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Uncovering the Multifaceted Roles of DDX21: Bridging Biological Insights and Medical Applications

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生物组学研究杂志(英文) 2024年第3期7卷 119-133页

作者： shen jinze Chen Ruixiu Guo Kailin Zhong Chenming Duan Shiwei Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of Medicine Hangzhou City University Hangzhou Zhejiang China Medical Genetics Center School of Medicine Ningbo University Ningbo Zhejiang China

DDX21 belongs to the DEAD-box (DDX) family of helicases but deviates from the characteristic sequence Asp–Glu–Ala–Asp (DEAD) to Asp–Glu–Val–Asp. In addition to the typical helicase activity associated with the DEAD-box family, DDX21 also possesses foldase and adenosine triphosphatase activities. It plays crucial roles in various molecular processes, including the regulation of transcription, ribosomal RNA processing, modification, and unwinding of RNA spatial structures. DDX21 is subject to intricate regulation by multiple upstream factors, including expression control and posttranslational modification. In numerous cancer types, abnormal expression of DDX21 has been observed to influence cancer cell behaviors, such as the cell cycle, proliferation, invasion, migration, and apoptosis. In addition, DDX21 modulates innate immunity following viral infection and plays a dual role in the viral infection process. This review comprehensively explores the protein structure, molecular regulatory mechanisms, and pathophysiological functions of DDX21. Consequently, this study not only offers potential avenues for future research but also sparks novel ideas for targeted treatments for both cancer and viral infections.

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Current insights into the oncogenic roles of lncRNA LINC00355

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Cancer Innovation 2023年第6期2卷 448-462页

作者： jinze shen Xinming Su Ming Pan Zehua Wang Yufei Ke Qurui Wang Jingyin Dong Shiwei Duan Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhouZhejiangChina

Long noncoding RNAs(lncRNAs)are a class of nonprotein-coding transcripts that are longer than 200 ***00355 is a lncRNA located on chromosome 13q21.31 and is consistently upregulated in various *** regulates the expression of downstream genes at both transcriptional and posttranscriptional levels,including eight microRNAs(miR-15a-5p,miR-34b-5p,miR-424-5p,miR-1225,miR-217-5p,miR-6777-3p,miR-195,and miR-466)and three protein-coding genes(ITGA2,RAD18,and UBE3C).LINC00355 plays a role in regulating various biological processes such as cell cycle progression,proliferation,apoptosis,epithelial-mesenchymal transition,invasion,and metastasis of cancer *** is involved in the regulation of the Wnt/β-catenin signaling pathway and p53 signaling *** of LINC00355 has been identified as a high-risk factor in cancer patients and its increased expression is associated with poorer overall survival,recurrence-free survival,and disease-free ***00355 upregulation has been linked to several unfavorable clinical characteristics,including advanced tumor node metastasis and World Health Organization stages,reduced Karnofsky Performance Scale scores,increased tumor size,greater depth of invasion,and more extensive lymph node ***00355 induces chemotherapy resistance in cancer cells by regulating five downstream genes,namely HMGA2,ABCB1,ITGA2,WNT10B,and CCNE1 *** summary,LINC00355 is a potential oncogene with great potential as a diagnostic marker and therapeutic target for cancer.

关键词： ceRNA chemotherapy resistance lncRNA LINC00355 miRNA prognosis

钨精矿粉含量对激光烧结(Fe-Cr)-Al合金组织性能的影响

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稀有金属材料与工程 2015年第7期44卷 1782-1785页

作者：李刚韩凤沈宇沈金泽王妍辽宁工程技术大学辽宁阜新123000

在(Fe-Cr)(40)-Al(60)粉末中掺杂0.5%、1%、3%、5%(质量分数)钨精矿粉末,压制成坯,并对压坯进行激光引燃自蔓延烧结,制备原位自生颗粒增强复合材料。采用OM、XRD等微观组织结构表征手段及合金密度、孔隙率、硬度、磨损性能等宏观力学性... 详细信息

