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Genes & Diseases 2023年第3期10卷 864-876页

作者： Zicai Dong Chuan Yang jiulin tan Ce Dou Yueqi Chen Department of Biomedical Materials Science Army Medical UniversityChongqing 400038China Department of Orthopedics Southwest HospitalArmy Medical UniversityChongqing 400038China

The skeletal system is a dynamically balanced system, which undergoes continuous bone resorption and formation to maintain bone matrix homeostasis. As an important ADP-ribosylase and NAD+-dependent deacylase, SIRT6 (SIR2-like protein 6) is widely expressed on various kinds of bone cells, such as chondrocytes, osteoblasts, osteoclasts. The aberration of SIRT6 impairs gene expression (e.g., NF-κB and Wnt target genes) and cellular functions (e.g., DNA repair, glucose and lipid metabolism, telomeric maintenance), which disturbs the dynamic balance and ultimately leads to several bone-related diseases. In this review, we summarize the critical roles of SIRT6 in the onset and progression of bone-related diseases including osteoporosis, osteoarthritis, rheumatoid arthritis, and intervertebral disc degeneration, as well as the relevant signaling pathways. In addition, we discuss the advances in the development of SIRT6 activators and elucidate their pharmacological profiles, which may provide novel treatment strategies for these skeletal diseases.

关键词： Intervertebral disc degeneration(IDD) Osteoarthritis(OA) Osteoporosis(OP) Rheumatoid arthritis(RA) SIRT6(SIR2-Like protein 6) SIRT6 activator

Post lithium-sulfur battery era:challenges and opportunities towards practical application

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Science China Chemistry 2024年第1期67卷 106-121页

作者： Jiahang Chen Yang Zhang Jun Yang Yanna Nuli jiulin Wang State Key Laboratory of Chemistry and Utilization of Carbon-Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China Department of Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Lithium-sulfur(Li-S)batteries have been regarded as a promising next-generation energy storage system owing to the high theoretical energy density and natural abundance of *** fundamental researches have pushed the flourishing development on electrochemical behaviors in recent 20 *** is time to evolve into post-Li-S battery era with the pursuit towards practical *** the landmark leap,numerous new challenges appear under harsh conditions,such as high sulfur loading,low cathode density,lean electrolyte and limited lithium ***,we summarize the considerable parameters of pouch Li-S cells and review the pioneering studies focused on the cathode structure,conversion kinetics,electrode interphase and battery *** interwoven relationship of these key points is concluded and discussed,which provides guidance to future researches aiming to safe and long-lifespan Li-S batteries with high energy density.

关键词： lithium-sulfur batteries practical application harsh conditions energy density pouch cells

Long non-coding RNA HCAR promotes endochondral bone repair by upregulating VEGF and MMP13 in hypertrophic chondrocyte through sponging miR-15b-5p

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Genes & Diseases 2022年第2期9卷 456-465页

作者： Yun Bai Xiaoshan Gong Rui Dong Zhen Cao Ce Dou Chuan Liu Jianmei Li Fei Kang Jingjin Dai Chunrong Zhao Zhansone Tian jiulin tan Qijie Dai Shiwu Dong Department of Biomedical Materials Science School of Biomedical EngineeringThird Military Medical UniversityChongqing 400038PR China Department of Orthopedics Southwest HospitalThird Military Medical UniversityChongqing 400038PR China State Key Laboratory of Trauma Burns and Combined InjuryThird Military Medical UniversityChongqing 400038PR China Institute of Trauma Orthopedics Army General Hospital of PLABeijing 100700PR China

Endochondral bone formation is an important route for bone *** emerging evidence has revealed the functions of long non-coding RNAs(lncRNAs)in bone and cartilage development,the effect of lncRNAs in endochondral bone repair is still largely ***,we identified a lncRNA,named Hypertrophic Chondrocyte Angiogenesis-related lncRNA(HCAR),and proved it to promote the endochondral bone repair by upregulating the expression of matrix metallopeptidase 13(Mmp13)and vascular endothelial growth factorα(Vegfa)in hypertrophic ***-HCAR knockdown in hypertrophic chondrocytes restrained the cartilage matrix remodeling and decrease the CD31hiEmcnhi vessels number in a bone repair ***,we proved that lnc-HCAR was mainly enriched in the cytoplasm using fluorescence in situ hybridization(FISH)assay,and it acted as a molecular sponge for ***,in hypertrophic chondrocytes,lnc-HCAR competitively bound to miR-15b-5p to increase Vegfa and Mmp13 *** results proved that lncRNA is deeply involved in endochondral bone repair,which will provide a new theoretical basis for future strategies for promoting fracture healing.

