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Efficacy and Safety of Primary Radiotherapy in Combination with EGFR-TKIs for Non-Small Cell Lung Cancer Harboring EGFR Mutation

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Journal of Biosciences and Medicines 2024年第9期12卷 142-154页

作者： Dongxu Ao Meng Wang jinyuan xie Yang Zhang Xinran Zhang Ya Shu Chenshi Lin Qingqing Ye Department of Oncology The First Affiliated Hospital of Yangtze University Jingzhou China Department of Joint Surgery and Sports Medicine Jingmen Central Hospital Jingmen China Department of Breast Surgery The First Affiliated Hospital of Yangtze University Jingzhou China

Objective: To evaluate the efficacy and safety of EGFR-TKI with the radiotherapy in EGFR mutant metastatic NSCLC. Methods: Retrospective analysis of 72 patients with stage IV lung cancer with EGFR-sensitive mutation. Patients in the A group were treated with the first-generation EGFR-TKI (Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor) combined with radiotherapy for primary tumors (34 cases). The B group was treated with the first-generation EGFR-TKI alone until the disease progressed (38 cases). PFS, OS, pulmonary infection and hematological toxicity during treatment were commented in both groups. Results: The objective remission rate was 47.1% (16/34) in the A group and 21.1% (8/38) in the B group. There was a significant difference between the two groups. There was no significant difference in hematological toxicity between the A group and the B group. There were 10 patients (29.4%) with degree II pulmonary infection in the A group and 3 patients (7.9%) in the B group. The difference between the two groups was statistically significant, suggesting that the incidence of pneumonia in the A group was higher than that in the B group. The median PFS (Progression-Free Survival)) and OS (Overall Survival) of the A group were significantly longer than those of the B group (16.5 months vs 9 months) and the median OS (36 months vs 19 months). The PFS and OS in the A group were significantly longer than those in the B group. Conclusion: EGFR-TKI combined with primary radiotherapy can significantly prolong the drug resistance time of EGFR mutant metastatic NSCLC.

关键词： Non-Small Cell Lung Cancer Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Radiotherapy

Quantitative estimation and spatial reconstruction of urban and rural construction land in Jiangsu Province, 1820-1985

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Journal of Geographical Sciences 2017年第10期27卷 1185-1208页

作者： xie jinyuan JIN Xiaobin LIN Yinan CHENG Yinong YANG Xuhong BAI Qing ZHOU Yinkang School of Geographic and Oceanographic Sciences Nanjing University Nanjing 210023 China Natural Resources Research Center of Nanjing University Nanjing 210023 China School of History and Archives Yunnan University Kunming 650091 China

Land cover is the most evident landscape signal to characterize the influence of human activities on terrestrial ecosystems. Since the industrial revolution, the expansion of construction land has profoundly changed the status of land use coverage and changes. This study is proposed to reconstruct the spatial pattern of construction land （urban construction land and rural settlement land） for five historical periods over the past 200 years in Jiangsu Province with 200 m × 200 m grids on the basis of quantitative estimation. Urban construction land is estimated based on data about city walls, four gates along walls, and other socio-economic factors. Rural settlement land is calculated based on the rural population and per capita housing allowance. The spatial pattern of historical construction land is simulated based on the distribution of modern construction land in 1985 with a quantitative-boundary- suitability control method and thorough consideration over connectivity of different land use types. The study concludes that：（1） the amount of construction land in Jiangsu Province is estimated at 963.46 km^2 in 1820, 1043.46 km^2 in 1911, 1672.40 km^2 in 1936, 1980.34 km^2 in 1952 and 10,687.20 km^2 in 1985; and （2） the spatial distribution of construction land features the great proclivity to water bodies and main roads and the strong polarization of existent residence. The results are verified directly and indirectly by applying the trend verification of construction land changes and patterns, the correlation analysis between rural settlement land and local arable land, and quantitative accuracy test of the reconstructed construction land to actual historical survey maps covering four sample regions in 1936.

关键词： construction land reconstruction grid past 200 years Jiangsu

An alternative approach to improve the compatibility of PCE in cement paste blend with coal gangue powder

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Waste Disposal and Sustainable Energy 2024年第1期6卷 139-150页

作者： Zonglin xie Yuxuan Li Dahui Sun Yi Tian jinyuan Hu Qiang Yuan Zheng Chen School of Civil Engineering Central South UniversityChangshaChina China Railway NO.9 Group CO. LTDShenyangChina National Engineering Research Center for High-Speed Railway Construction Technology ChangshaChina Guangxi Key Laboratory of Disaster Prevention and Engineering Safety Guangxi UniversityNanningChina

