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Revision of bilateral self-expandable metallic stents placed using the stent-in-stent technique for malignant hilar biliary obstruction

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Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 437-442页

作者： Jun Hyuk Son Hee Seung Lee Sang Hyub Lee Seungmin Bang jinwoo kang Woo Hyun Paik Ji Kon Ryu Yong-Tae Kim Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul National University College of MedicineSeoulKorea Department of Internal Medicine Inje University Ilsan Paik HospitalGoyangKorea Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoulKorea Department of Gastroenterology and Hepatology SMG-SNU Boramae Medical CenterSeoulKorea

Background: Endoscopic biliary decompression using bilateral self-expandable metallic stent(SEMS) placed using the stent-in-stent(SIS) technique is considered favorable for unresectable malignant hilar biliary obstruction(MHBO). However, occlusion of the bilateral SIS placement is frequent and revision can be challenging. This study was performed to investigate the efficacy, the long-term patency and the appropriate approach for revision of occluded bilateral SIS placement in unresectable MHBO. Methods: From January 2011 to July 2016, thirty-eight patients with unresectable MHBO underwent revision of occluded bilateral SIS placement. Clinical data including success rates and patency of revision, were retrospectively analyzed. Results: The technical success rate of revision was 76.3%. The clinical success rate of revision was 51.7% and mean patency of revision was 49.1 days. No significant predictive factor for clinical failure of revision was observed. The cell size of SEMS was not found to have significant effects on clinical success rates or revision patency. Conclusions: Revision of occluded bilateral SIS placement for MHBO showed fair patency and clinical success rate. Revision method and cell size of SEMS were not found to influence clinical outcomes.

关键词： Malignant hilar biliary obstruction Self-expandable metallic stent Stent-in-stent Revision

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Folfirinox chemotherapy prolongs stent patency in patients with malignant biliary obstruction due to unresectable pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 590-595页

作者： jinwoo kang Sang Hyub Lee Jin Ho Choi Woo Hyun Paik Dong-Won Ahn Ji Bong Jeong Ji Kon Ryu Yong-Tae Kim Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul National University College of MedicineSeoulKorea Department of Internal Medicine SMG-SNU Boramae Medical CenterSeoulKorea

Background:Stent insertion for biliary decompression to relieve jaundice and subsequent biliary infection is necessary for patients with biliary obstruction caused by pancreatic cancer,and it is important to keep the stent patent as long as ***,few studies have compared stent patency in terms of chemotherapy in patients with pancreatic *** study aimed to evaluate the differences in stent patency in terms of recently evolving ***:Between January 2015 and May 2017,161 patients with pancreatic cancer who had undergone biliary stent insertion with a metal stent were retrospectively *** relationship between chemotherapy and stent patency was ***,overall survival according to the treatment,risk factors for stent patency,and long-term adverse events were ***:Median stent patency was 42 days for patients with the best supportive care and 217 days for patients with chemotherapy(conventional gemcitabine-based chemotherapy and folfirinox)(P<0.001).Furthermore,the folfirinox group showed the longest median stent patency and overall survival,with 283 days and 466 days,respectively(P<0.001)despite higher adverse events *** who underwent folfirinox chemotherapy after stent insertion had better stent patency in multivariate analysis(HR=0.26;95%CI:0.12–0.60;P=0.001).Conclusions:Compared with patients who received best supportive care only,patients who underwent chemotherapy after stent insertion had better stent *** prolonged stent patency can be expected for patients with folfirinox than conventional gemcitabine-based chemotherapy.

