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Frontiers in Biology 2014年第4期9卷 317-323页

作者： Sampriya sharma jitender sharma Rishi Pal MANDHAN Department of Biotechnology Kurukshetra University Kurukshetra 136119 India

Production of high titers of an alkaline, extracellular and thermo-tolerant pectinase by a newly isolated yeast Pseudozyma sp. SPJ was carried out under solid state fermentation. Citrus peel, the inexpensive agro-industrial residue used as substrate, was experienced to be unsurpassed. Response surface methodology was conducted to optimize the culture conditions for Pseudozyma sp. SPJ for hyper production of pectinase. Plackett Burman design was applied to identify the most effective culture variables. Out of nine variables studied, incubation time, moisture content and ammonium sulfate were detected as most important. A full factorial Central Composite Design was used to optimize the levels of these variables, which resulted in 17-fold increase （71.19 IU/g to 1215.66 IU/g dry substrate） in the enzyme yield. The results of analysis of variance and multiple regression analysis implies that the effect of incubation time （p 〈 0.000） and moisture content （p 〈 0.018） is more than ammonium sulfate. And also the interaction of moisture content with ammonium sulfate （p 〈 0.002） is more significant.

关键词： pectinase Pseudozyma sp. SPJ response surface methodology solid state fermentation

Insights on antioxidant therapeutic strategies in type 2 diabetes mellitus:A narrative review of randomized control trials

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World Journal of Diabetes 2023年第6期14卷 919-929页

作者： Dharmsheel Shrivastav Pradeep Kumar Dabla jitender sharma Aroop Viswas Rashid Mir Amity Institute of Biotechnology Amity University RajasthanJaipur 303002India Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchDelhi 110002India Department of Medical Lab Technology Faculty of Applied Medical SciencesUniversity of TabukTabuk 71491Saudi Arabia

BACKGROUND Type 2 diabetes mellitus(T2DM)is a metabolic disease of impaired glucose *** in generation and elimination of free radicals generate oxidative stress which modulates glucose metabolism and insulin regulation,resulting in the occurrence and progression of diabetes and associated *** supplements in T2DM can be seen as a potential preventive and effective therapeutic *** To compare randomized controlled trials(RCTs)in which antioxidants have been shown to have a therapeutic effect in T2DM *** We systematically searched the electronic database PubMed by *** evaluating the effect of antioxidant therapy on glycaemic control as well as oxidant and antioxidant status as primary outcomes were *** outcomes considered were:A reduction in blood glucose;changes in oxidative stress and antioxidant ***-length papers of the shortlisted articles were assessed for the eligibility criteria and 17 RCTs were *** The administration of fixed-dose antioxidants significantly reduces fasting blood sugar and glycated hemoglobin and is associated with decreased malondialdehyde,advanced oxidation protein products,and increased total antioxidant *** Antioxidant supplements can be a beneficial approach for the treatment of T2DM.

关键词： Diabetes Antioxidants Oxidative stress Malondialdehyde Polyphenols Antioxidant therapy

Changes in Adenosine Metabolism in Asthma. A Study on Adenosine, 5&#39-NT, Adenosine Deaminase and Its Isoenzyme Levels in Serum, Lymphocytes and Erythrocytes

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Open Journal of Respiratory Diseases 2015年第2期5卷 33-49页

作者： jitender sharma Bala K. Menon Vannan K. Vijayan Surendra K. Bansal Department of Biochemistry Vallabhbhai Patel Chest Institute University of Delhi Delhi India Department of Respiratory Allergy and Applied Immunology Vallabhbhai Patel Chest Institute University of Delhi Delhi India Department of Pulmonary Medicine Vallabhbhai Patel Chest Institute University of Delhi Delhi India Bhopal Memorial Hospital and Research Centre Bhopal India

Background: Adenosine deaminase (ADA) and 5'-nucleotidase (5'-NT) play a crucial role in adenosine metabolism in healthy individuals. Adenosine is an inflammatory mediator of asthma. Changes in adenosine metabolism and role of ADA and 5'-NT in regulating adenosine level in asthmatics and correlation of these changes with severity of asthma are not clearly understood. Methods: In this study, we screened 5217 patients, of which 2416 were diagnosed with asthma. Further, of 2416 asthmatics, only 45 patients who strictly fulfilled the selection criteria were enrolled in the study. The patients were classified into mild, moderate and severe persistent groups;each group consisted of fifteen patients. Fifteen healthy subjects served as controls. Adenosine levels and activities of 5'-NT, total ADA, ADA1 and ADA2 in serum, lymphocytes and erythrocytes were determined. The data were analysed statistically and p vice versa.

