were ***,excellent performance was also demonstrated in Li||LiNi_(0.83)Co_(0.11)Mn_(0.06)O_(2)(NCM83)full cells and Cul/NCM83 anodefree cells using high mass-loading *** work provides a simple interphase engineering strategy through regulating the electrolyte solvation structures for high-energy-density LMBs.

关键词： Lithium metal batteries Lithium nitrate Trimethyl phosphate Solvation structures Solid-electrolyte interphases

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A Fully-Decoupled RAN Architecture for 6G Inspired by Neurotransmission

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Journal of Communications and Information Networks 2019年第4期4卷 15-23页

作者： Quan Yu Haibo Zhou Jiacheng Chen Ying Li Jian Jing jiwei(Jackokie)zhao Bo Qian Jian Wang Peng Cheng Laboratory Shenzhen 518000China School of Electronic Science and Engineering Nanjing UniversityNanjing 210023China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China

While the commercial deployment and promotion of 5G is ongoing,mobile communication networks are still facing three fundamental challenges,i.e.,spectrum resource scarcity,especially for low-frequency spectrum,exacerbated by fragmented spectrum allocation,user-centric network service provision when facing billions of personalized user demands in the era of Internet of everything(IoE),and proliferating operation costs mainly due to huge energy consumption of network *** address these issues,it is imperative to consider and develop disruptive technologies in the next generation mobile communication networks,namely *** this paper,by studying brain neurons and the neurotransmission,we propose the fully-decoupled radio access network(FD-RAN).In the FD-RAN,base stations(BSs)are physically decoupled into control BSs and data BSs,and the data BSs are further physically split into uplink BSs and downlink *** first review the fundamentals of neurotransmission and then propose the 6G design principles inspired by the *** on the principles,we propose the FD-RAN architecture,elastic resource cooperation in FD-RAN,and improved transport service layer *** proposed fully decoupled and flexible architecture can profoundly facilitate resource cooperation to enhance the spectrum utilization,reduce the network energy consumption and improve the quality of user *** research topics in this direction are envisioned and discussed.

关键词： 6G architecture design RAN neural net-work neurotransmission

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高速铁路隧道缓冲结构的气动作用分析

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西南交通大学学报 2012年第2期47卷 175-180页

作者：李人宪关永久赵晶赵继维西南交通大学机械工程学院四川成都610031

为了减轻高速列车进出隧道时引起的洞口压力波效应,常在隧道入口加建缓冲结构.采用计算流体力学数值分析的方法,仿真计算了高速铁路隧道入口缓冲结构参数对列车以350 km/h进入隧道时的气动作用,分析了过渡段长度、缓冲段长度、缓冲结构... 详细信息

为了减轻高速列车进出隧道时引起的洞口压力波效应,常在隧道入口加建缓冲结构.采用计算流体力学数值分析的方法,仿真计算了高速铁路隧道入口缓冲结构参数对列车以350 km/h进入隧道时的气动作用,分析了过渡段长度、缓冲段长度、缓冲结构开孔率、缓冲结构入口形式对隧道口内气体压力的影响和缓冲结构对隧道内会车压力波的影响.计算结果表明:过渡段长度和缓冲结构入口形式对隧道内气动影响很小,其他参数一定时缓冲段长度存在一最优值;缓冲结构上开孔有助于减小气体压力升高率,缓冲结构的存在有助于降低隧道内会车压力波峰值.

关键词：高速铁路隧道缓冲结构空气动力学

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卡尔达诺关于四次方程特殊法则的构造原理——兼论数学史的研究范式

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自然科学史研究 2008年第3期27卷 325-336页

作者：赵继伟西北大学数学与科学史研究中心西安710069

复原了卡尔达诺关于四次方程的4条特殊法则的构造过程,指出这4条形式差异很大的法则所采用的相同的构造方法,由此揭示了这些法则的真正涵义和它们通过命题的形式所表达出的数学内容并不相同,同时也解释了卡尔达诺为什么能得到这些法则... 详细信息

复原了卡尔达诺关于四次方程的4条特殊法则的构造过程,指出这4条形式差异很大的法则所采用的相同的构造方法,由此揭示了这些法则的真正涵义和它们通过命题的形式所表达出的数学内容并不相同,同时也解释了卡尔达诺为什么能得到这些法则。对这一构造过程的复原体现了曲安京所概括的三种数学史研究范式之间的联系。

关键词：四次方程卡尔达诺《大术》数学史研究范式

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中国式现代化的文明观:生成逻辑、核心要义与显著特征

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社会主义研究 2024年第4期 64-71页

作者：赵继伟湖北经济学院马克思主义学院湖北经济学院湖北省高等学校人文社会科学重点研究基地大学生思想政治教育评价中心

从唯物史观看,文明是对人类社会进步的概括性总称,是人类认识世界和改造世界的积极性成果,人类文明有其自身内在的演进逻辑。中国式现代化的文明观立足于马克思主义文明观,不仅来源于对中华优秀传统文化的继承与发展,也得益于对西方现... 详细信息

从唯物史观看,文明是对人类社会进步的概括性总称,是人类认识世界和改造世界的积极性成果,人类文明有其自身内在的演进逻辑。中国式现代化的文明观立足于马克思主义文明观,不仅来源于对中华优秀传统文化的继承与发展,也得益于对西方现代文明成果的批判性反思与超越,有着极其丰富的思想内涵与内容体系。中国式现代化的文明观是以唯物史观为世界观与方法论指导的文明观,是一个有机的、不可分割的整体,最终指向“自由人的共同体”,指引着人类文明前进进步的方向,具有极其重要的世界意义。中国式现代化的文明观具有多样性、民族性、平等性、包容性、开放性等显著特征。中国式现代化的文明观凸显了文明的独特性,丰富了世界文明的多样性,在世界范围内促进了不同文明之间的交流互鉴,推动了人类文明的进步,对人类未来文明的发展,具有非常积极的引领作用。

关键词：中国式现代化的文明观中华民族现代文明人类文明新形态

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