关键词： Stent patency Malignant distal biliary obstruction Pancreatic cancer Folfirinox Chemotherapy

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Fatty liver is an independent risk factor for gallbladder polyps

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World Journal of Gastroenterology 2020年第44期26卷 6979-6992页

作者： Dong-Won Ahn Ji Bong Jeong jinwoo kang Su Hwan Kim Ji Won Kim Byeong Gwan Kim Kook Lae Lee Sohee Oh Soon Ho Yoon Sang Joon Park Doo Hee Lee Department of Internal Medicine Seoul National University College of MedicineSeoul 03080South Korea Department of Internal Medicine Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061South Korea Department of Biostatistics Medical Research Collaborating CenterSeoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061South Korea Department of Radiology Seoul National University College of MedicineSeoul National University HospitalSeoul 03080South Korea Department of Research and Development MEDICALIP Co.Ltd.Seoul 03127South Korea

BACKGROUND Gallbladder polyps(GBPs)are known to be associated with obesity and metabolic ***,to date,the relationship between GBPs and abnormal body fat distribution,such as fatty liver,visceral obesity,or sarcopenia,has not yet been *** To evaluate whether GBPs are associated with fatty liver,visceral obesity,or *** We retrospectively reviewed the medical records of subjects who underwent various laboratory tests,body composition measurement with a non-invasive body composition analyzer,and abdominal ultrasonography during health checkups.A total of 1405 subjects with GBPs were compared with 2810 age-and sex-matched *** The mean age of the subjects was 46.8±11.7 years,and 63.8%were *** to multiple logistic regression analysis,the presence of fatty liver[odds ratio(OR)1.413;95%confidence interval(CI)1.218-1.638;P<0.001]was an independent risk factor for GBP,together with low levels of alanine aminotransferase(OR 0.993;95%CI 0.989-0.996;P<0.001).Additionally,fatty liver showed both independent(OR 1.629;95%CI,1.335-1.988;P<0.001)and dosedependent(moderate to severe fatty liver;OR 2.137;95%CI,1.662-2.749;P<0.001)relationship with large GBPs(≥5 mm).The presence of sarcopenia and high visceral fat area were not significantly associated with *** Fatty liver was found to be closely associated with GBPs irrespective of sarcopenia and visceral obesity.

关键词： Gallbladder polyp Fatty liver Sarcopenia Visceral obesity Risk factors Body fat distribution

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Material properties and machining performance of hybrid Ti_2AlN bulk material for micro electrical discharge machining

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中国有色金属学会会刊：英文版 2012年第S3期22卷 781-786页

作者： Eui-Seong CHOI jinwoo SUNG Qi-min WANG Kwang-Ho KIM Ahmed BUSNAINA Myung Chang kang National Core Research Center for Hybrid Materials Solution Pusan National University School of Mechanical and Electronic Engineering Guangdong University of Technology Department of Mechanical and Industrial Engineering College of EngineeringNortheastern University

Mn+1AXn(MAX) phases are a family of nanolaminated compounds that possess unique combination of typical ceramic properties and typical metallic *** a member of MAX phase,Ti2 AlN bulk materials are attractive for some high-temperature *** synthesis,characteristics and machining performance of hybrid Ti2 AlN bulk materials were focused on in this *** bulk samples mainly consisting of Ti2 AlN MAX phase with density close to theoretic one were synthesized by a spark plasma sintering *** electron microscopy results indicate homogenous distribution of Ti2 AlN grains in the ***-hardness values are almost constant under different loads (6-6.5 GPa).A machining test was carried out to compare the effect of material properties on micro-electrical discharge machining (micro-EDM) performance for Ti2 AlN bulk samples and Ti6242 *** machining performance of the Ti2 AlN sample is better than that of the Ti6242 *** inherent mechanism was discussed by considering their electrical and thermal conductivity.

关键词： hybrid Ti2AlN bulk micro-electrical discharge machining electrical conductivity micro-hole shape

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Spinodal decomposition:a new approach to hierarchically porous inorganic materials for energy storage

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National Science Review 2020年第11期7卷 1635-1637页

作者： Seongseop Kim jinwoo Lee Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology (KAIST)

Hierarchically inorganic porous materials exhibit porosity on two or more distinct length scales, and therefore combine the benefits of the different pore sizes, which is highly desirable in a variety of applications in catalysis, separation and energy storage [1]. The macropores provide large diffusion pathways for rapid mass transfer and reservoirs for mass-buffering, and mesopores and micropores provide a high surface area [2].