关键词： Asthma Adenosine Metabolism Adenosine Deaminase 5'-Nucleotidase

One pot three component synthesis of spiro [indolo-3,10’-indeno[1,2-b]quinolin]-2,4,11’-triones as a new class of antifungal and antimicrobial agents

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Chinese Chemical Letters 2017年第1期28卷 136-142页

作者： Kalawati Meena Sudesh Kumari jitender M.Khurana Amita Malik Chetan sharma Harsh Panwar Department of Chemistry University of Delhi Delhi 110007 India Dyal Singh College University of Delhi Lodhi Road Delhi 110003 India Department of Dairy Microbiology College of Dairy Science and Technology Guru Angad Dev Veterinary and Animal Science UniversityLudhiana 141004 India

A simple and efficient three component procedure has been developed for the synthesis of highly substituted spiro[indolo-3,100-indeno[1,2-b]quinolin]-2,4,11＇-triones by one pot three component condensation of enaminones, isatin and indane-1,3-dione in ethanol：water（1：1） in presence of ceric ammonium nitrate（CAN） as catalyst. This method provides several advantages such as lesser reaction time, high yield of products and operational simplicity. The antimicrobial activity of some of the compounds has been investigated against six microbial strains, some of the tested compounds showed good antimicrobial activity.

关键词： Multicomponent reactions Isatin Spirooxindole Heterocycles Antimicrobial activity

Nurses and nursing students’knowledge regarding blood transfusion:A comparative cross-sectional study

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Journal of Integrative Nursing 2022年第3期4卷 137-144页

作者： Rakhi GAUR Shiv Kumar MUDGAL Neha SUYAL Suresh Kumar sharma Rajat AGARWAL Ritu RAJ Chaturvedi jitender College of Nursing AIIMSDeogharJharkhandIndia Government Nursing College HaldwaniUttarakhandIndia College of Nursing AIIMSJodhpurRajasthanIndia Department of CTVS AIIMSDeogharJharkhandIndia Department of Medicine AIIMSDeogharJharkhandIndia Department of Neurosurgery AIIMSRishikeshUttarakhandIndia

Objective:The objective of this study is to measure and compare the knowledge of nursing students and nurses on blood transfusion in an Indian *** and Methods:The present comparative,cross-sectional study enrolled 296 nurses and 177 nursing students through a purposive sampling from a medical university hospital and different nursing *** data were collected in the month of June and July of year 2021,using a self-structured *** questionnaire had two sections:Section-I contained demographic data(8 items for nurses and 5 for students)and section-II included 26 items that assessed nurses’and nursing students’knowledge on blood ***:Findings indicated that nurses and nursing students had insufficient knowledge about blood ***,however,had significantly greater total blood transfusion knowledge scores than nursing students(16.51±3.85 vs.12.10±3.28;P<0.001).The marital status(adjusted odds ratio[AOR]=0.456,95%confidence interval[CI]0.244,0.853;P=0.037),educational level(AOR=5.072,95%CI 1.982,9.634(P=0.003);AOR=6.540,95%CI 2.54,16.871;P=0.001)and work experience(AOR=0.216,95%CI 0.067,0.702[P=0.037];AOR=0.331,95%CI 0.135,0.811;P=0.013)were the significant predictors of the level of knowledge among *** attendance in any educational programme on blood transfusion(AOR=0.225,95%CI:0.062,0.818;P=0.041)was a significant predictor of the level of knowledge among nursing ***:Nurses and nursing students have unsatisfactory knowledge on blood transfusion;emphasizing the critical need for immediate and successful teaching activities in this area.

关键词： Blood transfusion comparative knowledge nurses nursing students

Green Approach for <i>In-Situ</i>Growth of CdS Nanorods in Low Band Gap Polymer Network for Hybrid Solar Cell Applications

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Advances in Nanoparticles 2014年第3期3卷 106-113页

作者： Ramil K. Bhardwaj Vishal Bharti Abhishek sharma Dibyajyoti Mohanty Vikash Agrawal Nakul Vats Gauri D. sharma Neeraj Chaudhary Shilpa Jain jitender Gaur Kamalika Banerjee Suresh Chand J & S Research and Innovations Delhi India Physics of Energy Harvesting CSIR-National Physical Laboratory New Delhi India Physics of Energy Harvesting CSIR-National Physical Laboratory New Delhi India School of Science India Gandhi National Open University New Delhi India School of Science India Gandhi National Open University New Delhi India