在(Fe-Cr)(40)-Al(60)粉末中掺杂0.5%、1%、3%、5%(质量分数)钨精矿粉末,压制成坯,并对压坯进行激光引燃自蔓延烧结,制备原位自生颗粒增强复合材料。采用OM、XRD等微观组织结构表征手段及合金密度、孔隙率、硬度、磨损性能等宏观力学性能及腐蚀性能测试方法,研究不同钨精矿粉末含量对烧结合金组织及性能的影响。结果表明:烧结合金物相主要为Al Fe,Al Fe3,Al2O3,W,WO3及(Al-Fe)4Cr。烧结合金组织均匀细小,以颗粒状弥散分布于基体中。当钨精矿粉含量为1%时,烧结合金密度最大,为3.969 g/cm3,孔隙率最小,为9.01%;合金硬度最高,为13 210 MPa;磨损率最低,为0.47 mg/mm2;自腐蚀电位最大,为325.790 m V,腐蚀电流密度最小,为182.2μA·mm-2,耐蚀性能最好。

关键词： Fe-Al金属间化合物激光烧结显微组织耐蚀性能

Ti、B掺杂对高碳铬铁粉末激光熔覆涂层组织及性能的影响

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金属热处理 2014年第9期39卷 120-123页

作者：李刚沈金泽葛少成辽宁工程技术大学材料科学与工程学院辽宁阜新123000 辽宁工程技术大学安全科学与工程学院辽宁阜新123000

采用激光熔覆在Q235钢表面制备高碳铬铁涂层,利用OM、XRD、硬度测试、摩擦磨损等,研究掺杂0.5%Ti和0.5%B对涂层组织性能影响。结果表明,熔覆涂层物相为α-Fe、CrFe、(Cr,Fe)7C3、Cr7C3;加入Ti元素产生TiC,加入B元素产生BC,且Ti、B的加入... 详细信息

采用激光熔覆在Q235钢表面制备高碳铬铁涂层,利用OM、XRD、硬度测试、摩擦磨损等,研究掺杂0.5%Ti和0.5%B对涂层组织性能影响。结果表明,熔覆涂层物相为α-Fe、CrFe、(Cr,Fe)7C3、Cr7C3;加入Ti元素产生TiC,加入B元素产生BC,且Ti、B的加入,使组织变得均匀细密。当添加0.5%B+0.5%Ti时,沿涂层截面中部硬度达到最大值1731 HV20,磨损率达到最小值0.85 mg/mm2,耐蚀性最好,腐蚀电流达到最小124.4μA/mm2。

关键词： Ti、B元素激光熔覆高碳铬铁涂层显微组织性能

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扫描速度对高碳铬铁激光熔覆层组织性能影响

辽宁工程技术大学学报（自然科学版） 2015年第12期34卷 1414-1418页

作者：李刚沈金泽韩凤辽宁工程技术大学材料科学与工程学院辽宁阜新123000

利用激光熔覆技术,在不同激光扫描速度下(扫描速度分别为:1.5 mm/s、2.0 mm/s、2.5 mm/s、3.0 mm/s)制备高碳铬铁熔覆涂层.采用金相显微镜对涂层进行显微组织分析,X射线衍射仪分析涂层的物相组成,硬度计测试涂层硬度值,磨粒磨损试验机... 详细信息

利用激光熔覆技术,在不同激光扫描速度下(扫描速度分别为:1.5 mm/s、2.0 mm/s、2.5 mm/s、3.0 mm/s)制备高碳铬铁熔覆涂层.采用金相显微镜对涂层进行显微组织分析,X射线衍射仪分析涂层的物相组成,硬度计测试涂层硬度值,磨粒磨损试验机测试涂层耐蚀性等,得出激光扫描速度对激光熔覆涂层的组织和性能的影响规律.实验结果表明:熔覆涂层组成相为:α-Fe,Cr Fe,(Cr Fe)7C3,Cr7C3.随扫描速度增加,熔覆层组织细化,硬度值变大,当扫描速度达到3.0 mm/s时,涂层硬度值较大,最大值为854.18 HV;磨损率较小,为1.18 mg/mm2;腐蚀电流密度较小,为102.7μA/cm2,此时耐蚀性较好.