关键词： Bone marrow mesenchymal stem cells Bone repair Chondrocyte Enchondral bone repair Long non coding RNA

Wearable ultrasensitive and rapid human physiological monitoring based on microfiber Sagnac interferometer

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Science China(Information Sciences) 2024年第3期67卷 281-290页

作者： Xin WANG Hongyou ZHOU Meihua CHEN Yongcheng HE Zhishen ZHANG jiulin GAN Zhongmin YANG State Key Laboratory Luminescent Materials and Devices Institute of Optical Communication MaterialsSpecial Glass Fiber and Device Engineering Technology Research and Development Center of Guangdong ProvinceGuangdong Provincial Key Laboratory of Fiber Laser Materials and Applied TechniquesSouth China University of Technology Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology Foshan University

High-sensitive and fast-responding flexible strain sensors are essential for the smart wearable devices that precisely and dynamically perceive the weak deformations induced by human physiological signals. Here, a flexible strain sensor via polydimethylsiloxane(PDMS)-encapsulated microfiber Sagnac interferometer was designed and prepared for monitoring the human pulse signals and sound vibrations. The sensor achieved a record-breaking sensitivity(gauge factor, GF = 9977) and an extremely low detection limit(0.00025%) due to the strong polarization-dependent coupling effect in the microfiber coupler and the polarization-mixing effect in the Sagnac loop. The relative intensity demodulation method also enabled a fast response time of 10 μs. The wearable pulse measurements were implemented by attaching this flexible strain sensor directly to human skin at various locations and the waveform details were accurately captured. Taking advantage of the ultra-high sensitivity and fast response performance of the prepared sensor, the real-time dynamic acquisition of the underwater weak signal, such as the hydro-acoustic waves with a wide range of 20 Hz–16.86 k Hz, has been demonstrated. These initial results pave the way for a new and innovative category of underwater wearable devices with rapid detection of human physiological signals and weak environmental vibrations.

关键词： flexible strain sensor microfiber Sagnac interferometer underwater detection

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Embedding Tensors on 3-Hom-Lie Algebras

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Journal of Mathematical Research with Applications 2024年第2期44卷 187-198页

作者： Wen TENG jiulin JIN Yu ZHANG School of Mathematics and Statistics Guizhou University of Finance and Economics School of Science Guiyang University

In this paper, we introduce the notion of embedding tensors on 3-Hom-Lie algebras and show that embedding tensors induce naturally 3-Hom-Leibniz algebras. Moreover, the cohomology theory of embedding tensors on 3-Hom-Lie algebras is defined. As an application,we show that if two linear deformations of an embedding tensor on a 3-Hom-Lie algebra are equivalent, then their infinitesimals belong to the same cohomology class in the first cohomology group.

关键词： 3-Hom-Lie algebra embedding tensor representation cohomology deformation

Novel modular quasi-zero stiffness vibration isolator with high linearity and integrated fluid damping

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Frontiers of Mechanical Engineering 2024年第1期19卷 105-128页

作者： Wei ZHANG Jixing CHE Zhiwei HUANG Ruiqi GAO Wei JIANG Xuedong CHEN jiulin WU State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

Passive vibration isolation systems have been widely applied due to their low power consumption and high ***,the design of vibration isolators is usually limited by the narrow space of installation,and the requirement of heavy loads needs the high supporting stiffness that leads to the narrow isolation frequency *** improve the vibration isolation performance of passive isolation systems for dynamic loaded equipment,a novel modular quasi-zero stiffness vibration isolator(MQZS-VI)with high linearity and integrated fluid damping is *** MQZS-VI can achieve high-performance vibration isolation under a constraint mounted space,which is realized by highly integrating a novel combined magnetic negative stiffness mechanism into a damping structure:The stator magnets are integrated into the cylinder block,and the moving magnets providing negative-stiffness force also function as the piston supplying damping force *** analytical model of the novel MQZS-VI is established and verified *** effects of geometric parameters on the characteristics of negative stiffness and damping are then elucidated in detail based on the analytical model,and the design procedure is proposed to provide guidelines for the performance optimization of the ***,static and dynamic experiments are conducted on the *** experimental results demonstrate the proposed analytical model can be effectively utilized in the optimal design of the MQZS-VI,and the optimized MQZS-VI broadened greatly the isolation frequency band and suppressed the resonance peak simultaneously,which presented a substantial potential for application in vibration isolation for dynamic loaded equipment.

关键词： vibration isolation quasi-zero stiffness damping magnetic spring integrated design

Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering

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Bioactive Materials 2021年第10期6卷 2039-2057页

作者： Yong tang Keyu Luo Yin Chen Yueqi Chen Rui Zhou Can Chen jiulin tan Moyuan Deng Qijie Dai Xueke Yu Jian Liu Chengmin Zhang Wenjie Wu Jianzhong Xu Shiwu Dong Fei Luo National&Regional United Engineering Lab of Tissue Engineering Department of OrthopedicsSouthwest HospitalThird Military Medical UniversityChongqingChina Department of Biomedical Materials Science Third Military Medical UniversityChongqingChina Department of Spine Surgery Center for OrthopedicsDaping HospitalThird Military Medical UniversityChongqingChina State Key Laboratory of Trauma Burns and Combined InjuryInstitute of Combined InjuryChongqing Engineering Research Center for NanomedicineCollege of Preventive MedicineThird Military Medical UniversityChongqingChina Department of Orthopaedics 72nd Group Army HospitalHuzhou UniversityHuzhouZhejiangChina

