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In vitro antibacterial activity and major bioactive components of Cinnamomum verum essential oils against cariogenic bacteria,Streptococcus mutans and Streptococcus sobrinus

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Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 308-314页

作者： Okhee Choi Su Kyung Cho Junheon kim Chung Gyoo Park jinwoo kim Division of Applied Life Science (BK21 Plus) Gyeongsang National University Institute of Agriculture & Life Science Gyeongsang National University

Objective:To evaluate the antibacterial activity of Cinnamomum verum(***) from32 different essential oils against cariogenic bacteria,Streptococcus mutans(***)and Streptococcus sobrinus(***).Methods:The antibacterial activities of each essential oil were individually investigated against *** and *** essential oil of *** was selected for further evaluation against *** and *** chromatography mass spectrometry was used to determine the major constituents of *** essential *** addition,the minimum inhibitory concentration(MIC) and minimum bactericidal concentration of the most effective constituent was ***:The essential oil from *** exhibited the greatest antibacterial *** chromatography mass spectrometry analysis revealed that the major components of *** essential oil were cinnamaldehyde(56.3%),cinnamyl acetate(7.1%) and bphellandrene(6.3%).The MIC of cinnamaldehyde was measured using broth dilution *** MIC of cinnamaldehyde was 0.02%(v/v) against both bacterial strains *** minimum bactericidal concentration of cinnamaldehyde against *** and *** were 0.2% and 0.1%(v/v),***:The essential oil of *** and its major component cinnamaldehyde possessed considerable in vitro antibacterial activities against cariogenic bacteria,*** and *** *** results showed that the essential oil of *** and its bioactive component,cinnamaldehyde,have potential for application as natural agents for the prevention and treatment of dental caries.

关键词： Streptococcus mutans Streptococcus sobrinus Cariogenic bacteria Essential oil Antibacterial activity Cinnamaldehyde

Effect of Korean Magnolia obovata Extract on Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cells

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Chinese Journal of Integrative Medicine 2020年第9期26卷 677-682页

作者： Hyunjhung Jhun Suji Baek jinwoo kim Kang-Pa Lee Hun-Young Park Won-Hwan Park Kiwon Lim Jisu kim Technical Assistance Center Korea Food Research InstituteJeonbuk(55365)Republic of Korea Department of Medical Science School of MedicineKonkuk UniversitySeoulRepublic of Korea Department of Bio-Science College of Natural ScienceDongguk UniversityGyeongbuk(38066)Republic of Korea Physical Activity&Performance Institute Konkuk UniversitySeoul(05029)Republic of Korea Department of Diagnostic College of Korean MedicineDongguk University GoyangGyeonggi-do(10326)Republic of Korea

Objective:To investigate the effects of Korean Magnolia obovata crude extract(KME)on plateletderived growth factor(PDGF)-BB-induced proliferation and migration of vascular smooth muscle cells(VSMCs).Methods:KME composition was analyzed by high-performance liquid chromatography(HPLC).VSMCs were isolated from the aorta of a Sprague-Dawley rat,incubated in serum free-Dulbecco's modified Eagle's medium in the presence or absence of KME(10,30,100,and 300(xg/mL),then further treated with PDGF-BB(10 ng/mL).VSMC proliferation was detected using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and VSMC migration was determined using the Boyden chamber and scratch wound healing *** blot analysis was used to detect phosphorylation of extracellular signal-regulated protein kinases 1 and 2(p-ERK1/2),protein kinase B(p-Akt),and stress-activated protein kinase/c-Jun NH2-terminal kinase(p-SAPK/JNK).The antimigration and proliferation effects of KME were tested using aortic sprout ***:The HPLC analysis identified honokiol(0.45 mg/g)and magnolol(0.34 mg/g)as the major components of ***(30,100,and 300μg/m L)significantly decreased the proliferation and migration of PDGF-BB-stimulated(10 ng/mL)VSMCs and the PDGF-BB-induced phosphorylation of EKR1/2,Akt,and SAPK/JNK(P<0.05).Furthermore,PDGF-BBinduced VSMCs treated with 300μg/m L of KME showed reduction in aortic sprout ***:KME could inhibit abnormal proliferation and migration of VSMCs by down-regulating the phosphorylation of EKR1/2 and ***,KME might be a functional food for preventing vascular disorders.

