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Journal of Environmental Sciences 2024年第7期141卷 194-204页

作者： Tingting Xie Liming Cao jinyi zheng Peng Xuan Xiaofeng Huang Laboratory of Atmospheric Observation Supersite School of Environment and EnergyPeking University Shenzhen Graduate SchoolShenzhen 518055China

Effective density(ρ_(eff))is one of the most important physical properties of atmospheric particles,providing important references in exploring the emissions and aging processes of fresh *** this study,a combined system of differential mobility analyzer,centrifugal particle mass analyzer,and condensation particle counter was used to periodically measure theρ_(eff)of atmospheric particles in Shenzhen from Oct.2021 to *** showed that theρ_(eff)of particles with various size presented a bimodal distribution,which could be divided into main density(ρ_(m),main peak,corresponding to relatively dense particles after aging)and sub density(ρ_(s),sub peak,corresponding to fresh particles).The occurrence frequencies ofρ_(s)of particles with diameters of 50 and 80 nm were less than 20%,but were as high as about 40%of that with diameters from 120 to 350 ***ρ_(m)showed increasing trend with the size of particles,whileρ_(s)decreased as the increasing of the size of ***ρ_(eff)on pollution day varied significantly with chemical *** increasing of the proportion of sulfate could promote the increasing ofρ_(eff),while black carbon and organic matter caused opposite effects,which may be related to various factors,including the difference of the material density and morphology of various chemical ***ρ_(eff)of 50,80 and 120 nm particles decreased considerably during the new particle formation event,indicating that organic condensation was an important contributor to new particle growth.

关键词： DMA-CPMA-CPC Effective density Main/sub density Size distribution

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改进RRT算法的采摘机械臂路径规划

重庆理工大学学报（自然科学） 2024年第1期38卷 338-345页

作者：赵辉郑缙奕岳有军王红君天津理工大学电气工程与自动化学院天津300384 天津市复杂系统控制理论与应用重点实验室天津300384

针对采用传统的快速随机扩展树(RRT)算法的采摘机械臂在果园工作环境中搜索路径时间长,最终路径不平滑、拐点多等问题,提出了一种改进的RRT避障算法。改进的算法采用高斯采样策略,减少了采样的随机性,避免产生更多不必要的随机树,增加... 详细信息

针对采用传统的快速随机扩展树(RRT)算法的采摘机械臂在果园工作环境中搜索路径时间长,最终路径不平滑、拐点多等问题,提出了一种改进的RRT避障算法。改进的算法采用高斯采样策略,减少了采样的随机性,避免产生更多不必要的随机树,增加规划的导向性;再添加A*代价函数去除路径的冗余点,最后使用贪婪算法简化路径,减少拐点,让机械臂可以快速、准确、平稳地沿着最佳路径运动到目标点。仿真表明,改进后的算法有效地减少了路径规划的时间,缩短了路径长度,具有良好的可行性和有效性。

关键词：机械臂 RRT 高斯采样贪婪算法

Author correction to‘3-O-Acetyl-11-keto-bboswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma’[Acta Pharm Sin B 10(2020)301-312]

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3783-3784页

作者： Wan Li Liwen Ren Xiangjin zheng jinyi Liu Jinhua Wang Tengfei Ji Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China

The authors apologize for two inadvertent mistakes in Fig.5:the image of immunofluorescence of LC3B in the Vehicle group(Fig.5c)and the image of transmission electron microscope in the AKBA 10 mmol/L group(Fig.5f)were provided *** corrected Fig.5 is shown *** original data of these figures have been provided to the Editorial Office,and the corresponding authors or the Editorial Office can be contacted for original data access.

关键词： correction Office image

Correction: MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3533-3536页

作者： Qin Tang Wan Li Xiangjin zheng Liwen Ren jinyi Liu Sha Li Jinhua Wang Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical College 100050 Beijing China

After online publication of the article[1]the authors noticed inadvertent errors in the panel of 95-D cells(+MELK and-siSlug)invasion in Fig.2J which is partly overlapped with the panel of the 95-D cells(+MELK and+siS... 详细信息

关键词： MMP7 metastasis death

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手术对颅脑损伤病人血清心肌酶的影响

中国现代医生 2011年第5期49卷 4-5,16页

作者：章剑郑金意郑元回浙江省苍南县人民医院神经外科浙江苍南325800

目的探讨应用手术治疗与非手术治疗颅脑损伤并发心肌损伤患者的血清心肌酶的变化及对脑心综合征的治疗方法。方法选择出血量为15～40mL、GCS 9～15分的颅脑损伤病人,非手术治疗和手术治疗各20例。外伤24h、3d、7d和15d抽晨血测定心肌酶... 详细信息