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Toward multicomponent mesoporous single-crystalline metal oxides

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National Science Review 2024年第5期11卷 92-93页

作者： Minkyeong Ban jinwoo Lee Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology (KAIST)

Mesoporous metal oxide materials have attracted significant interest due to their porous frameworks and large surface areas, finding applications in sensors, catalysis and energy storage [1]. The performance of these ... 详细信息

关键词： single metal crystalline mesoporous multicomponent oxides toward

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Detection of landuse/landcover changes using remotely-sensed data

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Journal of Forestry Research 2016年第6期27卷 1343-1350页

作者： jinwoo Park Jungsoo Lee Department of Forest Management College of Forest and Environmental Sciences Kangwon National University

We evaluated the use of spatial sampling and satellite images to identify deforested areas in Wonju, South Korea. The changes in land cover were identified using a grid of sample points overlaid onto medium and high-resolution remote sensing （RS） satellite images. Deforestation identified in this way （hereafter, RSD） was compared to administrative data on deforestation. We also compared high-resolution satellite images （HR-RSD） and actual deforestation based on categories which were Intergovernmental Panel on Climate Change data. RSD generated by medium-resolution satellite images overesti- mated the amount of deforested area by 1.5-2.4 times the actual deforested area, whereas RSD generated by HR- RSD underestimated the amount of deforested area by 0.4-0.9 times the actual area. The highest degree of matching （90 %） was found in HR-RSD with a grid interval of 500 m and the accuracy of HR-RSD was the highest, at 67 %. The results also revealed that the largest cause of deforestation was the establishment of settlements followed by conversion to cropland and grassland. We conclude that for the identification of deforestation using satellite images, HR-RSD with a grid interval of 500 m is most suitable.

关键词： Deforestation Spatial sampling method Remotely sensed data. Land cover change Spatial resolution

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Importance of nutrient availability for soluble microbial products formation during a famine period of activated sludge:Evidence from multiple analyses

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Journal of Environmental Sciences 2019年第10期31卷 112-121页

作者： Tahir Maqbool jinwoo Cho Jin Hur Department of Environment and Energy Sejong University

Much remains unknown about compositional variations in soluble microbial products(SMP)with the shift of the substrate condition from a feast to a famine phase in biological treatment *** study demonstrated that the formation of SMP could be suppressed by up to 75%during the famine phase with the addition of essential *** contrast,presence of electron acceptor did not play any significant role during the stress condition,showing the similar amounts of SMP(r=0.98,p0.95).The fluorescence excitation-emission matrix coupled with parallel factor analysis(EEM-PARAFAC)revealed the presence of four different fluorescent components,including two protein-like(C1 and C4),fulvic-like(C2),and humic-like(C3)components,in the SMP and bEPS formed at different *** C1 and C4 showed increasing trends(R^2>0.95)with the length of starvation in the bioreactors without essential *** availability was found to be a key factor to quench the production of large-sized *** study provides a wealth of information on operation conditions of activated sludge treatment systems to minimize large sized SMP molecules(particularly proteins),which typically exert many environmental concerns to effluent organic matter quality.

关键词： Soluble microbial products Nutrient availability EEM-PARAFAC SEC-OCD-OND Famine phase

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Effect of Korean Magnolia obovata Extract on Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cells

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Chinese Journal of Integrative Medicine 2020年第9期26卷 677-682页

作者： Hyunjhung Jhun Suji Baek jinwoo Kim kang-Pa Lee Hun-Young Park Won-Hwan Park Kiwon Lim Jisu Kim Technical Assistance Center Korea Food Research InstituteJeonbuk(55365)Republic of Korea Department of Medical Science School of MedicineKonkuk UniversitySeoulRepublic of Korea Department of Bio-Science College of Natural ScienceDongguk UniversityGyeongbuk(38066)Republic of Korea Physical Activity&Performance Institute Konkuk UniversitySeoul(05029)Republic of Korea Department of Diagnostic College of Korean MedicineDongguk University GoyangGyeonggi-do(10326)Republic of Korea