Coal gangue(CG)is an environmental waste that faces an urgent demand for disposal in *** utilization of CG in construction materials has broad application prospects and gained increasing ***,the poor compatibility of polycarboxylate superplasticizer(PCE)with CG powder hinders its efficiency in a wide range of ***,this paper attempts to improve the compatibility of PCE with CG powder in cement paste based on the regulation of aggregation and the adsorption behavior of *** light scattering(DLS)and fluorescence spectroscopy tests were carried out to understand the improved *** results indicated that the addition of CG powder increases the ionic strengths of the cement liquid phase,which makes PCE tend to aggregate at a lower concentration compared with no CG powder ***(CH_(3)COO)_(2)Cu is beneficial for enhancing the workability of cement paste by reducing PCE aggregation while maintaining the compressive strength of cement ***,(CH_(3)COO)_(2)Cu extra addition can be regarded as an effective and sustainable way to improve the workability of cement paste with CG powder.

关键词： Coal gangue powder Polycarboxylate superplasticizer Compatibility Aggregation

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高位自卸汽车的设计

汽车技术 1989年第3期 11-16,10页

作者：谢金元谢玉兵湖北汽车改装厂

论述了高位自卸汽车的方案选定,介绍了该车的主要结构、工作原理及液压传动系统的设计计算。

关键词：汽车自卸汽车设计高位

深度贫困地区农村人口金融能力测评及影响因素分析

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财经理论与实践 2020年第3期41卷 25-30页

作者：罗荷花谢晋元湖南农业大学经济学院湖南长沙410128

选取我国湖南省、湖北省、江西省和陕西省四个省份中九个深度贫困县的1058户农村人口的调研数据,从金融知识、金融意识、金融技能、金融行为四个方面对农村人口金融能力进行测评,分析其影响因素,结果显示:深度贫困地区农村人口金融能力... 详细信息

选取我国湖南省、湖北省、江西省和陕西省四个省份中九个深度贫困县的1058户农村人口的调研数据,从金融知识、金融意识、金融技能、金融行为四个方面对农村人口金融能力进行测评,分析其影响因素,结果显示:深度贫困地区农村人口金融能力整体较低,且贫困人口比非贫困人口的金融能力更低;农村人口金融能力受金融教育时间、受教育程度、家庭社会关系、家庭人均收入等因素影响;农村贫困人口与非贫困人口金融能力的影响因素各有异同。

关键词：深度贫困地区金融能力异质性农村人口

Mass extinctions, their causes and consequences: an interview with Douglas *** and Shuzhong Shen

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National Science Review 2024年第1期11卷 66-70页

作者： Shucheng xie State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences at Wuhan

‘Mass extinctions’ have been a hot topic for several decades. What triggers a mass extinction? How does a mass extinction impact the evolution of life? How does our ecosystem recover after a mass extinction? These questions attracted the interest of both scientists and the public *** spoke to two renowned researchers in the field of mass extinctions: Prof. Douglas H. Erwin from the National Museum of Natural History of the USA, and Prof. Shuzhong Shen from Nanjing University, China.

关键词： Stratigraphy

预应力混凝土-ECC复合功能梯度构件抗弯性能研究

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铁道科学与工程学报 2023年第6期20卷 2280-2293页

作者：杨刚冯凡丁谢金元金伟姜清辉武汉大学土木建筑工程学院湖北武汉430072 中国电建集团成都勘测设计研究院有限公司四川成都610072

预应力与纤维水泥基材料均可有效限制混凝土结构开裂,进而提高结构耐久性。为研究两者联合使用的力学性能与双重阻裂效应,研发了预应力混凝土与超高韧性水泥基复合材料(Engineered Cementitious Composite,ECC)组合形成的新型功能梯度... 详细信息

预应力与纤维水泥基材料均可有效限制混凝土结构开裂,进而提高结构耐久性。为研究两者联合使用的力学性能与双重阻裂效应,研发了预应力混凝土与超高韧性水泥基复合材料(Engineered Cementitious Composite,ECC)组合形成的新型功能梯度构件。根据ECC替换受拉区混凝土高度的不同,设计4组不同类型的功能梯度试件以及1组普通钢筋混凝土试件并开展四点弯曲试验,研究预应力与ECC材料对试件起裂荷载、正常使用极限状态、变形能力、钢筋与钢绞线应变、裂缝间距与宽度以及裂缝的扩展特性的影响。试验结果表明:预应力以及ECC材料均对试件的起裂荷载有提升作用,两者结合使用下,试件起裂荷载较普通混凝土试件提升了100%左右,其中预应力对起裂荷载的影响更大。ECC的加入对试件的正常使用极限状态有着明显改善,使正常使用极限状态对应荷载值提升至0.81~0.95倍的极限承载力。试件的延性也随着ECC替换的比例增大,得到显著提升,延性提升了58.1%~94.9%。预应力筋在钢筋屈服前为非主要受力筋,在钢筋屈服后成为主要受力筋继续承担荷载,此外,预应力与ECC二者均对钢筋的屈服有延缓作用并随着ECC替换比例的提高而增强,极大地改善了结构的耐久性。对于裂缝,两者结合使用极大地限制了裂缝的出现与发展,使得试件在中低荷载下保持不裂,高荷载下保持裂而不扩。最后基于试验数据修正了规范给出的裂缝计算公式,公式中考虑了对钢筋等效应力的折减、材料和替换比例等因素,提出了适用于预应力功能梯度构件的裂缝计算公式,为进一步研究预应力功能梯度构件的裂缝计算提供了基础。