关键词： extracellular signal-regulated protein kinases 1 and 2 Akt platelet-derived growth factor-BB smooth muscle cell functional food

Anti-quorum sensing and anti-biofilm formation activities of plant extracts from South Korea

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Asian Pacific Journal of Tropical Biomedicine 2018年第8期8卷 411-417页

作者： Okhee Choi Dong-Wan Kang Su Kyung Cho Yeyeong Lee Byeongsam Kang Juyoung Bae Seunghoe kim Jeong Hoon Lee Seung Eun Lee jinwoo kim Institute of Agriculture & Life Science Gyeongsang National University Gyeonsangnam-do Agriculture Extension Services Department of Plant Medicine Gyeongsang National University Division of Applied Life Science Gyeongsang National University National Institute of Horticultural and Herbal Science Rural Development Administration

Objective: To investigate anti-quorum sensing(anti-QS) and anti-biofilm formation(antiBF) activities of the ethanol extracts of 388 plants. Methods: The anti-QS activity of the plant extracts was evaluated by disc-diffusion assays using the bio-reporter strain, Chromobacterium violaceum CV017. Pseudomonas aeruginosa PAO1, Yersinia enterocolitica ATCC 9610, and Agrobacterium tumefaciens C58, which possess QS systems, were used to evaluate the antiBF activity of the plant extracts. Results: Among 388 plant extracts, the Cornus controversa(C. controversa) and Cynanchum wilfordii extracts exhibited the strongest anti-QS activity. The C. controversa extract exhibited anti-BF activity against Pseudomonas aeruginosa, Yersinia enterocolitica and Agrobacterium tumefaciens, whereas the Cynanchum wilfordii extract exhibited no anti-BF activity against Pseudomonas aeruginosa. In addition, the C. controversa extract suppressed soft rot of cabbage. Conclusions: The C. controversa extract inhibits bacterial QS and BF, and is capable of controlling soft rot. Therefore, this extract has potential for the prevention and treatment of bacterial infections and for the development of alternatives to antibiotics.

关键词： Plant extracts Quorum sensing Biofilm formation Cornus controversa

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林风眠与朴生光女性人物画比较研究

林风眠与朴生光女性人物画比较研究

作者： kim jinwoo 中国美术学院

学位级别：硕士

林风眠先生是中国现代美术界伟大的美术家及美术教育家,他为了中国艺术的发展而不断地努力与奋斗,这些努力的痕迹皆保留在其作品中。林先生主要画人物,其中又以女性人物占最多,如裸体女、古装仕女画、现代女性、戏曲人物等,他通过女性... 详细信息

林风眠先生是中国现代美术界伟大的美术家及美术教育家,他为了中国艺术的发展而不断地努力与奋斗,这些努力的痕迹皆保留在其作品中。林先生主要画人物,其中又以女性人物占最多,如裸体女、古装仕女画、现代女性、戏曲人物等,他通过女性人物的形象来实现及表达他所追求的美。韩国画家朴生光先生从小在日本习画,而后大半生的时间亦在日本画坛活动。虽然如此,但他本人却从没忘记过韩国画,朴先生通过长时间的沉潜研究,最终在其晚年成功的完成了他独特的画风。这些属于朴先生独特的画风皆反映了韩国的宗教、历史、文化等方面,取材的人物形象也表现了韩国历史的文化魅力,如韩国古装女性人物、裸体女、巫女、历史人物等,其中亦有不少女性人物主题,而这些女性为题材的作品蕴含了朴生光画风形成的主要因素。由于上述两位画家生活在同一个时代,并在相似的时代文化滋养下,形成了各自独特的画风。两位画家作品之形式语言有着共同点与差别。两位画家都非常重视各自国家的历史与美术史。他们很自然的将他们国家的传统艺术历史意识的反映在其画风之中,但是他们两人注重的不是为人所知的传统美术经典,而是民间艺术。林风眠绘画创作中借鉴不少敦煌壁画和民间陶瓷艺术等传统因子,这些传统因素的介入,使林风眠的绘画中呈现着中华传统民族的韵味与气质。而朴生光则借鉴了佛画、古建彩绘与民间绘画样式中的巫风俗图。虽然他们都使用民间艺术的独特因素,但各个画风上却表现出不一样的语言形式。本文基于上述的思考,欲将他们的艺术语言进行比较,从他们的女性人物画里固有的形式、色彩、构图等的要素为基础,总结出作为大画家如何形成各自独特的画风与对民族绘画奉献他们无尽地热情。本文中我把研究范围缩小到人物画语言的对比上,以便能更进一步地理解他们绘画语言的异同点。

关键词：形式语言朴生光林风眠女性人物画民间艺术

The 3D-printed titanium implant with pre-mounted dental implants for reconstruction of osteoradionecrosis of the mandible: Case Report and Literature Review

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The 3D-printed titanium implant with pre-mounted dental impl...

Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

2019第一届全国口腔颌面-头颈肿瘤学术大会——聚合引领、协同发展

作者：李静雯 ODKHUU-Michidgerel kim-jinwoo Ewha Womans University Medical Center

Purpose/Background:We proposed to review previous efforts to reconstruct the segmentally resected mandible and report the novel method of reconstructing the mandible with 3D-printed titanium implant with installed den... 详细信息

关键词： Reconstruction Dental Implant squamous cell carcinoma

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Research 2024年第1期2023卷 637-649页

作者： Hyun-Kyung So Hyebeen kim jinwoo Lee Chang-Lim You Chae-Eun Yun Hyeon-Ju Jeong Eun-Ju Jin Yunju Jo Dongryeol Ryu Gyu-Un Bae Jong-Sun Kang Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonKorea Single Cell Network Research Center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Diseases AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1(Prmt1)in muscle stem cell function and muscle *** the current study,we set out to determine the role of Prmt1 in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1(mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1 deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative stress,and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stress response in motor ***,Prmt1 inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1 ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1 is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

Spinodal decomposition:a new approach to hierarchically porous inorganic materials for energy storage

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National Science Review 2020年第11期7卷 1635-1637页

作者： Seongseop kim jinwoo Lee Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology (KAIST)

Hierarchically inorganic porous materials exhibit porosity on two or more distinct length scales, and therefore combine the benefits of the different pore sizes, which is highly desirable in a variety of applications in catalysis, separation and energy storage [1]. The macropores provide large diffusion pathways for rapid mass transfer and reservoirs for mass-buffering, and mesopores and micropores provide a high surface area [2].

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Functional Materials and Innovative Strategies for Wearable Thermal Management Applications

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Nano-Micro Letters 2023年第9期15卷 562-603页

作者： Yeongju Jung Minwoo kim Taegyeom kim Jiyong Ahn jinwoo Lee Seung Hwan Ko Applied Nano and Thermal Science Lab Department of Mechanical EngineeringSeoul National University1 Gwanak-roGwanak-guSeoul 08826South Korea Department of Mechanical Roboticsand Energy EngineeringDongguk University30 Pildong-ro 1-gilJung-guSeoul 04620South Korea Institute of Advanced Machinery and Design(SNU-IAMD) Seoul National UniversityGwanak-roGwanak-guSeoul 08826South Korea Institute of Engineering Research Seoul National University1 Gwanak-roGwanak-guSeoul 08826South Korea

Thermal management is essential in our body as it affects various bodily functions,ranging from thermal discomfort to serious organ failures,as an example of the worst-case *** have been extensive studies about wearable materials and devices that augment thermoregulatory functionalities in our body,employing diverse materials and systematic approaches to attaining thermal *** paper reviews the recent progress of functional materials and devices that contribute to thermoregulatory wearables,particularly emphasizing the strategic methodology to regulate body *** exist several methods to promote personal thermal management in a wearable *** instance,we can impede heat transfer using a thermally insulating material with extremely low thermal conductivity or directly cool and heat the skin ***,we classify many studies into two branches,passive and active thermal management modes,which are further subdivided into specific *** from discussing the strategies and their mechanisms,we also identify the weaknesses of each strategy and scrutinize its potential direction that studies should follow to make substantial contributions to future thermal regulatory wearable industries.

关键词： Thermal management Passive heat transfer Active heat transfer Wearable materials Wearable device

Micro Manipulation Using Magnetic Microrobots

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Journal of Bionic Engineering 2016年第4期13卷 515-524页

作者： Hoyeon kim Jamel Ali U Kei Cheang jinwoo Jeong din Seok kim Min dun kim Department of Mechanical Engineering Southern Methodist University Dallas TX75272 USA Department of MechanicaI Engineering and Mechanics Drexel University Philadelphia PA 19104 USA Center for Bionics Korea Institute of Science and Technology 5 Hwarang-ro 14-gil Seongbuk-gu Seou102792 Republic of Korea

When developing microscale robotic systems it is desired that they are capable of performing microscale tasks such as small scale manipulation and transport. In this paper, we demonstrate the transport of microscale objects using single or multiple microrobots in low Reynolds number fluidic environment. The microrobot is composed of a ‘U＇ shaped SU-8 body, coated on one side with nickel. Once the nickel coating is magnetized, the motion of the microrobots can be driven by external magnetic fields. To invoke different responses from two microrobots under a global magnetic field, two batches of microrobots were fabricated with different thicknesses of nickel coating as a way to promote heterogeneity within the microrobot population. The heterogeneity in magnetic content induces different spatial and temporal responses under the same control input, resulting in differences in movement speed. The nickel coated microstructure is manually controlled through a user interface developed using C＋＋. This paper presents a control strategy to navigate the microrobots by controlling the direction and strength of ex- ternally applied magnetic field, as well as orientation of the microrobots based on their polarity. In addition, multiple micro- robots are used to perform transport tasks.

关键词： microrobot magnetic control microtransport magnetic polarity micromanipulation