关键词：激光熔覆扫描速度高碳铬铁粉组织磨损率

Current and future perspectives on the regulation and functions of miR-545 in cancer development

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Cancer Pathogenesis and Therapy 2024年第3期2卷 142-154页

作者： jinze shen Xinming Su Qurui Wang Yufei Ke Tianyu Zheng Yunan Mao Zehua Wang Jingyin Dong Shiwei Duan Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhouZhejiang 310015China

Micro ribonucleic acids(miRNAs)are a highly conserved class of single-stranded non-coding *** the miR-545/374a cluster,miR-545 resides in the intron of the long non-coding RNA(lncRNA)FTX on *** precursor form,pre-miR-545,is cleaved to generate two mature miRNAs,miR-545-3p and ***,these two miRNAs exhibit distinct aberrant expression patterns in different cancers;however,their expression in colorectal cancer remains ***,miR-545-3p is affected by 15 circular RNAs(circRNAs)and 10 long non-coding RNAs(lncRNAs),and it targets 27 protein-coding genes(PCGs)that participate in the regulation of four signaling *** contrast,miR-545-5p is regulated by one circRNA and five lncRNAs,it targets six PCGs and contributes to the regulation of one signaling *** miR-545-3p and miR-545-5p affect crucial cellular behaviors,including cell cycle,proliferation,apoptosis,epithelial-mesenchymal transition,invasion,and *** low miR-545-3p expression is associated with poor prognosis in three cancer types,studies on miR-545-5p are yet to be ***-545-3p operates within a diverse range of regulatory networks,thereby augmenting the efficacy of cancer chemotherapy,radiotherapy,and ***,miR-545-5p enhances immunotherapy efficacy by inhibiting T-cell immunoglobulin and mucin-domain containing-3(TIM-3)*** summary,miR-545 holds immense potential as a cancer biomarker and therapeutic *** aberrant expression and regulatory mechanisms of miR-545 in cancer warrant further investigation.

关键词： miR-545 Competing endogenous RNA Cell behavior Biomarker Therapeutic drug Immunotherapy

Gas exchange optimization in aircraft engines using sustainable aviation fuel:A design of experiment and genetic algorithm approach

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Energy and AI 2024年第3期17卷 261-280页

作者： Zheng Xu jinze Pei Shuiting Ding Longfei Chen Shuai Zhao Xiaowei shen Kun Zhu Longtao Shao Zhiming Zhong Huansong Yan Farong Du Xueyu Li Pengfei Yang shenghui Zhong Yu Zhou Hangzhou International Innovation Institute Beihang UniversityHangzhou311115China Research Institute of Aero-Engine Beihang UniversityBeijing102206China Civil Aviation University of China Tianjin300300China Aircraft/Engine Integrated System Safety Beijing Key Laboratory Beijing100083China Aero Engine Academy of China Beijing101304China School of Energy and Power Engineering Beihang UniversityBeijing100083China AVIC Chengdu Aircraft Design and Research Institute Chengdu610091China AVIC Nanjing Engineering Institute of Aircraft Systems Nanjing211106China School of Transportation Science and Engineering Beihang UniversityBeijing100083China Faculty of Science and Engineering University of Nottingham Ningbo ChinaNingbo315100China

The poppet valves two-stroke(PV2S)aircraft engine fueled with sustainable aviation fuel is a promising option for general aviation and unmanned aerial vehicle propulsion due to its high power-to-weight ratio,uniform torque output,and flexible valve ***,its high-altitude gas exchange performance remains unexplored,presenting new opportunities for optimization through artificial intelligence(AI)*** study uses validated 1D+3D models to evaluate the high-altitude gas exchange performance of PV2S aircraft *** valve timings of the PV2S engine exhibit considerable flexibility,thus the Latin hypercube design of experiments(DoE)methodology is employed to fit a response surface model.A genetic algorithm(GA)is applied to iteratively optimize valve timings for varying *** optimization process reveals that increasing the intake duration while decreasing the exhaust duration and valve overlap angles can significantly enhance high-altitude gas exchange *** optimal valve overlap angle emerged as 93°CA at sea level and 82°CA at 4000 m *** effects of operating parameters,including engine speed,load,and exhaust back pressure,on the gas exchange process at varying altitudes are further *** higher engine speed increases trapping efficiency but decreases the delivery ratio and charging efficiency at various *** effect is especially pronounced at elevated *** increase in exhaust back pressure will significantly reduce the delivery ratio and increase the trapping *** study demonstrates that integrating DoE with AI algorithms can enhance the high-altitude performance of aircraft engines,serving as a valuable reference for further optimization efforts.