目的探讨应用手术治疗与非手术治疗颅脑损伤并发心肌损伤患者的血清心肌酶的变化及对脑心综合征的治疗方法。方法选择出血量为15～40mL、GCS 9～15分的颅脑损伤病人,非手术治疗和手术治疗各20例。外伤24h、3d、7d和15d抽晨血测定心肌酶谱,对照组40例为同期健康体检者。结果颅脑损伤后24h、3d、7d血清AST、CK、CKMB、LDH高于对照组(P0.05)。结论颅脑损伤病人多合并心肌损伤,血清心肌酶呈现动态变化,24h开始升高,3d达到高峰,后逐渐下降,15d接近正常水平;手术不能从根本上治疗颅脑损伤并发的心肌损伤,应采取综合措施治疗脑心综合征。

关键词：手术颅脑损伤心肌损伤心肌酶

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钢管预置集料混凝土中长柱受压性能试验

中南大学学报（自然科学版） 2024年第6期55卷 2247-2259页

作者：吕晶郑健龙韩文超张金翼赵欢长安大学建筑工程学院陕西西安710061

为了探究钢管预置集料混凝土中长柱受压性能,首先,考虑混凝土类型、混凝土强度、径厚比、长径比和偏心率等参数影响,设计了11根钢管预置集料混凝土中长柱和3根普通钢管混凝土中长柱;其次,通过轴压和偏压试验,并结合有限元分析法,研究了... 详细信息

为了探究钢管预置集料混凝土中长柱受压性能,首先,考虑混凝土类型、混凝土强度、径厚比、长径比和偏心率等参数影响,设计了11根钢管预置集料混凝土中长柱和3根普通钢管混凝土中长柱;其次,通过轴压和偏压试验,并结合有限元分析法,研究了试件破坏形态、承载力、变形特征等变化规律;最后,基于极限平衡理论,提出了适用于钢管预置集料混凝土中长柱轴压与偏压承载力计算公式。研究结果表明:钢管预置集料混凝土中长柱破坏形态与普通钢管混凝土中长柱的破坏形态相似,均为弯曲失稳破坏;钢管预置集料混凝土中长柱承载能力与普通钢管混凝土中长柱承载能力相当,但钢管预置集料混凝土试件轴向刚度是普通钢管混凝土试件轴向刚度的1.2倍左右,表现出良好的抗变形能力;钢管预置集料混凝土中长柱径厚比由39.75降低至19.88,承载能力提高33.8%;长径比由6增大至15时,承载能力降低20.5%;偏心率由0.25增大至1.0时,承载力降低49.5%;钢管预置集料混凝土中长柱稳定系数受混凝土强度和径厚比影响较小,但随着长径比和偏心率增大而近乎呈线性降低趋势。本文提出的承载力计算公式可为钢管预置集料混凝土中长柱设计提供参考。

关键词：钢管混凝土预置集料混凝土中长柱受压性能承载力计算方法

循证护理知识基于思维导图呈现在军队老干部前列腺增生围手术期的应用价值

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基层医学论坛 2022年第12期26卷 14-17页

作者：郑金一柴佳丽中国人民解放军联勤保障部队第901医院安徽合肥230031

目的探讨循证护理知识借助于思维导图(Mind map,MP)呈现在老干部前列腺增生围手术期的应用效果。方法选取中国人民解放军联勤保障部队第901医院2016年8月—2020年8月期间行前列腺等离子电切术的军队老干部32例,按照入院时间分为2组,即... 详细信息

目的探讨循证护理知识借助于思维导图(Mind map,MP)呈现在老干部前列腺增生围手术期的应用效果。方法选取中国人民解放军联勤保障部队第901医院2016年8月—2020年8月期间行前列腺等离子电切术的军队老干部32例,按照入院时间分为2组,即常规护理组(RN组)和循证护理知识借助于思维导图呈现组(MP+EBN组),每组16例。比较2组患者护理宣教时间、疾病知识知晓情况及患者的依从性,术后并发症发生率和留置尿管时间。结果MP+EBN组的宣教时间少于RN组,差异有统计学意义(P<0.05);MP+EBN组对疾病知识知晓情况评分高于RN组,差异有统计学意义(P<0.05);MP+EBN组的护理依从性明显高于RN组,差异有统计学意义(P<0.05);MP+EBN组术后并发症发生率明显低于RN组,差异有统计学意义(P<0.05);MP+EBN组留置尿管时间短于RN组,差异有统计学意义(P<0.05)。结论将循证护理知识借助于思维导图模式呈现,利于老年患者理解,且提高依从性和缩短了宣教时间,降低术后并发症发生率,缩短了留置尿管时间,值得临床推广。

关键词：良性前列腺增生循证护理知识思维导图呈现护理价值

外伤性和血管性颅内出血患者心肌酶谱对比分析

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全科医学临床与教育 2007年第1期5卷 44-46页

作者：郑元回章剑郑金意谢玉程苍南县人民医院脑外科浙江苍南325800 苍南县人民医院检验科浙江苍南325800

目的探讨外伤性和血管性颅内出血患者心肌酶谱值变化对病情严重程度的影响及其与出血性质的关系方法选择外伤性和血管性颅内出血患者各40例分两组,入院时行GCS评分3-8分、9-15分重新分两组,入院24h内测定血清AST、CK、CKMB、LDH,同期健... 详细信息