关键词：功能梯度超高韧性水泥基复合材料抗弯性能双重阻裂裂缝计算

异质性国际资本流动对经济增长的影响——基于面板平滑转换模型

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财经理论与实践 2018年第3期39卷 31-37页

作者：何娟文谢晋元胡琼湖南大学金融与统计学院湖南长沙410079 湖南农业大学经济学院湖南长沙410128

通过建立面板平滑转换模型(PSTR),以资本账户开放度作为门限变量,以贸易开放度、总国内储蓄率和金融发展程度作为控制变量,研究新兴经济体异质性国际资本流动对经济增长的影响。结果发现:两者之间存在非线性关系,且当资本账户开放度从... 详细信息

通过建立面板平滑转换模型(PSTR),以资本账户开放度作为门限变量,以贸易开放度、总国内储蓄率和金融发展程度作为控制变量,研究新兴经济体异质性国际资本流动对经济增长的影响。结果发现:两者之间存在非线性关系,且当资本账户开放度从低体制状态向高体制状态转变时,直接投资的促进作用越来越显著,证券投资的促进作用逐渐减小,其他投资的促进作用由显著到不显著。为此,应平稳有序地推进我国资本账户开放,合理确定吸引国际资本流入的结构,保持较高的贸易开放度和储蓄率,以及合适的金融发展程度。

关键词：异质性国际资本流动经济增长非线性影响面板平滑转换模型

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地下厂房岩锚梁接触面非线性有限元模拟方法

工程科学与技术 2017年第4期49卷 70-77页

作者：王小威陈俊涛谢金元肖明邓建武汉大学水资源与水电工程科学国家重点实验室湖北武汉430072 武汉大学水工岩石力学教育部重点实验室湖北武汉430072 中国电建成都勘测设计研究院有限公司四川成都610072

地下厂房岩锚梁接触面是岩锚梁整体结构薄弱环节,建立合理的接触面模拟方法是岩锚梁有限元数值分析的重要内容。针对地下厂房岩锚梁与围岩接触问题,分别构建模拟岩锚梁与围岩接触面非线性特征的有限元数学模型和力学模型。在Desai薄层... 详细信息

地下厂房岩锚梁接触面是岩锚梁整体结构薄弱环节,建立合理的接触面模拟方法是岩锚梁有限元数值分析的重要内容。针对地下厂房岩锚梁与围岩接触问题,分别构建模拟岩锚梁与围岩接触面非线性特征的有限元数学模型和力学模型。在Desai薄层单元基础上,推导岩锚梁接触面单元有限元数学模型,该数学模型形式简单,便于有限元计算;结合非线性弹性理论和弹塑性理论,提出岩锚梁接触面3维非线性力学模型,该力学模型能够模拟岩锚梁接触面弹性阶段的非线性现象和塑性阶段的损伤软化现象。针对岩锚梁接触面闭合、张开、剪切滑动等变形特征,提出考虑接触面黏结、开裂、滑移现象的分段式抗滑安全系数。详细论述了所提模型的有限元实现方法,并据此编写了有限元程序。将本文模型应用于某地下厂房岩锚梁有限元分析计算中,与接触面等效连续模型相比,所提模型计算得到的岩锚梁梁体应力稍小,荷载更多的是由长锚杆承担,梁体的整体变形量增加了2~3 mm,说明接触面的存在使得岩锚梁整体稳定性降低,岩锚梁接触面处的安全系数也稍小,局部出现拉裂损伤,与实际工程岩锚梁接触面开裂现象相吻合,说明所提模型能够合理反映岩锚梁接触面非线性接触特征。为地下厂房岩锚梁稳定分析提供了一种有效的有限元分析方法。

关键词：岩锚梁接触面非线性力学模型损伤软化有限元模拟