关键词： Poppet valves two-stroke Design of experiment Genetic algorithm optimization Heavy fuel aircraft engine High altitude gas exchange performance

Thermo-responsive functionalized PNIPAM@Ag/Ag3PO4/CN-heterostructure photocatalyst with switchable photocatalytic activity

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Chinese Journal of Catalysis 2020年第10期41卷 1573-1588页

作者： Linlin Sun Yaju Zhou Xin Li jinze Li Dong shen Shikang Yin Huiqin Wang Pengwei Huo Yongsheng Yan Institute of Green Chemistry and Chemical Technology School of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang 212013JiangsuChina School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

It is extremely important for photocatalysts to exhibit intelligent responsiveness to their environment. Herein, a poly N-isopropyl acrylamide(PNIPAM)-modified Ag/Ag3PO4-20/CN hybrid material with excellent convertible photocatalytic activity is prepared. PNIPAM has good hydrophilicity below the lower critical solution temperature(LCST);this increases the capacity of the photocatalyst for adsorbing tetracycline(TC) molecules. In addition, the PNIPAM-modified Ag/Ag3PO4-20/CN can prevent the loss of Ag3PO4. The dispersity is improved by loading g-C3N4 nanosheets(CN) for enhancing the efficiency of photocatalytic activity. Furthermore, a Z-scheme heterostructure is formed between CN and Ag3PO4, accelerating the separation efficiency of the holes and electrons. Ag nanoparticles can be used as electron-shuttle mediators, and electrons receiving more energy are transferred via the localized surface plasmon resonance(LSPR) effect. Furthermore, the PNIPAM@Ag/Ag3PO4-20/CN photocatalyst exhibits an excellent degradation rate for the degradation of TC when the temperature is lower than the LCST. The photoluminescence spectra and photocurrent curves prove that the carrier-separation efficiency of PNIPAM@Ag/Ag3PO4-20/CN is higher than those of Ag/Ag3PO4/CN and CN. The main active species of ·O2-and h+ are detected to reveal the plausible mechanism of the PNIPAM@Ag/Ag3PO4-20/CN hybrid material system. This work provides a way to develop intelligent materials for switchable photocatalytic applications.

关键词： Intelligent responsiveness g-C3N4 nanosheets Ag3PO4 Ag Poly/N-isopropyl acrylamide

Sound Insulation Performance of Acoustic Metamaterials Based on Attachable Helmholtz Resonators

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Transactions of Nanjing University of Aeronautics and Astronautics 2022年第S1期39卷 23-31页

作者： ZUO Hongwei LI jinze shen Cheng YANG Shasha WANG Bin State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China Nanjing Center for Multifunctional Lightweight Materials and Structures(MLMS) Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong Kong 999077P.R.China School of Mechanical Engineering Nanjing Vocational University of Industry TechnologyNanjing 210023P.R.China Suzhou DingYu Energy Saving Equipment Co. Ltd.Suzhou 215213P.R.China

To address the control of low frequency noises,we propose an new perforated thin-plate acoustic metamaterials with the attachable Helmholtz resonator(AHR)which can be directly attached to the existing structure to suppress acoustic *** transmission loss of the aluminium plate with AHR has been simulated using the finite element method under a normal incident plane sound *** results show that AHR works well in the 50—500 Hz frequency band,with two peaks of insulation occurring and the corresponding frequency of the first insulation peak dropping to around 120 *** study of the effects of plate thickness,cavity depth,perforation radius and perforation length on the sound insulation performance of metamaterials demonstrates that the effective suppression of acoustic radiation at specific frequencies can be achieved by changing the acoustic radiation properties of the structure.

关键词： Helmholtz resonator acoustic metamaterials transmission loss