Objective:To investigate the effects of Korean Magnolia obovata crude extract(KME)on plateletderived growth factor(PDGF)-BB-induced proliferation and migration of vascular smooth muscle cells(VSMCs).Methods:KME composition was analyzed by high-performance liquid chromatography(HPLC).VSMCs were isolated from the aorta of a Sprague-Dawley rat,incubated in serum free-Dulbecco's modified Eagle's medium in the presence or absence of KME(10,30,100,and 300(xg/mL),then further treated with PDGF-BB(10 ng/mL).VSMC proliferation was detected using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and VSMC migration was determined using the Boyden chamber and scratch wound healing *** blot analysis was used to detect phosphorylation of extracellular signal-regulated protein kinases 1 and 2(p-ERK1/2),protein kinase B(p-Akt),and stress-activated protein kinase/c-Jun NH2-terminal kinase(p-SAPK/JNK).The antimigration and proliferation effects of KME were tested using aortic sprout ***:The HPLC analysis identified honokiol(0.45 mg/g)and magnolol(0.34 mg/g)as the major components of ***(30,100,and 300μg/m L)significantly decreased the proliferation and migration of PDGF-BB-stimulated(10 ng/mL)VSMCs and the PDGF-BB-induced phosphorylation of EKR1/2,Akt,and SAPK/JNK(P<0.05).Furthermore,PDGF-BBinduced VSMCs treated with 300μg/m L of KME showed reduction in aortic sprout ***:KME could inhibit abnormal proliferation and migration of VSMCs by down-regulating the phosphorylation of EKR1/2 and ***,KME might be a functional food for preventing vascular disorders.

关键词： extracellular signal-regulated protein kinases 1 and 2 Akt platelet-derived growth factor-BB smooth muscle cell functional food

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Anti-quorum sensing and anti-biofilm formation activities of plant extracts from South Korea

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Asian Pacific Journal of Tropical Biomedicine 2018年第8期8卷 411-417页

作者： Okhee Choi Dong-Wan kang Su Kyung Cho Yeyeong Lee Byeongsam kang Juyoung Bae Seunghoe Kim Jeong Hoon Lee Seung Eun Lee jinwoo Kim Institute of Agriculture & Life Science Gyeongsang National University Gyeonsangnam-do Agriculture Extension Services Department of Plant Medicine Gyeongsang National University Division of Applied Life Science Gyeongsang National University National Institute of Horticultural and Herbal Science Rural Development Administration

Objective: To investigate anti-quorum sensing(anti-QS) and anti-biofilm formation(antiBF) activities of the ethanol extracts of 388 plants. Methods: The anti-QS activity of the plant extracts was evaluated by disc-diffusion assays using the bio-reporter strain, Chromobacterium violaceum CV017. Pseudomonas aeruginosa PAO1, Yersinia enterocolitica ATCC 9610, and Agrobacterium tumefaciens C58, which possess QS systems, were used to evaluate the antiBF activity of the plant extracts. Results: Among 388 plant extracts, the Cornus controversa(C. controversa) and Cynanchum wilfordii extracts exhibited the strongest anti-QS activity. The C. controversa extract exhibited anti-BF activity against Pseudomonas aeruginosa, Yersinia enterocolitica and Agrobacterium tumefaciens, whereas the Cynanchum wilfordii extract exhibited no anti-BF activity against Pseudomonas aeruginosa. In addition, the C. controversa extract suppressed soft rot of cabbage. Conclusions: The C. controversa extract inhibits bacterial QS and BF, and is capable of controlling soft rot. Therefore, this extract has potential for the prevention and treatment of bacterial infections and for the development of alternatives to antibiotics.

关键词： Plant extracts Quorum sensing Biofilm formation Cornus controversa

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