In-situ growth of CdS nanorods (NRs) has been demonstrated via solvothermal, in a low band gap polymer, poly [[4,8-bis[(2-ethylhexyl)oxy] benzo [1,2-b:4,5-b’] dithiophene-2,6-diyl] [3-fluoro-2-[(2-ethylhexyl) carbonyl] thieno [3,4-b] thiophenediyl]] (PTB7). It is a high yielding, green approach as it removes use of volatile and hazardous chemicals such as pyridine as ligand which are conventionally used to synthesize precursors of CdS (NRs). Moreover the solvothermal process is a zero emission process being a close vessel synthesis and hence no material leaching into the atmosphere during the synthesis. The PTB7:CdS nanocomposite has been characterized by SEM, XRD, FTIR, UV-visible spectroscopy techniques. The photoluminescence (PL) spectroscopy study of PTB7 with CdS NRs has shown significant PL quenching by the incorporation of CdS NRs in PTB7;this shows that CdS NRs are efficient electron acceptors with the PTB7. The PTB7:CdS is used as active layer in the fabrication of hybrid solar cells (HSC) as donor-acceptor combination in the bulk heterojunction (BHJ) geometry. The HSCs fabricated using this active layer without any additional supporting fullerene based electron acceptor has given power conversion efficiency of above 1%.

关键词： CdS Nanorods PTB7 In-Situ Growth Solvothermal Hybrid Solar Cell

Metastatic high-grade neuroendocrine tumor of mandible

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 127-129页

作者： jitender Batra Chinmay D.Vakade Sonal Grover Gyanander Attresh Department of Oral and Maxillofacial Surgery Post Graduate Institute of Dental SciencesPt.B.D.Sharma UHSRohtak 124001HaryanaIndia Department of Oral and Maxillofacial Surgery Bapuji Dental College and HospitalDavangere 577004KarnatakaIndia

Neuroendocrine tumors of the oral cavity and jaws are exceedingly *** include paragangliomas,a melanotic neuroectodermal tumor of infants,small cell carcinomas,and Merckel cell *** have been non-functional in ***,lung,liver,colon,and prostate are the most common reported primary malignancies which can metastasize to the oral *** most cases,oral metastases involve maxilla and mandible rather than soft *** premolar-molar region is the most common *** purpose of this article is to describe a rare case of a high grade neuroendocrine tumor of the mandible which metastasized from the cervix.

关键词： Large/small cell carcinoma of mandible metastatic tumor/carcinoma to the mandible neuroendocrine/carcinoid tumor of mandible

The Corpse Is a Silent Witness Who Never Lies—A Case Report

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Forensic Medicine and Anatomy Research 2014年第3期2卷 43-47页

作者： Vijay Pal Pawan Mittal jitender K. Jakhar Yogesh Kumar Vashist A. D. Aggarwal Bhavesh Bohra Department of Forensic Medicine Government Medical College Patiala India Department of Forensic Medicine Jhalawar Medical College Jhalawar India Department of Forensic Medicine Pt. B. D. Sharma PGIMS Rohtak Pt. Bhagwat Dayal Sharma University of Health Sciences Rohtak India Department of Forensic Medicine Pt. B. D. Sharma PGIMS Rohtak Pt. Bhagwat Dayal Sharma University of Health Sciences Rohtak India Pt. Bhagwat Dayal Sharma University of Health Sciences Rohtak India

There are two very common sayings about corpse (dead body). The first common saying is that “the corpse is a silent witness who never lies” and the other common saying is that “the dead body is extremely eloquent and honestly informative, if one exercises patience in listening to it.” Both these sayings were proved in one of our cases. In the present case, decomposed body of an unidentified female individual aged about 25 - 26 years was recovered from the bank of western Yamuna canal in Haryana. The police made the efforts for establishing the identity of the deceased but could not succeed. The body was forwarded to the district hospital for autopsy along with the inquest report. However, the body being in advanced stage of decomposition so it was referred from the district hospital to the department of Forensic Medicine, PGIMS, Rohtak (Haryana) for the examination and the expert opinion regarding the cause of death. The findings observed on examination of the body helped to deduce the cause, time and manner of death whereas certain important objective features of identification were also observed and ultimately proper identity of the deceased could be established beyond the reasonable doubt by DNA profile of the samples preserved at autopsy. The autopsy findings, DNA profile and the results of examination of other materials (exhibits) taken from the body not only revealed the truth from the silent witness—the corpse, but also provided objective and scientific evidence to establish the corpus delicti in this case.

关键词： Corpus Delicti Rape Throttling Murder Putrefaction DNA Profile