A close relationship has been reported to exist between cadherin-mediated cell-cell adhesion and integrin-mediated cell mobility,and protein tyrosine phosphatase 1B(PTP1B)may be involved in maintaining this *** stable residence of mesenchymal stem cells(MSCs)and endothelial cells(ECs)in their niches is closely related to the regulation of ***,the exact role of the departure of MSCs and ECs from their niches during bone regeneration is largely ***,we show that the phosphorylation state of PTP1B tyrosine-152(Y152)plays a central role in initiating the departure of these cells from their niches and their subsequent recruitment to bone *** on our previous design of a PTP1B Y152 region-mimicking peptide(152RM)that significantly inhibits the phosphorylation of PTP1B Y152,further investigations revealed that 152RM enhanced cell migration partly via integrinαvβ3 and promoted MSCs osteogenic differentiation partly by inhibiting ***,152RM induced type H vessels formation by activating Notch *** bone matrix(DBM)scaffolds were fabricated with mesoporous silica nanoparticles(MSNs),and 152RM was then loaded onto them by electrostatic *** DBM-MSN/152RM scaffolds were demonstrated to induce bone formation and type H vessels expansion in *** conclusion,our data reveal that 152RM contributes to bone formation by coupling osteogenesis with angiogenesis,which may offer a potential therapeutic strategy for bone defects.

关键词： PTP1B Bone regeneration Angiogenesis Cell migration Type H vessels

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含螺旋孔的超材料夹层板的带隙特性研究

人工晶体学报 2024年第3期53卷 511-518页

作者：张玖林田霞河海大学力学与材料学院南京211100

本文提出一种新型低频宽带的穿孔超材料夹层板,旨在有效抑制板间横向振动。该结构的单胞由上下层面板、螺旋板、圆柱振子和支撑部件等构成。其中,螺旋板上设计4个螺纹孔,圆柱振子通过螺栓固定于板中心,螺旋板通过两侧横板与支撑部分连... 详细信息

本文提出一种新型低频宽带的穿孔超材料夹层板,旨在有效抑制板间横向振动。该结构的单胞由上下层面板、螺旋板、圆柱振子和支撑部件等构成。其中,螺旋板上设计4个螺纹孔,圆柱振子通过螺栓固定于板中心,螺旋板通过两侧横板与支撑部分连接。采用COMSOL仿真软件对胞元进行有限元分析,获得了无限周期结构的能带和共振模态,并计算了有限周期结构的传输透射率。结果表明,该结构能够产生两个宽幅的低频振动带隙,带隙范围内的振动衰减明显。本文进一步揭示了带隙机理,优化了结构参数,实现了两带隙的低频耦合,给出了符合工程实际需求的带隙。

关键词：超材料夹层板螺旋结构能带结构局域共振低频宽带振动控制

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配电网工程全过程管理分析及优化

大众用电 2023年第7期38卷 60-61页

作者：谭九林夏站国佟金锴国网永州供电公司国网涟源市供电公司沈阳工程学院

配电网工程建设涉及的专业众多,纵向需要省、市、县等各级供电公司的上下协作,横向需要本单位发展专业、财务专业、配网运维专业、配网建设专业、物资专业、安全监察专业、审计专业等众多专业的协同,此外还涉及设计单位、监理单位、施... 详细信息

配电网工程建设涉及的专业众多,纵向需要省、市、县等各级供电公司的上下协作,横向需要本单位发展专业、财务专业、配网运维专业、配网建设专业、物资专业、安全监察专业、审计专业等众多专业的协同,此外还涉及设计单位、监理单位、施工单位的协调。由于参与方众多,管理链条环环相扣,为保证按期完成建设任务,分析全过程管理模式下的关键环节中存在的问题,对于工程建设推进是否顺畅起着重要影响。

关键词：配电网工程配网运维全过程管理财务专业审计专业安全监察供电公司工程建设

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论生态环境侵权惩罚性赔偿中的“故意”

新疆社会科学 2024年第2期 83-94,149页

作者：刘玖林重庆大学法学院重庆400044

作为规范表达习近平生态文明思想的重要组成部分,生态环境侵权惩罚性赔偿是促进人与自然和谐共生的有效制度。故意是一种主观心理状态,廓清其规范语义乃准确适用生态环境侵权惩罚性赔偿的关键所在。基于法秩序统一性原理,《民法典》第1... 详细信息

作为规范表达习近平生态文明思想的重要组成部分,生态环境侵权惩罚性赔偿是促进人与自然和谐共生的有效制度。故意是一种主观心理状态,廓清其规范语义乃准确适用生态环境侵权惩罚性赔偿的关键所在。基于法秩序统一性原理,《民法典》第1232条之“故意”包括直接故意和间接故意,不应且不能包括重大过失。认识因素是界定故意的核心标准。故意的认识对象或指行为人对其行为违反法律规定的明知,或指行为人对其行为会造成损害后果的明知,但无需二者同时兼备。故意的认识类型包括确实知道以及通过欺诈规则和漠视规则的推定知道,但不包括应当知道。基于推定知道的或然性,司法解释在列举推定知道的典型情形时,还应增设相应的“除外规定”。

关键词：惩罚性赔偿生态环境侵权故意明知重大过失