目的探讨外伤性和血管性颅内出血患者心肌酶谱值变化对病情严重程度的影响及其与出血性质的关系方法选择外伤性和血管性颅内出血患者各40例分两组,入院时行GCS评分3-8分、9-15分重新分两组,入院24h内测定血清AST、CK、CKMB、LDH,同期健康体检者40例为对照组。将测定值分别进行对比分析。结果外伤性和血管性颅内出血患者血清心肌酶值均高于对照组有统计学意义;外伤性与血管性颅内出血患者血清心肌酶值升高对比无统计学意义;GCS 3-8分组、GCS 9-15分组与对照组两两对比均有统计学意义。结论外伤性和血管性颅内出血患者急性期血清心肌酶谱值的升高程度与出血性质无明显相关性,而与病情严重程度相关,可作为判断预后的指标之一。

关键词：外伤性颅内出血血管性颅内出血心肌酶谱临床分析

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1651-1664页

作者： Xiong Xie Qiaoshuai Lan jinyi Zhao Sulin Zhang Lu Liu Yumin Zhang Wei Xu Maolin Shao Jingjing Peng Shuai Xia Yan Zhu Keke Zhang Xianglei Zhang Ruxue Zhang jian Li Wenhao Dai Zhen Ge Shulei Hu Changyue Yu Jiang Wang Dakota Ma Mingyue zheng Haitao Yang Gengfu Xiao Zihe Rao Lu Lu Leike Zhang Fang Bai Yao Zhao Shibo Jiang Hong Liu Drug Discovery and Design Center State Key Laboratory of Drug ResearchCAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghai 200032China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China School of Chinese Materia Medica Nanjing University of Chinese Medicine138 Xian Lin RoadJiangsu 210023 NanjingChina School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China National Clinical Research Center for Infectious Disease Shenzhen Third People's HospitalShenzhen 518112China

Respiratory disease caused by coronavirus infection remains a global health *** several SARS-CoV-2-specific vaccines and direct-acting antivirals are available,their effcacy on emerging coronaviruses in the future,including SARS-CoV-2 variants,might be ***-targeting antivirals provide preventive and therapeutic strategies to overcome resistance and manage future outbreak of emerging *** L(CTSL)and calpain-1(CAPN1)are host cysteine proteases which play crucial roles in coronaviral entrance into cells and infection-related immune ***,two peptidomimetic a-ketoamide compounds,14a and 14b,were identified as potent dual target inhibitors against CTSL and *** X-ray crystal structures of human CTSL and CAPN1 in complex with 14a and 14b revealed the covalent binding of a-ketoamide groups of 14a and 14b to C25 of CTSL and C115 of *** showed potent and broad-spectrum anticoronaviral activities in vitro,and it is worth noting that they exhibited low nanomolar potency against SARS-CoV-2 and its variants of concern(VOCs)with ECso values ranging from 0.80 to 161.7 nM in various *** mechanistic exploration indicated that they exhibited anticoronaviral activity through blocking viral ***,14a and 14b exhibited good oral pharmacokinetic properties in mice,rats and dogs,and favorable safety in *** addition,both 14a and 14b treatments demonstrated potent antiviral potency against SARS-CoV-2 XBB 1.16 variant infection in a K18-hACE2 transgenic mouse *** 14b also showed effective antiviral activity against HCoV-OC43 infection in a mouse model with a final survival rate of 60%.Further evaluation showed that 14a and 14b exhibited excellent antiinflammatory effects in Raw 264.7 mouse macrophages and in mice with acute *** together,these results suggested that 14a and 14b are promising drug candidates,providing novel insight into developing pan-coronavirus inhibitors with anti

关键词： calpain overcome entrance

城市高品质发展形势下做好流动摊贩市容管理提振地摊经济问题的对策研究——以深圳市龙岗区坪地街道为例

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特区经济 2024年第6期 50-53页

作者：郭征孔令斌张晋熠深圳龙岗区委党校培训科广东深圳518118 深圳市龙岗区坪地街道办事处广东深圳518118

自国务院发文提出支持发展地摊经济政策后,地摊经济被视为促进就业和经济社会发展的一项重要举措。但如何规范流动摊贩管理、确保城市环境品质不降级,也是众多城市在推进城市管理中的一个难点问题。本文以深圳市龙岗区坪地街道为例,通... 详细信息

自国务院发文提出支持发展地摊经济政策后,地摊经济被视为促进就业和经济社会发展的一项重要举措。但如何规范流动摊贩管理、确保城市环境品质不降级,也是众多城市在推进城市管理中的一个难点问题。本文以深圳市龙岗区坪地街道为例,通过对该街道流动摊贩基本情况、群体特点、存在问题以及执法困境等方面的分析研究,并学习借鉴北京、上海等大城市流动摊贩市容管理经验,提出了针对性的对策与措施,对破除管理困局具有积极的现实意义。

关键词：地摊经济流动摊贩规范管理执法困境